Research

Publications

Below you can find a list of our published research.

6197 results

Cited 2 times since 2009 (0.1 per year) source: EuropePMC

Endocrine reviews, Volume 30, Issue 7, 1 1 2009, Pages 927-928 Unraveling the Directional Link between Adiposity and Inflammation: A Bidirectional Mendelian Randomization Approach. Welsh P, Polisecki E, Robertson M, Jahn S, Buckley BM, de Craen AJ, Ford I, Jukema JW, Macfarlane PW, Packard CJ, Stott DJ, Westendorp RG, Shepherd J, Hingorani AD, Smith GD, Schaefer E, Sattar N

Abstract

Cited 13 times since 2009 (0.8 per year) source: EuropePMC

Pacing and clinical electrophysiology : PACE, Volume 33, Issue 4, 1 1 2009, Pages 431-436 Implementation of lead safety recommendations. VAN Rees JB, Borleffs CJ, Bax JJ, Nagtegaal EM, VAN DER Velde ET, VAN Erven L, Schalij MJ

Background: The Medtronic Sprint Fidelis (SF) implantable cardioverter defibrillator (ICD; Medtronic Inc., Minneapolis, MN, USA) lead has a higher than expected failure rate. Because of patient safety, Medtronic announced two advisories consisting of (1) adjustments in device settings (October 2007) and (2) installation of a lead integrity algorithm (May 2008). The objective of this study was to evaluate the effect of Medtronic's announcements on patient safety. Methods: To comply with the... Abstract

Cited 33 times since 2009 (2.1 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 2, Issue 12, 1 1 2009, Pages 1425-1435 Role of left ventricular twist mechanics in the assessment of cardiac dyssynchrony in heart failure. Bertini M, Sengupta PP, Nucifora G, Delgado V, Ng AC, Marsan NA, Shanks M, van Bommel RJ, Schalij MJ, Narula J, Bax JJ

The authors discuss an incremental value of assessing left ventricular (LV) twist mechanics in patients with heart failure (HF) and its potential usefulness in characterizing response to cardiac resynchronization therapy (CRT) and reversal of LV remodeling at 6 months follow-up. They also underscore a critical relationship between LV lead position and changes in LV twist after CRT, and suggest that the reversal of LV remodeling in HF patients following CRT primarily results from restoration of t... Abstract

Cited 5 times since 2009 (0.3 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 54, Issue 25, 1 1 2009, Pages 2447-2458 Highlights of the 2009 scientific sessions of the European Society of Cardiology. Bax JJ, Casadei B, Di Mario C, Fagard R, Filippatos G, Fox KA, Metra M, Nihoyannopoulos P, Perk J, Rademakers F, Rosenhek R, Vardas PE, Pinto FJ, Ferrari R

Abstract

Cited 81 times since 2009 (5.2 per year) source: EuropePMC

European heart journal, Volume 30, Issue 24, 1 1 2009, Pages 3027-3036 Blunted frequency-dependent upregulation of cardiac output is related to impaired relaxation in diastolic heart failure. Wachter R, Schmidt-Schweda S, Westermann D, Post H, Edelmann F, Kasner M, Lüers C, Steendijk P, Hasenfuss G, Tschöpe C, Pieske B

Aims: We tested the hypothesis that, in heart failure with normal ejection fraction (HFNEF), diastolic dysfunction is accentuated at increasing heart rates, and this contributes to impaired frequency-dependent augmentation of cardiac output. Methods and results: In 17 patients with HFNEF (median age 69 years, 13 female) and seven age-matched control patients, systolic and diastolic function was analysed by pressure-volume loops at baseline heart rate and during atrial pacing to 100 and 120 min(-... Abstract

Cited 1 times since 2009 (0.1 per year) source: EuropePMC

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, Volume 16, Issue 6, 1 1 2009, Pages 690-693 Remote ischemic preconditioning in vascular surgery patients: the additional value to medical treatment. van Kuijk JP, Flu WJ, Verhagen HJ, Bax JJ, Poldermans D

Abstract

Cited 16 times since 2009 (1 per year) source: EuropePMC

The American journal of cardiology, Volume 104, Issue 11, 1 1 2009, Pages 1490-1493 Prognostic significance of QRS duration in patients with suspected coronary artery disease referred for noninvasive evaluation of myocardial ischemia. Schinkel AF, Elhendy A, van Domburg RT, Biagini E, Rizzello V, Veltman CE, Ten Kate GL, Sijbrands EJ, Akkerhuis KM, Geleijnse ML, Ten Cate FJ, Simoons ML, Bax JJ, Poldermans D

The purpose of this study was to evaluate the prognostic significance of QRS duration in patients with suspected coronary artery disease (CAD) referred for noninvasive evaluation of myocardial ischemia by dobutamine stress echocardiography. QRS duration is a prognostic marker in patients with previous myocardial infarction and/or heart failure. The relation between QRS duration and outcome of patients without known heart disease has not been evaluated. A total of 1,227 patients (707 men, mean ag... Abstract

Cited 158 times since 2009 (10.2 per year) source: EuropePMC

European heart journal, Volume 30, Issue 24, 1 1 2009, Pages 3037-3047 Strain analysis in patients with severe aortic stenosis and preserved left ventricular ejection fraction undergoing surgical valve replacement. Delgado V, Tops LF, van Bommel RJ, van der Kley F, Marsan NA, Klautz RJ, Versteegh MI, Holman ER, Schalij MJ, Bax JJ

Aims: To evaluate myocardial multidirectional strain and strain rate (S-and-SR) in severe aortic stenosis (AS) patients with preserved left ventricular (LV) ejection fraction (EF), using two-dimensional speckle-tracking strain imaging (2D-STI). The long-term effect of aortic valve replacement (AVR) on S-and-SR was also evaluated. Methods and results: Changes in LV radial, circumferential, and longitudinal S-and-SR were evaluated in 73 severe AS patients (65 +/- 13 years; aortic valve area 0.8 +/... Abstract

Cited 19 times since 2009 (1.2 per year) source: EuropePMC

Respiratory medicine, Volume 104, Issue 5, 25 4 2009, Pages 712-716 Association of COPD with carotid wall intima-media thickness in vascular surgery patients. van Gestel YR, Flu WJ, van Kuijk JP, Hoeks SE, Bax JJ, Sin DD, Poldermans D

Introduction: There is increasing evidence that non-invasive imaging modalities such as ultrasonography may be able to detect subclinical atherosclerotic lesions, and as such may be useful tools for risk-stratification. However, the clinical relevance of these observations remains unknown in patients with COPD. Therefore we investigated the association between COPD and carotid wall intima-media thickness (IMT) in patients undergoing vascular surgery and its relationship with mortality in these p... Abstract

Cited 31 times since 2009 (2 per year) source: EuropePMC

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 39, Issue 2, 25 4 2009, Pages 187-192 The proximal fixation strength of modern EVAR grafts in a short aneurysm neck. An in vitro study. Bosman WM, Steenhoven TJ, Suárez DR, Hinnen JW, Valstar ER, Hamming JF

Objectives: The study aims to measure the strength of the proximal fixation of endografts in short and long necks. Design: Three types of endografts were compared: Gore Excluder, Vascutek Anaconda and Medtronic Endurant. Materials and methods: The proximal part of the stent grafts was inserted in bovine arteries and the graft was then attached to a tensile testing machine. The force to obtain dislodgement (DF) from the aorta was recorded for each graft at proximal seal lengths of 10 and 15 mm. R... Abstract

Cited 59 times since 2009 (3.8 per year) source: EuropePMC

European journal of endocrinology, Volume 162, Issue 2, 23 4 2009, Pages 331-340 Cardiac dysfunction is reversed upon successful treatment of Cushing's syndrome. Pereira AM, Delgado V, Romijn JA, Smit JW, Bax JJ, Feelders RA

Objective: In patients with active Cushing's syndrome (CS), cardiac structural and functional changes have been described in a limited number of patients. It is unknown whether these changes reverse after successful treatment. We therefore evaluated the changes in cardiac structure and dysfunction after successful treatment of CS, using more sensitive echocardiographic parameters (based on two-dimensional strain imaging) to detect subtle changes in cardiac structure and function. Methods: I... Abstract

Cited 13 times since 2009 (0.8 per year) source: EuropePMC

European heart journal, Volume 31, Issue 6, 23 4 2009, Pages 712-718 Mortality risk score in primary prevention implantable cardioverter defibrillator recipients with non-ischaemic or ischaemic heart disease. Borleffs CJ, van Welsenes GH, van Bommel RJ, van der Velde ET, Bax JJ, van Erven L, Putter H, van der Bom JG, Rosendaal FR, Schalij MJ

Aims: To assess survival and to construct a baseline mortality risk score in primary prevention implantable cardioverter defibrillator (ICD) patients with non-ischaemic or ischaemic heart disease. Methods and results: Since 1996, data of all consecutive patients who received an ICD system in the Leiden University Medical Center were collected and assessed at implantation. For the current study, all 1036 patients [age 63 (SD 11) years, 81% male] with a primary indication for defibrillator implant... Abstract

Cited 165 times since 2009 (10.7 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 55, Issue 6, 20 3 2009, Pages 566-575 Optimizing hemodynamics in heart failure patients by systematic screening of left ventricular pacing sites: the lateral left ventricular wall and the coronary sinus are rarely the best sites. Derval N, Steendijk P, Gula LJ, Deplagne A, Laborderie J, Sacher F, Knecht S, Wright M, Nault I, Ploux S, Ritter P, Bordachar P, Lafitte S, Réant P, Klein GJ, Narayan SM, Garrigue S, Hocini M, Haissaguerre M, Clementy J, Jaïs P

Objectives: We sought to evaluate the impact of the left ventricular (LV) pacing site on hemodynamic response to cardiac resynchronization therapy (CRT). Background: CRT reduces morbidity and mortality in heart failure patients. However, 20% to 40% of eligible patients may not fully benefit from CRT device implantation. We hypothesized that selecting the optimal LV pacing site could be critical in this issue. Methods: Thirty-five patients with nonischemic dilated cardiomyopathy referred for CRT... Abstract

Cited 219 times since 2009 (14.1 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 3, Issue 1, 17 3 2009, Pages 94-102 Comparison of aortic root dimensions and geometries before and after transcatheter aortic valve implantation by 2- and 3-dimensional transesophageal echocardiography and multislice computed tomography. Ng AC, Delgado V, van der Kley F, Shanks M, van de Veire NR, Bertini M, Nucifora G, van Bommel RJ, Tops LF, de Weger A, Tavilla G, de Roos A, Kroft LJ, Leung DY, Schuijf J, Schalij MJ, Bax JJ

Background: 3D transesophageal echocardiography (TEE) may provide more accurate aortic annular and left ventricular outflow tract (LVOT) dimensions and geometries compared with 2D TEE. We assessed agreements between 2D and 3D TEE measurements with multislice computed tomography (MSCT) and changes in annular/LVOT areas and geometries after transcatheter aortic valve implantations (TAVI). Methods and results: Two-dimensional circular (pixr(2)), 3D circular, and 3D planimetered annular and LVOT are... Abstract

Cited 12 times since 2009 (0.8 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 3, Issue 1, 17 3 2009, Pages 86-93 Prediction of cardiac resynchronization therapy response: value of calibrated integrated backscatter imaging. Bertini M, Delgado V, den Uijl DW, Nucifora G, Ng AC, van Bommel RJ, Borleffs CJ, Boriani G, Schalij MJ, Bax JJ

Background: Left ventricular (LV) fibrosis is important for the response to cardiac resynchronization therapy (CRT). Calibrated integrated backscatter derived by 2D echocardiography quantifies myocardial ultrasound reflectivity, which may provide a surrogate of LV fibrosis. The aim of the study was first, to investigate the relation of myocardial ultrasound reflectivity assessed with calibrated integrated backscatter on CRT response, and second, to explore the "myocardial ultrasound reflect... Abstract

Cited 6 times since 2009 (0.4 per year) source: EuropePMC

Diabetes care, Volume 33, Issue 2, 16 3 2009, Pages 372-374 Increased carotid intima-media thickness as a predictor of the presence and extent of abnormal myocardial perfusion in type 2 diabetes. Djaberi R, Schuijf JD, Jukema JW, Rabelink TJ, Stokkel MP, Smit JW, de Koning EJ, Bax JJ

Objective: Identification of asymptomatic patients with type 2 diabetes at increased risk for coronary artery disease (CAD) remains a challenge. We evaluated the potential of carotid intima-media thickness (CIMT) for prediction of abnormal myocardial perfusion in this population. Research design and methods: CIMT and SPECT myocardial perfusion imaging were assessed in 98 asymptomatic patients with type 2 diabetes. An increased CIMT was defined as > or =75th percentile of reference values. RES... Abstract

Cited 14 times since 2009 (0.9 per year) source: EuropePMC

The American journal of cardiology, Volume 105, Issue 1, 14 2 2009, Pages 43-47 Impact of prophylactic beta-blocker therapy to prevent stroke after noncardiac surgery. van Lier F, Schouten O, Hoeks SE, van de Ven L, Stolker RJ, Bax JJ, Poldermans D

beta Blockers are widely used to improve the postoperative cardiac outcome in patients with coronary artery disease scheduled for noncardiac surgery. However, recently serious concerns regarding the safety of perioperative beta blockers have emerged. To assess the incidence, risk factors, and beta-blocker use associated with postoperative stroke in the Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography (DECREASE) trials, we evaluated all 3,884 patients of the DECREA... Abstract

Cited 7 times since 2009 (0.5 per year) source: EuropePMC

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 50, Issue 12, 12 2 2009, Pages 1980-1986 Endothelial dysfunction in diabetic patients with abnormal myocardial perfusion in the absence of epicardial obstructive coronary artery disease. Djaberi R, Roodt Jo, Schuijf JD, Rabelink TJ, de Koning EJ, Pereira AM, Stokkel MP, Smit JW, Bax JJ, Jukema JW

Unlabelled: In patients with diabetes mellitus, myocardial perfusion defects are often observed in the absence of obstructive epicardial coronary artery disease (CAD), thereby presenting a diagnostic problem. We hypothesized that these perfusion abnormalities may be explained by endothelial dysfunction or occult coronary atherosclerosis. Methods: Prospectively, 130 asymptomatic patients with diabetes mellitus underwent cardiovascular screening by coronary artery calcium (CAC) scoring, multislice... Abstract

Cited 90 times since 2009 (5.8 per year) source: EuropePMC

The Journal of clinical endocrinology and metabolism, Volume 95, Issue 1, 11 2 2009, Pages 93-99 Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach. Welsh P, Polisecki E, Robertson M, Jahn S, Buckley BM, de Craen AJ, Ford I, Jukema JW, Macfarlane PW, Packard CJ, Stott DJ, Westendorp RG, Shepherd J, Hingorani AD, Smith GD, Schaefer E, Sattar N

Context: Associations between adiposity and circulating inflammation markers are assumed to be causal, although the direction of the relationship has not been proven. Objective: The aim of the study was to explore the causal direction of the relationship between adiposity and inflammation using a bidirectional Mendelian randomization approach. Methods: In the PROSPER study of 5804 elderly patients, we related C-reactive protein (CRP) single nucleotide polymorphisms (SNPs) (rs1800947 and rs1205)... Abstract

Cited 31 times since 2009 (2 per year) source: EuropePMC

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 39, Issue 1, 11 2 2009, Pages 70-86 A systematic review of implementation of established recommended secondary prevention measures in patients with PAOD. Flu HC, Tamsma JT, Lindeman JH, Hamming JF, Lardenoye JH

Objective: Since patients with peripheral arterial occlusive disease (PAOD) are at high-risk for cardiovascular morbidity and mortality, preventive measures aimed to reduce cardiovascular adverse events are advocated in the current guidelines. We conducted a systematic review to assess the implementation of secondary prevention (SP) measures in PAOD patients. Methods: PubMed, Cochrane Library, EMBASE and Web of Science databases were searched to perform a systematic review of the literature from... Abstract