8507 results
Cited 2 times since 2022 (0.5 per year)
source: EuropePMC
Preventive veterinary medicine,
Volume 200, 25 4 2022, Pages 105582
Capacity of a Bayesian model to detect infected herds using disease dynamics and risk factor information from surveillance programmes: A simulation study.
Mercat M, van Roon AM, Santman-Berends I, van Schaik G, Nielen M, Graham D, More SJ, Guelbenzu-Gonzalo M, Fourichon C, Madouasse A
Control programmes against non-regulated infectious diseases of farm animals are widely implemented. Different control programmes have different definitions of "freedom from infection" which can lead to difficulties when trading animals between countries. When a disease is still present, in order to identify herds that are safe to trade with, estimating herd-level probabilities of being infected when classified "free from infection" using field data is of major interest. Our...
Abstract
Cited 38 times since 2022 (10 per year)
source: EuropePMC
Neurology,
Volume 98, Issue 4, 24 4 2022, Pages e343-e351
Cardiovascular Risk Factors and MRI Markers of Cerebral Small Vessel Disease: A Mendelian Randomization Study.
Taylor-Bateman V, Gill D, Georgakis MK, Malik R, Munroe P, Traylor M, International Consortium of Blood Pressure (ICBP)
Background and objectives: Cardiovascular risk factors have been implicated in the etiology of cerebral small vessel disease (CSVD); however, whether the associations are causal remains unclear in part due to the susceptibility of observational studies to reverse causation and confounding. Here, we use mendelian randomization (MR) to determine which cardiovascular risk factors are likely to be involved in the etiology of CSVD. Methods: We used data from large-scale genome-wide association studie...
Abstract
Nederlands tijdschrift voor geneeskunde,
Volume 166, 24 4 2022, Pages D6172
[Genotype-guided antithrombotic therapy].
van den Broek WWA, Azzahhafi J, van Schaik RHN, Ten Berg JM
Although current literature indicates both a clinical and a cost-effective benefit of routine genotype-guided treatment of patients treated with clopidogrel, this strategy is not recommended in guidelines. In cardiology, but also in neurology and vascular surgery, the current scientific evidence for this is still insufficient. Nevertheless, the role of pharmacogenetics will gain importance in today's medical world, where the demand for personalised medicine is on the rise. The implementatio...
Abstract
Cited 17 times since 2022 (4.5 per year)
source: EuropePMC
eLife,
Volume 11, 24 4 2022, Pages e74387
Dynamics and nanoscale organization of the postsynaptic endocytic zone at excitatory synapses.
Catsburg LA, Westra M, van Schaik AM, MacGillavry HD
At postsynaptic sites of neurons, a prominent clathrin-coated structure, the endocytic zone (EZ), controls the trafficking of glutamate receptors and is essential for synaptic plasticity. Despite its importance, little is known about how this clathrin structure is organized to mediate endocytosis. We used live-cell and super-resolution microscopy to reveal the dynamic organization of this poorly understood clathrin structure in rat hippocampal neurons. We found that a subset of endocytic protein...
Abstract
The American journal of cardiology,
Volume 169, 23 4 2022, Pages 93-99
Long-Term Impact of Preventive Tricuspid Valve Annuloplasty on Right Ventricular Remodeling.
Dietz MF, van Wijngaarden AL, Mack MJ, Braun J, Ajmone Marsan N, Delgado V, Klautz R, Bax JJ
In patients with primary mitral regurgitation (MR), concomitant tricuspid valve (TV) annuloplasty at the time of left-sided valve surgery is indicated in case of a dilated TV annulus ≥40 mm independent of the presence or severity of tricuspid regurgitation (TR). However, the long-term impact on right ventricular (RV) adverse remodeling is less well established and the benefit of preventive TV annuloplasty remains controversial. The aim of the study was to assess differences in long-term RV adver...
Abstract
Cited 13 times since 2022 (3.4 per year)
source: EuropePMC
ESC heart failure,
Volume 9, Issue 2, 22 4 2022, Pages 912-924
Functional classification of left ventricular remodelling: prognostic relevance in myocardial infarction.
Chimed S, van der Bijl P, Lustosa R, Fortuni F, Montero-Cabezas JM, Ajmone Marsan N, Gersh BJ, Delgado V, Bax JJ
Aims: The current definition of post ST-segment elevation myocardial infarction (STEMI) left ventricular (LV) remodelling is purely structural (LV dilatation) and does not consider LV function (ejection fraction, EF), even though it is known to be a predictor of long-term post-STEMI outcome. This study aimed to reclassify LV remodelling after STEMI by integrating LV dilatation and function (LVEF) and to investigate the prognostic implications. Methods and results: Data from an ongoing registry o...
Abstract
Cited 29 times since 2022 (7.6 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 35, Issue 5, 21 3 2022, Pages 477-485.e3
Left Atrial Reservoir Function and Outcomes in Secondary Mitral Regurgitation.
Stassen J, Namazi F, van der Bijl P, van Wijngaarden SE, Kamperidis V, Marsan NA, Delgado V, Bax JJ
Background: Left atrial (LA) size is a marker of disease severity and is related to worse outcomes in secondary mitral regurgitation (MR). The prognostic value of LA function assessed by LA reservoir strain (LARS), however, remains unknown. The aim of this study was to investigate the prognostic implications of LARS in patients with significant secondary MR. Methods: LARS was evaluated using speckle-tracking echocardiography in patients with more than mild (grade ≥ 2) secondary MR. The populatio...
Abstract
Cited 2 times since 2022 (0.5 per year)
source: EuropePMC
Life (Basel, Switzerland),
Volume 12, Issue 2, 21 3 2022, Pages 154
Near-Infrared Fluorescence with Indocyanine Green to Assess Bone Perfusion: A Systematic Review.
Michi M, Madu M, Winters HAH, de Bruin DM, van der Vorst JR, Driessen C
Background: Adequate perfusion of a bone flap is essential for successful reconstruction of osseous defects. Unfortunately, complications related to inadequate bone perfusion are common. Near-infrared fluorescence (NIRF) imaging enables intraoperative visualization of perfusion. NIRF has been investigated in reconstructive surgery to aid the surgeon in clinical perioperative assessment of soft tissue perfusion. However, little is known on the beneficial use of NIRF to assess bone perfusion. Ther...
Abstract
Cited 9 times since 2022 (2.4 per year)
source: EuropePMC
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract,
Volume 26, Issue 5, 20 3 2022, Pages 1063-1069
In-hospital Delay of Appendectomy in Acute, Complicated Appendicitis.
Bolmers MDM, de Jonge J, Bom WJ, van Rossem CC, van Geloven AAW, Bemelman WA, Snapshot Appendicitis Collaborative Study group
Background: Present theory is that uncomplicated and complicated appendicitis are different entities. Recent studies suggest it is safe to delay surgery in patients with uncomplicated appendicitis. We hypothesize that patients with complicated appendicitis are at higher risk for postoperative complications when surgery is delayed. Methods: Data was used from the multicenter, prospective SNAPSHOT appendicitis study of 1975 patients undergoing surgery for suspected appendicitis. Adult patients (≥ ...
Abstract
Cited 7 times since 2022 (1.8 per year)
source: EuropePMC
The Annals of thoracic surgery,
Volume 116, Issue 3, 20 3 2022, Pages 483-490
Outcomes of Surgical Bioprosthetic Aortic Valve Replacement in Patients Aged ≤65 and >65 Years.
Kiaii BB, Moront MG, Patel HJ, Ruel M, Bensari FN, Kress DC, Liu F, Klautz RJM, Sabik JF
Background: Implantation of a bioprosthetic valve is a reasonable choice for patients aged > 65 years. For middle-aged patients there is less certainty about whether a mechanical or bioprosthetic valve is best. Methods: The Pericardial Surgical Aortic Valve Replacement (PERIGON) Pivotal Trial is evaluating the safety and efficacy of the Avalus bioprosthesis (Medtronic). We evaluated clinical and echocardiographic outcomes through 5 years of follow-up, stratified by age ≤ 65 and >65 years....
Abstract
Cited 46 times since 2022 (12.1 per year)
source: EuropePMC
Frontiers in cardiovascular medicine,
Volume 8, 20 3 2022, Pages 827515
Robotic Cardiac Surgery in Europe: Status 2020.
Cerny S, Oosterlinck W, Onan B, Singh S, Segers P, Bolcal C, Alhan C, Navarra E, Pettinari M, Van Praet F, De Praetere H, Vojacek J, Cebotaru T, Modi P, Doguet F, Franke U, Ouda A, Melly L, Malapert G, Labrousse L, Gianoli M, Agnino A, Philipsen T, Jansens JL, Folliguet T, Palmen M, Pereda D, Musumeci F, Suwalski P, Cathenis K, Van den Eynde J, Bonatti J
Background: European surgeons were the first worldwide to use robotic techniques in cardiac surgery and major steps in procedure development were taken in Europe. After a hype in the early 2000s case numbers decreased but due to technological improvements renewed interest can be noted. We assessed the current activities and outcomes in robotically assisted cardiac surgery on the European continent. Methods: Data were collected in an international anonymized registry of 26 European centers with a...
Abstract
Cited 28 times since 2022 (7.4 per year)
source: EuropePMC
International journal of molecular sciences,
Volume 23, Issue 3, 19 3 2022, Pages 1057
N-6-Methyladenosine in Vasoactive microRNAs during Hypoxia; A Novel Role for METTL4.
van den Homberg DAL, van der Kwast RVCT, Quax PHA, Nossent AY
N-6-methyladenosine (m6A) is the most prevalent post-transcriptional RNA modification in eukaryotic cells. The modification is reversible and can be dynamically regulated by writer and eraser enzymes. Alteration in the levels of these enzymes can lead to changes in mRNA stability, alternative splicing or microRNA processing, depending on the m6A-binding proteins. Dynamic regulation of mRNA m6A methylation after ischemia and hypoxia influences mRNA stability, alternative splicing and translation,...
Abstract
Cited 3 times since 2022 (0.8 per year)
source: EuropePMC
The American journal of cardiology,
Volume 171, 19 3 2022, Pages 151-158
Prognostic Implications of Right Ventricular Free Wall Strain in Recipients of Cardiac Resynchronization Therapy.
Stassen J, van der Bijl P, Galloo X, Hirasawa K, Prihadi EA, Marsan NA, Bax JJ
Right ventricular (RV) function is an important prognostic marker in cardiac resynchronization therapy (CRT) recipients. Measuring RV systolic function with echocardiography, however, remains challenging due to the complexity of right heart morphology. Evaluation of RV function with RV free wall strain (FWS) may improve risk stratification in recipients of CRT compared with conventional RV function parameters. In 871 recipients of CRT (mean age 65 ± 11 years, 75% were men), RV function was asses...
Abstract
Cited 10 times since 2022 (2.6 per year)
source: EuropePMC
Journal of plastic, reconstructive & aesthetic surgery : JPRAS,
Volume 75, Issue 6, 14 2 2022, Pages 1820-1825
Quantification of near-infrared fluorescence imaging with indocyanine green in free flap breast reconstruction.
Van Den Hoven P, Verduijn PS, Van Capelle L, Tange FP, Michi M, Corion LUM, Sibinga Mulder BG, Mureau MAM, Vahrmeijer AL, Van Der Vorst JR
Background: One of the complications of free flap breast reconstruction is the occurrence of skin and fat necrosis. Intra-operative use of near-infrared (NIR) fluorescence imaging with Indocyanine Green (ICG) has the potential to predict these complications. In this study, the quantification of the fluorescence intensity measured in free flap breast reconstruction was performed to gain insight into the perfusion patterns observed with ICG NIR fluorescence imaging. Methods: ICG NIR fluorescence i...
Abstract
Cited 28 times since 2022 (7.3 per year)
source: EuropePMC
The Journal of biological chemistry,
Volume 298, Issue 3, 14 2 2022, Pages 101589
Immunosuppressive calcineurin inhibitor cyclosporine A induces proapoptotic endoplasmic reticulum stress in renal tubular cells.
Yilmaz DE, Kirschner K, Demirci H, Himmerkus N, Bachmann S, Mutig K
Current immunosuppressive strategies in organ transplantation rely on calcineurin inhibitors cyclosporine A (CsA) or tacrolimus (Tac). Both drugs are nephrotoxic, but CsA has been associated with greater renal damage than Tac. CsA inhibits calcineurin by forming complexes with cyclophilins, whose chaperone function is essential for proteostasis. We hypothesized that stronger toxicity of CsA may be related to suppression of cyclophilins with ensuing endoplasmic reticulum (ER) stress and unfolded...
Abstract
Cited 1 times since 2022 (0.3 per year)
source: EuropePMC
Frontiers in robotics and AI,
Volume 8, 13 2 2022, Pages 781985
Who Wants to Grant Robots Rights?
De Graaf MMA, Hindriks FA, Hindriks KV
The robot rights debate has thus far proceeded without any reliable data concerning the public opinion about robots and the rights they should have. We have administered an online survey (n = 439) that investigates layman's attitudes toward granting particular rights to robots. Furthermore, we have asked them the reasons for their willingness to grant them those rights. Finally, we have administered general perceptions of robots regarding appearance, capacities, and traits. Results show tha...
Abstract
Cited 33 times since 2022 (8.6 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 15, Issue 6, 12 2 2022, Pages 961-970
Prognostic Impact of Extra-Mitral Valve Cardiac Involvement in Patients With Primary Mitral Regurgitation.
van Wijngaarden AL, Mantegazza V, Hiemstra YL, Volpato V, van der Bijl P, Pepi M, Palmen M, Delgado V, Ajmone Marsan N, Tamborini G, Bax JJ
Background: In patients with severe primary mitral regurgitation (MR), the indication for surgery is currently based on the presence of symptoms, left ventricular dilatation and dysfunction, atrial fibrillation, and pulmonary hypertension. Objectives: The aim of this study was to evaluate the prognostic impact of the presence of extra-mitral valve cardiac involvement (including known risk factors but also severe left atrial [LA] dilatation and right ventricular [RV] dysfunction) in a large multi...
Abstract
Cited 2 times since 2022 (0.5 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 15, Issue 2, 12 2 2022, Pages 221-223
Apical Rocking and Septal Flash: Predictors of Secondary Mitral Regurgitation Improvement After Cardiac Resynchronization Therapy.
Bax JJ, van der Bijl P
Abstract
Cited 4 times since 2022 (1 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 15, Issue 5, 12 2 2022, Pages 745-746
Etiology and Outcomes of Isolated Tricuspid Regurgitation.
Bax JJ, van der Bijl P
Abstract
Cited 8 times since 2022 (2.1 per year)
source: EuropePMC
Cardiovascular revascularization medicine : including molecular interventions,
Volume 40, 11 2 2022, Pages 189-194
Bailout Intravascular Lithotripsy for the Treatment of Acutely Underexpanded Stents in Heavily Calcified Coronary Lesions: A Case Series.
Mousa MAA, Bingen BO, Amri IA, Digiacomo S, Karalis I, Jukema JW, Montero-Cabezas JM
Stent underexpansion is a common problem in heavily calcified coronary lesions treated with percutaneous coronary intervention, and has been associated with in-stent restenosis, stent thrombosis and, subsequently, poor clinical outcomes. Adequate preparation of heavily calcified coronary lesions (e.g. using non-compliant balloons, cutting/scoring balloons, rotational/orbital atherectomy or intravascular lithotripsy) prior to stent implantation is essential in preventing stent underexpansion. How...
Abstract
