Research

Publications

Below you can find a list of our published research.

8892 results

Cited 452 times since 2014 (40.1 per year) source: EuropePMC

BMJ (Clinical research ed.), Volume 349, 10 2 2014, Pages g4164 Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data. Holmes MV, Dale CE, Zuccolo L, Silverwood RJ, Guo Y, Ye Z, Prieto-Merino D, Dehghan A, Trompet S, Wong A, Cavadino A, Drogan D, Padmanabhan S, Li S, Yesupriya A, Leusink M, Sundstrom J, Hubacek JA, Pikhart H, Swerdlow DI, Panayiotou AG, Borinskaya SA, Finan C, Shah S, Kuchenbaecker KB, Shah T, Engmann J, Folkersen L, Eriksson P, Ricceri F, Melander O, Sacerdote C, Gamble DM, Rayaprolu S, Ross OA, McLachlan S, Vikhireva O, Sluijs I, Scott RA, Adamkova V, Flicker L, Bockxmeer FM, Power C, Marques-Vidal P, Meade T, Marmot MG, Ferro JM, Paulos-Pinheiro S, Humphries SE, Talmud PJ, Mateo Leach I, Verweij N, Linneberg A, Skaaby T, Doevendans PA, Cramer MJ, van der Harst P, Klungel OH, Dowling NF, Dominiczak AF, Kumari M, Nicolaides AN, Weikert C, Boeing H, Ebrahim S, Gaunt TR, Price JF, Lannfelt L, Peasey A, Kubinova R, Pajak A, Malyutina S, Voevoda MI, Tamosiunas A, Maitland-van der Zee AH, Norman PE, Hankey GJ, Bergmann MM, Hofman A, Franco OH, Cooper J, Palmen J, Spiering W, de Jong PA, Kuh D, Hardy R, Uitterlind

Objective: To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. Design: Mendelian randomisation meta-analysis of 56 epidemiological studies. Participants: 261 991 individuals of European descent, including 20 259 coronary heart disease cases and 10 164 stroke events. Data were available on ADH1B rs1229984 variant, alcohol phenotypes, and cardiovascular biomarkers. Main outcome measures: Odd... Abstract

Cited 15 times since 2014 (1.3 per year) source: EuropePMC

Annals of neurology, Volume 76, Issue 2, 9 2 2014, Pages 213-222 N-terminal pro-brain natriuretic peptide and cognitive decline in older adults at high cardiovascular risk. Wijsman LW, Sabayan B, van Vliet P, Trompet S, de Ruijter W, Poortvliet RK, van Peet PG, Gussekloo J, Jukema JW, Stott DJ, Sattar N, Ford I, Westendorp RG, de Craen AJ, Mooijaart SP

Objective: Elevated levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) are associated with cognitive impairment, which might be explained by cardiovascular diseases or risk factors. The aim of this study was to investigate the association of NT-proBNP with cognitive function and decline in older adults at high risk of cardiovascular disease. Methods: We studied 5,205 men and women (mean age = 75 years) who were recruited into the PROspective Study of Pravastatin in the Elderly at Ris... Abstract

Cited 16 times since 2014 (1.4 per year) source: EuropePMC

Neuro-oncology, Volume 17, Issue 1, 3 1 2014, Pages 145-150 A prospective open-label study of sirolimus for the treatment of anti-Hu associated paraneoplastic neurological syndromes. de Jongste AH, van Gelder T, Bromberg JE, de Graaf MT, Gratama JW, Schreurs MW, Hooijkaas H, Sillevis Smitt PA

Background: Several lines of evidence suggest a T cell-mediated immune response in paraneoplastic neurological syndromes with anti-Hu antibodies (Hu-PNS). In order to investigate whether suppression of T cell-mediated immune responses in Hu-PNS patients improved their neurological outcome, we performed a prospective open-label, single-arm study on sirolimus. Methods: Seventeen progressive Hu-PNS patients were treated with sirolimus with an intended treatment duration of 8 weeks. Primary outcome... Abstract

Cited 12 times since 2014 (1.1 per year) source: EuropePMC

Research in veterinary science, Volume 97, Issue 2, 2 1 2014, Pages 226-229 Associations between the decrease in bovine clinical mastitis and changes in dairy farmers' attitude, knowledge, and behavior in the Netherlands. van den Borne BH, Jansen J, Lam TJ, van Schaik G

The aim of this study was to associate changes in dairy farmers' self-reported attitude, knowledge, and behavior with the decrease in incidence rate of clinical mastitis (IRCM). Farmer-diagnosed clinical mastitis cases were obtained from two surveys conducted before (July 2004-June 2005) and at the end (2009) of a mastitis control program in the Netherlands. Information on farmers' attitude, knowledge, and behavior was also obtained by sending the farmers the same questionnaire during... Abstract

Cited 8 times since 2014 (0.7 per year) source: EuropePMC

International journal of cardiology, Volume 175, Issue 3, 2 1 2014, Pages 539-544 Predictors of response to intramyocardial bone marrow cell treatment in patients with refractory angina and chronic myocardial ischemia. Rodrigo SF, van Ramshorst J, Mann I, Leong DP, Cannegieter SC, Al Younis I, Dibbets-Schneider P, de Roos A, Fibbe WE, Zwaginga JJ, Bax JJ, Schalij MJ, Beeres SL, Atsma DE

Background: We previously showed that intramyocardial bone marrow cell (BMC) injection in patients with refractory angina and chronic myocardial ischemia improves myocardial perfusion, cardiac function and disease-related complaints. Treatment effect varied between patients, but the predictors of response remain to be identified. Therefore, the aim of the present study was to assess whether patient characteristics, procedural data and baseline measurements influence the response to intramyocardi... Abstract

Cited 15 times since 2014 (1.3 per year) source: EuropePMC

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 10, Issue 3, 1 1 2014, Pages 364-371 Geometry of left atrial appendage assessed with multidetector-row computed tomography: implications for transcatheter closure devices. van Rosendael PJ, Katsanos S, van den Brink OW, Scholte AJ, Trines SA, Bax JJ, Schalij MJ, Marsan NA, Delgado V

Aims: To assess the left atrial appendage (LAA) geometry with multidetector-row computed tomography (MDCT) and its implications for selection of closure devices. Methods and results: One hundred and ninety-seven patients who underwent MDCT prior to catheter ablation for atrial fibrillation were evaluated. Feasibility for Watchman and Amplatzer Cardiac Plug (ACP) devices was assessed based on the maximal cross-sectional diameter and perimeter of the ostium and at 10 mm depth and on the LAA diamet... Abstract

Cited 26 times since 2014 (2.3 per year) source: EuropePMC

Pharmacogenomics, Volume 15, Issue 10, 1 1 2014, Pages 1287-1295 Rescue morphine in mechanically ventilated newborns associated with combined OPRM1 and COMT genotype. Matic M, Simons SH, van Lingen RA, van Rosmalen J, Elens L, de Wildt SN, Tibboel D, van Schaik RH

Aim: Determine whether SNPs of OPRM1 118A>G (asn(40)asp), COMT 472G>A (val(158)met) and ARRB2 8622C>T are associated with morphine rescue in newborns on mechanical ventilation. Materials & methods: This is a pharmacogenetic analysis of a randomized controlled trial in (pre)term newborns (n = 64) at a level III Neonatal Intensive Care Unit (NICU) who received placebo infusion and for whom need and dose for rescue morphine was documented. Results: For OPRM1 and COMT separately, the ex... Abstract

Cited 23 times since 2014 (2 per year) source: EuropePMC

Asian journal of andrology, Volume 16, Issue 4, 1 1 2014, Pages 607-610 The 5-HT2C receptor gene Cys23Ser polymorphism influences the intravaginal ejaculation latency time in Dutch Caucasian men with lifelong premature ejaculation. Janssen PK, Schaik Rv, Olivier B, Waldinger MD

It has been postulated that the persistent short intravaginal ejaculation latency time (IELT) of men with lifelong premature ejaculation (LPE) is related to 5-hydroxytryptamine (HT)2C receptor functioning. The aim of this study was to investigate the relationship of Cys23Ser 5-HT2C receptor gene polymorphism and the duration of IELT in men with LPE. Therefore, a prospective study was conducted in 64 Dutch Caucasian men with LPE. Baseline IELT during coitus was assessed by stopwatch over a 1-mont... Abstract

Cited 5 times since 2014 (0.4 per year) source: EuropePMC

The Turkish journal of pediatrics, Volume 56, Issue 4, 1 1 2014, Pages 458-461 Development of end-stage renal disease at a young age in two cases with Joubert syndrome. Sönmez F, Güzünler-Şen M, Yılmaz D, Cömertpay G, Heise M, Çırak S, Uyanık G

Joubert syndrome (JS) is an autosomal recessive genetic disorder. To date, mutations in 20 genes of the genetically heterogeneous JS and JS-related disorders (JSRD) have been reported. Renal involvement occurs in 2-20% of JS cases. Identified renal abnormalities are cystic dysplasia and nephronophthisis. Here we report the clinical course and management of renal failure in early childhood. We present two cases diagnosed with JS that developed end-stage renal disease at young ages. In the genetic... Abstract

Cited 50 times since 2014 (4.4 per year) source: EuropePMC

Journal of cellular and molecular medicine, Volume 18, Issue 8, 1 1 2014, Pages 1509-1518 Serum supplemented culture medium masks hypertrophic phenotypes in human pluripotent stem cell derived cardiomyocytes. Dambrot C, Braam SR, Tertoolen LG, Birket M, Atsma DE, Mummery CL

It has been known for over 20 years that foetal calf serum can induce hypertrophy in cultured cardiomyocytes but this is rarely considered when examining cardiomyocytes derived from pluripotent stem cells (PSC). Here, we determined how serum affected cardiomyocytes from human embryonic- (hESC) and induced pluripotent stem cells (hiPSC) and hiPSC from patients with hypertrophic cardiomyopathy linked to a mutation in the MYBPC3 gene. We first confirmed previously published hypertrophic effects of... Abstract

Cited 17 times since 2014 (1.5 per year) source: EuropePMC

World journal of surgery, Volume 38, Issue 7, 1 1 2014, Pages 1713-1718 Incidence and epidemiology of casualties treated at the Dutch role 2 enhanced medical treatment facility at multi national base Tarin Kowt, Afghanistan in the period 2006-2010. Hoencamp R, Idenburg FJ, Hamming JF, Tan EC

Background: To improve care for the injured service member, we have analyzed battle casualty patterns and mechanisms. This study is the first documented report of wounding patterns and mechanisms of battle casualties treated at the Dutch role 2 enhanced medical treatment facility at the multi-national base Tarin Kowt, Uruzgan, Afghanistan. Methods: Participants were selected from the trauma registry at the Dutch role 2 enhanced medical treatment facility if they fitted the criteria 'battle... Abstract

Michigan medicine, Volume 113, Issue 4, 1 1 2014, Pages 12-13 Voice of medicine heard in state budget process. Schepers AR

Abstract

Cited 510 times since 2014 (45.1 per year) source: EuropePMC

Nature genetics, Volume 46, Issue 8, 29 5 2014, Pages 818-825 Whole-genome sequence variation, population structure and demographic history of the Dutch population. Genome of the Netherlands Consortium

Whole-genome sequencing enables complete characterization of genetic variation, but geographic clustering of rare alleles demands many diverse populations be studied. Here we describe the Genome of the Netherlands (GoNL) Project, in which we sequenced the whole genomes of 250 Dutch parent-offspring families and constructed a haplotype map of 20.4 million single-nucleotide variants and 1.2 million insertions and deletions. The intermediate coverage (∼13×) and trio design enabled extensive charact... Abstract

Cited 11 times since 2014 (1 per year) source: EuropePMC

International journal of cardiology, Volume 176, Issue 1, 28 4 2014, Pages 40-47 Beneficial effect of high dose statins on the vascular wall in patients with repaired aortic coarctation? Luijendijk P, Bouma BJ, Vriend JW, Groenink M, Vliegen HW, de Groot E, Pieper PG, van Dijk AP, Sieswerda GT, Konings TC, Stroes ES, Zwinderman AH, Mulder BJ

Background: Carotid intima-media thickness (CIMT) is a marker for atherosclerosis. Adult post-coarctectomy patients (CoA) demonstrate an increased cardiovascular risk and increased CIMT compared to controls. This study evaluates the effect of high dose statins on the change in CIMT and cardiovascular risk. Methods: We designed a multicenter, prospective, randomized, open label trial with blinded endpoint (PROBE design) to evaluate the effect of three year treatment with atorvastatin 80 mg on CIM... Abstract

Cited 4 times since 2014 (0.4 per year) source: EuropePMC

Journal of cardiovascular computed tomography, Volume 8, Issue 4, 27 4 2014, Pages 299-306 Aortic valve and aortic root features in CT angiography in patients considered for aortic valve repair. Regeer MV, Kamperidis V, Versteegh MI, Klautz RJ, Scholte AJ, Bax JJ, Schalij MJ, Marsan NA, Delgado V

Background: The underlying mechanism of aortic regurgitation and aortic valve and root characteristics are associated with the durability of surgical repair. Objective: We investigated whether multidetector CT (MDCT) identifies the characteristics of the aortic valve and root that may be associated with the ability to perform successful surgical repair. Methods: Sixty-one patients with aortic regurgitation and/or aortic root pathology who were evaluated for aortic valve or root repair and underw... Abstract

Cited 3 times since 2014 (0.3 per year) source: EuropePMC

Intensive care medicine, Volume 40, Issue 8, 27 4 2014, Pages 1177-1178 Using tramadol to measure CYP2D6 metabolism in critically ill adults. Lane K, Dixon JJ, McKeown D, Johnston A, van Schaik RH, van Fessem M, MacPhee IA, Philips BJ

Abstract

Cited 20 times since 2014 (1.8 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 7, Issue 4, 26 4 2014, Pages 671-676 Influence of steroid therapy on the incidence of pericarditis and atrial fibrillation after percutaneous epicardial mapping and ablation for ventricular tachycardia. Dyrda K, Piers SR, van Huls van Taxis CF, Schalij MJ, Zeppenfeld K

Background: This study evaluates the influence of 3 therapeutic approaches on the incidence of pericarditis and atrial fibrillation (AF) after percutaneous epicardial mapping and ablation for ventricular tachycardia. Methods and results: Eighty-five consecutive procedures (2006-2011) were retrospectively reviewed. After the first 17 procedures (20.0%), no steroids were administered. For the subsequent 30 procedures (35.3%), systemic steroids were administered intravenously or orally, whereas the... Abstract

Cited 31 times since 2014 (2.7 per year) source: EuropePMC

BMC musculoskeletal disorders, Volume 15, 26 4 2014, Pages 219 Fixation using alternative implants for the treatment of hip fractures (FAITH): design and rationale for a multi-centre randomized trial comparing sliding hip screws and cancellous screws on revision surgery rates and quality of life in the treatment of femoral neck fractures. FAITH Investigators

Background: Hip fractures are a common type of fragility fracture that afflict 293,000 Americans (over 5,000 per week) and 35,000 Canadians (over 670 per week) annually. Despite the large population impact the optimal fixation technique for low energy femoral neck fractures remains controversial. The primary objective of the FAITH study is to assess the impact of cancellous screw fixation versus sliding hip screws on rates of revision surgery at 24 months in individuals with femoral neck fractur... Abstract

Cited 7 times since 2014 (0.6 per year) source: EuropePMC

BMC health services research, Volume 14, 25 4 2014, Pages 280 Resource use and costs of type 2 diabetes patients receiving managed or protocolized primary care: a controlled clinical trial. van der Heijden AA, de Bruijne MC, Feenstra TL, Dekker JM, Baan CA, Bosmans JE, Bot SD, Donker GA, Nijpels G

Background: The increasing prevalence of diabetes is associated with increased health care use and costs. Innovations to improve the quality of care, manage the increasing demand for health care and control the growth of health care costs are needed. The aim of this study is to evaluate the care process and costs of managed, protocolized and usual care for type 2 diabetes patients from a societal perspective. Methods: In two distinct regions of the Netherlands, both managed and protocolized diab... Abstract

Cited 3 times since 2014 (0.3 per year) source: EuropePMC

The Journal of clinical endocrinology and metabolism, Volume 99, Issue 10, 25 4 2014, Pages E2060-6 Investigation of genotoxicity in acromegaly from peripheral blood lymphocyte cultures using a micronucleus assay. Unal OK, Cinkilic N, Gul OO, Cander S, Vatan O, Ersoy C, Yilmaz D, Tuncel E

Context: Although patients with acromegaly may have an increased risk of developing several types of cancers, the degree of risk for malignancy in these patients is unresolved. Objective: The present study aimed to investigate the potential genotoxic effects of acromegaly on the cell cycle in peripheral blood lymphocyte cultures. Design: This was a single center, crossover, case-control study conducted on the acromegalic patients in Turkey. Setting: The study was conducted in the outpatient clin... Abstract