7833 results
Cited 9 times since 2021 (2.1 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 29, Issue Suppl 1, 16 3 2021, Pages 5-12
How often and to what extent do admitted COVID-19 patients have signs of cardiac injury?
Habets MAW, Sturkenboom HN, Tio RA, Belfroid E, Hoogervorst-Schilp J, Siebelink HJ, Jansen CW, Smits PC
Background: COVID-19 can cause myocardial injury in a significant proportion of patients admitted to the hospital and seems to be associated with worse prognosis. The aim of this review was to study how often and to what extent COVID-19 causes myocardial injury and whether this is an important contributor to outcome with implications for management. Methods: A literature search was performed in Medline and Embase. Myocardial injury was defined as elevated cardiac troponin (cTn) levels with at le...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 29, Issue Suppl 1, 16 3 2021, Pages 35-44
Effect of anticoagulant therapy in COVID-19 patients.
Tieleman RG, Klok FA, Belfroid E, Hoogervorst-Schilp J, Schalkers I, Jansen CW, Siebelink HJ
Background: In patients hospitalised with COVID-19, an increased incidence of thromboembolic events, such as pulmonary embolism, deep vein thrombosis and stroke, has been reported. It is unknown whether anticoagulation can prevent these complications and improve outcome. Methods: A systematic literature search was performed to answer the question: What is the effect of (prophylactic and therapeutic dose) anticoagulation therapy in COVID-19 patients on cardiovascular and thromboembolic complicati...
Abstract
Cited 6 times since 2021 (1.4 per year)
source: EuropePMC
Thorax,
Volume 76, Issue 11, 15 3 2021, Pages 1150-1153
Genetic polymorphism in <i>ATIC</i> is associated with effectiveness and toxicity of pemetrexed in non-small-cell lung cancer.
Visser S, Koolen S, van Donk N, van Walree N, van der Leest C, Cornelissen R, van Schaik R, Mathijssen R, Aerts J, Stricker BH
Patients with advanced non-small-cell lung cancer who are treated with pemetrexed display a wide variation in clinical response and toxicity. In this prospective, multicentre cohort study, we investigated the association with treatment effectiveness and toxicity of 10 polymorphisms in nine candidate genes, covering the folate pathway (MTHFR), cell transport (SLC19A1/ABCC2/ABCC4), intracellular metabolism (FPGS/GGH) and target enzymes (TYMS/DHFR/ATIC) of pemetrexed. Adjusted for sex, ECOG perform...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
Journal of dairy science,
Volume 104, Issue 6, 15 3 2021, Pages 7000-7007
Possible causes of aberrations in adverse grouping behavior of dairy cows: A field study.
van Schaik G, Seinen P, Muskens J, van Erp T, Keurentjes J, Huss A, Kromhout H
In the Dutch national surveillance system, an increasing number of reports were received in the summer of 2017 from farmers about unusual behavior of their cows. The cows were grouping during the day in summer in one part of the barn and did not move for several hours, which, according to the farmers, led to reduced food and water intake and lying time and resulted in decreased milk production and increased risk of lameness. Many farmers perceived magnetic fields from, for instance, high-voltage...
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 29, Issue Suppl 1, 15 3 2021, Pages 2-4
Four guidelines on cardiovascular complications and cardiovascular disease, prognosis and treatment in COVID‑19.
Siebelink HJ, Jansen CW, Belfroid E, Hoogervorst-Schilp J
Abstract
Cited 3 times since 2021 (0.7 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 14, Issue 6, 14 2 2021, Pages 1110-1112
Valve Strain: A Further Step Toward a Full Understanding of Mitral Valve Function and Dysfunction.
Marsan NA, van Wijngaarden AL
Abstract
Cited 117 times since 2021 (27.5 per year)
source: EuropePMC
Molecular cell,
Volume 81, Issue 10, 12 2 2021, Pages 2216-2230.e10
Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance.
Schep R, Brinkman EK, Leemans C, Vergara X, van der Weide RH, Morris B, van Schaik T, Manzo SG, Peric-Hupkes D, van den Berg J, Beijersbergen RL, Medema RH, van Steensel B
DNA double-strand break (DSB) repair is mediated by multiple pathways. It is thought that the local chromatin context affects the pathway choice, but the underlying principles are poorly understood. Using a multiplexed reporter assay in combination with Cas9 cutting, we systematically measure the relative activities of three DSB repair pathways as a function of chromatin context in >1,000 genomic locations. This reveals that non-homologous end-joining (NHEJ) is broadly biased toward euchromat...
Abstract
Cited 20 times since 2021 (4.7 per year)
source: EuropePMC
Frontiers in pharmacology,
Volume 12, 12 2 2021, Pages 640032
Policy and Practice Review: A First Guideline on the Use of Pharmacogenetics in Clinical Psychiatric Practice.
van Westrhenen R, van Schaik RHN, van Gelder T, Birkenhager TK, Bakker PR, Houwink EJF, Bet PM, Hoogendijk WJG, van Weelden-Hulshof MJM
Effective pharmacologic treatments for psychiatric disorders are available, but their effect is limited due to patients' genetic heterogeneity and low compliance-related to frequent adverse events. Only one third of patients respond to treatment and experience remission. Pharmacogenetics is a relatively young field which focusses on genetic analyses in the context of the metabolism and outcome of drug treatment. These genetic factors can, among other things, lead to differences in the activ...
Abstract
Cited 3 times since 2021 (0.7 per year)
source: EuropePMC
European heart journal. Case reports,
Volume 5, Issue 4, 12 2 2021, Pages ytab068
Failing systemic right ventricle in a patient with dextrocardia and complex congenitally corrected transposition of the great arteries: a case report of successful transvenous cardiac resynchronization therapy.
Nederend M, van Erven L, Zeppenfeld K, Vliegen HW, Egorova AD
Background: Patients with congenitally corrected transposition of the great arteries (ccTGA) are prone to the development of advanced atrio-ventricular block requiring chronic ventricular pacing. The morphological right ventricle (RV) often develops systolic dysfunction as it is unable to withstand the chronic pressure overload it is exposed to when supporting the systemic circulation. Case summary: A 56-year-old woman with dextrocardia and complex ccTGA with a history of dual-chamber implantabl...
Abstract
Cited 3 times since 2021 (0.7 per year)
source: EuropePMC
Preventive veterinary medicine,
Volume 191, 8 2 2021, Pages 105344
Evaluation of the association between the introduction of data-driven tools to support calf rearing and reduced calf mortality in dairy herds in the Netherlands.
Santman-Berends IMGA, Nijhoving GH, van Wuijckhuise L, Muskens J, Bos I, van Schaik G
Between 2009 and 2017, calf mortality in the Dutch dairy sector showed a slight but steady increase. The Dutch dairy industry decided to act and supported the development of several data-driven tools that were implemented from 2018 on. The tools informed farmers about their calf mortality rates and stimulated them to improve. The Trend Analysis Surveillance Component of the Dutch cattle Health Surveillance System provided the possibility to evaluate the calf mortality in Dutch dairy herds before...
Abstract
Cited 12 times since 2021 (2.8 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 108, Issue 2, 8 2 2021, Pages 137-144
Prognostic implications of left atrial dilation in aortic regurgitation due to bicuspid aortic valve.
Butcher SC, Fortuni F, Kong W, Vollema EM, Prevedello F, Perry R, Ng ACT, Poh KK, Almeida AG, González-Gómez A, Shen M, Yeo TC, Shanks M, Popescu BA, Galian-Gay L, Fijalkowski M, Liang M, Tay E, Ajmone Marsan N, Selvanayagam JB, Pinto FJ, Zamorano J, Pibarot P, Evangelista A, Bax JJ, Delgado V
Objective: To investigate the prognostic value of left atrial volume index (LAVI) in patients with moderate to severe aortic regurgitation (AR) and bicuspid aortic valve (BAV). Methods: 554 individuals (45 (IQR 33-57) years, 80% male) with BAV and moderate or severe AR were selected from an international, multicentre registry. The association between LAVI and the combined endpoint of all-cause mortality or aortic valve surgery was investigated with Cox proportional hazard regression analyses. Re...
Abstract
Cited 10 times since 2021 (2.3 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 34, Issue 9, 8 2 2021, Pages 944-954
Ratio between Vena Contracta Width and Tricuspid Annular Diameter: Prognostic Value in Secondary Tricuspid Regurgitation.
Fortuni F, Dietz MF, Prihadi EA, van der Bijl P, De Ferrari GM, Bax JJ, Delgado V, Marsan NA
Background: Conventional approaches for the assessment of secondary tricuspid regurgitation (STR) severity do not correct for right heart dimensions. The authors hypothesized that STR severity can be proportional or disproportional to the dilation of the tricuspid annulus (TA) and investigated the prognostic impact of this novel definition. Methods: A total of 334 patients with moderate to severe STR and preserved left ventricular systolic function were included. The ratio between vena contracta...
Abstract
Cited 8 times since 2021 (1.9 per year)
source: EuropePMC
Journal of the Royal Society, Interface,
Volume 18, Issue 177, 7 1 2021, Pages 20201027
Non-uniform mixing of hepatic venous flow and inferior vena cava flow in the Fontan conduit.
Rijnberg FM, van der Woude SFS, van Assen HC, Juffermans JF, Hazekamp MG, Jongbloed MRM, Kenjeres S, Lamb HJ, Westenberg JJM, Wentzel JJ, Roest AAW
Fontan patients require a balanced hepatic blood flow distribution (HFD) to prevent pulmonary arteriovenous malformations. Currently, HFD is quantified by tracking Fontan conduit flow, assuming hepatic venous (HV) flow to be uniformly distributed within the Fontan conduit. However, this assumption may be unvalid leading to inaccuracies in HFD quantification with potential clinical impact. The aim of this study was to (i) assess the mixing of HV flow and inferior vena caval (IVC) flow within the...
Abstract
Cited 4 times since 2021 (0.9 per year)
source: EuropePMC
Circulation. Genomic and precision medicine,
Volume 14, Issue 2, 2 1 2021, Pages e003219
Role of Adenylate Cyclase 9 in the Pharmacogenomic Response to Dalcetrapib: Clinical Paradigm and Molecular Mechanisms in Precision Cardiovascular Medicine.
Rhainds D, Packard CJ, Brodeur MR, Niesor EJ, Sacks FM, Jukema JW, Wright RS, Waters DD, Heinonen T, Black DM, Laghrissi-Thode F, Dubé MP, Pfeffer MA, Tardif JC
Following the neutral results of the dal-OUTCOMES trial, a genome-wide study identified the rs1967309 variant in the adenylate cyclase type 9 (ADCY9) gene on chromosome 16 as being associated with the risk of future cardiovascular events only in subjects taking dalcetrapib, a CETP (cholesterol ester transfer protein) modulator. Homozygotes for the minor A allele (AA) were protected from recurrent cardiovascular events when treated with dalcetrapib, while homozygotes for the major G allele (GG) h...
Abstract
Circulation. Cardiovascular imaging,
Volume 14, Issue 4, 2 1 2021, Pages e011688
Multimodality Evaluation of a Septal Cystic Cavity and Ventricular Septal Defect in the Setting of Neurocysticercosis and Endocarditis.
Schuuring MJ, van der Bom T, Konings TC, Götte MJW, Koolbergen DR, Boekholdt SM, de Winter RJ
Abstract
Cited 108 times since 2021 (25.2 per year)
source: EuropePMC
Therapeutic drug monitoring,
Volume 43, Issue 2, 1 1 2021, Pages 150-200
Personalized Therapy for Mycophenolate: Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology.
Bergan S, Brunet M, Hesselink DA, Johnson-Davis KL, Kunicki PK, Lemaitre F, Marquet P, Molinaro M, Noceti O, Pattanaik S, Pawinski T, Seger C, Shipkova M, Swen JJ, van Gelder T, Venkataramanan R, Wieland E, Woillard JB, Zwart TC, Barten MJ, Budde K, Dieterlen MT, Elens L, Haufroid V, Masuda S, Millan O, Mizuno T, Moes DJAR, Oellerich M, Picard N, Salzmann L, Tönshoff B, van Schaik RHN, Vethe NT, Vinks AA, Wallemacq P, Åsberg A, Langman LJ
Abstract: When mycophenolic acid (MPA) was originally marketed for immunosuppressive therapy, fixed doses were recommended by the manufacturer. Awareness of the potential for a more personalized dosing has led to development of methods to estimate MPA area under the curve based on the measurement of drug concentrations in only a few samples. This approach is feasible in the clinical routine and has proven successful in terms of correlation with outcome. However, the search for superior correlate...
Abstract
Cited 26 times since 2021 (6.1 per year)
source: EuropePMC
Rheumatology (Oxford, England),
Volume 60, Issue 4, 1 1 2021, Pages 1784-1792
Intravenous immunoglobulins as first-line treatment in idiopathic inflammatory myopathies: a pilot study.
Lim J, Eftimov F, Verhamme C, Brusse E, Hoogendijk JE, Saris CGJ, Raaphorst J, De Haan RJ, van Schaik IN, Aronica E, de Visser M, van der Kooi AJ
Objectives: We explored efficacy and safety of IVIg as first-line treatment in patients with an idiopathic inflammatory myopathy. Methods: In this investigator-initiated phase 2 open-label study, we included 20 adults with a newly diagnosed, biopsy-proven idiopathic inflammatory myopathy, and a disease duration of less than 9 months. Patients with IBM and prior use of immunosuppressants were excluded. The standard treatment regimen consisted of IVIg (Privigen) monotherapy for 9 weeks: a loading...
Abstract
Cited 10 times since 2021 (2.3 per year)
source: EuropePMC
Academic medicine : journal of the Association of American Medical Colleges,
Volume 96, Issue 4, 1 1 2021, Pages 495-500
Accessible and Adaptable Faculty Development to Support Curriculum Reform in Medical Education.
van Schaik SM
Contemporary curricular reform in medical education focuses on areas that current physician-educators were likely not exposed to during medical school, such as interprofessional teamwork; informatics; health care systems improvement; and diversity, equity, and inclusion. Thus, faculty may not be ready to support the planned curricular reform without adequate faculty development to acquire the necessary knowledge and skills. In an era with increasing demands on faculty, new approaches that are fl...
Abstract
Cited 26 times since 2021 (6.1 per year)
source: EuropePMC
The Journal of antimicrobial chemotherapy,
Volume 76, Issue 5, 1 1 2021, Pages 1130-1134
Transferable Acinetobacter baumannii plasmid pDETAB2 encodes OXA-58 and NDM-1 and represents a new class of antibiotic resistance plasmids.
Liu H, Moran RA, Chen Y, Doughty EL, Hua X, Jiang Y, Xu Q, Zhang L, Blair JMA, McNally A, van Schaik W, Yu Y
Objectives: To characterize a blaOXA-58- and blaNDM-1-containing MDR plasmid from a rare Acinetobacter baumannii lineage and compare it with related plasmids to explore the distribution and evolution of a new plasmid group. Methods: A. baumannii DETAB-P2 was isolated from a rectal swab of an intensive care patient. Antibiotic susceptibility was determined using broth microdilution. DETAB-P2 was mated with A. baumannii ATCC 17978 and putative transconjugants were characterized by S1/PFGE and Sout...
Abstract
Cited 40 times since 2021 (9.3 per year)
source: EuropePMC
Human molecular genetics,
Volume 30, Issue 5, 1 1 2021, Pages 393-409
Genome-wide association study of circulating interleukin 6 levels identifies novel loci.
Ahluwalia TS, Prins BP, Abdollahi M, Armstrong NJ, Aslibekyan S, Bain L, Jefferis B, Baumert J, Beekman M, Ben-Shlomo Y, Bis JC, Mitchell BD, de Geus E, Delgado GE, Marek D, Eriksson J, Kajantie E, Kanoni S, Kemp JP, Lu C, Marioni RE, McLachlan S, Milaneschi Y, Nolte IM, Petrelis AM, Porcu E, Sabater-Lleal M, Naderi E, Seppälä I, Shah T, Singhal G, Standl M, Teumer A, Thalamuthu A, Thiering E, Trompet S, Ballantyne CM, Benjamin EJ, Casas JP, Toben C, Dedoussis G, Deelen J, Durda P, Engmann J, Feitosa MF, Grallert H, Hammarstedt A, Harris SE, Homuth G, Hottenga JJ, Jalkanen S, Jamshidi Y, Jawahar MC, Jess T, Kivimaki M, Kleber ME, Lahti J, Liu Y, Marques-Vidal P, Mellström D, Mooijaart SP, Müller-Nurasyid M, Penninx B, Revez JA, Rossing P, Räikkönen K, Sattar N, Scharnagl H, Sennblad B, Silveira A, Pourcain BS, Timpson NJ, Trollor J, CHARGE Inflammation Working Group, van Dongen J, Van Heemst D, Visvikis-Siest S, Vollenweider P, Völker U, Waldenberger M, Willemsen G, Zabaneh D, Morris RW, Arnett DK, Baune BT,
Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. We conducted a two-staged, discovery and replication meta genome-wide association study (GWAS) of circulating serum IL-6 levels comprising up to 67 428 (ndiscovery = 52 654 and nreplication = 14 774) individuals of European ancestry. The inv...
Abstract
