8892 results
Cited 41 times since 2014 (3.6 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 27, Issue 8, 3 1 2014, Pages 817-825
Left ventricular functional recovery and remodeling in low-flow low-gradient severe aortic stenosis after transcatheter aortic valve implantation.
Kamperidis V, Joyce E, Debonnaire P, Katsanos S, van Rosendael PJ, van der Kley F, Sianos G, Bax JJ, Ajmone Marsan N, Delgado V
Background: Speckle-tracking-derived global longitudinal strain (GLS) is a more sensitive method of detecting left ventricular (LV) functional recovery after transcatheter aortic valve implantation (TAVI) in patients with severe aortic stenosis. However, it remains unknown whether LV function improves in patients with low-flow, low-gradient severe aortic stenosis (LFLGSAS) after TAVI. The aim of the present was to evaluate LV functional recovery and remodeling after TAVI in patients with LFLGSAS...
Abstract
Cited 20 times since 2014 (1.8 per year)
source: EuropePMC
American journal of physical anthropology,
Volume 154, Issue 4, 3 1 2014, Pages 628-632
Brief Communication: Seasonality of diet composition is related to brain size in New World Monkeys.
van Woerden JT, van Schaik CP, Isler K
New World monkeys exhibit a more pronounced variability in encephalization than other primate taxa. In this comparative study, we tested two current hypotheses on brain size evolution, the Expensive Brain hypothesis and the Cognitive Buffer hypothesis, in a sample of 21 platyrrhine species. A high degree of habitat seasonality may impose an energetic constraint on brain size evolution if it leads to a high variation in caloric intake over time, as predicted by the Expensive Brain Hypothesis. How...
Abstract
Cited 32 times since 2014 (2.8 per year)
source: EuropePMC
Stem cells (Dayton, Ohio),
Volume 32, Issue 6, 1 1 2014, Pages 1493-1502
Insulin-like growth factor promotes cardiac lineage induction in vitro by selective expansion of early mesoderm.
Engels MC, Rajarajan K, Feistritzer R, Sharma A, Nielsen UB, Schalij MJ, de Vries AA, Pijnappels DA, Wu SM
A thorough understanding of the developmental signals that direct pluripotent stem cells (PSCs) toward a cardiac fate is essential for translational applications in disease modeling and therapy. We screened a panel of 44 cytokines/signaling molecules for their ability to enhance Nkx2.5(+) cardiac progenitor cell (CPC) formation during in vitro embryonic stem cell (ESC) differentiation. Treatment of murine ESCs with insulin or insulin-like growth factors (IGF1/2) during early differentiation incr...
Abstract
Cited 12 times since 2014 (1.1 per year)
source: EuropePMC
American journal of physical anthropology,
Volume 154, Issue 2, 1 1 2014, Pages 215-221
Health Is not always written in bone: using a modern comorbidity index to assess disease load in paleopathology.
van Schaik K, Vinichenko D, Rühli F
Paleopathology has revealed much about disease in the past but is usually limited to conditions with osteological manifestations; this often excludes acute soft tissue infections and causes of death for most individuals in the past and present. Our understanding of the evolution of disease is essential for contextualizing and predicting the epidemiological shifts that are happening in modern society, as high rates of infectious disease coexist alongside high rates of chronic disease in rates unl...
Abstract
Cited 9 times since 2014 (0.8 per year)
source: EuropePMC
Molecular diagnosis & therapy,
Volume 18, Issue 3, 1 1 2014, Pages 323-331
Lack of association of the p450 oxidoreductase *28 single nucleotide polymorphism with the lipid-lowering effect of statins in hypercholesterolemic patients.
Ragia G, Kolovou V, Tavridou A, Elens L, Tselepis AD, Elisaf M, Van Schaik RH, Kolovou G, Manolopoulos VG
Background and objective: Inter-individual variability exists in the statin (HMG-CoA reductase inhibitor) lipid-lowering response, which is partially attributed to genetic factors. The polymorphic enzyme P450 oxidoreductase (POR) transfers electrons from nicotinamide adenine dinucleotide phosphate (NADPH) to cytochrome P450 (CYP) 3A enzymes, which metabolize atorvastatin and simvastatin. The POR*28 allele is associated with increased activity of CYP3A enzymes. We analyzed the association of the...
Abstract
Cited 17 times since 2014 (1.5 per year)
source: EuropePMC
Pharmacogenomics,
Volume 15, Issue 9, 1 1 2014, Pages 1243-1251
Calcineurin inhibitors and hypertension: a role for pharmacogenetics?
Moes AD, Hesselink DA, Zietse R, van Schaik RH, van Gelder T, Hoorn EJ
Hypertension is a common side effect of calcineurin inhibitors (CNIs), which are drugs used to prevent rejection after transplantation. Hypertension after kidney transplantation has been associated with earlier graft failure and higher cardiovascular mortality in the recipient. Recent data indicate that enzymes and transporters involved in CNI pharmacokinetics and pharmacodynamics, including CYP3A5, ABCB1, WNK4 and SPAK, are also associated with salt-sensitive hypertension. These insights raise...
Abstract
The International journal of angiology : official publication of the International College of Angiology, Inc,
Volume 23, Issue 2, 1 1 2014, Pages 93-100
A Randomized Comparison between Everolimus-Eluting Stent and Cobalt Chromium Stent in Patients with Acute ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention Using Routine Intravenous Eptifibatide: The X-MAN (Xience vs. Multi-Link Stent in Acute Myocardial Infarction) Trial, A Pilot Study.
Dharma S, Wardeh AJ, Soerianata S, Firdaus I, Jukema JW
The objective of this study is to determine the efficacy and safety of an everolimus-eluting stent (EES/Xience; Abbott Vascular, Santa Clara, CA) compared with a cobalt chromium stent (CoCr/Multi-Link Vision; Abbott Vascular) in patients with acute ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) with routine administration of eptifibatide infusion. This is a prospective, single center, randomized trial comparing EES (n = 75) and CoCr stent (...
Abstract
Cited 36 times since 2014 (3.2 per year)
source: EuropePMC
Medical education,
Volume 48, Issue 6, 1 1 2014, Pages 583-592
Perceptions of interprofessional teamwork in low-acuity settings: a qualitative analysis.
van Schaik SM, O'Brien BC, Almeida SA, Adler SR
Context: Working effectively in interprofessional teams is a core competency for all health care professionals, yet there is a paucity of instruments with which to assess the associated skills. Published medical teamwork skills assessment tools focus primarily on high-acuity situations, such as cardiopulmonary arrests and crisis events in operating rooms, and may not generalise to non-high-acuity environments, such as in-patient wards and out-patient clinics. Objective: We undertook the current...
Abstract
Cited 70 times since 2014 (6.1 per year)
source: EuropePMC
Pharmacogenomics,
Volume 15, Issue 9, 1 1 2014, Pages 1223-1234
Personalized pharmacogenomics profiling using whole-genome sequencing.
Mizzi C, Peters B, Mitropoulou C, Mitropoulos K, Katsila T, Agarwal MR, van Schaik RH, Drmanac R, Borg J, Patrinos GP
Aim: Pharmacogenomics holds promise to rationalize drug use by minimizing drug toxicity and at the same time increase drug efficacy. There are currently several assays to screen for known pharmacogenomic biomarkers for the most commonly prescribed drugs. However, these genetic screening assays cannot account for other known or novel pharmacogenomic markers. Materials & methods: We analyzed whole-genome sequences of 482 unrelated individuals of various ethnic backgrounds to obtain their perso...
Abstract
Cited 5 times since 2014 (0.4 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 22, Issue 6, 1 1 2014, Pages 309
Obstruction of distal left anterior descending artery by the right ventricular lead of an implantable cardiac defibrillator.
Karalis I, Bleeker GB, Schalij MJ
Abstract
Cited 1 times since 2014 (0.1 per year)
source: EuropePMC
JAMA,
Volume 311, Issue 22, 1 1 2014, Pages 2335
Left atrial fibrosis and recurrent arrhythmia.
Tops LF, Schalij MJ
Abstract
Cited 33 times since 2014 (2.9 per year)
source: EuropePMC
American journal of physiology. Heart and circulatory physiology,
Volume 307, Issue 3, 30 5 2014, Pages H361-9
Sildenafil treatment in established right ventricular dysfunction improves diastolic function and attenuates interstitial fibrosis independent from afterload.
Borgdorff MA, Bartelds B, Dickinson MG, van Wiechen MP, Steendijk P, de Vroomen M, Berger RM
Right ventricular (RV) function is an important determinant of prognosis in congenital heart diseases, pulmonary hypertension, and heart failure. Preventive sildenafil treatment has been shown to enhance systolic RV function and improve exercise capacity in a model of fixed RV pressure load. However, it is unknown whether sildenafil has beneficial effects when treatment is started in established RV dysfunction, which is clinically more relevant. Our aim was to assess the effects of sildenafil tr...
Abstract
Cited 18 times since 2014 (1.6 per year)
source: EuropePMC
Journal of cardiovascular electrophysiology,
Volume 25, Issue 9, 29 5 2014, Pages 998-1004
Chronic kidney disease and implantable cardioverter defibrillator related complications: 16 years of experience.
Buiten MS, DE Bie MK, VAN DER Heijden AC, Rotmans JI, Bootsma M, Marc Groeneveld JH, Wolterbeek R, Rabelink TJ, Jukema JW, Schalij MJ, VAN Erven L
Introduction: Implantable cardioverter defibrillator (ICD) implantation has become an accepted therapy for the prevention of sudden cardiac death. However, serious comorbidities such as chronic kidney disease (CKD) are influencing the beneficial effects of ICD therapy. In this study, the association between kidney function and the occurrence of ICD related complications was assessed. Methods: All patients receiving an ICD or cardiac resynchronization therapy-defibrillator between 1996 and 2012 w...
Abstract
Cited 40 times since 2014 (3.5 per year)
source: EuropePMC
Human molecular genetics,
Volume 23, Issue 20, 26 4 2014, Pages 5545-5557
Genome-wide association study yields variants at 20p12.2 that associate with urinary bladder cancer.
Rafnar T, Sulem P, Thorleifsson G, Vermeulen SH, Helgason H, Saemundsdottir J, Gudjonsson SA, Sigurdsson A, Stacey SN, Gudmundsson J, Johannsdottir H, Alexiusdottir K, Petursdottir V, Nikulasson S, Geirsson G, Jonsson T, Aben KK, Grotenhuis AJ, Verhaegh GW, Dudek AM, Witjes JA, van der Heijden AG, Vrieling A, Galesloot TE, De Juan A, Panadero A, Rivera F, Hurst C, Bishop DT, Sak SC, Choudhury A, Teo MT, Arici C, Carta A, Toninelli E, de Verdier P, Rudnai P, Gurzau E, Koppova K, van der Keur KA, Lurkin I, Goossens M, Kellen E, Guarrera S, Russo A, Critelli R, Sacerdote C, Vineis P, Krucker C, Zeegers MP, Gerullis H, Ovsiannikov D, Volkert F, Hengstler JG, Selinski S, Magnusson OT, Masson G, Kong A, Gudbjartsson D, Lindblom A, Zwarthoff E, Porru S, Golka K, Buntinx F, Matullo G, Kumar R, Mayordomo JI, Steineck DG, Kiltie AE, Jonsson E, Radvanyi F, Knowles MA, Thorsteinsdottir U, Kiemeney LA, Stefansson K
Genome-wide association studies (GWAS) of urinary bladder cancer (UBC) have yielded common variants at 12 loci that associate with risk of the disease. We report here the results of a GWAS of UBC including 1670 UBC cases and 90 180 controls, followed by replication analysis in additional 5266 UBC cases and 10 456 controls. We tested a dataset containing 34.2 million variants, generated by imputation based on whole-genome sequencing of 2230 Icelanders. Several correlated variants at 20p12, repres...
Abstract
Cited 22 times since 2014 (1.9 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 21, Issue 5, 24 4 2014, Pages 913-920
I-123 mIBG and Tc-99m myocardial SPECT imaging to predict inducibility of ventricular arrhythmia on electrophysiology testing: a retrospective analysis.
Zhou Y, Zhou W, Folks RD, Manatunga DN, Jacobson AF, Bax JJ, Garcia EV, Chen J
Objectives: The purpose of this study is to assess mIBG uptake in scar border zone and its relation with ventricular arrhythmia (VA) inducibility on electrophysiology (EP) testing using I-123 mIBG SPECT and resting Tc-99m SPECT myocardial perfusion imaging (MPI). Methods: Forty-seven patients from a previous clinical trial were retrospectively analyzed. These patients underwent I-123 mIBG and resting Tc-99m tetrofosmin SPECT, and EP testing. Twenty-eight patients were positive (EP+) and 19 patie...
Abstract
Cited 500 times since 2014 (43.8 per year)
source: EuropePMC
Lab on a chip,
Volume 14, Issue 13, 23 4 2014, Pages 2202-2211
Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs.
Bertassoni LE, Cecconi M, Manoharan V, Nikkhah M, Hjortnaes J, Cristino AL, Barabaschi G, Demarchi D, Dokmeci MR, Yang Y, Khademhosseini A
Vascularization remains a critical challenge in tissue engineering. The development of vascular networks within densely populated and metabolically functional tissues facilitate transport of nutrients and removal of waste products, thus preserving cellular viability over a long period of time. Despite tremendous progress in fabricating complex tissue constructs in the past few years, approaches for controlled vascularization within hydrogel based engineered tissue constructs have remained limite...
Abstract
Cited 6 times since 2014 (0.5 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 101, Issue 4, 22 4 2014, Pages 311-319
Diagnosis and treatment of pulmonary hypertension.
Haeck ML, Vliegen HW
Abstract
Cited 4 times since 2014 (0.4 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 15, Issue 10, 22 4 2014, Pages 1183
Helical flow pattern in the right pulmonary artery after Fontan palliation.
Houtzager JH, Westenberg JJ, de Koning PJ, Hazekamp MG, Roest AA
Abstract
Cited 138 times since 2014 (12.1 per year)
source: EuropePMC
Annals of the rheumatic diseases,
Volume 74, Issue 10, 20 3 2014, Pages 1842-1847
The relative contribution of mechanical stress and systemic processes in different types of osteoarthritis: the NEO study.
Visser AW, de Mutsert R, le Cessie S, den Heijer M, Rosendaal FR, Kloppenburg M, NEO Study Group
Objective: To study the relative contribution of surrogates for mechanical stress and systemic processes with osteoarthritis (OA) in weight-bearing and non-weight-bearing joints. Methods: The Netherlands Epidemiology of Obesity study is a population-based cohort including 6673 participants (range 45-65 years, 56% women, median body mass index 26 kg/m(2)). Weight (kg) and fat mass (kg) were measured, fat-free mass (kg) was calculated. The metabolic syndrome was defined following the Adult Treatme...
Abstract
Cited 16 times since 2014 (1.4 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 100, Issue 17, 16 3 2014, Pages 1360-1365
Persistent neo-aortic growth during adulthood in patients after an arterial switch operation.
van der Bom T, van der Palen RL, Bouma BJ, van Veldhuisen SL, Vliegen HW, Konings TC, Zwinderman AH, Blom NA, Koolbergen DR, Hazekamp MG, Mulder BJ
Objective: After the arterial switch operation (ASO), disproportional neo-aortic growth during childhood has been reported. Even though it has been suggested neo-aortic dilation will stabilise in adulthood, data are lacking. The aim of this study was to assess the change in neo-aortic dimensions, prevalence of neo-aortic dilation >40 mm and long-term outcome in adults who underwent ASO in childhood. Methods: All 116 ASO patients operated in a tertiary referral centre and born before 1995 were...
Abstract
