Research

Publications

Below you can find a list of our published research.

8094 results

Cited 5 times since 2020 (0.9 per year) source: EuropePMC

Ocular immunology and inflammation, Volume 28, Issue 7, 16 3 2020, Pages 1049-1055 Immunoblot and Polymerase Chain Reaction to Diagnose Ocular Syphilis and Neurosyphilis in HIV-positive and HIV-negative Patients. Smit D, De Graaf M, Meyer D, de Groot-Mijnes JDF

Purpose: To evaluate immunoblot (IB) and polymerase chain reaction (PCR) to diagnose ocular- and neurosyphilis. Methods: Prospective cross-sectional study. Aqueous humor (AH) and cerebrospinal fluid (CSF) samples were tested for treponemal DNA or antibodies to treponemal antigens. Results: Thirteen of 106 cases had positive syphilis serology of which 69.2% were HIV+ (median CD4+ = 181 cells/µL). Four cases met CDC criteria for neurosyphilis (3 confirmed, 1 probable) and 2 additional cases requir... Abstract

Cited 7 times since 2020 (1.3 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 13, Issue 5, 15 3 2020, Pages 1152-1160 Stress-Only Adenosine CMR Improves Diagnostic Yield in Stable Symptomatic Patients With Coronary Artery Calcium. Rijlaarsdam-Hermsen D, Lo-Kioeng-Shioe M, van Domburg RT, Deckers JW, Kuijpers D, van Dijkman PRM

Objectives: This study assessed whether adenosine stress-only perfusion cardiac magnetic resonance (CMR) following a positive coronary artery calcium (CAC) score improved the diagnostic yield of invasive coronary angiography (CAG) in patients with stable chest pain. The study also established the association between positive CAC scores and stress-induced myocardial ischemia. Background: The diagnostic yield of catheterization among patients with suspected coronary artery disease (CAD) is low. Im... Abstract

Cited 42 times since 2020 (7.7 per year) source: EuropePMC

Nature medicine, Volume 26, Issue 1, 13 2 2020, Pages 110-117 Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug-metabolite atlas. Liu J, Lahousse L, Nivard MG, Bot M, Chen L, van Klinken JB, Thesing CS, Beekman M, van den Akker EB, Slieker RC, Waterham E, van der Kallen CJH, de Boer I, Li-Gao R, Vojinovic D, Amin N, Radjabzadeh D, Kraaij R, Alferink LJM, Murad SD, Uitterlinden AG, Willemsen G, Pool R, Milaneschi Y, van Heemst D, Suchiman HED, Rutters F, Elders PJM, Beulens JWJ, van der Heijden AAWA, van Greevenbroek MMJ, Arts ICW, Onderwater GLJ, van den Maagdenberg AMJM, Mook-Kanamori DO, Hankemeier T, Terwindt GM, Stehouwer CDA, Geleijnse JM, 't Hart LM, Slagboom PE, van Dijk KW, Zhernakova A, Fu J, Penninx BWJH, Boomsma DI, Demirkan A, Stricker BHC, van Duijn CM

Progress in high-throughput metabolic profiling provides unprecedented opportunities to obtain insights into the effects of drugs on human metabolism. The Biobanking BioMolecular Research Infrastructure of the Netherlands has constructed an atlas of drug-metabolite associations for 87 commonly prescribed drugs and 150 clinically relevant plasma-based metabolites assessed by proton nuclear magnetic resonance. The atlas includes a meta-analysis of ten cohorts (18,873 persons) and uncovers 1,071 dr... Abstract

Cited 9 times since 2020 (1.6 per year) source: EuropePMC

Clinical therapeutics, Volume 42, Issue 2, 11 2 2020, Pages 276-285 Pharmacokinetic, Pharmacodynamic, and Safety Profiles of Ferric Carboxymaltose in Chinese Patients with Iron-deficiency Anemia. Ding Y, Zhu X, Li X, Zhang H, Wu M, Liu J, Palmen M, Roubert B, Li C

Purpose: Iron deficiency (ID) is one of the most commonly known nutritional deficiencies and is considered the primary cause of anemia (iron-deficiency anemia). Ferric carboxymaltose (FCM), an intravenous iron preparation, has been widely used for >10 years for iron-deficiency anemia treatment worldwide because of its many advantages. Methods: This single-center, open-label, single dose escalation study in Chinese subjects was designed to assess the pharmacokinetic/pharmacodynamic parameters... Abstract

Cited 1 times since 2020 (0.2 per year) source: EuropePMC

EJVES vascular forum, Volume 47, 11 2 2020, Pages 87-89 Rupture of a Median Sacral Artery Aneurysm in a Patient with Vascular Ehlers Danlos Syndrome. Verhagen MJ, van der Meer RW, van Rijswijk CSP, van Schaik J

Introduction: Vascular Ehlers Danlos syndrome is a rare connective tissue disease that is associated with various arterial complications. Report: A 25 year old man with vascular Ehlers Danlos syndrome presented with acute lower back pain as a result of a ruptured aneurysm of the median sacral artery (MSA). Prior medical history included several vascular events resulting in a right iliac occlusion. The unusual location of aneurysmal disease of the MSA might be explained by extensive collateral fl... Abstract

Cited 16 times since 2020 (2.9 per year) source: EuropePMC

Biotechnology progress, Volume 36, Issue 3, 9 2 2020, Pages e2947 Application of Raman spectroscopy in monoclonal antibody producing continuous systems for downstream process intensification. Yilmaz D, Mehdizadeh H, Navarro D, Shehzad A, O'Connor M, McCormick P

Monoclonal antibodies (mAbs) are biopharmaceuticals produced by mammalian cell lines in bioreactors at a variety of scales. Cell engineering, media optimization, process monitoring, and control strategies for in vitro production have become crucial subjects to meet increasing demand for these high value pharmaceuticals. Raman Spectroscopy has gained great attention in the pharmaceutical industry for process monitoring and control to maintain quality assurance. For the first time, this article de... Abstract

Cited 3 times since 2020 (0.5 per year) source: EuropePMC

The American journal of cardiology, Volume 125, Issue 7, 9 2 2020, Pages 1108-1114 Prognostic Implications of Renal Dysfunction in Patients With Aortic Stenosis. Vollema EM, Prihadi EA, Ng ACT, Gegenava T, Ajmone Marsan N, Bax JJ, Delgado V

Aortic stenosis (AS) and renal dysfunction share risk factors and often occur simultaneously. The influence of renal dysfunction on the prognosis of patients with various grades of AS has not been extensively described. The present study aimed to assess the prognostic implications of renal dysfunction in a large cohort of patients with aortic sclerosis and patients with various grades of AS. Patients diagnosed with various grades of AS by transthoracic echocardiography were assessed and divided... Abstract

Cited 518 times since 2020 (94.7 per year) source: EuropePMC

Nature communications, Volume 11, Issue 1, 9 2 2020, Pages 163 Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure. Shah S, Henry A, Roselli C, Lin H, Sveinbjörnsson G, Fatemifar G, Hedman ÅK, Wilk JB, Morley MP, Chaffin MD, Helgadottir A, Verweij N, Dehghan A, Almgren P, Andersson C, Aragam KG, Ärnlöv J, Backman JD, Biggs ML, Bloom HL, Brandimarto J, Brown MR, Buckbinder L, Carey DJ, Chasman DI, Chen X, Chen X, Chung J, Chutkow W, Cook JP, Delgado GE, Denaxas S, Doney AS, Dörr M, Dudley SC, Dunn ME, Engström G, Esko T, Felix SB, Finan C, Ford I, Ghanbari M, Ghasemi S, Giedraitis V, Giulianini F, Gottdiener JS, Gross S, Guðbjartsson DF, Gutmann R, Haggerty CM, van der Harst P, Hyde CL, Ingelsson E, Jukema JW, Kavousi M, Khaw KT, Kleber ME, Køber L, Koekemoer A, Langenberg C, Lind L, Lindgren CM, London B, Lotta LA, Lovering RC, Luan J, Magnusson P, Mahajan A, Margulies KB, März W, Melander O, Mordi IR, Morgan T, Morris AD, Morris AP, Morrison AC, Nagle MW, Nelson CP, Niessner A, Niiranen T, O'Donoghue ML, Owens AT, Palmer CNA, Parry HM, Perola M, Portilla-Fernandez E, Psaty BM, Regeneron Genetics Center, Rice KM, Ridker PM

Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one o... Abstract

Cited 5 times since 2020 (0.9 per year) source: EuropePMC

European journal of case reports in internal medicine, Volume 7, Issue 1, 9 2 2020, Pages 001351 Magnetic Resonance Direct Thrombus Imaging (MRDTI) Can Distinguish Between Old and New Thrombosis in the Abdominal Aorta: a Case Report. van Dam LF, Kroft LJ, Dronkers CE, van Schaik J, van Haren GR, Huisman MV, Klok FA

A 43-year-old man complaining of abdominal angina for several months showed a large suprarenal aneurysm of the abdominal aorta with extensive circumferential wall thrombosis, complete occlusion of the right renal artery and a critically stenosed left renal artery on CT angiography. He suffered from severe hypertension and renal failure. A percutaneous transluminal angioplasty (PTA) was planned. After the PTA procedure, which was complicated by the development of left renal artery occlusion, succ... Abstract

Cited 10 times since 2020 (1.8 per year) source: EuropePMC

Science advances, Volume 6, Issue 2, 8 2 2020, Pages eaaw2685 Early sociability fosters later exploratory tendency in wild immature orangutans. Schuppli C, van Noordwijk M, Atmoko SU, van Schaik C

Exploration is essential for skill acquisition and strongly facilitates cognitive performance. In humans, it is widely known that exploration and later cognitive performance are highly dependent on early social inputs. Here, we aim to shed light on the evolutionary roots of this process by studying the effects of variation in opportunities for social learning on the exploratory tendency of immature orangutans (Pongo spp.) in nature. We based our analyses on mixed cross-sectional, longitudinal da... Abstract

Cited 12 times since 2020 (2.2 per year) source: EuropePMC

Aging, Volume 12, Issue 2, 7 1 2020, Pages 1496-1511 Association of cardiovascular structure and function with cerebrovascular changes and cognitive function in older patients with end-stage renal disease. Zijlstra LE, Trompet S, Jukema JW, Kroft LJM, de Bresser J, van Osch MJP, Hammer S, Witjes MN, van Buren M, Mooijaart SP

The Dutch prospective multicenter cohort study COPE (Cognitive decline in Older Patients with End stage renal disease) aimed to investigate the association of cardiovascular structure and function with cerebrovascular changes and cognitive function in 85 older patients with chronic kidney disease stage 4 and 5, awaiting either dialysis or conservative care. MRI was performed measuring aortic stiffness (pulse wave velocity [PWV]) and cardiac systolic function (ejection fraction and cardiac index)... Abstract

Cited 73 times since 2020 (13.3 per year) source: EuropePMC

Nature communications, Volume 11, Issue 1, 7 1 2020, Pages 39 Heritability estimates for 361 blood metabolites across 40 genome-wide association studies. Hagenbeek FA, Pool R, van Dongen J, Draisma HHM, Jan Hottenga J, Willemsen G, Abdellaoui A, Fedko IO, den Braber A, Visser PJ, de Geus EJCN, Willems van Dijk K, Verhoeven A, Suchiman HE, Beekman M, Slagboom PE, van Duijn CM, BBMRI Metabolomics Consortium, Harms AC, Hankemeier T, Bartels M, Nivard MG, Boomsma DI

Metabolomics examines the small molecules involved in cellular metabolism. Approximately 50% of total phenotypic differences in metabolite levels is due to genetic variance, but heritability estimates differ across metabolite classes. We perform a review of all genome-wide association and (exome-) sequencing studies published between November 2008 and October 2018, and identify >800 class-specific metabolite loci associated with metabolite levels. In a twin-family cohort (N = 5117), these met... Abstract

Cited 22 times since 2020 (4 per year) source: EuropePMC

Journal of arrhythmia, Volume 36, Issue 1, 3 1 2020, Pages 1-58 2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias: Executive summary. Cronin EM, Bogun FM, Maury P, Peichl P, Chen M, Namboodiri N, Aguinaga L, Leite LR, Al-Khatib SM, Anter E, Berruezo A, Callans DJ, Chung MK, Cuculich P, d'Avila A, Deal BJ, Bella PD, Deneke T, Dickfeld TM, Hadid C, Haqqani HM, Kay GN, Latchamsetty R, Marchlinski F, Miller JM, Nogami A, Patel AR, Pathak RK, Saenz Morales LC, Santangeli P, Sapp JL, Sarkozy A, Soejima K, Stevenson WG, Tedrow UB, Tzou WS, Varma N, Zeppenfeld K

Ventricular arrhythmias are an important cause of morbidity and mortality and come in a variety of forms, from single premature ventricular complexes to sustained ventricular tachycardia and fibrillation. Rapid developments have taken place over the past decade in our understanding of these arrhythmias and in our ability to diagnose and treat them. The field of catheter ablation has progressed with the development of new methods and tools, and with the publication of large clinical trials. There... Abstract

Cited 110 times since 2020 (20 per year) source: EuropePMC

European heart journal, Volume 41, Issue 3, 1 1 2020, Pages 359-367 Machine learning of clinical variables and coronary artery calcium scoring for the prediction of obstructive coronary artery disease on coronary computed tomography angiography: analysis from the CONFIRM registry. Al'Aref SJ, Maliakal G, Singh G, van Rosendael AR, Ma X, Xu Z, Alawamlh OAH, Lee B, Pandey M, Achenbach S, Al-Mallah MH, Andreini D, Bax JJ, Berman DS, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan K, Chow BJW, Cury RC, DeLago A, Feuchtner G, Hadamitzky M, Hausleiter J, Kaufmann PA, Kim YJ, Leipsic JA, Maffei E, Marques H, Gonçalves PA, Pontone G, Raff GL, Rubinshtein R, Villines TC, Gransar H, Lu Y, Jones EC, Peña JM, Lin FY, Min JK, Shaw LJ

Aims: Symptom-based pretest probability scores that estimate the likelihood of obstructive coronary artery disease (CAD) in stable chest pain have moderate accuracy. We sought to develop a machine learning (ML) model, utilizing clinical factors and the coronary artery calcium score (CACS), to predict the presence of obstructive CAD on coronary computed tomography angiography (CCTA). Methods and results: The study screened 35 281 participants enrolled in the CONFIRM registry, who underwent ≥64 de... Abstract

Cited 3590 times since 2020 (653.8 per year) source: EuropePMC

European heart journal, Volume 41, Issue 3, 1 1 2020, Pages 407-477 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. Knuuti J, Wijns W, Saraste A, Capodanno D, Barbato E, Funck-Brentano C, Prescott E, Storey RF, Deaton C, Cuisset T, Agewall S, Dickstein K, Edvardsen T, Escaned J, Gersh BJ, Svitil P, Gilard M, Hasdai D, Hatala R, Mahfoud F, Masip J, Muneretto C, Valgimigli M, Achenbach S, Bax JJ, ESC Scientific Document Group

Abstract

Cited 14 times since 2020 (2.5 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 28, Issue 1, 1 1 2020, Pages 44-50 Prognostic value of the coronary artery calcium score in suspected coronary artery disease: a study of 644 symptomatic patients. Rijlaarsdam-Hermsen D, Lo-Kioeng-Shioe MS, Kuijpers D, van Domburg RT, Deckers JW, van Dijkman PRM

Aim: The long-term value of coronary artery calcium (CAC) scanning has not been studied extensively in symptomatic patients, but was evaluated by us in 644 consecutive patients referred for stable chest pain. Methods: We excluded patients with a history of cardiovascular disease and with a CAC score of zero. CAC scanning was done with a 16-row MDCT scanner. Endpoints were: (a) overall mortality, (b) mortality or non-fatal myocardial infarction and (c) the composite of mortality, myocardial infar... Abstract

Cited 1 times since 2020 (0.2 per year) source: EuropePMC

Current medical imaging, Volume 16, Issue 9, 1 1 2020, Pages 1105-1110 Evaluation of Mandibular Third Molar Region in a Turkish Population Using Cone-Beam Computed Tomography. Orhan BK, Yılmaz D, Ozemre MO, Kamburoğlu K, Gulen O, Gulsahi A

Objectives: To evaluate impacted mandibular third molar tooth region and obtain linear measurements using CBCT images and to assess the relationship between the impacted third molar and the mandibular canal. Methods: CBCT scans of 351 patients (208 females, 143 males) were assessed. Age, gender, and impaction site were recorded for each patient. The relationship of third molars with the vertical axis of second molars, 2nd molar resorption and the relationship between third molar apices and the m... Abstract

Cited 24 times since 2020 (4.4 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 28, Issue 1, 1 1 2020, Pages 16-26 A randomised comparison of the effect of haemodynamic monitoring with CardioMEMS in addition to standard care on quality of life and hospitalisations in patients with chronic heart failure : Design and rationale of the MONITOR HF multicentre randomised clinical trial. Brugts JJ, Veenis JF, Radhoe SP, Linssen GCM, van Gent M, Borleffs CJW, van Ramshorst J, van Pol P, Tukkie R, Spee RF, Emans ME, Kok W, van Halm V, Handoko L, Beeres SLMA, Post MC, Boersma E, Lenzen MJ, Manintveld OC, Koffijberg H, van Baal P, Versteegh M, Smilde TD, van Heerebeek L, Rienstra M, Mosterd A, Delnoy PPH, Asselbergs FW, Brunner-La Rocca HP, de Boer RA

Background: Assessing haemodynamic congestion based on filling pressures instead of clinical congestion can be a way to further improve quality of life (QoL) and clinical outcome by intervening before symptoms or weight gain occur in heart failure (HF) patients. The clinical efficacy of remote monitoring of pulmonary artery (PA) pressures (CardioMEMS; Abbott Inc., Atlanta, GA, USA) has been demonstrated in the USA. Currently, the PA sensor is not reimbursed in the European Union as its benefit w... Abstract

Cited 4 times since 2020 (0.7 per year) source: EuropePMC

Mayo Clinic proceedings, Volume 95, Issue 1, 1 1 2020, Pages 12-14 Renal Impairment, Cardiovascular Disease, and the Short-Term Efficacy and Safety of PCSK9 Targeted by Inclisiran. Zijlstra LE, Trompet S, Mooijaart SP, van Buren M, Jukema JW

Abstract

Cited 2 times since 2020 (0.4 per year) source: EuropePMC

Endocrine connections, Volume 9, Issue 1, 1 1 2020, Pages 55-62 The kidney, subclinical thyroid disease and cardiovascular outcomes in older patients. Zijlstra LE, van Velzen DM, Simsek S, Mooijaart SP, van Buren M, Stott DJ, Ford I, Jukema JW, Trompet S

Objective: Thyroid hormones have been implicated to play a role in cardiovascular disease, along with studies linking thyroid hormone to kidney function. The aim of this study is to investigate whether kidney function modifies the association of subclinical thyroid dysfunction and the risk of cardiovascular outcomes. Methods: In total, 5804 patients were included in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). For the current analysis, 426 were excluded because of overt... Abstract