Research

Publications

Below you can find a list of our published research.

6125 results

Cited 8 times since 2022 (2.7 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 23, Issue 4, 1 1 2022, Pages 515-523 Orientation of the right superior pulmonary vein affects outcome after pulmonary vein isolation. Szegedi N, Vecsey-Nagy M, Simon J, Szilveszter B, Herczeg S, Kolossváry M, Idelbi H, Osztheimer I, Klaudia Nagy V, Tahin T, Széplaki G, Delgado V, Bax JJ, Maurovich-Horvat P, Merkely B, Gellér L

Aims: Controversial results have been published regarding the influence of pulmonary vein (PV) anatomical variations on outcomes after pulmonary vein isolation (PVI). However, no data are available on the impact of PV orientation on the long-term success rates of point-by-point PVI. We sought to determine the impact of PV anatomy and orientation on atrial fibrillation (AF)-free survival in patients undergoing PVI using the radiofrequency point-by-point technique. Methods and results: We retrospe... Abstract

Cited 7 times since 2022 (2.3 per year) source: EuropePMC

American journal of epidemiology, Volume 191, Issue 5, 1 1 2022, Pages 886-899 Evaluation of the Value of Waist Circumference and Metabolomics in the Estimation of Visceral Adipose Tissue. Boone SC, van Smeden M, Rosendaal FR, le Cessie S, Groenwold RHH, Jukema JW, van Dijk KW, Lamb HJ, Greenland P, Neeland IJ, Allison MA, Criqui MH, Budoff MJ, Lind LL, Kullberg J, Ahlström H, Mook-Kanamori DO, de Mutsert R

Visceral adipose tissue (VAT) is a strong prognostic factor for cardiovascular disease and a potential target for cardiovascular risk stratification. Because VAT is difficult to measure in clinical practice, we estimated prediction models with predictors routinely measured in general practice and VAT as outcome using ridge regression in 2,501 middle-aged participants from the Netherlands Epidemiology of Obesity study, 2008-2012. Adding waist circumference and other anthropometric measurements on... Abstract

The Journal of cardiovascular nursing, Volume 37, Issue 2, 1 1 2022, Pages 192-196 Type D Personality Associated With Increased Risk for Mortality in Adults With Congenital Heart Disease. Kauw D, Schoormans D, Sieswerda GT, Van Melle JP, Vliegen HW, Van Dijk APJ, Hulsbergen-Zwarts MS, Post MC, Ansink TJ, Mulder BJM, Bouma BJ, Schuuring MJ

Background: Type D personality has been previously shown to increase the risk for mortality in patients with acquired heart disease. Objective: We aimed to compare mortality in adult patients with congenital heart disease (CHD) with and without type D. Methods: Survival was assessed using prospective data from the Dutch national Congenital Corvitia registry for adults with CHD. Patients were randomly selected from the registry and characterized at inclusion in 2009 for the presence of type D usi... Abstract

Cited 13 times since 2022 (4.3 per year) source: EuropePMC

JAMA cardiology, Volume 7, Issue 3, 1 1 2022, Pages 309-319 Association of Plaque Location and Vessel Geometry Determined by Coronary Computed Tomographic Angiography With Future Acute Coronary Syndrome-Causing Culprit Lesions. Han D, Lin A, Kuronuma K, Tzolos E, Kwan AC, Klein E, Andreini D, Bax JJ, Cademartiri F, Chinnaiyan K, Chow BJW, Conte E, Cury RC, Feuchtner G, Hadamitzky M, Kim YJ, Leipsic JA, Maffei E, Marques H, Plank F, Pontone G, Villines TC, Al-Mallah MH, de Araújo Gonçalves P, Danad I, Gransar H, Lu Y, Lee JH, Lee SE, Baskaran L, Al'Aref SJ, Yoon YE, Van Rosendael A, Budoff MJ, Samady H, Stone PH, Virmani R, Achenbach S, Narula J, Chang HJ, Min JK, Lin FY, Shaw LJ, Slomka PJ, Dey D, Berman DS

Importance: Distinct plaque locations and vessel geometric features predispose to altered coronary flow hemodynamics. The association between these lesion-level characteristics assessed by coronary computed tomographic angiography (CCTA) and risk of future acute coronary syndrome (ACS) is unknown. Objective: To examine whether CCTA-derived adverse geometric characteristics (AGCs) of coronary lesions describing location and vessel geometry add to plaque morphology and burden for identifying culpr... Abstract

Cited 3 times since 2022 (1 per year) source: EuropePMC

The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland, Volume 21, Issue 1, 28 4 2022, Pages 1-7 Exploring the surgical personality. Sier VQ, Schmitz RF, Schepers A, van der Vorst JR

Surgery is a demanding field, requiring determination and emotional stability. This review explores the surgical personality, addressing international personality differences between surgical and non-surgical specialties. Across the globe, surgically-interested individuals (i.e., medical students, residents, surgeons) generally scored higher on conscientiousness, open mindedness, and extraversion, and lower on neuroticism compared to non-surgically-interested contemporaries. Extraversion was inv... Abstract

The international journal of cardiovascular imaging, Volume 38, Issue 5, 26 4 2022, Pages 927-929 Patterns of cardiac involvement characterized by strain echocardiography in amyloidosis. Tjahjadi C, Fortuni F, Stassen J, Marsan NA, Delgado V, Bax JJ

Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 30, Issue 6, 24 4 2022, Pages 338-339 Multiple culprit lesions in ST-segment elevation myocardial infarction with cardiogenic shock: a case of simultaneous thrombosis of two infarct-related arteries. Caliskan R, Ince H, Arslan F

Abstract

Cited 5 times since 2022 (1.7 per year) source: EuropePMC

JMIR cardio, Volume 6, Issue 1, 22 4 2022, Pages e29473 A Preoperative Virtual Reality App for Patients Scheduled for Cardiac Catheterization: Pre-Post Questionnaire Study Examining Feasibility, Usability, and Acceptability. Aardoom JJ, Hilt AD, Woudenberg T, Chavannes NH, Atsma DE

Background: Pre- and postoperative anxiety is a common phenomenon associated with negative postoperative outcomes. Symptoms of posttraumatic stress disorder, such as fear, nightmares, and sleep deprivation, are prevalent in approximately 30% to 50% of patients following discharge from intensive care units after cardiac surgery. Preliminary evidence suggests a promising role of virtual reality (VR) in preventing stress-related reactions using stress inoculation training. Such training enables cog... Abstract

Frontiers in psychiatry, Volume 13, 22 4 2022, Pages 774251 Incorporating Baseline Outcome Data in Individual Participant Data Meta-Analysis of Non-randomized Studies. Syrogiannouli L, Wildisen L, Meuwese C, Bauer DC, Cappola AR, Gussekloo J, den Elzen WPJ, Trompet S, Westendorp RGJ, Jukema JW, Ferrucci L, Ceresini G, Åsvold BO, Chaker L, Peeters RP, Imaizumi M, Ohishi W, Vaes B, Völzke H, Sgarbi JA, Walsh JP, Dullaart RPF, Bakker SJL, Iacoviello M, Rodondi N, Del Giovane C

Background: In non-randomized studies (NRSs) where a continuous outcome variable (e.g., depressive symptoms) is assessed at baseline and follow-up, it is common to observe imbalance of the baseline values between the treatment/exposure group and control group. This may bias the study and consequently a meta-analysis (MA) estimate. These estimates may differ across statistical methods used to deal with this issue. Analysis of individual participant data (IPD) allows standardization of methods acr... Abstract

The American journal of cardiology, Volume 170, 21 3 2022, Pages 1-9 Prognostic Relevance of Right Ventricular Remodeling after ST-Segment Elevation Myocardial Infarction in Patients Treated With Primary Percutaneous Coronary Intervention. Chimed S, van der Bijl P, Lustosa RP, Hirasawa K, Yedidya I, Fortuni F, van der Velde E, Montero-Cabezas JM, Marsan NA, Gersh BJ, Delgado V, Bax JJ

ST-segment elevation myocardial infarction (STEMI) often leads to changes in right ventricular (RV) function and size over time. The prognostic implications of RV remodeling after STEMI, however, are unknown. RV remodeling in patients who underwent STEMI with primary percutaneous coronary intervention (PCI) was defined by RV end-systolic area (RV ESA) change at 6 months after STEMI compared with baseline. The optimal threshold of RV ESA change (≥40%) to define RV remodeling was derived from spli... Abstract

Cited 1 times since 2022 (0.3 per year) source: EuropePMC

International journal of cardiology, Volume 355, 18 3 2022, Pages 65-71 Prognostic implications of staging cardiac remodeling in patients undergoing cardiac resynchronization therapy. Stassen J, Khidir M, Galloo X, Hirasawa K, Knuuti J, Marsan NA, Delgado V, van der Bijl P, Bax JJ

Background: Cardiac resynchronization therapy (CRT) candidates often present with significant mitral and tricuspid regurgitation, pulmonary hypertension and right ventricular dysfunction when referred for device implantation. This study investigated the prognostic value of a novel cardiac staging system, based on the extent of cardiac remodeling prior to implantation. Methods: Data were collected from an ongoing registry of CRT recipients. Patients were divided into 4 groups according to the ext... Abstract

Cited 3 times since 2022 (1 per year) source: EuropePMC

Heart rhythm, Volume 19, Issue 6, 18 3 2022, Pages 927-936 Impact of baseline left ventricular volume on left ventricular reverse remodeling after cardiac resynchronization therapy. Galloo X, Stassen J, Hirasawa K, Chimed S, Cosyns B, Ajmone Marsan N, Delgado V, van der Bijl P, Bax JJ

Background: Left ventricular (LV) dilatation may limit LV reverse remodeling after cardiac resynchronization therapy (CRT). Objective: The purpose of this study was to evaluate the impact of baseline LV volumes on LV reverse remodeling after CRT and whether this is associated with improved survival. Methods: Patients were stratified into quintiles according to baseline LV end-diastolic volume indexed for body surface area (LVEDVi). LV reverse remodeling was defined as ≥15% reduction in LV end-sy... Abstract

European heart journal. Case reports, Volume 6, Issue 3, 17 3 2022, Pages ytac087 Successful hybrid cardiac resynchronization therapy in a patient with failing systemic right ventricle and significant tricuspid regurgitation in transposition of the great arteries after atrial switch procedure according to Mustard. Nederend M, Zeppenfeld K, Jongbloed MRM, Egorova AD

Background: Patients with a systemic right ventricle (sRV) in the context of transposition of the great arteries (TGA) late after atrial switch are prone to heart failure. Complications like tricuspid valve regurgitation (TR) can further aggravate sRV dysfunction. Tricuspid valve regurgitation is usually secondary to annular dilatation and restriction. Criteria for cardiac resynchronization therapy (CRT) in this patient group are not well defined and should be considered on a case-by-case basis.... Abstract

Cited 3 times since 2022 (1 per year) source: EuropePMC

European heart journal. Case reports, Volume 6, Issue 2, 16 3 2022, Pages ytac067 Case report of the broad spectrum of late complications in an adult patient with univentricular physiology palliated by the Fontan circulation. Nederend M, Egorova AD, Vliegen HW, Roest AAW, Ruijter BN, Korteweg T, Ninaber MK, Zeppenfeld K, Hazekamp MG, Kiès P, Jongbloed MRM

Background: At the most severe end of the spectrum of congenital heart disease are patients with an univentricular physiology. They comprise a heterogeneous group of congenital heart malformations that have the common characteristic that the cardiac morphology is not equipped for sustaining a biventricular circulation. Case summary: Here, we present a case of an adult patient after Fontan palliation, illustrative of the complex clinical course and the broad spectrum of complications that can be... Abstract

Cited 10 times since 2022 (3.3 per year) source: EuropePMC

Frontiers in cardiovascular medicine, Volume 9, 15 3 2022, Pages 708298 Abutting Left Atrial Appendage and Left Superior Pulmonary Vein Predicts Recurrence of Atrial Fibrillation After Point-by-Point Pulmonary Vein Isolation. Szegedi N, Simon J, Szilveszter B, Salló Z, Herczeg S, Száraz L, Kolossváry M, Orbán G, Széplaki G, Nagy KV, Mahdiui ME, Smit JM, Delgado V, Bax JJ, Maurovich-Horvat P, Merkely B, Gellér L

Introduction: The role of the spatial relationship between the left superior pulmonary vein (LSPV) and left atrial appendage (LAA) is unknown. We sought to evaluate whether an abutting LAA and LSPV play a role in AF recurrence after catheter ablation for paroxysmal AF. Methods: Consecutive patients, who underwent initial point-by-point radiofrequency catheter ablation for paroxysmal AF at the Heart and Vascular Center of Semmelweis University, Budapest, Hungary, between January of 2014 and Decem... Abstract

Cited 17 times since 2022 (5.6 per year) source: EuropePMC

Frontiers in cardiovascular medicine, Volume 9, 14 2 2022, Pages 820962 The Intriguing Role of TLR Accessory Molecules in Cardiovascular Health and Disease. Bezhaeva T, Karper J, Quax PHA, de Vries MR

Activation of Toll like receptors (TLR) plays an important role in cardiovascular disease development, progression and outcomes. Complex TLR mediated signaling affects vascular and cardiac function including tissue remodeling and repair. Being central components of both innate and adaptive arms of the immune system, TLRs interact as pattern recognition receptors with a series of exogenous ligands and endogenous molecules or so-called danger associated molecular patterns (DAMPs) that are released... Abstract

Cited 2 times since 2022 (0.7 per year) source: EuropePMC

BMC pediatrics, Volume 22, Issue 1, 12 2 2022, Pages 85 Myocardial infarction due to thrombotic occlusion despite anticoagulation in Kawasaki disease - a case report. van Stijn D, Schoenmaker NJ, Planken RN, Koolbergen DR, Gouw SC, Kuijpers TW, Blom NA, Kuipers IM

Background: Kawasaki disease (KD) is a pediatric vasculitis. Mainly the coronary arteries become affected due to acute inflammation and formation of coronary artery aneurysms (CAAs) can occur. The larger the CAA, the higher the risk for clinical complications and major adverse cardiac events, as the blood flow changes to vortex or turbulent flow facilitating thrombosis. Such patients may develop life threatening thrombotic coronary artery occlusion and myocardial ischemiaunless anti-platelet and... Abstract

Cited 7 times since 2022 (2.3 per year) source: EuropePMC

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 63, Issue 5, 11 2 2022, Pages 743-750 Aortic and Iliac Involvement in Brucellosis - A Rare but Life Threatening Manifestation: A Review of the Literature. Willems SA, Brouwers JJWM, Eefting D

Objective: Brucellosis is the most common zoonosis worldwide. Although cardiovascular complications in human brucellosis comprise only 3% of morbidity, they are the principal cause of death. Endocarditis covers the majority of these cases. Infected aneurysms and ulcerative processes of the aorta are rare but can be life threatening as well. Currently, limited information is available about aortic and iliac involvement in brucellosis. Methods: A PubMed, Web of Science, and AccessMedicine search (... Abstract

Cited 1 times since 2022 (0.3 per year) source: EuropePMC

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 63, Issue 5, 10 2 2022, Pages 773-774 Hypothesis of the High Mortality of Female Patients Following Elective Open Abdominal Aortic Aneurysm Repair. Bulder RMA, Tedjawirja VN, Hamming JF, Koelemay MJ, Balm R, Lindeman JHN, study group collaborators

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Cited 33 times since 2022 (10.8 per year) source: EuropePMC

Water research, Volume 214, 5 1 2022, Pages 118162 Prevalence and circulation patterns of SARS-CoV-2 variants in European sewage mirror clinical data of 54 European cities. Agrawal S, Orschler L, Schubert S, Zachmann K, Heijnen L, Tavazzi S, Gawlik BM, de Graaf M, Medema G, Lackner S

For community-level monitoring, the European Commission under the EU Sewage Sentinel System recommends wastewater-based SARS-CoV-2 surveillance. Tracking SARS-CoV-2 variants in a community is pivotal for appropriate public health response. Genome sequencing of SARS-CoV-2 in wastewater samples for tracking variants is challenging, often resulting in low coverage genome sequences, thereby impeding the detection of the SARS-CoV-2 mutations. Therefore, we aimed at high-coverage SARS-CoV-2 genome seq... Abstract