Research

Publications

Below you can find a list of our published research.

6196 results

Cited 15 times since 2008 (0.9 per year) source: EuropePMC

Stem cells (Dayton, Ohio), Volume 26, Issue 12, 18 3 2008, Pages 3210-3217 Phenotypic and functional reversal within the early human hematopoietic compartment. Knaän-Shanzer S, van der Velde-van Dijke I, van de Watering MJ, de Leeuw PJ, Valerio D, van Bekkum DW, de Vries AA

The fate of phenotypically defined human hematopoietic stem cells (hHSCs) in culture and the link between their surface marker expression profile and function are still controversial. We studied these aspects of hHSC biology by relating the expression of the early lineage markers (ELM) CD33, CD38, and CD71 on the surface of human umbilical cord blood (UCB) CD34(+) cells to their long-term nonobese diabetic/severe combined immunodeficient (NOD/SCID) mouse repopulation activity (LT-SRA). In uncult... Abstract

Cited 8 times since 2008 (0.5 per year) source: EuropePMC

Journal of applied physiology (Bethesda, Md. : 1985), Volume 105, Issue 6, 18 3 2008, Pages 1725-1732 Enhanced airway dilation by positive-pressure inflation of the lungs compared with active deep inspiration in patients with asthma. Slats AM, Janssen K, de Jeu RC, van der Plas DT, Schot R, van den Aardweg JG, Sterk PJ

Deep inspiration temporarily reduces induced airways obstruction in healthy subjects. This bronchodilatory effect of deep inspiration is impaired in asthma. Passive machine-assisted lung inflation may augment bronchodilation compared with an active deep inspiration in patients with asthma by either opening closed airways or by reducing fluid flux across the airway wall during deep inspiration, and thereby increasing the tethering forces on the airway wall. We recruited 24 patients with asthma [1... Abstract

Cited 9 times since 2008 (0.5 per year) source: EuropePMC

European journal of endocrinology, Volume 159, Issue 6, 11 2 2008, Pages 705-712 Cardiac manifestations of GH deficiency after treatment for acromegaly: a comparison to patients with biochemical remission and controls. van der Klaauw AA, Bax JJ, Bleeker GB, Holman ER, Delgado V, Smit JW, Romijn JA, Pereira AM

Objective: Both GH excess and GH deficiency (GHD) lead to specific cardiac pathology. The aim of this study was to evaluate cardiac morphology and function in patients with GHD after treatment for acromegaly. Design: Cross-sectional study. Patients and methods: Cardiac parameters were studied by conventional two-dimensional echocardiography and tissue Doppler imaging in 53 patients with acromegaly (16 patients with GHD, 20 patients with biochemical remission, and 17 patients with active disease)... Abstract

Cited 29 times since 2008 (1.7 per year) source: EuropePMC

The American journal of cardiology, Volume 102, Issue 10, 6 1 2008, Pages 1366-1372 Comparison between tissue Doppler imaging and velocity-encoded magnetic resonance imaging for measurement of myocardial velocities, assessment of left ventricular dyssynchrony, and estimation of left ventricular filling pressures in patients with ischemic cardiomyopathy. Marsan NA, Westenberg JJ, Tops LF, Ypenburg C, Holman ER, Reiber JH, de Roos A, van der Wall EE, Schalij MJ, Roelandt JR, Bax JJ

Velocity-encoded magnetic resonance imaging (VE-MRI), commonly used to perform flow measurements, can be applied for myocardial velocity analysis, similar to tissue Doppler imaging (TDI). In this study, a comparison between VE-MRI and TDI was performed for the assessment of left ventricular dyssynchrony and left ventricular filling pressures. Ten healthy volunteers and 22 patients with heart failure secondary to ischemic cardiomyopathy underwent both VE-MRI and TDI. Longitudinal myocardial peak... Abstract

Cited 2 times since 2008 (0.1 per year) source: EuropePMC

Journal of internal medicine, Volume 264, Issue 6, 6 1 2008, Pages 571-585 Reduced leucocyte cholesteryl ester transfer protein expression in acute coronary syndromes. Ye D, Kraaijeveld AO, Grauss RW, Willems SM, van Vark-van der Zee LC, de Jager SC, Jauhiainen M, Kuivenhoven JA, Dallinga-Thie GM, Atsma DE, Hogendoorn PC, Biessen EA, Van Berkel TJ, Jukema JW, van Eck M

Objective: Cholesterol ester transfer protein (CETP) plays an important role in HDL cholesterol metabolism. Leucocytes, including monocyte-derived macrophages in the arterial wall synthesize and secrete CETP, but its role in atherosclerosis is unclear. The aim of the current study was to investigate the effect of acute coronary syndromes (ACS) on leucocyte CETP expression. Research design: Peripheral blood mononuclear cells (PBMCs) were freshly isolated from hospitalized ACS patients displaying... Abstract

Cited 19 times since 2008 (1.1 per year) source: EuropePMC

European journal of heart failure, Volume 10, Issue 9, 2 1 2008, Pages 878-883 Myocardial collagen metabolism in failing hearts before and during cardiac resynchronization therapy. Umar S, Bax JJ, Klok M, van Bommel RJ, Hessel MH, den Adel B, Bleeker GB, Henneman MM, Atsma DE, van der Wall EE, Schalij MJ, van der Laarse A

Background: In patients with heart failure cardiac resynchronization therapy (CRT) leads to reverse ventricular remodelling. Aim: To evaluate whether myocardial collagen metabolism in patients with heart failure is implicated in adverse ventricular remodelling and response to CRT. Methods: Collagen synthesis and degradation were assessed from the concentrations of aminoterminal propeptides of type I and type III collagen (PINP and PIIINP) and carboxyterminal telopeptide of type I collagen (ICTP)... Abstract

Cited 11 times since 2008 (0.7 per year) source: EuropePMC

Critical care medicine, Volume 36, Issue 9, 1 1 2008, Pages 2576-2582 Negative effects of rofecoxib treatment on cardiac function after ischemia-reperfusion injury in APOE3Leiden mice are prevented by combined treatment with thromboxane prostanoid-receptor antagonist S18886 (terutroban). van der Hoorn JW, Jukema JW, Bekkers ME, Princen HM, Corda S, Emeis JJ, Steendijk P

Objective: Selective cyclooxygenase-2 inhibition by rofecoxib was associated with increased risk of cardiovascular events. We hypothesized that concomitant treatment with thromboxane prostanoid receptor antagonist S18886 might ameliorate possible negative effects. We evaluated the effects of S18886, rofecoxib, and the interaction of both compounds in a combined treatment on myocardial infarct (MI) size and cardiac function after experimental ischemia/reperfusion injury in hyperlipidemic APOE*3Le... Abstract

Cited 13 times since 2008 (0.8 per year) source: EuropePMC

Current opinion in cardiology, Volume 23, Issue 5, 1 1 2008, Pages 431-439 Myocardial perfusion single photon emission computed tomography for the assessment of mechanical dyssynchrony. Boogers MM, Chen J, Bax JJ

Purpose of review: Assessment of left ventricular dyssynchrony is important in the selection of patients for cardiac resynchronization therapy (CRT). In this review, the role of nuclear imaging [particularly gated myocardial perfusion single photon emission computed tomography (GMPS)] for assessment of cardiac dyssynchrony is discussed. In addition, the role of positron emission tomography for evaluation of effects of CRT is addressed. Recent findings: Phase analysis of GMPS yields accurate info... Abstract

Cited 102 times since 2008 (6.1 per year) source: EuropePMC

European journal of immunology, Volume 38, Issue 9, 1 1 2008, Pages 2389-2400 Development of human plasmacytoid dendritic cells depends on the combined action of the basic helix-loop-helix factor E2-2 and the Ets factor Spi-B. Nagasawa M, Schmidlin H, Hazekamp MG, Schotte R, Blom B

Plasmacytoid dendritic cells (pDC) are central players in the innate and adaptive immune response against viral infections. The molecular mechanism that underlies pDC development from progenitor cells is only beginning to be elucidated. Previously, we reported that the Ets factor Spi-B and the inhibitors of DNA binding protein 2 (Id2) or Id3, which antagonize E-protein activity, are crucially involved in promoting or impairing pDC development, respectively. Here we show that the basic helix-loop... Abstract

Cited 1 times since 2008 (0.1 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 52, Issue 11, 1 1 2008, Pages 921-923 Aggressive therapy is not always the best therapy. Bruschke AV, Jukema JW

Abstract

Cited 27 times since 2008 (1.6 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 94, Issue 9, 1 1 2008, Pages 1214-1226 Cell therapy for ischaemic heart disease. Beeres SL, Atsma DE, van Ramshorst J, Schalij MJ, Bax JJ

Abstract

Cited 36 times since 2008 (2.2 per year) source: EuropePMC

The Journal of bone and joint surgery. British volume, Volume 90, Issue 9, 1 1 2008, Pages 1205-1209 Early magnetic resonance imaging compared with bone scintigraphy in suspected scaphoid fractures. Beeres FJ, Rhemrev SJ, den Hollander P, Kingma LM, Meylaerts SA, le Cessie S, Bartlema KA, Hamming JF, Hogervorst M

We evaluated 100 consecutive patients with a suspected scaphoid fracture but without evidence of a fracture on plain radiographs using MRI within 24 hours of injury, and bone scintigraphy three to five days after injury. The reference standard for a true radiologically-occult scaphoid fracture was either a diagnosis of fracture on both MRI and bone scintigraphy, or, in the case of discrepancy, clinical and/or radiological evidence of a fracture. MRI revealed 16 scaphoid and 24 other fractures. B... Abstract

Cited 16 times since 2008 (1 per year) source: EuropePMC

PloS one, Volume 3, Issue 8, 29 5 2008, Pages e3084 Targeted chromosomal insertion of large DNA into the human genome by a fiber-modified high-capacity adenovirus-based vector system. Gonçalves MA, Holkers M, van Nierop GP, Wieringa R, Pau MG, de Vries AA

A prominent goal in gene therapy research concerns the development of gene transfer vehicles that can integrate exogenous DNA at specific chromosomal loci to prevent insertional oncogenesis and provide for long-term transgene expression. Adenovirus (Ad) vectors arguably represent the most efficient delivery systems of episomal DNA into eukaryotic cell nuclei. The most advanced recombinant Ads lack all adenoviral genes. This renders these so-called high-capacity (hc) Ad vectors less cytotoxic/imm... Abstract

Cited 180 times since 2008 (10.8 per year) source: EuropePMC

BMJ (Clinical research ed.), Volume 337, 29 5 2008, Pages a1331 Drug eluting and bare metal stents in people with and without diabetes: collaborative network meta-analysis. Stettler C, Allemann S, Wandel S, Kastrati A, Morice MC, Schömig A, Pfisterer ME, Stone GW, Leon MB, de Lezo JS, Goy JJ, Park SJ, Sabaté M, Suttorp MJ, Kelbaek H, Spaulding C, Menichelli M, Vermeersch P, Dirksen MT, Cervinka P, De Carlo M, Erglis A, Chechi T, Ortolani P, Schalij MJ, Diem P, Meier B, Windecker S, Jüni P

Objective: To compare the effectiveness and safety of three types of stents (sirolimus eluting, paclitaxel eluting, and bare metal) in people with and without diabetes mellitus. Design: Collaborative network meta-analysis. Data sources: Electronic databases (Medline, Embase, the Cochrane Central Register of Controlled Trials), relevant websites, reference lists, conference abstracts, reviews, book chapters, and proceedings of advisory panels for the US Food and Drug Administration. Manufacturers... Abstract

Cited 21 times since 2008 (1.3 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 34, Issue 6, 28 4 2008, Pages 1149-1157 Early and late outcome of left ventricular reconstruction surgery in ischemic heart disease. Klein P, Bax JJ, Shaw LJ, Feringa HH, Versteegh MI, Dion RA, Klautz RJ

A systematic review of the literature was performed to determine early and late mortality associated with left ventricular (LV) reconstruction surgery and to assess the influence of different surgical techniques, concomitant surgical procedures, clinical and hemodynamic parameters on mortality. The MEDLINE database (January 1980-January 2005) was searched and from the pooled data, hospital mortality and survival were calculated. Summary estimates of relative risks (RR) were calculated for the te... Abstract

Cited 3 times since 2008 (0.2 per year) source: EuropePMC

The American journal of cardiology, Volume 102, Issue 9, 27 4 2008, Pages 1156-1158 Prognostic significance of myocardial ischemia by dobutamine stress echocardiography in patients without angina pectoris after coronary revascularization. Pedone C, Elhendy A, Biagini E, van Domburg RT, Schinkel AF, Di Pasquale G, Bax JJ, Poldermans D

The clinical utility of stress testing in patients without angina pectoris after revascularization has been questioned. Dobutamine stress echocardiography (DSE) is an established technique for detection of myocardial ischemia and cardiac risk stratification. We studied the prognostic value of DSE in 393 patients without typical angina pectoris after coronary revascularization. Ischemia was incremental to clinical data in predicting all-cause death (hazard ratio 3.5, 95% confidence interval 1.8 t... Abstract

Cited 1 times since 2008 (0.1 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 24, Issue 8, 12 2 2008, Pages 907-909 Coronary artery calcium screening: sufficient evidence for accurate risk assessment? van der Wall EE, Schuijf JD, Jukema JW, Bax JJ

Abstract

Cited 10 times since 2008 (0.6 per year) source: EuropePMC

Molecular and cellular biochemistry, Volume 320, Issue 1-2, 9 2 2008, Pages 75-84 Integrin stimulation-induced hypertrophy in neonatal rat cardiomyocytes is NO-dependent. Umar S, van der Valk EJ, Schalij MJ, van der Wall EE, Atsma DE, van der Laarse A

Prolonged myocardial stretch typically leads to hypertrophy of cardiomyocytes. As integrins are cellular receptors of stretch, we hypothesize that integrin stimulation induces cardiomyocyte hypertrophy. Integrins of neonatal rat cardiomyocytes (NRCMs) were stimulated with a peptide containing the Arg-Gly-Asp (RGD) sequence for 24 h. For comparison, alpha(1)-adrenergic stimulation by phenylephrine (PE) for 24 h was applied. Saline-treated NRCMs were used as control. The hypertrophic response was... Abstract

Cited 46 times since 2008 (2.7 per year) source: EuropePMC

Heart rhythm, Volume 5, Issue 9, 6 1 2008, Pages 1257-1264 Real-time three-dimensional echocardiography as a novel approach to assess left ventricular and left atrium reverse remodeling and to predict response to cardiac resynchronization therapy. Marsan NA, Bleeker GB, Ypenburg C, Van Bommel RJ, Ghio S, Van de Veire NR, Delgado V, Holman ER, van der Wall EE, Schalij MJ, Bax JJ

Background: Real-time 3-dimensional echocardiography (RT3DE) is a novel promising technique for the assessment of left ventricular (LV) dyssynchrony. Objective: This study sought to explore the value of RT3DE to assess LV and left atrium (LA) reverse remodeling and to predict response to cardiac resynchronization therapy (CRT). Methods: A total of 57 consecutive heart failure patients scheduled for CRT were included, and RT3DE was performed before and 6 months after implantation. LV dyssynchrony... Abstract

Cited 156 times since 2008 (9.3 per year) source: EuropePMC

European heart journal, Volume 29, Issue 19, 5 1 2008, Pages 2373-2381 Evaluation of plaque characteristics in acute coronary syndromes: non-invasive assessment with multi-slice computed tomography and invasive evaluation with intravascular ultrasound radiofrequency data analysis. Pundziute G, Schuijf JD, Jukema JW, Decramer I, Sarno G, Vanhoenacker PK, Boersma E, Reiber JH, Schalij MJ, Wijns W, Bax JJ

Aims: Atherosclerotic plaque characteristics play an important role in the development of coronary events. We investigated coronary plaque characteristics on multi-slice computed tomography (MSCT) and virtual histology intravascular ultrasound (VH IVUS) in patients with acute coronary syndromes (ACS) and stable coronary artery disease (CAD). Methods and results: Fifty patients (25 with ACS, 25 with stable CAD) underwent 64-slice MSCT followed by VH IVUS in 48 (96%) patients. In ACS patients, 32%... Abstract