8257 results
Cited 31 times since 2020 (6.2 per year)
source: EuropePMC
Histopathology,
Volume 77, Issue 1, 7 1 2020, Pages 92-99
Performance of the pattern-based interpretation of p53 immunohistochemistry as a surrogate for TP53 mutations in vulvar squamous cell carcinoma.
Kortekaas KE, Solleveld-Westerink N, Tessier-Cloutier B, Rutten TA, Poelgeest MIE, Gilks CB, Hoang LN, Bosse T
Aims: The most commonly mutated gene in vulvar squamous cell carcinoma (VSCC) is TP53 and its prognostic value, particularly in HPV-independent VSCC, is uncertain. In other tumours, p53 immunohistochemistry (IHC) is an excellent surrogate marker for TP53 mutations. In order to study this in VSCC, we assigned six p53 IHC patterns into two final classes: 'wild-type' or 'mutant'. We determined the performance and interobserver variability of this pattern-based p53 IHC approach....
Abstract
Cited 6 times since 2020 (1.2 per year)
source: EuropePMC
The Annals of thoracic surgery,
Volume 110, Issue 6, 7 1 2020, Pages 2062-2069
Mechanical Mitral Valve Replacement: A Multicenter Study of Outcomes With Use of 15- to 17-mm Prostheses.
IJsselhof RJ, Slieker MG, Gauvreau K, Muter A, Marx GR, Hazekamp MG, Accord R, van Wetten H, van Leeuwen W, Haas F, Schoof PH, Nathan M
Background: The aim of this study was to evaluate early and mid-term outcomes (mortality and prosthetic valve reintervention) after mitral valve replacement with 15- to 17-mm mechanical prostheses. Methods: A multicenter, retrospective cohort study was performed among patients who underwent mitral valve replacement with a 15- to 17-mm mechanical prosthesis at 6 congenital cardiac centers: 5 in The Netherlands and 1 in the United States. Baseline, operative, and follow-up data were evaluated. Res...
Abstract
Cited 6 times since 2020 (1.2 per year)
source: EuropePMC
Kidney international reports,
Volume 5, Issue 8, 5 1 2020, Pages 1327-1332
A Randomized Trial of Liposomal Prednisolone (LIPMAT) to Enhance Radiocephalic Fistula Maturation: A Pilot Study.
Voorzaat BM, van der Bogt KEA, Bezhaeva T, van Schaik J, Eefting D, van der Putten K, van Nieuwenhuizen RC, Groeneveld JO, Hoogeveen EK, van der Meer IM, Statius van Eps RG, Vogt L, Huisman L, Gabreëls BATF, Boom H, Verburgh CA, Boon D, Metselaar JM, Weijmer MC, Rotmans JI
Abstract
Cited 1 times since 2020 (0.2 per year)
source: EuropePMC
Journal of electrocardiology,
Volume 61, 5 1 2020, Pages 141-146
Lack of diagnostic utility of the ECG-derived ventricular gradient in patients with suspected acute pulmonary embolism.
Meijer FMM, Hendriks SV, Huisman MV, van der Hulle T, Swenne CA, Kies P, Jongbloed MRM, Egorova AD, Vliegen HW, Klok FA
Introduction: The YEARS algorithm was successfully developed to reduce the number of computed tomography pulmonary angiography (CTPA) investigations in the diagnostic management of patients with suspected pulmonary embolism (PE), although half of patients still needed to be referred for CTPA. We hypothesized that ECG derived ventricular gradient optimized for right ventricular pressure overload (VG-RVPO), an easy to use tool for detecting PE-induced pulmonary hypertension (PH), may further impro...
Abstract
Cited 1 times since 2020 (0.2 per year)
source: EuropePMC
Circulation reports,
Volume 2, Issue 7, 5 1 2020, Pages 364-371
Effect of Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve on Physicians' Clinical Behavior - Differences Between Sites With and Without Appropriate Use Criteria as Designated by the Japanese Reimbursement System.
Matsuo H, Kawasaki T, Amano T, Kawase Y, Sobue Y, Kondo T, Morino Y, Yoda S, Sakamoto T, Ito H, Shite J, Otake H, Tanaka N, Terashima M, Kadota K, Patel MR, Nieman K, Rogers C, Norgaard BL, Bax JJ, Chinnaiyan KM, Berman DS, Fairbairn TA, Hurwitz Koweek LM, Leipsic J, Akasaka T
Background: Coronary computed tomography angiography (CCTA)-derived fractional flow reserve (FFRCT) is an established tool for identifying lesion-specific ischemia that is now approved for use by the Japanese insurance system. However, current clinical reimbursement is strictly limited to institutions with designated appropriate use criteria (AUC). This study assessed differences in physicians' behavior (e.g., use and interpretation of FFRCT, final management) according to Japanese AUC and...
Abstract
Cited 2 times since 2020 (0.4 per year)
source: EuropePMC
Nederlands tijdschrift voor geneeskunde,
Volume 164, 4 1 2020, Pages D4191
[Pharmacogenetics in daily practice].
van Gelder T, van Schaik RHN
With the exception of a few medical specialties, the implementation of pharmacogenetic tests in daily practice has thus far been limited. The Royal Dutch Pharmacists Association (KNMP) has developed pharmacogenetics-based therapeutic doserecommendations for 80 medicinal product combinations on the basis of a systematic literature review. Genotyping of patients can take place on a reactive or pre-emptive basis; the advantage of pre-emptive genotyping is that it provides genetic information the mo...
Abstract
Cited 2 times since 2020 (0.4 per year)
source: EuropePMC
PloS one,
Volume 15, Issue 6, 4 1 2020, Pages e0233769
Phenotypic and lifestyle determinants of HbA1c in the general population-The Hoorn Study.
Wisgerhof W, Ruijgrok C, den Braver NR, Borgonjen-van den Berg KJ, van der Heijden AAWA, Elders PJM, Beulens JWJ, Alssema M
Aim: To investigate the relative contribution of phenotypic and lifestyle factors to HbA1c, independent of fasting plasma glucose (FPG) and 2h post-load glucose (2hPG), in the general population. Methods: The study populations included 2309 participants without known diabetes from the first wave of the Hoorn Study (1989) and 2619 from the second wave (2006). Multivariate linear regression models were used to analyze the relationship between potential determinants and HbA1c in addition to FPG and...
Abstract
Cited 2 times since 2020 (0.4 per year)
source: EuropePMC
International journal of STD & AIDS,
Volume 31, Issue 8, 2 1 2020, Pages 800-807
Designing an electronic blood-borne virus risk alert to improve uptake of testing.
van Schaik P, Lorrimer S, Chadwick D
The primary aim of the current study was to test the effect of the presentation design of a test alert system on healthcare workers' (HCWs') decision-making regarding blood-borne virus (BBV) testing. The secondary aim was to determine HCWs' acceptance of the system. An online survey used a within-subjects research design with four design factors as independent variables. The dependent variable was clinical decision. Ten realistic descriptions of hypothetical patients were presente...
Abstract
Cited 4 times since 2020 (0.8 per year)
source: EuropePMC
Annals of vascular surgery,
Volume 68, 2 1 2020, Pages 159-165
Identifying Factors Influencing Decision Making in Patients Diagnosed with Carotid Body Tumors: An Exploratory Study.
Alimohamad H, Yilmaz D, Hamming JF, Schepers A
Background: Carotid body tumors (CBTs) are rare highly vascularized and slow enlarging tumors arising from the paraganglionic tissue at the carotid bifurcation. Main treatment options for CBTs are surgical resection or "wait and scan" strategy. The choice for either strategy may be equally good medically in many patients. A structured "shared decision making" (SDM) might be helpful for guiding patients. Objectives: To develop an SDM strategy for the surgical treatment, we aim...
Abstract
Journal of religion and health,
Volume 59, Issue 3, 1 1 2020, Pages 1189-1200
Determination of the Personal Values of the University Students in Different Departments.
Tunç GÇ, Yılmaz D, Özyazıcıoğlu N
This research aims to examine the personal values of the first-year university students studying in different departments. This is a descriptive cross-sectional survey study. Research population is composed of first-grade students approving to participate and studying in the Nursing Department in the School of Health, Biology Department in the Faculty of Science and Letters and the Department of Early Childhood Education in the Faculty of Education of Uludağ University. "Student Information...
Abstract
Cited 64 times since 2020 (12.9 per year)
source: EuropePMC
JAMA cardiology,
Volume 5, Issue 6, 1 1 2020, Pages 709-713
An Exploratory Analysis of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibition and Aortic Stenosis in the FOURIER Trial.
Bergmark BA, O'Donoghue ML, Murphy SA, Kuder JF, Ezhov MV, Ceška R, Gouni-Berthold I, Jensen HK, Tokgozoglu SL, Mach F, Huber K, Gaciong Z, Lewis BS, Schiele F, Jukema JW, Pedersen TR, Giugliano RP, Sabatine MS
Importance: Despite recent advances in treatment of severe aortic valve stenosis (AS), AS remains a life-threatening condition with no proven disease-modifying therapy. Low-density lipoprotein cholesterol (LDL-C) and lipoprotein(a) (Lp[a]) have been implicated in the pathobiology of AS. The proprotein convertase subtilisin/kexin type 9 inhibitor evolocumab reduces circulating LDL-C concentrations by 50% to 60% and Lp(a) by 20% to 30%. Objective: To determine whether evolocumab reduces the risk o...
Abstract
Cited 23 times since 2020 (4.6 per year)
source: EuropePMC
Bioinformatics (Oxford, England),
Volume 36, Issue 12, 1 1 2020, Pages 3874-3876
gplas: a comprehensive tool for plasmid analysis using short-read graphs.
Arredondo-Alonso S, Bootsma M, Hein Y, Rogers MRC, Corander J, Willems RJL, Schürch AC
Summary: Plasmids can horizontally transmit genetic traits, enabling rapid bacterial adaptation to new environments and hosts. Short-read whole-genome sequencing data are often applied to large-scale bacterial comparative genomics projects but the reconstruction of plasmids from these data is facing severe limitations, such as the inability to distinguish plasmids from each other in a bacterial genome. We developed gplas, a new approach to reliably separate plasmid contigs into discrete componen...
Abstract
Cited 37 times since 2020 (7.4 per year)
source: EuropePMC
European heart journal,
Volume 41, Issue 24, 1 1 2020, Pages 2248-2258
Effect of alirocumab on cardiovascular outcomes after acute coronary syndromes according to age: an ODYSSEY OUTCOMES trial analysis.
Sinnaeve PR, Schwartz GG, Wojdyla DM, Alings M, Bhatt DL, Bittner VA, Chiang CE, Correa Flores RM, Diaz R, Dorobantu M, Goodman SG, Jukema JW, Kim YU, Pordy R, Roe MT, Sy RG, Szarek M, White HD, Zeiher AM, Steg PG, ODYSSEY OUTCOMES Investigators
Aims: Lowering low-density lipoprotein cholesterol (LDL-C) reduces cardiovascular risk irrespective of age, but the evidence is less strong for older patients. Methods and results: This prespecified analysis from ODYSSEY OUTCOMES compared the effect of alirocumab vs. placebo in 18 924 patients with recent acute coronary syndrome (ACS) according to age. We examined the effect of assigned treatment on occurrence of the primary study outcome, a composite of coronary heart disease death, myocardial...
Abstract
Cited 7 times since 2020 (1.4 per year)
source: EuropePMC
Human nature (Hawthorne, N.Y.),
Volume 31, Issue 2, 1 1 2020, Pages 155-173
Why Class Formation Occurs in Humans but Not among Other Primates : A Primate Coalitions Model.
Pandit SA, Pradhan GR, van Schaik CP
Most human societies exhibit a distinct class structure, with an elite, middle classes, and a bottom class, whereas animals form simple dominance hierarchies in which individuals with higher fighting ability do not appear to form coalitions to "oppress" weaker individuals. Here, we extend our model of primate coalitions and find that a division into a bottom class and an upper class is inevitable whenever fitness-enhancing resources, such as food or real estate, are exploitable or trad...
Abstract
Cited 4 times since 2020 (0.8 per year)
source: EuropePMC
Interactive cardiovascular and thoracic surgery,
Volume 30, Issue 6, 1 1 2020, Pages 846-853
Treatment and outcome of plastic bronchitis in single ventricle patients: a systematic review.
Harteveld LM, Blom NA, Hazekamp MG, Ten Harkel ADJ
Plastic bronchitis (PB) is a life-threatening complication in single ventricle (SV) patients of which the exact pathophysiology, outcome and optimal treatment are still unclear. This study aims to systematically review the literature to give insight into the characteristics, outcome and management options of SV patients with PB. A systematic review was conducted, using the electronic database PubMed to find records published up to August 2018, describing SV patients and PB in which characteristi...
Abstract
Cited 3 times since 2020 (0.6 per year)
source: EuropePMC
Clinical rehabilitation,
Volume 34, Issue 7, 31 5 2020, Pages 901-915
A multicomponent intervention to decrease sedentary time during hospitalization: a quasi-experimental pilot study.
Conijn D, van Bodegom-Vos L, Volker WG, Mertens B, Vermeulen HM, Huurman V, van Schaik J, Vliet Vlieland T, Meesters J
Objective: The aim of this study was to evaluate the feasibility and preliminary effects of a multicomponent intervention to decrease sedentary time during and shortly after hospitalization. Design: This is a quasi-experimental pilot study comparing outcomes in patients admitted before and after the implementation of the intervention. Setting: The study was conducted in a university hospital. Subjects: Participants were adult patients undergoing elective organ transplantation or vascular surgery...
Abstract
Cited 14 times since 2020 (2.8 per year)
source: EuropePMC
Progress in cardiovascular diseases,
Volume 63, Issue 4, 30 5 2020, Pages 434-441
Clinical presentation and outcomes of adults with bicuspid aortic valves: 2020 update.
Yang LT, Tribouilloy C, Masri A, Bax JJ, Delgado V, Girdauskas E, Evangelista A, Sundt TM, Svensson LG, Enriquez-Sarano M, Michelena HI
The congenital bicuspid aortic valve (BAV) is a heterogeneous condition that is better understood considering 3 types of valvulo-aortopathy presentations: A typical-presentation valvulo-aortopathy, a complex-presentation valvulo-aortopathy and an uncomplicated/undiagnosed-presentation. The burden of BAV-related complications has been elucidated in patients with the typical-presentation valvulo-aortopathy and is discussed in this review. These patients enjoy an overall normal expected long-term s...
Abstract
Cited 4 times since 2020 (0.8 per year)
source: EuropePMC
Forensic science international,
Volume 313, 29 5 2020, Pages 110344
Chemical attribution of the homemade explosive ETN - Part II: Isotope ratio mass spectrometry analysis of ETN and its precursors.
Bezemer K, McLennan L, Hessels R, Schoorl J, van den Elshout J, van der Heijden A, Hulsbergen A, Koeberg M, Busby T, Yevdokimov A, de Rijke E, Schoenmakers P, Smith J, Oxley J, van Asten A
In this follow-up study the collaboration between two research groups from the USA and the Netherlands was continued to expand the framework of chemical attribution for the homemade explosive erythritol tetranitrate (ETN). Isotope ratio mass spectrometry (IRMS) analysis was performed to predict possible links between ETN samples and its precursors. Carbon, nitrogen, hydrogen and oxygen isotope ratios were determined for a wide variety of precursor sources and for ETN samples that were prepared w...
Abstract
Cited 2 times since 2020 (0.4 per year)
source: EuropePMC
Cardiovascular revascularization medicine : including molecular interventions,
Volume 21, Issue 12, 29 5 2020, Pages 1493-1499
Association Between Flow Impairment in Dominant Coronary Atrial Branches and Atrial Arrhythmias in Patients With ST-Segment Elevation Myocardial Infarction.
Montero Cabezas JM, Abou R, Goedemans L, Ajmone Marsan N, Bax JJ, Delgado V
Objectives: The impact of atrial ischemia in the occurrence of atrial arrhythmias may vary based on the amount of jeopardized myocardium. We sought to determine the association between coronary flow impairment in dominant coronary atrial branches (CAB) and atrial arrhythmias at 1-year follow-up in ST-segment elevation myocardial infarction (STEMI) patients. Methods: Patients with STEMI involving the right or circumflex coronary artery were included. Dominant CAB was defined as the most developed...
Abstract
Cited 7 times since 2020 (1.4 per year)
source: EuropePMC
Journal of aging and health,
Volume 32, Issue 9, 27 4 2020, Pages 1267-1274
Association of High-Density Lipoprotein Cholesterol With Cognitive Function: Findings From the PROspective Study of Pravastatin in the Elderly at Risk.
Grasset L, Smit RAJ, Caunca MR, Elfassy T, Odden MC, van der Grond J, van Buchem MA, Stott DJ, Sattar N, Trompet S, Jukema JW, Zeki Al Hazzouri A
Objective: We aimed to examine whether variability in high-density lipoprotein cholesterol (HDL-c) over time was associated with cognitive function. Method: We conducted a post hoc analysis of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) trial. Our sample included 4,428 participants with at least two repeated HDL-c measures between Months 3 and 24 postbaseline and with cognitive assessments at Month 30. HDL-c variability was defined as the intraindividual standard deviat...
Abstract
