Research

Publications

Below you can find a list of our published research.

8153 results

Cited 1 times since 2025 (3.6 per year) source: EuropePMC

JACC. Cardiovascular interventions, Volume 18, Issue 12, 1 1 2025, Pages 1540-1553 Aortic Valve Replacement in Women: A Pooled Analysis of the RHEIA and PARTNER 3 Trials. Eltchaninoff H, Windecker S, Mack MJ, Pibarot P, Thourani VH, Bax JJ, Cohen DJ, Bonaros N, Makkar R, Bleiziffer S, Szeto WY, Berthoumieu P, Hahn RT, Hovorka T, Mareš J, Taylor J, Tchetche D, Leon MB

Background: In women with severe aortic stenosis, there are limited data regarding outcome differences following transcatheter (TAVR) vs surgical aortic valve replacement (SAVR). Objectives: The authors sought to examine outcomes of TAVR vs SAVR in a patient-level pooled analysis of women in the RHEIA and PARTNER 3 trials. Methods: Patients in both trials were randomly allocated to a balloon-expandable SAPIEN 3/Ultra valve or to surgical bioprostheses. Individual patient data of female participa... Abstract

Nucleic acids research, Volume 53, Issue 12, 1 1 2025, Pages gkaf549 Extrusion fountains are restricted by WAPL-dependent cohesin release and CTCF barriers. Liu NQ, Magnitov M, Schijns MMGA, van Schaik T, Teunissen H, van Steensel B, de Wit E

Interphase chromosomes are mainly shaped by loop extrusion and compartmentalisation mechanisms. However, their temporal component and cause-effect relationships remain largely unknown. In this study, we use acute degradation of WAPL, CTCF and cohesin in mouse embryonic stem cells to investigate the dynamics of loop extrusion and its relationship to compartmentalisation. Stabilisation of cohesin on chromatin by depletion of WAPL results in the formation of extended loops and promotes looping betw... Abstract

Cited 1 times since 2025 (3.6 per year) source: EuropePMC

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, Volume 36, Issue 6, 1 1 2025, Pages e70113 ADRB2 genotype-guided treatment for childhood asthma: Cost analysis of the PUFFIN and PACT trials. Slob EMA, Frederix GWJ, Vijverberg SJH, Noij LCE, Ruffles T, Vasbinder EC, Mukhopadhyay S, van Schaik RHN, Kersten ETG, Pijnenburg MW, Koppelman GH, Maitland-van der Zee AH, PUFFIN and PACT investigators

Background: Long-acting β2-agonists (LABA) are commonly used to treat asthma. Some children do not respond well to LABA, which may be due to +46G>A-/rs1042713 (Arg16 amino acid) in the ADRB2 gene encoding the β2 receptor. Arg16Gly ADRB2 genotyping to guide treatment step-up decisions in children with uncontrolled asthma despite inhaled corticosteroids (ICS) has been shown to reduce asthma exacerbations. We investigated whether ADRB2 genotype-guided treatment is cost-saving. Methods: Total sem... Abstract

Journal of the peripheral nervous system : JPNS, Volume 30, Issue 2, 1 1 2025, Pages e70031 Validity and Responsiveness of Balance Measurements Using Posturography in Patients With Immune-Mediated Neuropathies. Michael MR, van Veen R, Wieske L, Merkies ISJ, van Schaik IN, Eftimov F

Background and aims: Validated objective measures for balance in immune mediated neuropathies are lacking. In this study, we investigated the clinimetric properties of posturography using a force platform, a quantitative assessment of postural control. Methods: We assessed patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and IgM-related polyneuropathy (IgM-PNP) using sway parameters (path, area and amplitude) measured at multiple time points. Validity was investigated by as... Abstract

Cited 1 times since 2025 (3.6 per year) source: EuropePMC

The clinical teacher, Volume 22, Issue 3, 1 1 2025, Pages e70073 Faculty Development for the People: Workplace-Based Solutions for Busy Clinicians. Brode EC, Bernal JM, Cornes SB, Santhosh L, Rivera JA, Kulkarni SA, Mandal JR, Henry DM, Bartz KS, Van Schaik SM

Background: Across clinical learning environments (CLEs), learners often encounter supervising clinicians who do not self-identify as educators and, therefore, may not seek out faculty development to augment their teaching skills. To reach those faculty, we conducted a proof-of-concept project framed by Billet's theory on workplace learning, bringing tailored faculty development to the clinical workplace. Approach: We recruited 22 faculty champions from 8 clinical departments at our institu... Abstract

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 67, Issue 6, 1 1 2025, Pages ezaf161 Sex difference in aortic root replacement with a stentless bioprosthesis†. Dagnegård H, Schneider AW, Timmermans PT, Glaser N, Kolseth SM, Vanky F, Gudbjartsson T, Haaverstad R, Cotovanu A, Sartipy U, Klautz RJM, Smerup M, Hjortnaes J, North Atlantic Freestyle Collaboration

Objectives: To investigate and quantify differences in survival and reinterventions between sexes after aortic root replacement with a stentless bioprosthesis, stratified for preoperative valve lesion. Methods: Elective adults undergoing aortic root replacement with the Freestyle bioprosthesis at six North-Atlantic centres were included. Survival analyses were performed using the Kaplan-Meier method or Aalen-Johansen with death as competing risk as relevant. Results were quantified using uni- an... Abstract

Radiology. Cardiothoracic imaging, Volume 7, Issue 3, 1 1 2025, Pages e240200 Pericoronary Adipose Tissue Attenuation in Patients with Future Acute Coronary Syndromes: The ICONIC Study. Kwan AC, Tzolos E, Klein E, Han D, Lin A, Kuronuma K, Chen B, Flores Tomasino G, Gransar H, Slomka PJ, Cheng S, Gebhard C, Kaufmann P, Bax JJ, Cademartiri F, Chinnaiyan K, Chow BJW, Conte E, Cury RC, Feuchtner G, Hadamitzky M, Kim YJ, Leipsic JA, Maffei E, Marques H, Plank F, Pontone G, Villines TC, Al-Mallah MH, Gonçalves PA, Danad I, Lu Y, Lee JH, Lee SE, Baskaran L, Al'Aref SJ, Budoff MJ, Samady H, Stone PH, Virmani R, Achenbach S, Narula J, Chang HJ, Shaw LJ, Berman DS, Lin F, Dey D

Purpose Pericoronary adipose tissue attenuation (PCATa) measured at coronary CT angiography (CCTA) is an imaging biomarker of coronary inflammation associated with long-term adverse cardiac events. The authors hypothesized that PCATa may independently identify patients at risk for acute coronary syndromes (ACS). Materials and Methods The authors performed a retrospective substudy of the Incident Coronary Syndromes Identified by Computed Tomography (ICONIC) study, a propensity-matched case-contro... Abstract

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Volume 39, Issue 12, 1 1 2025, Pages e70735 Fibrogenic Gene Signature as Early Prediction for the Efficacy of Pharmacological Interventions for MASH-Associated Fibrosis. Inia JA, Morrison MC, van Koppen A, Gart E, Caspers MPM, Menke AL, Worms N, Kleemann R, Verschuren L, Jukema JW, Princen HMG, Hanemaaijer R, van den Hoek AM

The incidence of metabolic dysfunction-associated steatohepatitis (MASH) and associated liver fibrosis is rapidly increasing, while pharmacological treatment options remain limited. Despite great efforts in developing novel MASH therapeutics, many investigative therapeutics that reduced fibrosis in preclinical models ultimately failed in clinical trials. To this end, we explored the possibility of predicting the efficacy of therapeutics by evaluating changes in the expression of a fibrogenic gen... Abstract

Substance abuse treatment, prevention, and policy, Volume 20, Issue 1, 28 4 2025, Pages 23 Effect and acceptability of an mHealth smoking cessation intervention 'Stopcoach' combined with smoking cessation counseling for people from multiple levels of socioeconomic position: a multi-methods study. de Frel DL, Zijp A, van den Putte B, Troelstra S, Hermsen S, Heemskerk E, Janssen VR, Atsma DE, Chavannes NH, Meijer E

Introduction: Smoking cessation interventions tend to be less effective for people of lower socioeconomic position (SEP) compared to those of higher SEP. Mobile phone-based interventions have been shown to increase abstinence from smoking. Stopcoach is an mHealth smoking cessation intervention that specifically targets people with a lower SEP. A pilot study showed the potential and feasibility of Stopcoach but as yet no research exists that assesses the effectiveness of Stopcoach. Objective: Thi... Abstract

Open heart, Volume 12, Issue 1, 27 4 2025, Pages e003355 Clinical course and outcomes of supravalvular aortic stenosis in adults. de Keijzer AR, Keuning ZA, Meccanici F, van Kimmenade RRL, van Melle JP, Bouma BJ, Kluin J, Jongbloed MRM, Voskuil M, Roos-Hesselink JW, van den Bosch AE

Background: Supravalvular aortic stenosis (SVAS) is a rare condition with limited data on patients beyond childhood. This study aims to investigate the clinical course and outcomes of SVAS in adults. Methods: All adult (≥18 years) patients with SVAS, prospectively registered in the Dutch Congenital Cor Vitia database between 2001 and 2019, were included. Survival and event-free survival were assessed. Evolution of peak velocity was analysed using linear mixed models. Differences in previous oper... Abstract

Chemistry & biodiversity, 27 4 2025, Pages e00911 Formation of Colchicine-incorporated Hybrid Nanoflower With an Intrinsic Peroxidase-Mimic and Enhanced Antimicrobial Activities. Yilmaz E, Koca FD, Saticioglu IB, Ozen B, Yilmaz DD, Nisari M, Ocsoy I

We report the formation of colchicine-Cu3(PO4)2 hybrid nanoflowers (Colc-NFs) with intrinsic catalytic and antimicrobial activities with and without hydrogen peroxide (H2O2). While the colchicine molecule, known as a secondary metabolite with anti-inflammatory properties, was used as an organic part of Colc-NFs, the Cu2+ ion acted as an inorganic part of Colc-NFs. The acetamide group in the colchicine structure may react with Cu2+ ions in phosphate-buffered saline to form Colc-NFs. The Colc-NFs... Abstract

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, Volume 106, Issue 2, 27 4 2025, Pages 869-878 Comparison of Procedural and Clinical Outcomes of Angiography- Versus Imaging-Guided Percutaneous Coronary Intervention With Intravascular Lithotripsy. Phagu AAS, van Oort MJH, Oliveri F, Bingen BO, Mincione G, Paradies V, Claessen BEPM, Dimitriu-Leen AC, Vossenberg TN, Kefer J, Girgis H, van der Kley F, Jukema JW, Al Amri I, Montero-Cabezas JM

Background: Intravascular lithotripsy (IVL) is an innovative treatment for coronary artery calcification (CAC). Aims: This study aimed to compare procedural and clinical outcomes of intracoronary imaging (ICI)-guided percutaneous coronary intervention (PCI) versus angiography-guided PCI with IVL in patients with CAC. Methods: A total of 509 patients were analyzed from the BENELUX-IVL registry (May 2019 to September 2024). Angiography-guided PCI with IVL was defined as therapy under solely fluoro... Abstract

The Journal of dermatological treatment, Volume 36, Issue 1, 27 4 2025, Pages 2503273 Treatment goals and preferences of pediatric atopic dermatitis patients, young adults, and caregivers. van der Rijst LP, de Bruin-Weller MS, Zuithoff NPA, Spillekom-van Koulil S, Seyger MMB, de Graaf M

Purpose: Understanding the treatment goals and preferences of young atopic dermatitis (AD) patients and their caregivers is crucial for enhancing patient-centered care. This study aims to identify these goals and preferences and explore heterogeneity among subgroups. Materials and methods: A web-based survey was conducted among children (6-11 years), adolescents (12-17 years), and young adults (18-30 years) with AD and caregivers of AD patients. Survey questions included multiple-choice, four-po... Abstract

Journal of cardiac failure, 23 4 2025, Pages S1071-9164(25)00236-2 The Association Between Serially Measured Circulating Biomarker Patterns and Pulmonary Artery Pressures Measured by Invasive Hemodynamic Monitoring. Barry-Loncq DE Jong M, Allach Y, Abou Kamar S, Clephas PRD, Brunner-LA Rocca HP, Handoko ML, VAN Halm VP, Kok WEM, Asselbergs FW, VAN Kimmenade RRJ, Beeres SLMA, Rienstra M, Szymanski MK, DE Boer RA, Kardys I, Brugts JJ

Background: Invasive hemodynamic monitoring devices provide relevant insights into the hemodynamic status of heart failure (HF) patients. Additionally, circulating biomarkers have been advocated as additives in HF management by offering prognostic information and therapeutic targets. However, limited data exist correlating serially measured biomarkers to hemodynamic pressures provided by invasive sensors. This study aims to investigate the association between serial biomarker patterns and pulmon... Abstract

Bone research, Volume 13, Issue 1, 23 4 2025, Pages 55 Age- and sex-specific deterioration on bone and osteocyte lacuno-canalicular network in a mouse model of premature aging. Yılmaz D, Marques FC, Gregorio L, Schlatter J, Gehre C, Pararajasingam T, Qiu W, Mathavan N, Qin XH, Wehrle E, Kuhn GA, Müller R

Age-related osteoporosis poses a significant challenge in musculoskeletal health; a condition characterized by reduced bone density and increased fracture susceptibility in older individuals necessitates a better understanding of underlying molecular and cellular mechanisms. Emerging evidence suggests that osteocytes are the pivotal orchestrators of bone remodeling and represent novel therapeutic targets for age-related bone loss. Our study uses the prematurely aged PolgD257A/D257A (PolgA) mouse... Abstract

BMC medical education, Volume 25, Issue 1, 22 4 2025, Pages 757 The effect of three different techniques used to improve vein prominence on the first peripheral venous catheterization experience in nursing students: a randomized controlled study. Yılmaz H, Yılmaz D, Çinar HG

Background: Peripheral venous catheterization (PVC) insertion is a complex sensory-motor skill that can be difficult for nursing students to acquire. Objectives: The authors aimed to examine the effect of three techniques used to improve vein prominence on achievement, knowledge, and psychomotor skills in the first PVC experience in nursing students. Methods: A single-center, parallel-group, randomized control study. Near-infrared light visualization (n = 49) and isometric exercise (n = 50) tech... Abstract

The international journal of cardiovascular imaging, Volume 41, Issue 7, 22 4 2025, Pages 1371-1379 Evolution and prognostic implications of cardiac damage in women after transcatheter aortic valve implantation. Myagmardorj R, Fortuni F, Galloo X, Nabeta T, Meucci MC, Butcher SC, van der Kley F, Ajmone Marsan N, Bax JJ

Recently, a cardiac damage staging system has been proposed in patients with severe AS to improve risk stratification, but there is still paucity of data in women. Accordingly, we aimed to characterize the change in cardiac damage after transcatheter aortic valve implantation (TAVI), and to assess the prognostic value of cardiac damage staging in women. A total of 334 women (mean age 81 ± 7 years) with severe AS undergoing TAVI were included and retrospectively analyzed. Echocardiography was per... Abstract

Healthcare (Basel, Switzerland), Volume 13, Issue 11, 22 4 2025, Pages 1217 Bridging Barriers: Engaging Ethnic Minorities in Cardiovascular Research. Bacour N, Grewal S, Ploem MC, Suurmond J, Klautz RJM, Grewal N

Background/Objectives: We address the ongoing under-representation of ethnic minority groups in cardiovascular research in this opinion paper-a challenge that limits both scientific validity and equitable healthcare outcomes. We aim to outline the underlying causes of this issue and propose concrete strategies to address it. Methods: To engage ethnic minorities in cardiovascular research, we thoroughly studied the existing literature and gathered expert opinions to identify barriers and formulat... Abstract

American journal of preventive cardiology, Volume 22, 22 4 2025, Pages 101008 The interactions of Lipoprotein(a) with common cardiovascular risk factors in cardiovascular disease risk: evidence based on the UK Biobank. Ao L, Noordam R, Jukema JW, van Heemst D, Willems van Dijk K

Background: : Although Lipoprotein(a) (Lp(a)) is associated with cardiovascular disease, it is unclear whether the associated risk is similar in the presence of other concomitant risk factors. Here, we aimed to investigate the interactions between Lp(a) and common cardiovascular risk factors on coronary artery disease (CAD), calcific aortic valve stenosis (CAVS) and ischemic stroke (IS). Methods: : We included 127,958 unrelated European-ancestry participants from UK Biobank (54.7 % women) with d... Abstract

European urology oncology, 20 3 2025, Pages S2588-9311(25)00104-X Towards Defining Follow-up Strategies for Patients with Primary Intermediate-risk Non-muscle-invasive Bladder Cancer. Contieri R, Martini A, Beijert IJ, Mertens LS, Hentschel AE, Bründl J, Compérat EM, Plass K, Rodríguez O, Subiela Henríquez JD, Hernández V, de la Peña E, Alemany I, Turturica D, Pisano F, Soria F, Čapoun O, Bauerová L, Pešl M, Maxim Bruins H, Runneboom W, Herdegen S, Breyer J, Brisuda A, Calatrava A, Rubio-Briones J, Seles M, Mannweiler S, Bosschieter J, Kusuma VRM, Ashabere D, Huebner N, Seisen T, Claps F, Masson-Lecomte A, Liedberg F, Cohen D, Lunelli L, Cussenot O, Sheikh SE, Volanis D, Côté JF, Rouprêt M, Haitel A, Shariat SF, Mostafid AH, Nieuwenhuijzen JA, Zigeuner R, Dominguez-Escrig JL, Hacek J, Zlotta AR, Burger M, Evert M, de Kaa CAH, van der Heijden AG, Kiemeney LALM, Soukup V, Molinaro L, Hurle R, Paciotti M, Moschini M, Pradere B, Perdonà S, Gontero P, Llorente C, Algaba F, Palou J, N'Dow J, Ribal MJ, van der Kwast TH, Babjuk M, Sylvester RJ, van Rhijn BWG

Background and objective: The current European Association of Urology (EAU) guidelines on non-muscle-invasive bladder cancer (NMIBC) categorize patients into four risk groups. In 2024, a specific follow-up schedule was introduced for intermediate-risk (IR) disease. However, recommendations are based on expert opinion and restricted to patients with IR-NMIBC who have primary low-grade or high-grade/grade 2 disease. Our aim was to identify a subgroup of patients with IR-NMIBC who may require more... Abstract