8892 results
Cited 115 times since 2013 (9.5 per year)
source: EuropePMC
Circulation,
Volume 128, Issue 12, 22 4 2013, Pages 1310-1324
Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
Sabater-Lleal M, Huang J, Chasman D, Naitza S, Dehghan A, Johnson AD, Teumer A, Reiner AP, Folkersen L, Basu S, Rudnicka AR, Trompet S, Mälarstig A, Baumert J, Bis JC, Guo X, Hottenga JJ, Shin SY, Lopez LM, Lahti J, Tanaka T, Yanek LR, Oudot-Mellakh T, Wilson JF, Navarro P, Huffman JE, Zemunik T, Redline S, Mehra R, Pulanic D, Rudan I, Wright AF, Kolcic I, Polasek O, Wild SH, Campbell H, Curb JD, Wallace R, Liu S, Eaton CB, Becker DM, Becker LC, Bandinelli S, Räikkönen K, Widen E, Palotie A, Fornage M, Green D, Gross M, Davies G, Harris SE, Liewald DC, Starr JM, Williams FM, Grant PJ, Spector TD, Strawbridge RJ, Silveira A, Sennblad B, Rivadeneira F, Uitterlinden AG, Franco OH, Hofman A, van Dongen J, Willemsen G, Boomsma DI, Yao J, Swords Jenny N, Haritunians T, McKnight B, Lumley T, Taylor KD, Rotter JI, Psaty BM, Peters A, Gieger C, Illig T, Grotevendt A, Homuth G, Völzke H, Kocher T, Goel A, Franzosi MG, Seedorf U, Clarke R, Steri M, Tarasov KV, Sanna S, Schlessinger D, Stott DJ, Sattar N, Buckley BM, Rum
Background: Estimates of the heritability of plasma fibrinogen concentration, an established predictor of cardiovascular disease, range from 34% to 50%. Genetic variants so far identified by genome-wide association studies explain only a small proportion (90 000 subjects of European ancestry, the first genome-wide association meta-analysis of fibrinogen levels in 7 studies in blacks totaling 8289 samples, and a genome-wide association study in Hispanics totaling 1366 samples. Evaluation for asso...
Abstract
Cited 2 times since 2013 (0.2 per year)
source: EuropePMC
European heart journal,
Volume 34, Issue 41, 21 3 2013, Pages 3168-3170
High coronary plaque load: a heavy burden.
de Graaf MA, Jukema JW
Abstract
Cited 80 times since 2013 (6.6 per year)
source: EuropePMC
European heart journal,
Volume 34, Issue 42, 21 3 2013, Pages 3251-3258
Stabilization of atherosclerotic plaques: an update.
Ylä-Herttuala S, Bentzon JF, Daemen M, Falk E, Garcia-Garcia HM, Herrmann J, Hoefer I, Jauhiainen S, Jukema JW, Krams R, Kwak BR, Marx N, Naruszewicz M, Newby A, Pasterkamp G, Serruys PW, Waltenberger J, Weber C, Tokgözoglu L, ESC Working Group of Atherosclerosis and Vascular Biology
Abstract
Cited 8 times since 2013 (0.7 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
20 3 2013
The role of exercise echocardiography in the management of mitral valve disease.
Jansen R, Kracht PA, Cramer MJ, Tietge WJ, van Herwerden LA, Klautz RJ, Kluin J, Chamuleau SA
Purpose: Exercise echocardiography can assess the dynamic component of mitral valve (MV) disease and may therefore be helpful for the clinical decision-making by the heart team. The purpose of this study is to determine the role of exercise echocardiography in the management of disproportionately symptomatic or otherwise atypical patients with mitral regurgitation (MR) and stenosis (MS) in clinical practice. Methods: Data of 14 MR and 14 MS patients, including echocardiograms at rest, were prese...
Abstract
Cited 75 times since 2013 (6.2 per year)
source: EuropePMC
Circulation research,
Volume 113, Issue 9, 20 3 2013, Pages 1065-1075
Quaking, an RNA-binding protein, is a critical regulator of vascular smooth muscle cell phenotype.
van der Veer EP, de Bruin RG, Kraaijeveld AO, de Vries MR, Bot I, Pera T, Segers FM, Trompet S, van Gils JM, Roeten MK, Beckers CM, van Santbrink PJ, Janssen A, van Solingen C, Swildens J, de Boer HC, Peters EA, Bijkerk R, Rousch M, Doop M, Kuiper J, Schalij MJ, van der Wal AC, Richard S, van Berkel TJ, Pickering JG, Hiemstra PS, Goumans MJ, Rabelink TJ, de Vries AA, Quax PH, Jukema JW, Biessen EA, van Zonneveld AJ
Rationale: RNA-binding proteins are critical post-transcriptional regulators of RNA and can influence pre-mRNA splicing, RNA localization, and stability. The RNA-binding protein Quaking (QKI) is essential for embryonic blood vessel development. However, the role of QKI in the adult vasculature, and in particular in vascular smooth muscle cells (VSMCs), is currently unknown. Objective: We sought to determine the role of QKI in regulating adult VSMC function and plasticity. Methods and results: We...
Abstract
Cited 293 times since 2013 (24.1 per year)
source: EuropePMC
mBio,
Volume 4, Issue 4, 20 3 2013, Pages e00534-13
Emergence of epidemic multidrug-resistant Enterococcus faecium from animal and commensal strains.
Lebreton F, van Schaik W, McGuire AM, Godfrey P, Griggs A, Mazumdar V, Corander J, Cheng L, Saif S, Young S, Zeng Q, Wortman J, Birren B, Willems RJ, Earl AM, Gilmore MS
Unlabelled: Enterococcus faecium, natively a gut commensal organism, emerged as a leading cause of multidrug-resistant hospital-acquired infection in the 1980s. As the living record of its adaptation to changes in habitat, we sequenced the genomes of 51 strains, isolated from various ecological environments, to understand how E. faecium emerged as a leading hospital pathogen. Because of the scale and diversity of the sampled strains, we were able to resolve the lineage responsible for epidemic,...
Abstract
Cited 23 times since 2013 (1.9 per year)
source: EuropePMC
International psychogeriatrics,
Volume 25, Issue 11, 15 3 2013, Pages 1899-1907
The development and evaluation of the DK-20: a knowledge of dementia measure.
Shanahan N, Orrell M, Schepers AK, Spector A
Background: Raising understanding of dementia has become a key focus of international health and social care. An up-to-date, psychometrically sound measure of dementia knowledge that embraces a biopsychosocial perspective is lacking. The aim of this study is to develop and evaluate the psychometric properties of the DK-20, a dementia knowledge questionnaire aimed at unqualified care staff. Methods: Domain and item generation followed recommended measure development procedures. A pilot and large-...
Abstract
Cited 26 times since 2013 (2.1 per year)
source: EuropePMC
Diabetes care,
Volume 36, Issue 10, 15 3 2013, Pages 3054-3061
Stratified patient-centered care in type 2 diabetes: a cluster-randomized, controlled clinical trial of effectiveness and cost-effectiveness.
Slingerland AS, Herman WH, Redekop WK, Dijkstra RF, Jukema JW, Niessen LW
Objective: Diabetes treatment should be effective and cost-effective. HbA1c-associated complications are costly. Would patient-centered care be more (cost-) effective if it was targeted to patients within specific HbA1c ranges? Research design and methods: This prospective, cluster-randomized, controlled trial involved 13 hospitals (clusters) in the Netherlands and 506 patients with type 2 diabetes randomized to patient-centered (n=237) or usual care (controls) (n=269). Primary outcomes were cha...
Abstract
Cited 10 times since 2013 (0.8 per year)
source: EuropePMC
Physiological measurement,
Volume 34, Issue 9, 14 2 2013, Pages 991-1012
Towards true unipolar ECG recording without the Wilson central terminal (preliminary results).
Gargiulo GD, McEwan AL, Bifulco P, Cesarelli M, Jin C, Tapson J, Thiagalingam A, van Schaik A
We present an innovative bio-potential front-end capable of recording true unipolar ECG leads for the first time without making use of the Wilson central terminal. In addition to the convenience in applications such as continuous monitoring and rapid diagnosis, the information in unipolar recordings may yield unique diagnostic information as it avoids the need to essentially subtract data or make use of the averaging effect imposed from the Wilson central terminal. The system also allows direct,...
Abstract
Cited 19 times since 2013 (1.6 per year)
source: EuropePMC
The American journal of cardiology,
Volume 112, Issue 10, 14 2 2013, Pages 1533-1539
In-hospital major bleeding and its clinical relevance in patients with ST elevation myocardial infarction treated with primary percutaneous coronary intervention.
Boden H, Velders MA, van der Hoeven BL, Cannegieter SC, Schalij MJ
Advances in antithrombotic therapy for ST elevation myocardial infarction (STEMI) enhance the risk of bleeding. Therefore, the incidence, determinants, and prognostic implications of in-hospital major bleeding after primary percutaneous coronary intervention for STEMI were investigated. In 963 consecutive patients, the incidence of bleeding was evaluated according to commonly used classifications including Can Rapid risk stratification of Unstable angina patients Suppress Adverse outcomes with E...
Abstract
Cited 60 times since 2013 (4.9 per year)
source: EuropePMC
Virus research,
Volume 178, Issue 1, 13 2 2013, Pages 15-20
Transmission of influenza A/H5N1 viruses in mammals.
Imai M, Herfst S, Sorrell EM, Schrauwen EJ, Linster M, De Graaf M, Fouchier RA, Kawaoka Y
Highly pathogenic avian H5N1 influenza A viruses occasionally infect humans and cause severe respiratory disease and fatalities. Currently, these viruses are not efficiently transmitted from person to person, although limited human-to-human transmission may have occurred. Nevertheless, further adaptation of avian H5N1 influenza A viruses to humans and/or reassortment with human influenza A viruses may result in aerosol transmissible viruses with pandemic potential. Although the full range of fac...
Abstract
Cited 53 times since 2013 (4.3 per year)
source: EuropePMC
Journal of dairy science,
Volume 96, Issue 10, 9 2 2013, Pages 6264-6273
Evaluating results of the Welfare Quality multi-criteria evaluation model for classification of dairy cattle welfare at the herd level.
de Vries M, Bokkers EA, van Schaik G, Botreau R, Engel B, Dijkstra T, de Boer IJ
The Welfare Quality multi-criteria evaluation (WQ-ME) model aggregates scores of single welfare measures into an overall assessment for the level of animal welfare in dairy herds. It assigns herds to 4 welfare classes: unacceptable, acceptable, enhanced, or excellent. The aim of this study was to demonstrate the relative importance of single welfare measures for WQ-ME classification of a selected sample of Dutch dairy herds. Seven trained observers quantified 63 welfare measures of the Welfare Q...
Abstract
Cited 7 times since 2013 (0.6 per year)
source: EuropePMC
PloS one,
Volume 8, Issue 8, 9 2 2013, Pages e70676
Pathway analysis using genome-wide association study data for coronary restenosis--a potential role for the PARVB gene.
Verschuren JJ, Trompet S, Sampietro ML, Heijmans BT, Koch W, Kastrati A, Houwing-Duistermaat JJ, Slagboom PE, Quax PH, Jukema JW
Background: Coronary restenosis after percutaneous coronary intervention (PCI) still remains a significant limitation of the procedure. The causative mechanisms of restenosis have not yet been fully identified. The goal of the current study was to perform gene-set analysis of biological pathways related to inflammation, proliferation, vascular function and transcriptional regulation on coronary restenosis to identify novel genes and pathways related to this condition. Methods: The GENetic DEterm...
Abstract
Cited 158 times since 2013 (13 per year)
source: EuropePMC
Nature,
Volume 501, Issue 7468, 7 1 2013, Pages 560-563
Limited airborne transmission of H7N9 influenza A virus between ferrets.
Richard M, Schrauwen EJ, de Graaf M, Bestebroer TM, Spronken MI, van Boheemen S, de Meulder D, Lexmond P, Linster M, Herfst S, Smith DJ, van den Brand JM, Burke DF, Kuiken T, Rimmelzwaan GF, Osterhaus AD, Fouchier RA
Wild waterfowl form the main reservoir of influenza A viruses, from which transmission occurs directly or indirectly to various secondary hosts, including humans. Direct avian-to-human transmission has been observed for viruses of subtypes A(H5N1), A(H7N2), A(H7N3), A(H7N7), A(H9N2) and A(H10N7) upon human exposure to poultry, but a lack of sustained human-to-human transmission has prevented these viruses from causing new pandemics. Recently, avian A(H7N9) viruses were transmitted to humans, cau...
Abstract
Cited 8 times since 2013 (0.7 per year)
source: EuropePMC
PloS one,
Volume 8, Issue 8, 7 1 2013, Pages e72285
A LacI-family regulator activates maltodextrin metabolism of Enterococcus faecium.
Zhang X, Rogers M, Bierschenk D, Bonten MJ, Willems RJ, van Schaik W
Enterococcus faecium is a gut commensal of humans and animals. In the intestinal tract, E. faecium will have access to a wide variety of carbohydrates, including maltodextrins and maltose, which are the sugars that result from the enzymatic digestion of starch by host-derived and microbial amylases. In this study, we identified the genetic determinants for maltodextrin utilization of E. faecium E1162. We generated a deletion mutant of the mdxABCD-pulA gene cluster that is homologous to maltodext...
Abstract
Cited 179 times since 2013 (14.7 per year)
source: EuropePMC
Epigenetics & chromatin,
Volume 6, Issue 1, 6 1 2013, Pages 26
Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array.
Slieker RC, Bos SD, Goeman JJ, Bovée JV, Talens RP, van der Breggen R, Suchiman HE, Lameijer EW, Putter H, van den Akker EB, Zhang Y, Jukema JW, Slagboom PE, Meulenbelt I, Heijmans BT
Background: DNA methylation has been recognized as a key mechanism in cell differentiation. Various studies have compared tissues to characterize epigenetically regulated genomic regions, but due to differences in study design and focus there still is no consensus as to the annotation of genomic regions predominantly involved in tissue-specific methylation. We used a new algorithm to identify and annotate tissue-specific differentially methylated regions (tDMRs) from Illumina 450k chip data for...
Abstract
Cited 20 times since 2013 (1.6 per year)
source: EuropePMC
Clinical cancer research : an official journal of the American Association for Cancer Research,
Volume 19, Issue 18, 5 1 2013, Pages 5210-5217
A pharmacogenetic predictive model for paclitaxel clearance based on the DMET platform.
de Graan AJ, Elens L, Smid M, Martens JW, Sparreboom A, Nieuweboer AJ, Friberg LE, Elbouazzaoui S, Wiemer EA, van der Holt B, Verweij J, van Schaik RH, Mathijssen RH
Purpose: Paclitaxel is used in the treatment of solid tumors and displays high interindividual variation in exposure. Low paclitaxel clearance could lead to increased toxicity during treatment. We present a genetic prediction model identifying patients with low paclitaxel clearance, based on the drug-metabolizing enzyme and transporter (DMET)-platform, capable of detecting 1,936 genetic variants in 225 metabolizing enzyme and drug transporter genes. Experimental design: In 270 paclitaxel-treated...
Abstract
Journal of molecular and cellular cardiology,
Volume 63, 2 1 2013, Pages 118-121
Mediators of inflammation after cardiac ischemia: the role of invariant natural killer T (iNKT) cells.
Arslan F
Abstract
Cited 6 times since 2013 (0.5 per year)
source: EuropePMC
Cardiovascular & hematological disorders drug targets,
Volume 13, Issue 2, 1 1 2013, Pages 111-122
Anti-apoptotic serpins as therapeutics in cardiovascular diseases.
Kuiper J, Quax PH, Bot I
Acute cardiovascular syndromes such as myocardial infarction and stroke are a major cause of death in the Western society and are generally caused by rupture of an atherosclerotic plaque. Treatment of atherosclerosis, the main underlying cause of acute cardiovascular syndromes, is still inadequate for most of the patients. Therefore, there is a need for new therapeutic strategies in addition to the existing lipid-lowering drugs such as statins. Lipid accumulation, inflammation and matrix degrada...
Abstract
Cited 51 times since 2013 (4.2 per year)
source: EuropePMC
Lancet (London, England),
Volume 382, Issue 9892, 1 1 2013, Pages 644-657
Future treatment strategies in ST-segment elevation myocardial infarction.
Windecker S, Bax JJ, Myat A, Stone GW, Marber MS
Over the past five decades, management of acute ST-segment elevation myocardial infarction (STEMI) has evolved substantially. Current treatment encompasses a systematic chain of network activation, antithrombotic drugs, and rapid instigation of mechanical reperfusion, although pharmacoinvasive strategies remain relevant. Secondary prevention with drugs and lifestyle modifications completes the contemporary management package. Despite a tangible improvement in outcomes, STEMI remains a frequent c...
Abstract
