6131 results
Cited 52 times since 2011 (3.7 per year)
source: EuropePMC
Current pharmaceutical design,
Volume 17, Issue 19, 1 1 2011, Pages 1890-1910
Clinical applications of the urokinase receptor (uPAR) for cancer patients.
Boonstra MC, Verspaget HW, Ganesh S, Kubben FJ, Vahrmeijer AL, van de Velde CJ, Kuppen PJ, Quax PH, Sier CF
Since decades the urokinase plasminogen activator (uPA) system has been associated with the invasion of malignant cells. The receptor of urokinase (uPAR) is one of the key players in this proteolytic cascade, because it focuses uPA's proteolytic activity to the cell surface and in addition functions as a signaling receptor. uPAR is highly expressed in virtually all human cancers, suggesting possible clinical applications as diagnostic marker, predictive tool of survival or clinical response...
Abstract
Cited 12 times since 2010 (0.8 per year)
source: EuropePMC
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery,
Volume 41, Issue 3, 30 5 2011, Pages 418-428
T-cell-pre-stimulated monocytes promote neovascularisation in a murine hind limb ischaemia model.
Hellingman AA, Zwaginga JJ, van Beem RT, TeRM/Smart Mix Consortium, Hamming JF, Fibbe WE, Quax PH, Geutskens SB
Aim: Monocytes play a significant role in neovascularisation. The stimuli that differentiate monocytes along a pro-angio-/arteriogenic-supporting pathway are currently unclear. We investigated whether pre-stimulation of human monocytes with soluble T-cell-derived factors improves revascularisation in murine hind limb ischaemia as a new option for therapeutic angio- and arteriogenesis. Design: Human monocytes were cultured with or without soluble T-cell-derived factors. Unstimulated and pre-stimu...
Abstract
Cited 9 times since 2010 (0.6 per year)
source: EuropePMC
Foot (Edinburgh, Scotland),
Volume 21, Issue 3, 23 4 2010, Pages 124-128
Foot and ankle fractures at the supination line.
Schepers T, van Schie-van der Weert EM, de Vries MR, van der Elst M
Background: The supination line is a fictive line along the foot and ankle, on which over twenty fracture types and approximately ten different ligamentous sprain-injuries have been identified. Objective: The current study was conducted to evaluate the incidence of different types of supination line injuries visible at the initial radiographs at the Emergency Department and to determine the type and percentage of misdiagnosed injuries. Method: Retrospective study of consecutive patients who visi...
Abstract
Cited 18 times since 2010 (1.3 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 19, Issue 1, 22 4 2010, Pages 24-30
Improvements in 25 Years of Implantable Cardioverter Defibrillator Therapy.
van Welsenes GH, Borleffs CJ, van Rees JB, Atary JZ, Thijssen J, van der Wall EE, Schalij MJ
In 1980, Dr. Michel Mirowski and his team inserted the first implantable cardioverter defibrillator (ICD) in a patient. Initially, ICD therapy was not widely accepted, and many physicians actually considered this therapy unethical. Large secondary and primary prevention trials, demonstrating a beneficial effect of ICD therapy in selected patients not only on arrhythmic death but also on all-cause mortality, stimulated a rapid growth in the number of implants and increased patient's and phys...
Abstract
Cited 16 times since 2010 (1.1 per year)
source: EuropePMC
The American journal of cardiology,
Volume 107, Issue 4, 22 4 2010, Pages 609-614
Usefulness of repeated N-terminal pro-B-type natriuretic peptide measurements as incremental predictor for long-term cardiovascular outcome after vascular surgery.
Goei D, van Kuijk JP, Flu WJ, Hoeks SE, Chonchol M, Verhagen HJ, Bax JJ, Poldermans D
Plasma N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) levels improve preoperative cardiac risk stratification in vascular surgery patients. However, single preoperative measurements of NT-pro-BNP cannot take into account the hemodynamic stress caused by anesthesia and surgery. Therefore, the aim of the present study was to assess the incremental predictive value of changes in NT-pro-BNP during the perioperative period for long-term cardiac mortality. Detailed cardiac histories, rest left...
Abstract
Cited 7 times since 2010 (0.5 per year)
source: EuropePMC
The American journal of cardiology,
Volume 107, Issue 5, 22 4 2010, Pages 736-740
Value of the surface electrocardiogram in detecting right ventricular dilatation in the presence of left bundle branch block.
Van Bommel RJ, Marsan NA, Delgado V, van Rijnsoever EP, Schalij MJ, Bax JJ, Wellens HJ
Approximately 20% of patients with heart failure have left bundle branch block (LBBB) on surface electrocardiogram (ECG). In this group of patients, detection of right ventricular (RV) dilatation on standard ECG can be of clinical relevance because RV enlargement is an important prognostic marker. Consequently, the aim of this study was to evaluate diagnostic accuracy for several electrocardiographic criteria in determining significant RV dilatation in these patients. Standard 12-lead ECGs were...
Abstract
Cited 170 times since 2010 (12 per year)
source: EuropePMC
Circulation,
Volume 123, Issue 1, 20 3 2010, Pages 70-78
Relative merits of left ventricular dyssynchrony, left ventricular lead position, and myocardial scar to predict long-term survival of ischemic heart failure patients undergoing cardiac resynchronization therapy.
Delgado V, van Bommel RJ, Bertini M, Borleffs CJ, Marsan NA, Arnold CT, Nucifora G, van de Veire NR, Ypenburg C, Boersma E, Holman ER, Schalij MJ, Bax JJ
Background: The relative merits of left ventricular (LV) dyssynchrony, LV lead position, and myocardial scar to predict long-term outcome after cardiac resynchronization therapy remain unknown and were evaluated in the present study. Methods and results: In 397 ischemic heart failure patients, 2-dimensional speckle tracking imaging was performed, with comprehensive assessment of LV radial dyssynchrony, identification of the segment with latest mechanical activation, and detection of myocardial s...
Abstract
The international journal of cardiovascular imaging,
Volume 27, Issue 7, 18 3 2010, Pages 1089-1093
Functional analysis by 64-slice CT scanning: prediction of left ventricular dysfunction together with reduction in radiation exposure?
van der Wall EE, de Graaf FR, van Velzen JE, Jukema JW, Schuijf JD, Bax JJ
Abstract
Cited 1 times since 2010 (0.1 per year)
source: EuropePMC
Case reports in oncology,
Volume 4, Issue 2, 17 3 2010, Pages 323-326
Imatinib treatment alone in Philadelphia-positive acute lymphoblastic leukemia: is it enough?
Ay Y, Yilmaz D, Balkan C, Karapinar B, Karadas N, Kavakli K
BCR-ABL fusion gene t(9;22)(q34;q11) occurs in only 3% of pediatric acute lymphoblastic leukemia (ALL) cases. Previously, less than 40% of Philadelphia-positive ALL patients were cured with intensive chemotherapy. The use of imatinib (340 mg/m(2)/day) added to an intensive chemotherapy regimen has improved the outcome in this population at 3 years to an event-free survival of 80%. Imatinib treatment alone was administered after remission induction chemotherapy to a patient with Philadelphia-posi...
Abstract
Cited 16 times since 2010 (1.1 per year)
source: EuropePMC
Journal of the American Society of Nephrology : JASN,
Volume 22, Issue 3, 16 3 2010, Pages 508-517
γ-Adducin stimulates the thiazide-sensitive NaCl cotransporter.
Dimke H, San-Cristobal P, de Graaf M, Lenders JW, Deinum J, Hoenderop JG, Bindels RJ
The thiazide-sensitive NaCl cotransporter (NCC) plays a key role in renal salt reabsorption and the determination of systemic BP, but the molecular mechanisms governing the regulation of NCC are not completely understood. Here, through pull-down experiments coupled to mass spectrometry, we found that γ-adducin interacts with the NCC transporter. γ-Adducin colocalized with NCC to the distal convoluted tubule. (22)Na(+) uptake experiments in the Xenopus laevis oocyte showed that γ-adducin stimulat...
Abstract
Cited 1 times since 2010 (0.1 per year)
source: EuropePMC
BMC bioinformatics,
Volume 11, 14 2 2010, Pages 598
Initial steps towards a production platform for DNA sequence analysis on the grid.
Luyf AC, van Schaik BD, de Vries M, Baas F, van Kampen AH, Olabarriaga SD
Background: Bioinformatics is confronted with a new data explosion due to the availability of high throughput DNA sequencers. Data storage and analysis becomes a problem on local servers, and therefore it is needed to switch to other IT infrastructures. Grid and workflow technology can help to handle the data more efficiently, as well as facilitate collaborations. However, interfaces to grids are often unfriendly to novice users. Results: In this study we reused a platform that was developed in...
Abstract
Cited 2 times since 2010 (0.1 per year)
source: EuropePMC
International journal of clinical oncology,
Volume 16, Issue 5, 8 2 2010, Pages 574-576
Blue toe syndrome and sunitinib.
Postema PG, Regeer MV, van der Valk PR, Stroes ES, Richel DJ
We present a patient with metastatic renal cell carcinoma treated with sunitinib, a multitargeted tyrosine kinase inhibitor. The patient experienced bilateral blue toe syndrome which we related to sunitinib use. Discontinuation of sunitinib to lower the patient's prothrombotic state and increase the ability to form collaterals, together with the addition of low-molecular-weight heparin to treat the occluding thrombi, resulted in waning of the blue toe syndrome. This case adds to the accumul...
Abstract
Cited 5 times since 2010 (0.4 per year)
source: EuropePMC
Atherosclerosis,
Volume 215, Issue 1, 8 2 2010, Pages 125-129
Mannose binding lectin 2 haplotypes do not affect the progression of coronary atherosclerosis in men with proven coronary artery disease treated with pravastatin.
Alipour A, Cabezas MC, Elte JW, Vallvé JC, Ribalta J, Zwinderman AH, Defesche JC, Jukema JW
Objective: Mannose binding lectin (MBL) is one of the three initiators of complement activation. Polymorphisms of the MBL2 gene and its promoter, and especially haplotypes, determine MBL plasma levels. MBL deficiency has been associated with the development of atherosclerosis. We evaluated whether the rate of angiographic progression of coronary atherosclerosis during pravastatin treatment was associated with MBL2 haplotypes in REGRESS, a placebo-controlled 2 years intervention study. Methods: T...
Abstract
Cited 9 times since 2010 (0.6 per year)
source: EuropePMC
European heart journal,
Volume 32, Issue 3, 7 1 2010, Pages 365-370
Influence of smoking on the prognostic value of cardiovascular computed tomography coronary angiography.
van Werkhoven JM, Schuijf JD, Pazhenkottil AP, Herzog BA, Ghadri JR, Jukema JW, Boersma E, Kroft LJ, de Roos A, Kaufmann PA, Bax JJ
Aims: Computed tomography coronary angiography (CTA) is an important non-invasive imaging modality increasingly used for the diagnosis and prognosis of coronary artery disease (CAD). The purpose of the current study was to determine the influence of smoking status on the prognostic value of CTA in patients with suspected or known CAD. Methods and results: In 1207 patients (57% male, age 57 ± 12 years) referred for CTA, the presence of significant CAD (≥ 50% stenosis) was determined. During follo...
Abstract
Cited 3 times since 2010 (0.2 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 28, Issue 1, 7 1 2010, Pages 193-197
320-row CT scanning: reduction in tube current parallels reduction in radiation exposure?
van der Wall EE, van Velzen JE, de Graaf FR, Jukema JW, Schuijf JD, Bax JJ
Abstract
Cited 13 times since 2010 (0.9 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 97, Issue 3, 6 1 2010, Pages 231-236
Relationship between temporal sequence of right ventricular deformation and right ventricular performance in patients with corrected tetralogy of Fallot.
van der Hulst AE, Roest AA, Delgado V, Holman ER, de Roos A, Blom NA, Bax JJ
Objective: Right ventricular (RV) dysfunction is common in patients with corrected tetralogy of Fallot (cToF). Abnormalities in the temporal pattern of RV mechanical activation have been observed in patients with cToF, but the relationship with RV performance remains unclear. This study characterises RV performance and the temporal sequence of RV deformation in patients with cToF and healthy controls. Study design: 37 patients with cToF were compared with 18 controls. Using two-dimensional speck...
Abstract
Cited 13 times since 2010 (0.9 per year)
source: EuropePMC
Journal of cardiovascular electrophysiology,
Volume 22, Issue 6, 6 1 2010, Pages 677-683
Upgrading to biventricular pacing guided by pressure-volume loop analysis during implantation.
Delnoy PP, Ottervanger JP, Vos DH, Elvan A, Misier AR, Beukema WP, Steendijk P, van Hemel NM
Introduction: cardiac resynchronization therapy (CRT) may improve prognosis in patients with chronic right ventricular (RV) pacing, and optimal lead position can decrease nonresponders. We evaluated the clinical and echocardiographic response to CRT in patients with previous chronic RV pacing, using pressure-volume loop analyses to determine the optimal left ventricular (LV) lead position during implantation. Methods and results: In this single-blinded, randomized, controlled crossover study, 40...
Abstract
Cited 19 times since 2010 (1.3 per year)
source: EuropePMC
Current medical research and opinion,
Volume 27, Issue 1, 6 1 2010, Pages 141-150
Rationale and design of dal-VESSEL: a study to assess the safety and efficacy of dalcetrapib on endothelial function using brachial artery flow-mediated vasodilatation.
Kastelein JJ, Duivenvoorden R, Deanfield J, de Groot E, Jukema JW, Kaski JC, Münzel T, Taddei S, Lehnert V, Burgess T, Kallend D, Lüscher TF
Objective: Dalcetrapib increases high-density lipoprotein cholesterol (HDL-C) levels through effects on cholesteryl ester transfer protein (CETP). As part of the dalcetrapib dal-HEART clinical trial programme, the efficacy and safety of dalcetrapib is assessed in coronary heart disease (CHD) patients in the dal-VESSEL study (ClinicalTrials.gov identifier: NCT00655538), the design and methods of which are presented here. RESEARCH DESIGN AND STUDY METHOD: Men and women with CHD or CHD risk equival...
Abstract
Cited 117 times since 2010 (8.2 per year)
source: Scopus
American heart journal,
Volume 160, Issue 6, 1 1 2010, Pages 1113-1120
Impact of left ventricular systolic function on clinical and echocardiographic outcomes following transcatheter aortic valve implantation for severe aortic stenosis.
Ewe SH, Ajmone Marsan N, Pepi M, Delgado V, Tamborini G, Muratori M, Ng AC, van der Kley F, de Weger A, Schalij MJ, Fusari M, Biglioli P, Bax JJ
Background: This study aimed to evaluate the impact of baseline left ventricular (LV) systolic function on clinical and echocardiographic outcomes following transcatheter aortic valve implantation (TAVI). Survival of patients undergoing TAVI was also compared with that of a population undergoing surgical aortic valve replacement. Methods: One hundred forty-seven consecutive patients (mean age=80±7 years) undergoing TAVI in 2 centers were included. Mean follow-up period was 9.1±5.1 months. Result...
Abstract
Cited 30 times since 2010 (2.1 per year)
source: EuropePMC
The Annals of thoracic surgery,
Volume 90, Issue 6, 1 1 2010, Pages 1922-1929
Mitral valve morphology assessment: three-dimensional transesophageal echocardiography versus computed tomography.
Shanks M, Delgado V, Ng AC, van der Kley F, Schuijf JD, Boersma E, van de Veire NR, Nucifora G, Bertini M, de Roos A, Kroft L, Schalij MJ, Bax JJ
Background: Advances in the minimally invasive mitral valve repair techniques increase the demands on accurate and reliable morphologic assessment of the mitral valve using three-dimensional imaging modalities. The present study compared mitral valve geometry measurements obtained by three-dimensional transesophageal echocardiography (TEE) to those obtained with multidetector row computed tomography (MDCT) used as a standard reference. Methods: Clinical preoperative MDCT and intraoperative three...
Abstract
