Research

Publications

Below you can find a list of our published research.

6205 results

Cited 27 times since 2015 (2.6 per year) source: EuropePMC

European heart journal. Acute cardiovascular care, Volume 5, Issue 1, 5 1 2015, Pages 3-12 Opportunities for improvement in anti-thrombotic therapy and other strategies for the management of acute coronary syndromes: Insights from EPICOR, an international study of current practice patterns. Bueno H, Sinnaeve P, Annemans L, Danchin N, Licour M, Medina J, Pocock S, Sánchez-Covisa J, Storey RF, Jukema JW, Zeymer U, Van de Werf F, EPICOR Investigators

Aims: To describe international patterns and opportunities for improvement of pre- and in-hospital care of patients hospitalized for acute coronary syndromes (ACS), with special focus on anti-thrombotic therapy. Methods and results: EPICOR (long-tErm follow-uP of anti-thrombotic management patterns In acute CORonary syndrome patients), an international, cohort study, which enrolled 10,568 consecutive ACS survivors from 555 hospitals in 20 countries across Europe and Latin America (September 2010... Abstract

Cited 5 times since 2015 (0.5 per year) source: EuropePMC

European heart journal, Volume 36, Issue 4, 2 1 2015, Pages 206-213 The year in cardiology 2014: imaging. Gaemperli O, Marsan NA, Delgado V, Bax JJ

Abstract

Cited 38 times since 2015 (3.7 per year) source: EuropePMC

Kardiologia polska, Volume 73, Issue 12, 1 1 2015, Pages 1207-1294 [2015 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation]. Roffi M, Patrono C, Collet JP, Mueller C, Valgimigli M, Andreotti F, Bax JJ, Borger MA, Brotons C, Chew DP, Gencer B, Hasenfuss G, Kjeldsen K, Lancellotti P, Landmesser U, Mehilli J, Mukherjee D, Storey RF, Windecker S

Abstract

Cited 94 times since 2015 (9 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 17 Suppl 1, 1 1 2015, Pages i1-75 Statistics on the use of cardiac electronic devices and electrophysiological procedures in the European Society of Cardiology countries: 2014 report from the European Heart Rhythm Association. Raatikainen MJ, Arnar DO, Zeppenfeld K, Merino JL, Levya F, Hindriks G, Kuck KH

Aims: There has been large variations in the use of invasive electrophysiological therapies in the member countries of the European Society of Cardiology (ESC). The aim of this analysis was to provide comprehensive information on cardiac implantable electronic device (CIED) and catheter ablation therapy trends in the ESC countries over the last five years. Methods: The European Heart Rhythm Association (EHRA) has collected data on CIED and catheter ablation therapy since 2008. Last year 49 of th... Abstract

Cited 85 times since 2015 (8.2 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 65, Issue 3, 1 1 2015, Pages 246-254 The risk for type B aortic dissection in Marfan syndrome. den Hartog AW, Franken R, Zwinderman AH, Timmermans J, Scholte AJ, van den Berg MP, de Waard V, Pals G, Mulder BJ, Groenink M

Background: Aortic dissections involving the descending aorta are a major clinical problem in patients with Marfan syndrome. Objectives: The purpose of this study was to identify clinical parameters associated with type B aortic dissection and to develop a risk model to predict type B aortic dissection in patients with Marfan syndrome. Methods: Patients with the diagnosis of Marfan syndrome and magnetic resonance imaging or computed tomographic imaging of the aorta were followed for a median of... Abstract

Cited 28 times since 2015 (2.7 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 23, Issue 1, 1 1 2015, Pages 20-25 High survival rate of 43% in out-of-hospital cardiac arrest patients in an optimised chain of survival. Boyce LW, Vliet Vlieland TP, Bosch J, Wolterbeek R, Volker G, van Exel HJ, Heringhaus C, Schalij MJ, Goossens PH

Aims: Survival to hospital discharge after out-of-hospital cardiac arrest (OHCA) varies widely. This study describes short-term survival after OHCA in a region with an extensive care path and a follow-up of 1 year. Methods: Consecutive patients ≥16 years admitted to the emergency department between April 2011 and December 2012 were included. In July 2014 a follow-up took place. Socio-demographic data, characteristics of the OHCA and interventions were described and associations with survival wer... Abstract

Cited 8 times since 2014 (0.8 per year) source: EuropePMC

PloS one, Volume 9, Issue 12, 31 5 2015, Pages e111156 No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects. Baumert J, Huang J, McKnight B, Sabater-Lleal M, Steri M, Chu AY, Trompet S, Lopez LM, Fornage M, Teumer A, Tang W, Rudnicka AR, Mälarstig A, Hottenga JJ, Kavousi M, Lahti J, Tanaka T, Hayward C, Huffman JE, Morange PE, Rose LM, Basu S, Rumley A, Stott DJ, Buckley BM, de Craen AJ, Sanna S, Masala M, Biffar R, Homuth G, Silveira A, Sennblad B, Goel A, Watkins H, Müller-Nurasyid M, Rückerl R, Taylor K, Chen MH, de Geus EJ, Hofman A, Witteman JC, de Maat MP, Palotie A, Davies G, Siscovick DS, Kolcic I, Wild SH, Song J, McArdle WL, Ford I, Sattar N, Schlessinger D, Grotevendt A, Franzosi MG, Illig T, Waldenberger M, Lumley T, Tofler GH, Willemsen G, Uitterlinden AG, Rivadeneira F, Räikkönen K, Chasman DI, Folsom AR, Lowe GD, Westendorp RG, Slagboom PE, Cucca F, Wallaschofski H, Strawbridge RJ, Seedorf U, Koenig W, Bis JC, Mukamal KJ, van Dongen J, Widen E, Franco OH, Starr JM, Liu K, Ferrucci L, Polasek O, Wilson JF, Oudot-Mellakh T, Campbell H, Navarro P, Bandinelli S, Eriksson J, Boomsma DI, Dehghan A, Clarke R

Plasma fibrinogen is an acute phase protein playing an important role in the blood coagulation cascade having strong associations with smoking, alcohol consumption and body mass index (BMI). Genome-wide association studies (GWAS) have identified a variety of gene regions associated with elevated plasma fibrinogen concentrations. However, little is yet known about how associations between environmental factors and fibrinogen might be modified by genetic variation. Therefore, we conducted large-sc... Abstract

Cited 1 times since 2014 (0.1 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 22, Issue 3, 30 5 2015, Pages 408-418 Clinical topic: Nuclear imaging in hypertrophic cardiomyopathy. Delgado V, Bax JJ

Non-invasive cardiac imaging plays a central role in the diagnosis and management of patients with hypertrophic cardiomyopathy. Transthoracic echocardiography is the imaging technique of first choice to evaluate wall thickness, left ventricular systolic and diastolic function, presence of left ventricular outflow tract obstruction, and abnormal mitral anatomy, whereas cardiac magnetic resonance provides additional information on tissue characterization (replacement fibrosis) using late gadoliniu... Abstract

Cited 21 times since 2014 (2 per year) source: EuropePMC

The journals of gerontology. Series A, Biological sciences and medical sciences, Volume 70, Issue 8, 24 4 2014, Pages 982-988 Associations Between Thrombin Generation and the Risk of Cardiovascular Disease in Elderly Patients: Results From the PROSPER Study. Loeffen R, Winckers K, Ford I, Jukema JW, Robertson M, Stott DJ, Spronk HM, ten Cate H, Lowe GD, PROSPER Study Group

Background: Hypercoagulability may be an important contributor to the pathophysiology of atherosclerosis and atherothrombosis. As thrombin fulfills a central role in coagulation and links to several cellular mechanisms involved in arterial disease, we hypothesized that thrombin generation is associated with cardiovascular events in elderly patients. Methods: We studied the relationship between plasma thrombin generation and incident coronary heart disease (CHD) and stroke in the PROspective Stud... Abstract

Cited 12 times since 2014 (1.1 per year) source: Scopus

The American journal of cardiology, Volume 115, Issue 5, 18 3 2014, Pages 664-669 Effect of aortic regurgitation following transcatheter aortic valve implantation on outcomes. Ewe SH, Muratori M, van der Kley F, Pepi M, Delgado V, Tamborini G, Fusini L, de Weger A, Gripari P, Bartorelli A, Bax JJ, Marsan NA

The prognosis of aortic regurgitation (AR) after transcatheter aortic valve implantation (TAVI) and the changes in AR grade over time remain unclear. This study evaluated the midterm survival associated with AR after TAVI and examined the evolution of AR over time and its effect on cardiac performance. Successful TAVI was performed in 314 patients (age 81 ± 7 years, 36% men). Serial transthoracic echocardiography and clinical assessment were available in 175 patients who survived >12 months.... Abstract

Cited 3 times since 2014 (0.3 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 149, Issue 4, 18 3 2014, Pages 968 Long-term follow-up after the arterial switch operation: Not as perfect as we would have hoped? Hazekamp MG

Abstract

Cited 3 times since 2014 (0.3 per year) source: EuropePMC

Behavior modification, Volume 39, Issue 3, 16 3 2014, Pages 390-412 Cognitive behavior therapy for anxiety in people with dementia: a clinician guideline for a person-centered approach. Charlesworth G, Sadek S, Schepers A, Spector A

This article describes a 10-session cognitive-behavioral therapy (CBT) used in a randomized controlled trial with people with anxiety and mild-to-moderate dementia. The aim of the therapy is to reduce symptoms of anxiety by increasing a sense of safety and self-efficacy. The therapy is characterized by a person-centered approach to CBT, using individual tailoring to accommodate for cognitive deficits and other challenges. Three phases of therapy are described: (a) socialization to model (includi... Abstract

Cited 3 times since 2014 (0.3 per year) source: EuropePMC

Injury, Volume 46, Issue 5, 16 3 2014, Pages 863-869 Impact of combat events on first responders: experiences of the armed conflict in Uruzgan, Afghanistan. Hoencamp R, Idenburg FJ, Vermetten E, Tan E, Plat MC, Hoencamp E, Leenen LP, Hamming JF

Introduction: Care for battle casualties demands special skills from medics, nurses, and tactical commanders. To date, no inventory has been performed evaluating the first responders (medics, nurses and tactical commanders) around battle casualties. Method: This observational cohort study was conducted amongst the first responders (n=195) who were deployed to Southern Afghanistan (2009-2010) in three Marine companies. The survey focused on four main topics: (1) participants general background, (... Abstract

Cited 34 times since 2014 (3.3 per year) source: EuropePMC

BMC nephrology, Volume 15, 11 2 2014, Pages 197 Soluble Klotho is not independently associated with cardiovascular disease in a population of dialysis patients. Buiten MS, de Bie MK, Bouma-de Krijger A, van Dam B, Dekker FW, Jukema JW, Rabelink TJ, Rotmans JI

Background: Dialysis patients suffer from a high burden of cardiovascular disease (CVD). Partly this is due to progressive deterioration of calcium-phosphate homeostasis. Previous studies suggested that besides FGF-23, low levels of Klotho, a protein linked to aging, might constitute a key factor in this detrimental relationship. The purpose of the present study was to determine the relationship between serum Klotho (sKlotho) and the presence of CVD in dialysis patients. Methods: Plasma levels o... Abstract

Cited 8 times since 2014 (0.8 per year) source: EuropePMC

Forensic science international, Volume 248, 8 2 2014, Pages 101-112 Isotopic and elemental profiling of ammonium nitrate in forensic explosives investigations. Brust H, Koeberg M, van der Heijden A, Wiarda W, Mügler I, Schrader M, Vivo-Truyols G, Schoenmakers P, van Asten A

Ammonium nitrate (AN) is frequently encountered in explosives in forensic casework. It is widely available as fertilizer and easy to implement in explosive devices, for example by mixing it with a fuel. Forensic profiling methods to determine whether material found on a crime scene and material retrieved from a suspect arise from the same source are becoming increasingly important. In this work, we have explored the possibility of using isotopic and elemental profiling to discriminate between di... Abstract

Cited 29 times since 2014 (2.8 per year) source: EuropePMC

Journal of molecular and cellular cardiology, Volume 79, 5 1 2014, Pages 244-253 Clinical symptoms of right ventricular failure in experimental chronic pressure load are associated with progressive diastolic dysfunction. Borgdorff MA, Koop AM, Bloks VW, Dickinson MG, Steendijk P, Sillje HH, van Wiechen MP, Berger RM, Bartelds B

Background: Right ventricular failure (RVF) due to pressure load is a major cause of death in congenital heart diseases and pulmonary hypertension. The mechanisms of RVF are unknown. We used an experimental approach based upon clinical signs of RVF to delineate functional and biological processes associated with RVF. Methods and results: Wistar rats were subjected to a pulmonary artery banding (PAB n=12) or sham surgery (CON, n=7). After 52±5days, 5/12 PAB rats developed clinical symptoms of RVF... Abstract

Cited 48 times since 2014 (4.6 per year) source: Scopus

PloS one, Volume 9, Issue 12, 4 1 2014, Pages e111952 ACE inhibitors potently reduce vascular inflammation, results of an open proof-of-concept study in the abdominal aortic aneurysm. Kortekaas KE, Meijer CA, Hinnen JW, Dalman RL, Xu B, Hamming JF, Lindeman JH

Background: Independent of their blood pressure lowering effect, ACE inhibitors are thought to reduce vascular inflammation. The clinical relevance of this effect is unclear with the current knowledge. Abdominal aortic aneurysms (AAA) are characterized by a broad, non-specific inflammatory response, and thus provide a clinical platform to evaluate the anti-inflammatory potential of ACE inhibitors. Methods and results: Eleven patients scheduled for open AAA repair received ramipril (5 mg/day) dur... Abstract

Cited 39 times since 2014 (3.7 per year) source: EuropePMC

PLoS genetics, Volume 10, Issue 12, 4 1 2014, Pages e1004799 Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers. Taylor AE, Morris RW, Fluharty ME, Bjorngaard JH, Åsvold BO, Gabrielsen ME, Campbell A, Marioni R, Kumari M, Hällfors J, Männistö S, Marques-Vidal P, Kaakinen M, Cavadino A, Postmus I, Husemoen LL, Skaaby T, Ahluwalia TS, Treur JL, Willemsen G, Dale C, Wannamethee SG, Lahti J, Palotie A, Räikkönen K, Kisialiou A, McConnachie A, Padmanabhan S, Wong A, Dalgård C, Paternoster L, Ben-Shlomo Y, Tyrrell J, Horwood J, Fergusson DM, Kennedy MA, Frayling T, Nohr EA, Christiansen L, Ohm Kyvik K, Kuh D, Watt G, Eriksson J, Whincup PH, Vink JM, Boomsma DI, Davey Smith G, Lawlor D, Linneberg A, Ford I, Jukema JW, Power C, Hyppönen E, Jarvelin MR, Preisig M, Borodulin K, Kaprio J, Kivimaki M, Smith BH, Hayward C, Romundstad PR, Sørensen TI, Munafò MR, Sattar N

We previously used a single nucleotide polymorphism (SNP) in the CHRNA5-A3-B4 gene cluster associated with heaviness of smoking within smokers to confirm the causal effect of smoking in reducing body mass index (BMI) in a Mendelian randomisation analysis. While seeking to extend these findings in a larger sample we found that this SNP is associated with 0.74% lower body mass index (BMI) per minor allele in current smokers (95% CI -0.97 to -0.51, P = 2.00 × 10(-10)), but also unexpectedly found t... Abstract

Cited 4 times since 2014 (0.4 per year) source: EuropePMC

International journal of cardiology, Volume 183, 3 1 2014, Pages 249-257 Abnormal sinoatrial node development resulting from disturbed vascular endothelial growth factor signaling. Calkoen EE, Vicente-Steijn R, Hahurij ND, van Munsteren CJ, Roest AA, DeRuiter MC, Steendijk P, Schalij MJ, Gittenberger-de Groot AC, Blom NA, Jongbloed MR

Background: Sinus node dysfunction is frequently observed in patients with congenital heart disease (CHD). Variants in the Vascular Endothelial Growth Factor-A (VEGF) pathway are associated with CHD. In Vegf(120/120) mice, over-expressing VEGF120, a reduced sinoatrial node (SAN) volume was suggested. Aim of the study is to assess the effect of VEGF over-expression on SAN development and function. Methods: Heart rate was measured in Vegf(120/120) and wildtype (WT) embryos during high frequency ul... Abstract

Cited 2 times since 2014 (0.2 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 21, Issue 6, 1 1 2014, Pages 1245-1251 Multimodality imaging: bird's eye view from The European Society of Cardiology Congress 2014 Barcelona, August 30-September 3, 2014. Bax JJ, Delgado V, Achenbach S, Sechtem U, Knuuti J

Abstract