Research

Publications

Below you can find a list of our published research.

8892 results

Cited 48 times since 2014 (4.4 per year) source: Scopus

PloS one, Volume 9, Issue 12, 4 1 2014, Pages e111952 ACE inhibitors potently reduce vascular inflammation, results of an open proof-of-concept study in the abdominal aortic aneurysm. Kortekaas KE, Meijer CA, Hinnen JW, Dalman RL, Xu B, Hamming JF, Lindeman JH

Background: Independent of their blood pressure lowering effect, ACE inhibitors are thought to reduce vascular inflammation. The clinical relevance of this effect is unclear with the current knowledge. Abdominal aortic aneurysms (AAA) are characterized by a broad, non-specific inflammatory response, and thus provide a clinical platform to evaluate the anti-inflammatory potential of ACE inhibitors. Methods and results: Eleven patients scheduled for open AAA repair received ramipril (5 mg/day) dur... Abstract

Cited 43 times since 2014 (4 per year) source: EuropePMC

PLoS genetics, Volume 10, Issue 12, 4 1 2014, Pages e1004799 Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers. Taylor AE, Morris RW, Fluharty ME, Bjorngaard JH, Åsvold BO, Gabrielsen ME, Campbell A, Marioni R, Kumari M, Hällfors J, Männistö S, Marques-Vidal P, Kaakinen M, Cavadino A, Postmus I, Husemoen LL, Skaaby T, Ahluwalia TS, Treur JL, Willemsen G, Dale C, Wannamethee SG, Lahti J, Palotie A, Räikkönen K, Kisialiou A, McConnachie A, Padmanabhan S, Wong A, Dalgård C, Paternoster L, Ben-Shlomo Y, Tyrrell J, Horwood J, Fergusson DM, Kennedy MA, Frayling T, Nohr EA, Christiansen L, Ohm Kyvik K, Kuh D, Watt G, Eriksson J, Whincup PH, Vink JM, Boomsma DI, Davey Smith G, Lawlor D, Linneberg A, Ford I, Jukema JW, Power C, Hyppönen E, Jarvelin MR, Preisig M, Borodulin K, Kaprio J, Kivimaki M, Smith BH, Smith BH, Hayward C, Romundstad PR, Sørensen TI, Munafò MR, Sattar N

We previously used a single nucleotide polymorphism (SNP) in the CHRNA5-A3-B4 gene cluster associated with heaviness of smoking within smokers to confirm the causal effect of smoking in reducing body mass index (BMI) in a Mendelian randomisation analysis. While seeking to extend these findings in a larger sample we found that this SNP is associated with 0.74% lower body mass index (BMI) per minor allele in current smokers (95% CI -0.97 to -0.51, P = 2.00 × 10(-10)), but also unexpectedly found t... Abstract

Cited 5 times since 2014 (0.5 per year) source: EuropePMC

International journal of cardiology, Volume 183, 3 1 2014, Pages 249-257 Abnormal sinoatrial node development resulting from disturbed vascular endothelial growth factor signaling. Calkoen EE, Vicente-Steijn R, Hahurij ND, van Munsteren CJ, Roest AA, DeRuiter MC, Steendijk P, Schalij MJ, Gittenberger-de Groot AC, Blom NA, Jongbloed MR

Background: Sinus node dysfunction is frequently observed in patients with congenital heart disease (CHD). Variants in the Vascular Endothelial Growth Factor-A (VEGF) pathway are associated with CHD. In Vegf(120/120) mice, over-expressing VEGF120, a reduced sinoatrial node (SAN) volume was suggested. Aim of the study is to assess the effect of VEGF over-expression on SAN development and function. Methods: Heart rate was measured in Vegf(120/120) and wildtype (WT) embryos during high frequency ul... Abstract

Cited 47 times since 2014 (4.3 per year) source: EuropePMC

BMJ open diabetes research & care, Volume 2, Issue 1, 3 1 2014, Pages e000034 Inflammation increases plasma angiopoietin-like protein 4 in patients with the metabolic syndrome and type 2 diabetes. Tjeerdema N, Georgiadi A, Jonker JT, van Glabbeek M, Alizadeh Dehnavi R, Tamsma JT, Smit JW, Kersten S, Rensen PC

Background: Angiopoietin-like protein 4 (ANGPTL4) inhibits lipoprotein lipase and associates with dyslipidemia. The expression of ANGPTL4 is regulated by free fatty acids (FFA) that activate lipid-sensing peroxisome proliferator-activated receptors (PPARs), but FFA can also activate pattern recognition receptors including Toll-like receptor 4 (TLR4) in macrophages. Objective: To assess whether systemic low-grade inflammation is a determinant for plasma ANGPTL4 levels in patients with the metabol... Abstract

Cited 2 times since 2014 (0.2 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 21, Issue 6, 1 1 2014, Pages 1245-1251 Multimodality imaging: bird's eye view from The European Society of Cardiology Congress 2014 Barcelona, August 30-September 3, 2014. Bax JJ, Delgado V, Achenbach S, Sechtem U, Knuuti J

Abstract

Cited 130 times since 2014 (11.9 per year) source: EuropePMC

Proceedings of the National Academy of Sciences of the United States of America, Volume 111, Issue 50, 1 1 2014, Pages E5383-92 Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue. Zhang M, D'Aniello C, Verkerk AO, Wrobel E, Frank S, Ward-van Oostwaard D, Piccini I, Freund C, Rao J, Seebohm G, Atsma DE, Schulze-Bahr E, Mummery CL, Greber B, Bellin M

Jervell and Lange-Nielsen syndrome (JLNS) is one of the most severe life-threatening cardiac arrhythmias. Patients display delayed cardiac repolarization, associated high risk of sudden death due to ventricular tachycardia, and congenital bilateral deafness. In contrast to the autosomal dominant forms of long QT syndrome, JLNS is a recessive trait, resulting from homozygous (or compound heterozygous) mutations in KCNQ1 or KCNE1. These genes encode the α and β subunits, respectively, of the ion c... Abstract

Cited 1 times since 2014 (0.1 per year) source: EuropePMC

Clinical and experimental immunology, Volume 178 Suppl 1, 1 1 2014, Pages 1-2 7th International Immunoglobulin Conference: Foreword. Jolles S, Jordan SC, Orange JS, van Schaik IN

Abstract

Cited 1 times since 2014 (0.1 per year) source: EuropePMC

Criminal behaviour and mental health : CBMH, Volume 24, Issue 5, 1 1 2014, Pages 365-367 MAOA, COMT and 5-HTTLPR frequencies in convicted and never convicted Afro-Caribbeans in the Netherlands. Vinkers DJ, Bogaerts S, Van Schaik RH

Abstract

Cited 44 times since 2014 (4 per year) source: EuropePMC

Inflammatory bowel diseases, Volume 20, Issue 12, 1 1 2014, Pages 2292-2298 Influence of combination therapy with immune modulators on anti-TNF trough levels and antibodies in patients with IBD. van Schaik T, Maljaars JP, Roopram RK, Verwey MH, Ipenburg N, Hardwick JC, Veenendaal RA, van der Meulen-de Jong AE

Background: It is important to identify factors that can reduce the incidence of immunogenicity against anti-tumor necrosis factor medication in patients with inflammatory bowel disease. The objective of our study was to evaluate the influence of cotreatment with immune modulators (IMs) on trough levels (TLs) and antidrug antibodies. Methods: The records of all patients with inflammatory bowel disease at the Leiden University Medical Center who received either adalimumab or infliximab (IFX) in t... Abstract

Cited 26 times since 2014 (2.4 per year) source: EuropePMC

PloS one, Volume 9, Issue 12, 1 1 2014, Pages e113674 Prevalence of rotavirus genotypes in children younger than 5 years of age before the introduction of a universal rotavirus vaccination program: report of rotavirus surveillance in Turkey. Durmaz R, Kalaycioglu AT, Acar S, Bakkaloglu Z, Karagoz A, Korukluoglu G, Ertek M, Torunoglu MA, Turkish Rotavirus Surveillance Network

Background: Group A rotaviruses are the most common causative agent of acute gastroenteritis among children less than 5 years of age throughout the world. This sentinel surveillance study was aimed to obtain baseline data on the rotavirus G and P genotypes across Turkey before the introduction of a universal rotavirus vaccination program. Methods: Rotavirus antigen-positive samples were collected from 2102 children less than 5 years of age who attended hospitals participating in the Turkish Rota... Abstract

Cited 10 times since 2014 (0.9 per year) source: EuropePMC

Clinical and experimental immunology, Volume 178 Suppl 1, 1 1 2014, Pages 163-168 Immunoglobulins: current understanding and future directions. Jolles S, Jordan SC, Orange JS, van Schaik IN

Abstract

Cited 15 times since 2014 (1.4 per year) source: EuropePMC

Pharmacogenomics, Volume 15, Issue 16, 1 1 2014, Pages 1963-1972 POR*28 SNP is associated with lipid response to atorvastatin in children and adolescents with familial hypercholesterolemia. Drogari E, Ragia G, Mollaki V, Elens L, Van Schaik RH, Manolopoulos VG

Background: In children and adolescents with familial hypercholesterolemia (FH) pharmacotherapy with statins is the cornerstone in the current regimen to reduce low-density lipoprotein cholesterol (LDLc) and premature coronary heart disease risk. There is, however, a great interindividual variation in response to therapy, partially attributed to genetic factors. The polymorphic enzyme POR transfers electrons from NADPH to CYP450 enzymes including CYP3A, which metabolize atorvastatin. POR*28 poly... Abstract

Cited 25 times since 2014 (2.3 per year) source: EuropePMC

European heart journal, Volume 35, Issue 48, 1 1 2014, Pages 3417-3425 Non-invasive cardiac imaging evaluation of patients with chronic systolic heart failure: a report from the European Association of Cardiovascular Imaging (EACVI). Gimelli A, Lancellotti P, Badano LP, Lombardi M, Gerber B, Plein S, Neglia D, Edvardsen T, Kitsiou A, Scholte AJ, Schröder S, Cosyns B, Gargiulo P, Zamorano JL, Perrone-Filardi P

Abstract

Cited 22 times since 2014 (2 per year) source: EuropePMC

Lung cancer (Amsterdam, Netherlands), Volume 87, Issue 2, 29 5 2014, Pages 201-203 Tumor flare after start of RAF inhibition in KRAS mutated NSCLC: a case report. Mellema WW, Burgers SA, Smit EF

Here we describe a case of striking tumor flare after start of treatment with sorafenib and metformin as part of a phase II clinical trial. Previous reports have described a paradoxal activation of the MAPK pathway after treatment with a weak RAF inhibitor. This mechanism is based on inhibition of a negative feedback loop to upstream effectors of RAF and subsequently increased stimulation of the RAS-RAF-MEK-ERK (MAPK) pathway. We suggest that sorafenib may contribute to tumor progression through... Abstract

Cited 7 times since 2014 (0.6 per year) source: EuropePMC

Vascular, Volume 23, Issue 6, 27 4 2014, Pages 645-647 Persistent endoleak after endovascular aneurysm repair for acute Q-fever-infected aortocaval fistula. Prinsen JH, Boersma D, van Loenhout R, van Schaik PM, Verhoeven BA

We present a case of an endovascular aneurysm repair for a Q-fever-infected acute abdominal aortic aneurysm with aortocaval fistula. Type 2 endoleak persisted after successful endovascular repair. Abstract

Cited 87 times since 2014 (8 per year) source: EuropePMC

European journal of heart failure, Volume 17, Issue 1, 27 4 2014, Pages 51-62 Subclinical left ventricular dysfunction by echocardiographic speckle-tracking strain analysis relates to outcome in sarcoidosis. Joyce E, Ninaber MK, Katsanos S, Debonnaire P, Kamperidis V, Bax JJ, Taube C, Delgado V, Ajmone Marsan N

Aims: Limited data exist on the risk of developing cardiac sarcoidosis (CS) and/or adverse events in sarcoidosis patients. Using LV global longitudinal strain (GLS), an emerging sensitive parameter of LV function, we evaluated the prevalence of subclinical cardiac dysfunction in sarcoidosis and investigated whether LVGLS predicts adverse outcomes in this population. Methods and results: A total of 130 patients with proven sarcoidosis undergoing echocardiography at our referral centre were identi... Abstract

Cited 64 times since 2014 (5.9 per year) source: EuropePMC

British journal of cancer, Volume 112, Issue 3, 27 4 2014, Pages 594-600 Recurrent urinary tract infection and risk of bladder cancer in the Nijmegen bladder cancer study. Vermeulen SH, Hanum N, Grotenhuis AJ, Castaño-Vinyals G, van der Heijden AG, Aben KK, Mysorekar IU, Kiemeney LA

Background: Controversy exists on whether urinary tract infection (UTI) is a risk factor for urinary bladder cancer (UBC). Here, the association is investigated using data from one of the largest bladder cancer case-control studies worldwide. Methods: Information on (i) history and age at onset of regular cystitis ('regular low-UTI') and (ii) number and age at onset of UTI treated with antibiotics ('UTI-ab') from 1809 UBC patients and 4370 controls was analysed. Odds ratios (... Abstract

Cited 2 times since 2014 (0.2 per year) source: EuropePMC

Journal of chromatography. A, Volume 1374, 27 4 2014, Pages 224-230 Impurity profiling of trinitrotoluene using vacuum-outlet gas chromatography-mass spectrometry. Brust H, Willemse S, Zeng T, van Asten A, Koeberg M, van der Heijden A, Bolck A, Schoenmakers P

In this work, a reliable and robust vacuum-outlet gas chromatography-mass spectrometry (GC-MS) method is introduced for the identification and quantification of impurities in trinitrotoluene (TNT). Vacuum-outlet GC-MS allows for short analysis times; the analysis of impurities in TNT was performed in 4min. This study shows that impurity profiling of TNT can be used to investigate relations between TNT samples encountered in forensic casework. A wide variety of TNT samples were analyzed with the... Abstract

Cited 6 times since 2014 (0.6 per year) source: EuropePMC

Frontiers in neuroscience, Volume 8, 25 4 2014, Pages 377 Racing to learn: statistical inference and learning in a single spiking neuron with adaptive kernels. Afshar S, George L, Tapson J, van Schaik A, Hamilton TJ

This paper describes the Synapto-dendritic Kernel Adapting Neuron (SKAN), a simple spiking neuron model that performs statistical inference and unsupervised learning of spatiotemporal spike patterns. SKAN is the first proposed neuron model to investigate the effects of dynamic synapto-dendritic kernels and demonstrate their computational power even at the single neuron scale. The rule-set defining the neuron is simple: there are no complex mathematical operations such as normalization, exponenti... Abstract

Cited 67 times since 2014 (6.1 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 8, Issue 1, 24 4 2014, Pages 102-109 Re-entry using anatomically determined isthmuses: a curable ventricular tachycardia in repaired congenital heart disease. Kapel GF, Reichlin T, Wijnmaalen AP, Piers SR, Holman ER, Tedrow UB, Schalij MJ, Stevenson WG, Zeppenfeld K

Background: Ventricular tachycardia (VT) is an important cause of late morbidity and mortality in repaired congenital heart disease. The substrate often includes anatomic isthmuses that can be transected by radiofrequency catheter ablation similar to isthmus block for atrial flutter. This study evaluates the long-term efficacy of isthmus block for treatment of re-entry VT in adults with repaired congenital heart disease. Methods and results: Thirty-four patients (49±13 years; 74% male) with repa... Abstract