8866 results
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
Volume 106, Issue 1, 19 3 2025, Pages 711-719
Efficacy and Safety of Intravascular Lithotripsy in the Management of Underexpanded Stents: A Systematic Review and Meta-Analysis.
Sagris M, Soulaidopoulos S, Papanikolaou A, Ktenopoulos N, van Oort MJH, Montero-Cabezas JM, Patsourakos N, Honton B, Tousoulis D, Tsioufis K
Background: Stent underexpansion significantly heightens the risk of major adverse cardiac events (MACE), and available treatment options for this condition remain limited. Intravascular Lithotripsy (IVL) technology disrupts superficial and deep calcium by using localized pulsative sonic pressure waves, emerges as a promising tool for underexpanded stents. Aims: This study examines the overall efficacy and safety of IVL, an until-now off-label modality, in the management of underexpanded stents....
Abstract
Cited 1 times since 2025 (3.1 per year)
source: EuropePMC
BMJ open,
Volume 15, Issue 5, 16 3 2025, Pages e095504
Study protocol of the multicentre, randomised, triple-blind, placebo-controlled MERCURI-2 trial: promoting effective renoprotection in cardiac surgery patients by inhibition of sodium glucose cotransporter (SGLT)-2.
Oosterom-Eijmael M, Monteiro de Oliveira NP, Niesten ED, Tolsma M, Snellen FT, Gerritse BM, Scohy TV, Rettig T, Godfried MB, Voogd MF, Wink J, van der Werff LM, Eberl S, Preckel B, Hermanides J, van Raalte DH, Hulst AH, MERCURI-2 study group
Introduction: Acute kidney injury (AKI) is a major complication after cardiac surgery and is associated with postoperative morbidity and mortality. Currently, no effective therapy exists to reduce the incidence of postoperative AKI. Sodium-glucose cotransporter-2 (SGLT2) inhibitors are effective in reducing AKI in outpatient settings for patients with chronic kidney disease. We hypothesised that perioperative SGLT2 inhibition will also reduce AKI incidence after cardiac surgery according to Kidn...
Abstract
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
Volume 55, Issue 7, 15 3 2025, Pages 552-563
Complementary Analysis of Local and Systemic Effects of Dupilumab in Paediatric AD Using Tape Strips and Serum.
van der Rijst LP, Knol EF, Zuithoff NPA, den Hartog Jager CF, van Wijk F, de Bruin-Weller MS, de Graaf M
Objective: This study investigates local and systemic immune-related proteins in tape strips and serum of paediatric atopic dermatitis (AD) patients treated with dupilumab, and explores their correlation with clinical severity. Methods: Twenty paediatric AD patients (
Abstract
Journal of clinical medicine,
Volume 14, Issue 10, 13 2 2025, Pages 3393
Pseudoaneurysmectomy After Left Ventricular Free Wall Rupture Repair: A Case Report.
Baldan BU, Klein P, Stöger JL, Klautz RJM, Palmen M
Background/Objectives: Left ventricular (LV) pseudoaneurysm is a rare but life-threatening complication after acute myocardial infarction, often resulting from inadequate excision of damaged myocardium and use of only a xenopericardial patch during primary LV free wall rupture repair. Methods: A 62-year-old female developed a giant LV pseudoaneurysm one year after initial surgical repair of a free wall rupture with a xenopericardial patch. Imaging confirmed a large pseudoaneurysm with a broad ne...
Abstract
CJC open,
Volume 7, Issue 7, 13 2 2025, Pages 887-896
Concomitant Atrial Fibrillation Ablation in Surgical Aortic Valve Replacement: A Systematic Review and Meta-Analysis.
Polat E, Kharbanda RK, Ghafar M, Schoones JW, Klautz RJM, de Riva M, Palmen M, Girdauskas E, Tomšič A
Background: Atrial fibrillation (AF) is common in patients undergoing surgical aortic valve replacement; however, surgical ablation remains underused due to limited data on its efficacy. Methods: We conducted a systematic review of the literature by searching PubMed, Embase, Web of Science, Emcare, and the Cochrane Library for studies reporting outcomes of concomitant surgical AF ablation in patients undergoing surgical aortic valve replacement. The primary outcomes included freedom from AF recu...
Abstract
Cited 1 times since 2025 (3 per year)
source: EuropePMC
Arthritis & rheumatology (Hoboken, N.J.),
12 2 2025
Differences in Dynamics of Specific Antinuclear Antibodies and Their Susceptibility to B Cell-Targeting Treatment in Patients With Systemic Lupus Erythematosus.
van Dooren HJ, van Schaik M, Dorjée AL, Arends EJ, Mackay M, Cooney L, Fox DA, Wofsy D, Smilek D, Aranow C, Dall'Era M, Huizinga TWJ, van Kooten C, Toes REM, Diamond B, Teng YKO, Suurmond J
Objective: The presence of antinuclear antibodies (ANAs) is characteristic for systemic lupus erythematosus (SLE). Antibody dynamics over time are thought to reflect the cellular source of ANAs and their therapeutic targetability. Anti-double-stranded DNA (anti-dsDNA) is the most prevalent and well-studied of all ANAs, and fluctuations in anti-dsDNA serum levels are associated with disease activity. Antibody dynamics of other ANAs, such as antibodies targeting RNA-binding proteins (RBPs), are of...
Abstract
Heart & lung : the journal of critical care,
Volume 73, 12 2 2025, Pages 108-113
Intravascular lithotripsy and temporary mechanical circulatory support for the treatment of heavily calcified coronary artery disease: insights from the BENELUX-IVL registry.
Oliveri F, Merino I, van Oort MJH, Al Amri I, Bingen BO, Arslan F, Claessen BE, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, van der Kley F, Jukema JW, Montero-Cabezas J
Background: Intravascular lithotripsy (IVL) is increasingly utilized for the treatment of heavily calcified coronary lesions. However its use in conjunction with temporary mechanical circulatory support (tMCS) remains underexplored. Objective: This study aims to evaluate the current use of tMCS and IVL for the treatment of heavily calcified coronary lesions. Method: From the BENELUX-IVL prospective registry, patients who underwent IVL during PCI and required tMCS during the procedure were select...
Abstract
Annals of surgery,
8 2 2025
Combined Clinical and Histopathological Risk Stratification for Prediction of (severe) Endoscopic Postoperative Recurrence in Patients with Crohn's Disease after Ileocolic Resection: Results from A Prospective Multicenter Cohort Study.
Bak MTJ, Bak MTJ, Oudijk L, Ooms AHAG, Beelen EMJ, van der Bilt JDW, Romberg-Camps M, Dijkstra G, Duijvestein M, van der Marel S, Stassen LPS, Maljaars PWJ, Buskens CJ, Lange JFM, Kats-Ugurlu G, Jansen SV, Jharap BJH, Horjus CS, van Schaik FDM, West RL, de Boer NKH, Janneke van der Woude C, Parikh K, van Ruler O, Doukas M, de Vries AC, RAP-CD study group; on behalf of the Dutch Initiative on Crohn and Colitis (ICC) & Dutch Initiative on Crohn and Colitis – Surgery (ICC-S)
Objective: This study assessed the association of histopathological features in the resection specimen of CD patients with (severe) endoscopic postoperative recurrence (ePOR) in a large prospective, multicenter cohort study. Summary background data: The predictive value of histopathologic features of the intestinal resection specimen for the risk of Crohn's disease (CD) recurrence after ileocolic (re-)resection (ICR) remains a matter of debate. Methods: CD patients (≥16 y) scheduled for ICR...
Abstract
Psychological research,
Volume 89, Issue 3, 8 2 2025, Pages 98
Moral decision-making 'on the fly'.
Kusev P, Martin R, van Schaik P, Teal J
Over a century of research has focused on the consistency and inconsistency of human moral decision preferences. We proposed and found that moral decision preferences are flexible and shift towards newly learned moral rules when their application leads to utilitarian choices. Hence, decision-makers' psychological concept of morality is continually under construction (on the fly); based on learning, informed by changes in moral rules and specific moral contexts. Accordingly, in two experimen...
Abstract
Molecular therapy. Nucleic acids,
Volume 36, Issue 2, 5 1 2025, Pages 102553
Validation of tRNA-derived fragments as diagnostic biomarkers in suspected acute stroke; limitations in analysis and quantification methods.
Woudenberg T, van der Bent ML, van den Homberg DAL, Nguyen TTM, Wermer MJH, van den Wijngaard IR, Quax PHA, Nossent AY, Kruyt ND
In acute stroke, timely diagnosis is essential to prevent extensive neuronal damage and improve patient outcomes. However, differentiating between ischemic stroke, intracerebral hemorrhage, and stroke mimics remains challenging. Transfer RNA-derived fragments (tRFs) have emerged as potential biomarkers for distinguishing between these stroke subtypes. Here we used reverse transcription-quantitative PCR (RT-qPCR) to investigate the expression of specific tRFs that we previously identified in smal...
Abstract
Developmental psychology,
5 1 2025
Psychological needs and well-being through the eyes of vocational students in Aruba, Dutch Caribbean.
Proveyer Llopiz MR, van Schaik SDM, Harkness S, Super CM, Denessen EJPG
Well-being has been thoroughly studied worldwide mostly using questionnaires. Still, it is unclear what well-being means in specific contexts, as studies found that both well-being and underlying psychological needs may vary across cultures. In Aruba, concerns were raised regarding youth well-being. Therefore, this project used a mixed-method approach to explore the development of young people's well-being in Aruba. By taking a culture and human development approach, this project aims to co...
Abstract
Cancers,
Volume 17, Issue 9, 3 1 2025, Pages 1557
Patterns of Recurrence After Postoperative Stereotactic Radiotherapy for Brain Metastases.
Crouzen JA, Petoukhova AL, Hakstege M, van Schaik EEMW, Nandoe Tewarie RDS, Nabuurs RJA, Vos MJ, Kerkhof M, van der Vaart T, Koekkoek JAF, Hagenbeek RE, Yildirim FM, Wiltink LM, van der Voort van Zyp NCMG, Kiderlen M, Broekman MLD, Mast ME, Zindler JD
Background/objectives: Neurosurgical resection is the standard treatment for large brain metastases (BMs). Postoperative stereotactic radiotherapy (SRT) is used to reduce local recurrence (LR) but does not always prevent leptomeningeal disease (LMD). This study aims to analyze patterns of tumor recurrence and to identify opportunities for the further improvement of treatment efficacy. Methods: We included 147 patients who underwent resection and SRT for BMs. The distance between the resection ca...
Abstract
The Science of the total environment,
Volume 980, 3 1 2025, Pages 179386
Towards a European sustainable beneficiation of rare earth elements bearing minerals: a review.
Gajendra N, Yilmaz D, Vila MC, de Lurdes Dinis M, Levei EA, Török AI, Avsar D, Kladis A, Preveniou A, Hansen AM, Aaen SB, Ferrando-Climent L
This review explores the multifaceted aspects of sustainable extraction of rare earth elements (REEs) bearing minerals within Europe, stressing the exploitation of local deposits, that together with the integration of cleaner and greener approaches (including circular economy approaches) might help to reduce dependency on imports and contribute to a greener economy. The mineralogical characteristics and distribution of REEs in European deposits are examined, alongside current and emerging benefi...
Abstract
Cited 1 times since 2025 (2.8 per year)
source: EuropePMC
Journal of the Society for Cardiovascular Angiography & Interventions,
Volume 4, Issue 5, 1 1 2025, Pages 102635
Coronary Compliance Modification by Intravascular Lithotripsy: New Predictor of Stent Expansion in Calcified Coronary Lesions.
Oliveri F, Van Oort MJH, Al Amri I, Bingen BO, Claessen BE, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, Van der Kley F, Jukema JW, Montero-Cabezas JM
Background: Intravascular lithotripsy (IVL) has been demonstrated to be effective in treating balloon-crossable calcified coronary lesions by inducing calcium fractures and facilitating stent expansion (SE), theoretically by improving coronary artery compliance (CACom). Direct evidence of this theory has not yet been provided. Methods: From the BENELUX-IVL prospective registry (NCT06577038) enrolling patients with calcified coronary artery lesions treated with IVL, intravascular ultrasound-guide...
Abstract
Cited 1 times since 2025 (2.8 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 85, Issue 17, 1 1 2025, Pages 1695-1705
Proactive Mapping and Preventive Ablation Reduce Defibrillator Implantation Rates in Tetralogy of Fallot.
Kimura Y, Wallet J, Brouwer C, Bokma JP, Bertels RA, Jongbloed MRM, Hazekamp MG, Blom NA, Zeppenfeld K
Background: In patients with repaired tetralogy of Fallot (rTOF) and spontaneous ventricular tachycardia (VT), transection of slow-conducting anatomical isthmus (SCAI) by ablation results in excellent long-term VT-free survival. In patients without prior VT, proactive electroanatomical mapping and preventive SCAI ablation may impact patient selection for primary prevention implantable cardioverter-defibrillator (ICD) implantation. Objectives: The purpose of this study was to evaluate long-term o...
Abstract
European heart journal. Cardiovascular Imaging,
Volume 26, Issue 6, 1 1 2025, Pages 1082
Mitral valve stretched to its limit: a case of an aborted sudden cardiac death with extensive fibrotic ventricular remodelling.
van Rosendael PJ, Biesbroek PS, Meijs TA, Gotte MJW, Hopman LHGA
Abstract
European heart journal. Cardiovascular Imaging,
Volume 26, Issue 6, 1 1 2025, Pages 945-954
CCTA-Derived coronary plaque burden offers enhanced prognostic value over CAC scoring in suspected CAD patients.
Dahdal J, Jukema RA, Maaniitty T, Nurmohamed NS, Raijmakers PG, Hoek R, Driessen RS, Twisk JWR, Bär S, Planken RN, van Royen N, Nijveldt R, Bax JJ, Saraste A, van Rosendael AR, Knaapen P, Knuuti J, Danad I
Aims: To assess the prognostic utility of coronary artery calcium (CAC) scoring and coronary computed tomography angiography (CCTA)-derived quantitative plaque metrics for predicting adverse cardiovascular outcomes. Methods and results: The study enrolled 2404 patients with suspected coronary artery disease (CAD) but without a prior history of CAD. All participants underwent CAC scoring and CCTA, with plaque metrics quantified using an artificial intelligence (AI)-based tool (Cleerly, Inc). Perc...
Abstract
Cited 1 times since 2025 (2.8 per year)
source: EuropePMC
Brain : a journal of neurology,
Volume 148, Issue 5, 1 1 2025, Pages 1531-1539
N-methyl-d-aspartate receptor hypofunction causes recurrent and transient failures of perceptual inference.
Weilnhammer V, Rothkirch M, Yilmaz D, Fritsch M, Ptasczynski LE, Reichenbach K, Roediger L, Corlett P, Sterzer P
Perception integrates external sensory signals with internal predictions that reflect prior knowledge about the world. Previous research suggests that this integration is governed by slow alternations between an external mode, driven by sensory signals, and an internal mode, shaped by prior knowledge. Using a double-blind, placebo-controlled, cross-over experiment in healthy human participants, we investigated the effects of the N-methyl-D-aspartate receptor (NMDAR) antagonist S-ketamine on the...
Abstract
Cited 1 times since 2025 (2.8 per year)
source: EuropePMC
European heart journal. Cardiovascular pharmacotherapy,
Volume 11, Issue 3, 1 1 2025, Pages 230-240
Cost-effectiveness of implementing a genotype-guided de-escalation strategy in patients with acute coronary syndrome.
van den Broek WWA, van den Broek WWA, Azzahhafi J, Chan Pin Yin DRPP, van der Sangen NMR, Sivanesan S, Dijksman LM, Walhout RJ, Tjon Joe Gin M, Breet NJ, Langerveld J, Vlachojannis GJ, van Bommel RJ, Appelman Y, van Schaik RHN, Henriques JPS, Kikkert WJ, Ten Berg JM
Aims: A genotype-guided P2Y12-inhibitor de-escalation strategy, switching acute coronary syndrome (ACS) patients without a CYP2C19 loss-of-function allele from ticagrelor or prasugrel to clopidogrel, has shown to reduce bleeding risk without affecting the effectivity of therapy by increasing ischaemic risk. We estimated the cost-effectiveness of this personalized approach compared to standard dual antiplatelet therapy (DAPT; aspirin plus ticagrelor/prasugrel) in the Netherlands. Methods and resu...
Abstract
Cited 1 times since 2025 (2.8 per year)
source: EuropePMC
Rheumatology (Oxford, England),
Volume 64, Issue 5, 1 1 2025, Pages 2979-2986
Type I interferon biomarker in idiopathic inflammatory myopathies: associations of Siglec-1 with disease activity and treatment response.
Kamperman RG, Veldkamp SR, Evers SW, Lim J, van Schaik I, van Royen-Kerkhof A, van Wijk F, van der Kooi AJ, Jansen M, Raaphorst J
Objectives: Novel biomarkers are needed to guide therapy in idiopathic inflammatory myopathies (IIM). Expression of Siglec-1, a type I interferon biomarker, was examined in adult patients with IIM in relation to disease activity and treatment response. Methods: We analyzed PBMC samples from 19 newly diagnosed adult IIM patients who participated in a phase-2 pilot study on efficacy of intravenous immunoglobulin (IVIG) monotherapy, and from 9 healthy controls. Siglec-1 expression on monocytes was...
Abstract
