Research

Publications

Below you can find a list of our published research.

6196 results

Journal of cell science, Volume 137, Issue 20, 31 5 2024, Pages jcs262041 Cell-cell junctions in focus - imaging junctional architectures and dynamics at high resolution. Janssen V, Huveneers S

Studies utilizing electron microscopy and live fluorescence microscopy have significantly enhanced our understanding of the molecular mechanisms that regulate junctional dynamics during homeostasis, development and disease. To fully grasp the enormous complexity of cell-cell adhesions, it is crucial to study the nanoscale architectures of tight junctions, adherens junctions and desmosomes. It is important to integrate these junctional architectures with the membrane morphology and cellular topog... Abstract

JACC. Basic to translational science, Volume 10, Issue 3, 30 5 2024, Pages 383-395 EPA Induces an Anti-Inflammatory Transcriptome in T Cells, Implicating a Triglyceride-Independent Pathway in Cardiovascular Risk Reduction. Reilly NA, Dekkers KF, Molenaar J, Arumugam S, Kuipers TB, Ariyurek Y, Hoeksema MA, Jukema JW, Heijmans BT

Twice-daily intake of purified eicosapentaenoic acid (EPA) reduces atherosclerotic cardiovascular disease risk in patients with high triglycerides, but its exact mechanism remains unclear. We exposed non-activated CD4+ T cells to 100μM EPA, oleic acid, palmitic acid, or control, and conducted RNA and ATAC-sequencing after 48 hours. EPA exposure downregulated immune response-related genes like HLA-DRA, CD69, and IL2RA, and upregulated oxidative stress prevention genes like NQO1. Transcription fac... Abstract

Scientific reports, Volume 14, Issue 1, 29 5 2024, Pages 26018 Accessible viral metagenomics for public health and clinical domains with Jovian. Schmitz D, Zwagemaker F, Nooij S, Janssens TKS, Cremer J, Verhagen R, Vennema H, Kroneman A, Koopmans MPG, Laros JFJ, de Graaf M

The integration of next-generation sequencing into clinical diagnostics and surveillance initiatives is impeded by the lack of data analysis pipelines that align with privacy legislation and laboratory certification protocols. To address these challenges, we developed Jovian, an open-source, virus-focused, metagenomic analysis workflow for Illumina data. Jovian generates scaffolds enriched with pertinent annotations, including taxonomic classification, combined with metrics needed for quality as... Abstract

Cited 7 times since 2024 (13.4 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 85, Issue 9, 28 4 2024, Pages 878-890 Transcatheter Aortic Valve Replacement in Patients With Systolic Heart Failure and Moderate Aortic Stenosis: TAVR UNLOAD. Van Mieghem NM, Elmariah S, Spitzer E, Pibarot P, Nazif TM, Bax JJ, Hahn RT, Popma A, Ben-Yehuda O, Kallel F, Redfors B, Chuang ML, Alu MC, Lindeboom W, Kolte D, Zahr FE, Kodali SK, Strote JA, Hermanides RS, Cohen DJ, Tijssen JGP, Leon MB

Background: Neurohormonal modulation and afterload reduction are key for treatment of heart failure with reduced ejection fraction (HFrEF). In HFrEF patients with concomitant moderate aortic stenosis (AS), treatment with transcatheter aortic valve replacement (TAVR) may be complementary to guideline-directed medical therapy (GDMT). Objectives: This study sought to determine whether TAVR for moderate AS provides clinical benefit in patients with HFrEF on top of GDMT. Methods: We performed an inve... Abstract

Translational lung cancer research, Volume 13, Issue 10, 28 4 2024, Pages 2813-2827 What do we know about the role of neoadjuvant targeted therapy in early-stage EGFR-mutant and ALK-fused non-small cell lung cancer?-a narrative review of the current literature. Kemper M, Elges S, Kies P, Wiebe K, Lenz G, Bleckmann A, Evers G

Background and objective: The standard first-line treatment for patients with advanced non-small cell lung cancer (NSCLC) harbouring epidermal growth factor receptor (EGFR) mutations or anaplastic lymphoma kinase (ALK) fusions is targeted therapy using tyrosine kinase inhibitors (TKIs). However, data are still lacking on the use of TKIs as a neoadjuvant or induction approach. Therefore, this narrative review aims to summarize the current knowledge on resectable EGFR-mutant and ALK-fused NSCLC re... Abstract

Cited 2 times since 2024 (3.7 per year) source: EuropePMC

GeroScience, Volume 47, Issue 2, 22 4 2024, Pages 2035-2045 Increased 1H-NMR metabolomics-based health score associates with declined cognitive performance and functional independence in older adults at risk of cardiovascular disease. Zonneveld MH, Al Kuhaili N, Mooijaart SP, Slagboom PE, Jukema JW, Noordam R, Trompet S

The 1-HMR metabolomics-based MetaboHealth score, comprised of 14 serum metabolic markers, associates with disease-specific mortality, but it is unclear whether the score also reflects cognitive changes and functional impairment. We aimed to assess the associations between the MetaboHealth score with cognitive function and functional decline in older adults at increased cardiovascular risk. A total of 5292 older adults free of dementia at baseline with mean age 75.3 years (SD = 3.4) from the Pros... Abstract

Nature communications, Volume 15, Issue 1, 17 3 2024, Pages 8953 Author Correction: Time-series sewage metagenomics distinguishes seasonal, human-derived and environmental microbial communities potentially allowing source-attributed surveillance. Becsei Á, Fuschi A, Otani S, Kant R, Weinstein I, Alba P, Stéger J, Visontai D, Brinch C, de Graaf M, Schapendonk CME, Battisti A, De Cesare A, Oliveri C, Troja F, Sironen T, Vapalahti O, Pasquali F, Bányai K, Makó M, Pollner P, Merlotti A, Koopmans M, Csabai I, Remondini D, Aarestrup FM, Munk P

Abstract

JACC. Advances, Volume 3, Issue 11, 14 2 2024, Pages 101327 30 Years' Experience in Percutaneous Pulmonary Artery Interventions in Transposition of the Great Arteries. Joosen RS, van der Palen RLF, Udink Ten Cate FEA, Voskuil M, Krings GJ, Bökenkamp R, Molenschot MC, Hahurij ND, Dickinson MG, Hazekamp MG, Schoof PH, Slieker MG, Straver B, Blom NA, Breur JMPJ

Background: Pulmonary artery (PA) stenosis is common after arterial switch operation (ASO) for transposition of the great arteries (TGA). Differences between balloon angioplasty (BA) and stents on right ventricular (RV) and PA pressures are not well studied. Objectives: The purpose of this study was to analyze percutaneous PA interventions' frequency after ASO, complications, and the effects of BA and stents on RV and PA pressures. Methods: All TGA patients with ASO between 1977 and 2022 in... Abstract

Cited 1 times since 2024 (1.8 per year) source: EuropePMC

European journal of clinical investigation, Volume 54, Issue 12, 13 2 2024, Pages e14317 Cardiac troponin elevation and mortality in takotsubo syndrome: New insights from the international takotsubo registry. Stähli BE, Schindler M, Schweiger V, Cammann VL, Szawan KA, Niederseer D, Würdinger M, Schönberger A, Schönberger M, Koleva I, Mercier JC, Petkova V, Mayer S, Citro R, Vecchione C, Bossone E, Gili S, Neuhaus M, Franke J, Meder B, Jaguszewski M, Noutsias M, Knorr M, Jansen T, D'Ascenzo F, Dichtl W, von Lewinski D, Burgdorf C, Kherad B, Tschöpe C, Sarcon A, Shinbane J, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Karakas M, Koenig W, Pott A, Meyer P, Roffi M, Banning A, Wolfrum M, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Napp LC, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Chan C, Bridgman P, Beug D, Delmas C, Lairez O, Gilyarova E, Shilova A, Gilyarov M, El-Battrawy I, Akin I, Poledniková K, Toušek P, Winchester DE, Massoomi M, Galuszka J, Ukena C, Poglajen G, Carrilho-Ferreira P, Hauck C, Paolini C, Bilato C, Kobayashi Y, Kato K, Ishibashi I, Himi T, Din J, Al-Shammari A, Prasad A, Rihal CS, Liu K, Schulze PC, Bianco M, Jörg L, Rickli H, Pestana G, Nguyen TH, Böhm

Background: The clinical relevance of cardiac troponin (cTn) elevation in takotsubo syndrome (TTS) remains uncertain. The present study sought to investigate the role of cardiac troponin (cTn) elevations in mortality prediction of patients with Takotsubo syndrome (TTS). Methods: Patients enrolled in the International Takotsubo (InterTAK) Registry from January 2011 to February 2020 with available data on peak cTn levels were included in the analysis. Peak cTn levels during the index hospitalizati... Abstract

Cited 1 times since 2024 (1.8 per year) source: EuropePMC

EBioMedicine, Volume 109, 12 2 2024, Pages 105391 Patterns of the within-host evolution of human norovirus in immunocompromised individuals and implications for treatment. Izquierdo-Lara RW, Villabruna N, Hesselink DA, Schapendonk CME, Ribó Pons S, Nieuwenhuijse D, Meier JIJ, Goodfellow I, Dalm VASH, Fraaij PLA, van Kampen JJA, Koopmans MPG, de Graaf M

Background: Currently, there is no licensed treatment for chronic norovirus infections, but the use of intra-duodenally-delivered immunoglobulins is promising; nevertheless, varying results have limited their wide use. Little is known about the relationship between norovirus genetic diversity and treatment efficacy. Methods: We analyzed the norovirus within-host diversity and evolution in a cohort of 20 immunocompromised individuals using next-generation sequencing (NGS) and clone-based sequenci... Abstract

Cited 1 times since 2024 (1.7 per year) source: EuropePMC

Journal of cardiovascular development and disease, Volume 11, Issue 10, 7 1 2024, Pages 310 Association between Left Atrial Function and Survival in Systemic Sclerosis. Giucă A, Galloo X, Meucci MC, Butcher SC, Popescu BA, Jurcuț R, Săftoiu A, Jurcuț C, Groșeanu L, Mușetescu AE, Ahmed S, De Vries-Bouwstra J, Bax JJ, Ajmone Marsan N

Systemic sclerosis (SSc) is a multisystemic autoimmune disorder in which cardiac involvement is frequent and portends negative prognosis. Left ventricular (LV) diastolic dysfunction is one of the most common cardiac alterations in these patients, and left atrial (LA) reservoir strain (ƐR) measurement using speckle tracking echocardiography has been proposed as a novel parameter for a better assessment of LV diastolic function. Therefore, the aim of this study was to test the prognostic value of... Abstract

Cited 3 times since 2024 (5 per year) source: EuropePMC

Journal of vascular surgery. Venous and lymphatic disorders, Volume 13, Issue 1, 2 1 2024, Pages 101970 Nutcracker syndrome (a Delphi consensus). Heilijgers F, Gloviczki P, O'Sullivan G, Chavent B, Avgerinos ED, Harth K, Black SA, Erben YM, Rotmans JI, Richards T, Chaer RA, Villalba L, Jayaraj A, Malgor RD, Tripathi RK, Dua A, Murphy E, Rinckenbach S, Vedantham S, Hamming JF, van der Vorst JR

Background: Nutcracker syndrome (NCS) describes the symptomatic compression of the left renal vein between the aorta and superior mesenteric artery. Whereas asymptomatic compression is a common radiological finding, patients with NCS can report a range of symptoms. There are no specific diagnostic criteria and interventions include a range of open surgical and endovascular procedures. Therefore, we wished to develop an international consensus document covering aspects of diagnosis, management, a... Abstract

Cited 2 times since 2024 (3.3 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 26, Issue 10, 1 1 2024, Pages euae235 Ventricular arrhythmias in acute heart failure: a clinical consensus statement of the Association for Acute CardioVascular Care, the European Heart Rhythm Association, and the Heart Failure Association of the European Society of Cardiology. Gorenek B, Wijnmaalen AP, Goette A, Mert GO, Porter B, Gustafsson F, Dan GA, Ector J, Stuehlinger M, Spartalis M, Gosau N, Amir O, Chioncel O

Patients presenting with or alerting emergency networks due to acute heart failure (AHF) form a diverse group with a plethora of symptoms, risks, comorbidities, and aetiologies. During AHF, there is an increased risk of destabilizing the functional substrate and modulatory adding to the risk of ventricular arrhythmias (VAs) already created by the structural substrate. New VAs during AHF have previously identified patients with higher intra-hospital and 60-day morbidity and mortality. Risk strati... Abstract

JACC. Cardiovascular interventions, Volume 17, Issue 20, 1 1 2024, Pages 2408-2410 The Promise and Challenges of Pressure-Guided Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Hypertension. Montero-Cabezas JM, Delgado V

Abstract

Giornale italiano di cardiologia (2006), Volume 25, Issue 10, 1 1 2024, Pages 699-710 [Ten questions about infective endocarditis]. Fortuni F, Ciliberti G, Marsan NA, Delgado V, Franchin L, Magnesa M, Spinelli A, Vitale E, Cangemi S, Cornara S, Gabrielli D, Colivicchi F, Grimaldi M, Oliva F

Infective endocarditis (IE) is an infective process involving the endocardium and, more frequently, the native heart valves, valvular prostheses and cardiac implantable electronic devices. IE can manifest with various non-specific symptoms making the diagnosis challenging. This condition is associated with high in-hospital and long-term mortality. Therefore, it is particularly important to prevent it by implementing an adequate antibiotic prophylaxis especially in patients at high risk undergoin... Abstract

Cited 2 times since 2024 (3.3 per year) source: EuropePMC

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Volume 38, Issue 20, 1 1 2024, Pages e70087 Therapeutic effects of FGF21 mimetic bFKB1 on MASH and atherosclerosis in Ldlr-/-.Leiden mice. Inia JA, Attema J, de Ruiter C, Menke AL, Caspers MPM, Verschuren L, Wilson M, Arlantico A, Brightbill HD, Jukema JW, van den Hoek AM, Princen HMG, Chen MZ, Morrison MC

Fibroblast growth factor 21 (FGF21) is a promising target for treatment of obesity-associated diseases including metabolic dysfunction-associated steatohepatitis (MASH) and atherosclerosis. We evaluated the effects of the bispecific anti-FGF21-β klotho (KLB) agonist antibody bFKB1 in a preclinical model of MASH and atherosclerosis. Low-density lipoprotein receptor knockout (Ldlr-/-).Leiden mice received a high-fat diet for 20 weeks, followed by treatment with an isotype control antibody or bFKB1... Abstract

Journal of cardiothoracic surgery, Volume 19, Issue 1, 1 1 2024, Pages 560 Aortic root replacement for bicuspid aortic valve dysfunction does not impair survival rates. Dolmaci OB, van Maasakker NE, Poelmann RE, Klautz RJ, Grewal N

Background: Patients with a bicuspid aortic valve carry an increased risk for developing an ascending aortic aneurysm due to intrinsic aortic wall alterations. A lower threshold for aortic surgery may therefore be considered in these patients, especially in those who require aortic valve surgery. This study aimed to compare the outcomes of an isolated aortic valve replacement with that of an aortic root replacement in bicuspid aortic valve patients with an indication for aortic valve surgery. Me... Abstract

Cited 2 times since 2024 (3.3 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 66, Issue 4, 1 1 2024, Pages ezae339 European Association of Cardiothoracic Surgeons future view on robotic cardiac surgery in Europe. Oosterlinck W, Gianoli M, Palmen M, Folliguet T, Bonatti J, Agnino A, Singh S, Franke U, Modi P, Pereda D, Kempfert J, Navarra E, Suwalski P, Vojacek J, Casselman F, Myers P, Sadaba JR, Melfi F, Hazekamp M, Bavaria J, Beyersdorf F, Milojevic M, Falk V, Cerny S

Abstract

Cited 6 times since 2024 (10 per year) source: EuropePMC

Brain communications, Volume 6, Issue 5, 1 1 2024, Pages fcae309 Sudden death in epilepsy: the overlap between cardiac and neurological factors. Shlobin NA, Thijs RD, Benditt DG, Zeppenfeld K, Sander JW

People with epilepsy are at risk of premature death, of which sudden unexpected death in epilepsy (SUDEP), sudden cardiac death (SCD) and sudden arrhythmic death syndrome (SADS) are the primary, partly overlapping, clinical scenarios. We discuss the epidemiologies, risk factors and pathophysiological mechanisms for these sudden death events. We reviewed the existing evidence on sudden death in epilepsy. Classification of sudden death depends on the presence of autopsy and expertise of the clinic... Abstract

European heart journal. Imaging methods and practice, Volume 2, Issue 4, 1 1 2024, Pages qyaf033 Factors affecting the performance of a novel artificial intelligence-based coronary computed tomography-derived ischaemia algorithm. Kiatkittikul P, Maaniitty T, Bär S, Nabeta T, Bax JJ, Saraste A, Knuuti J

Aims: AI-QCTischaemia is an FDA-cleared novel artificial intelligence-guided method that utilizes features from coronary computed tomography angiography (CCTA) to predict myocardial ischaemia. Objective: To identify factors associated with discrepancy between AI-QCTischaemia and positron emission tomography (PET) perfusion. Methods and results: Six hundred and sixty-two patients with suspected obstructive coronary artery disease (CAD) on CCTA and undergoing [15O]H2O PET were analysed using AI-QC... Abstract