Research

Publications

Below you can find a list of our published research.

6190 results

Cited 23 times since 1992 (0.7 per year) source: EuropePMC

Developmental biology, Volume 151, Issue 1, 1 1 1992, Pages 166-175 Modulation of activities and RNA level of the components of the plasminogen activation system during fusion of human myogenic satellite cells in vitro. Quax PH, Frisdal E, Pedersen N, Bonavaud S, Thibert P, Martelly I, Verheijen JH, Blasi F, Barlovatz-Meimon G

Primary cultures of human myogenic stem cells (satellite cells) mimic myogenic differentiation. During this process, the expression of the components of the plasminogen activation system underwent modulation. Activities and mRNA levels of tissue-type and urokinase-type plasminogen activator were increased in a reproducible pattern during differentiation. A modulation of the mRNA level of PAI-2 was also observed. Human satellite cells expressed a urokinase receptor and also the mRNA level of this... Abstract

Analytical and quantitative cytology and histology, Volume 14, Issue 2, 1 1 1992, Pages 120-128 Prognostic value of morphometry in acute lymphoblastic leukemia of childhood. Jukema JW, van Diest PJ, de Waal FC, Baak JP

The prognostic value of morphometric features was studied in a group of 33 children with acute lymphoblastic leukemia (ALL) and compared with clinical and hematologic parameters. Air dried, May-Grünwald-Giemsa-stained specimens were prepared from iliac crest biopsies, and for each patient, 150 blasts and their nuclei were selected according to a stratified selection method and measured on a graphic tablet system. Univariate overall survival analysis showed the French-American-British (FAB) class... Abstract

The Netherlands journal of medicine, Volume 40, Issue 1-2, 1 1 1992, Pages 69-75 Pulmonary embolism treated with a single dose of anisoylated lys-plasminogen streptokinase activator complex and systemic heparinization; a report of two cases. Schalij MJ, van de Meeberg PC, Marsman JW, Maingay D

Pulmonary embolism (PE) is an important cause of morbidity and mortality in the Western World. Systemic heparinization is usually applied as the treatment of first choice. However, a subgroup of patients presenting with massive PE and haemodynamic deterioration die in the acute phase or remain severely disabled. Several studies have demonstrated the beneficial effects of thrombolytic agents in the treatment of massive PE. This communication presents two patients with clinically massive PE of rec... Abstract

Deutsche medizinische Wochenschrift (1946), Volume 117, Issue 9, 1 1 1992, Pages 337-340 [Thrombocytopenia in digitoxin poisoning]. Schneider AW, Gilfrich HJ, Fechler L

Because she felt unwell, an 80-year-old woman who was receiving treatment with digitoxin (0.07 mg daily) raised the dose on her own initiative to twice or three times the previous level. She then experienced faintness, visual abnormalities and bradyarrhythmia (rate about 40/min). The ECG showed 2 degrees AV block. The digitoxin level was 70.8 ng/ml--far above the upper limit of the therapeutic range (7.5-25 ng/ml). One striking abnormality was thrombocytopenia (33,000/microliters), though the wh... Abstract

Cited 12 times since 1992 (0.4 per year) source: EuropePMC

Ultrasound in medicine & biology, Volume 18, Issue 5, 1 1 1992, Pages 441-449 Cerebral blood flow velocity: the influence of myocardial contractility on the velocity waveform of brain supplying arteries. Van Bel F, Steendijk P, Teitel DF, de Winter JP, Van der Velde ET, Baan J

Indices of Doppler-derived velocity waveforms of arteries perfusing the brain are used as relative measures of neonatal brain blood flow. Using a dog model, we investigated the influence of changes in myocardial contractility, induced by dobutamine, on the blood flow velocity waveform of the vertebral artery. The following indices of the velocity waveform were investigated during control states and during 5 or 10 micrograms/kg/min dobutamine infusion: peak systolic flow velocity (PSFV), temporal... Abstract

Cited 7 times since 1992 (0.2 per year) source: EuropePMC

European journal of nuclear medicine, Volume 19, Issue 9, 1 1 1992, Pages 783-789 The clinical impact of thallium-201 reinjection scintigraphy for detection of myocardial viability. Kuijper AF, Vliegen HW, van der Wall EE, Oosterhuis WP, Zwinderman AH, van Eck-Smit BL, Niemeyer MG, Pauwels EK

In a clinical study, the value of thallium-201 reinjection was studied in 139 patients with suspected or known coronary artery disease who showed one or more persistent defects after conventional stress-redistribution imaging. Fifty-nine (42%) patients had sustained a Q-wave myocardial infarction. Sixty-eight (49%) patients showed a reversible defect in at least one myocardial segment at redistribution, while 71 (51%) had persistent defects only. Following reinjection additional segmental fillin... Abstract

Cited 50 times since 1991 (1.5 per year) source: EuropePMC

Gastroenterology, Volume 101, Issue 6, 1 1 1991, Pages 1522-1528 Imbalance of plasminogen activators and their inhibitors in human colorectal neoplasia. Implications of urokinase in colorectal carcinogenesis. Sier CF, Verspaget HW, Griffioen G, Verheijen JH, Quax PH, Dooijewaard G, De Bruin PA, Lamers CB

Neoplastic growth and metastatic spread of adenocarcinomas is characterized by a marked increase of urokinase-type plasminogen activator (u-PA) and a decrease of tissue-type plasminogen activator (t-PA). In this study, the authors determined the activity and antigen levels of u-PA and t-PA, and their inhibitors, plasminogen-activator inhibitors types 1 and 2 (PAI-1 and PAI-2), in normal mucosa, adenomatous polyps, and adenocarcinomas of the human colon. The decrease in t-PA activity in the neopl... Abstract

Cited 22 times since 1991 (0.7 per year) source: EuropePMC

Journal of cardiothoracic and vascular anesthesia, Volume 5, Issue 6, 1 1 1991, Pages 539-545 Systolic and diastolic pressure-volume relationships during cardiac surgery. Schreuder JJ, Biervliet JD, van der Velde ET, ten Have K, van Dijk AD, Meyne NG, Baan J

Seven patients undergoing elective coronary artery bypass surgery were studied to assess left ventricular (LV) performance by pressure-volume loops. LV pressure was measured by micromanometry and instantaneous LV volume by a conductance catheter. Continuous pressure-volume relationships were determined during preload reduction before and after cardiopulmonary bypass (CPB). End-systolic elastance (Ees), as the slope of the end-systolic pressure-volume relationship (ESPVR), and diastolic elastance... Abstract

Cited 4 times since 1991 (0.1 per year) source: EuropePMC

The Thoracic and cardiovascular surgeon, Volume 39 Suppl 2, 1 1 1991, Pages 166-169 Follow-up of arterial switch operation. Hazekamp MG, Ottenkamp J, Quaegebeur JM, Hardjowijono R, Boot CA, Rohmer J, Huysmans HA

This report describes the experience of the Leiden University Hospital with the arterial switch operation for transposition of the great arteries, with and without ventricular septal defect, and for the Taussig-Bing-anomaly. The longest follow-up was 13 years and 9 months. Follow-up shows good results with almost all surviving patients in functional class I and with a sinus rhythm. Supravalvular pulmonary artery stenosis is noted in some of the patients but is almost always mild and does not sho... Abstract

Cited 92 times since 1991 (2.7 per year) source: EuropePMC

The Journal of cell biology, Volume 115, Issue 1, 1 1 1991, Pages 191-199 Metastatic behavior of human melanoma cell lines in nude mice correlates with urokinase-type plasminogen activator, its type-1 inhibitor, and urokinase-mediated matrix degradation. Quax PH, van Muijen GN, Weening-Verhoeff EJ, Lund LR, Danø K, Ruiter DJ, Verheijen JH

Five out of six human melanoma cell lines tested were able to degrade in vitro a smooth muscle cell extracellular matrix in a plasmin-dependent way. In three of these five cell lines, this process was mediated by tissue-type plasminogen activator (t-PA) and in the other two cell lines by urokinase-type plasminogen activator (u-PA). All melanoma cell lines produced t-PA mRNA and protein, whereas only the two cell lines showing u-PA-mediated matrix degradation produced u-PA mRNA and protein. These... Abstract

Cited 9 times since 1991 (0.3 per year) source: EuropePMC

Pediatric research, Volume 30, Issue 4, 1 1 1991, Pages 375-380 Acceleration of blood flow velocity in the carotid artery and myocardial contractility in the newborn lamb. van Bel F, Schipper IB, Klautz RJ, Teitel DF, Steendijk P, Baan J

We investigated the influence of quantitative changes in myocardial contractile state, reflected by changes in the end-systolic pressure-volume relationship (its slope and volume intercept) and by changes in the slope of the relationship between change in pressure per unit time and end-diastolic volume induced by beta-adrenergic stimulation or inhibition, on the Doppler derived blood flow velocity wave form of the carotid artery, using a newborn lamb model. Acceleration time of the velocity wave... Abstract

Cited 22 times since 1991 (0.7 per year) source: EuropePMC

The Journal of urology, Volume 146, Issue 4, 1 1 1991, Pages 961-965 The cold-knife technique for endourological management of stenoses in the upper urinary tract. Schneider AW, Conrad S, Busch R, Otto U

Between 1985 and October 1989 we managed 13 patients with primary and 43 with secondary obstruction of the upper urinary tract with the endourological cold-knife technique. We treated 26 patients with stenosis of the ureteropelvic junction, 9 with infundibular stenosis, 12 with ureteral obstruction after inflammation or radiation therapy, 7 with stricture of the ureter in kidney transplants and 2 with stenosis of the ureter after ureterosigmoidostomy. Endourological management was successful in... Abstract

Cited 60 times since 1991 (1.8 per year) source: EuropePMC

Cell regulation, Volume 2, Issue 10, 1 1 1991, Pages 793-803 Complementation between urokinase-producing and receptor-producing cells in extracellular matrix degradation. Quax PH, Pedersen N, Masucci MT, Weening-Verhoeff EJ, Danø K, Verheijen JH, Blasi F

The respective roles of urokinase plasminogen activator (u-PA) and the u-PA receptor in extracellular matrix degradation was investigated. Human pro-u-PA and the human u-PA receptor were expressed independently by two different mouse LB6 cell lines. The matrix degradation capacity of these cell lines individually or in coculture was studied. Although pro-u-PA-producing cells alone degrade the matrix in the presence of plasminogen, u-PA-receptor producing cells do not. Cocultivation of a small fr... Abstract

Cited 13 times since 1991 (0.4 per year) source: EuropePMC

The American journal of cardiology, Volume 68, Issue 2, 1 1 1991, Pages 181-186 Systemic neurohumoral activation and vasoconstriction during pacing-induced acute myocardial ischemia in patients with stable angina pectoris. Remme WJ, de Leeuw PW, Bootsma M, Look MP, Kruijssen DA

To identify the effect of myocardial ischemia on systemic neurohormones and vascular resistance, 32 untreated, normotensive patients with coronary artery disease underwent incremental atrial pacing until angina. Arterial and coronary venous lactate and arterial values of catecholamines and angiotensin II were determined at control, at maximal pacing rates, and at 1, 2, 5 and 30 minutes after pacing. Based on pacing-induced ST-segment depression (greater than or equal to 0.1 mV) or myocardial lac... Abstract

Cited 272 times since 1991 (8 per year) source: EuropePMC

Journal of virology, Volume 65, Issue 6, 1 1 1991, Pages 2910-2920 Equine arteritis virus is not a togavirus but belongs to the coronaviruslike superfamily. den Boon JA, Snijder EJ, Chirnside ED, de Vries AA, Horzinek MC, Spaan WJ

The nucleotide sequence of the genome of equine arteritis virus (EAV) was determined from a set of overlapping cDNA clones and was found to contain eight open reading frames (ORFs). ORFs 2 through 7 are expressed from six 3'-coterminal subgenomic mRNAs, which are transcribed from the 3'-terminal quarter of the viral genome. A number of these ORFs are predicted to encode structural EAV proteins. The organization and expression of the 3' part of the EAV genome are remarkably similar... Abstract

Cited 5 times since 1991 (0.1 per year) source: EuropePMC

New York state journal of medicine, Volume 91, Issue 5, 1 1 1991, Pages 196-200 A retrospective analysis of the metabolic status of stone formers in the New York City metropolitan areas. Hatch M, Schepers A, Grunberger I, Godec CJ

Eighty stone-forming patients were evaluated as outpatients for risk factors involved in stone formation. Analyses of the major stone risk parameters in the 24-hour collections indicated low volume (less than 2L) in about 79% of these patients. Forty percent of all patients were found to be hypocitraturic, 30% were hyperoxaluric, 18% were hypercalciuric, and 13% were hyperuricosuric. Sixty-one percent of the patients had a normal calcium load study; of these, four patients were uric acid stone f... Abstract

Cited 23 times since 1991 (0.7 per year) source: EuropePMC

Pediatric research, Volume 29, Issue 5, 1 1 1991, Pages 473-482 The end-systolic pressure-volume relationship in the newborn lamb: effects of loading and inotropic interventions. Teitel DF, Klautz R, Steendijk P, van der Velde ET, van Bel F, Baan J

Indices of global systolic performance of the newborn left ventricle exceed those of the adult, despite isolated tissue studies showing immature contractile mechanisms. To evaluate contractility in situ, we investigated the end-systolic pressure-volume relationship (ESPVR) by the conductance technique in nine newborn lambs. After percutaneous placement of catheters, we generated ESPVR by inferior vena cava occlusion, aortic occlusion, and volume infusion in two control states, during three level... Abstract

Cited 107 times since 1991 (3.1 per year) source: EuropePMC

European heart journal, Volume 12, Issue 4, 1 1 1991, Pages 488-494 Myocardial changes in pressure overload-induced left ventricular hypertrophy. A study on tissue composition, polyploidization and multinucleation. Vliegen HW, van der Laarse A, Cornelisse CJ, Eulderink F

Morphological changes in human myocardium associated with pressure overload-induced left ventricular hypertrophy were studied in 22 normal and 21 hypertrophic hearts obtained at autopsy. Samples were obtained from the left lateral ventricular wall, half way between the apex and the base. Myocyte dimensions, polyploidization, multinucleation and relative volume fractions were studied. Regression analysis in relation to indexed heart weight yielded statistically significant correlation coefficient... Abstract

Journal of cardiovascular pharmacology, Volume 18 Suppl 9, 1 1 1991, Pages S68-72 Improvement of left ventricular function in silent ischemia following myocardial infarction, after administration of diltiazem. van der Wall EE, Niemeyer MG, Vliegen HW, Manger Cats V, Blokland JA, Pauwels EK, Bruschke AV

In a group of 72 patients with acute myocardial infarction who underwent a maximal symptom-limited predischarge exercise test in conjunction with radionuclide angiography, 25 (35%) showed greater than 1 mm asymptomatic ST-T-segment depression during exercise. All 25 patients underwent repeated exercise radionuclide angiography 2 days later, 2 h after oral intake of 120 mg diltiazem. Double product was not significantly different before and after diltiazem both at rest and during exercise. Maxima... Abstract

Cited 13 times since 1991 (0.4 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 5, Issue 6, 1 1 1991, Pages 283-6; discussion 287 One stage repair of aortic arch anomalies and intracardiac defects. Hazekamp MG, Quaegebeur JM, Singh S, Hardjowijono R, Bogers AJ, Ottenkamp J, Rohmer J, Witsenburg M, Hess J, Bos E

Between August 1985 and May 1990, 27 neonates and infants underwent combined correction of intracardiac and aortic arch anomalies through a median sternotomy. Coarctation (CoA) was combined with VSD (6), AVSD (2), Taussig-Bing (TB) heart (5), transposition of the great arteries (TGA) (1), TGA + VSD (2), congenitally corrected TGA + VSD (1) and VSD + myxoid stenotic outlet valves (1). Interrupted aortic arch (IAA) was combined with VSD (10) and TB heart (1). Two patients had IAA type B as well as... Abstract