Research

Publications

Below you can find a list of our published research.

6143 results

Cited 7 times since 2018 (1 per year) source: EuropePMC

Journal of molecular and cellular cardiology, Volume 121, 4 1 2018, Pages 16-24 The protective role of Toll-like receptor 3 and type-I interferons in the pathophysiology of vein graft disease. Simons KH, de Vries MR, Peters HAB, Hamming JF, Jukema JW, Quax PHA

Background: Venous grafts are commonly used as conduits to bypass occluded arteries. Unfortunately, patency rates are limited by vein graft disease (VGD). Toll like receptors (TLRs) can be activated in vein grafts by endogenous ligands. This study aims to investigate the role of TLR3 in VGD. Methods: Vein graft surgery was performed by donor caval vein interpositioning in the carotid artery of recipient Tlr2-/-, Tlr3-/-, Tlr4-/- and control mice. Vein grafts were harvested 7, 14 and 28d after su... Abstract

Cited 24 times since 2018 (3.5 per year) source: EuropePMC

The American journal of cardiology, Volume 122, Issue 5, 2 1 2018, Pages 780-784 Interactions Among Vitamin D, Atrial Fibrillation, and the Renin-Angiotensin-Aldosterone System. Turin A, Bax JJ, Doukas D, Joyce C, Lopez JJ, Mathew V, Pontone G, Shah F, Singh S, Wilber DJ, Rabbat MG

Blockade of the renin-angiotensin-aldosterone system (RAAS) with angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARB) has been shown to decrease incident atrial fibrillation (AF). Vitamin D deficiency has been implicated but associations between vitamin D and AF are inconsistent. However, vitamin D deficiency results in renin and angiotensin upregulation. This study seeks to determine the relation between vitamin D deficiency and incident AF and characterize t... Abstract

Cited 9 times since 2018 (1.3 per year) source: EuropePMC

Circulation, Volume 137, Issue 23, 1 1 2018, Pages 2514-2527 Risk Stratification of Genetic, Dilated Cardiomyopathies Associated With Neuromuscular Disorders: Role of Cardiac Imaging. van der Bijl P, Delgado V, Bootsma M, Bax JJ

The etiology of dilated cardiomyopathy (DCM) can be grouped as either genetic or nongenetic. More than 50 pathogenic genes have been described, with sarcomeric and lamin A/C mutations being the most common. Mutation carriers for genetic DCM are often asymptomatic until cardiac disease manifests with heart failure, arrhythmias, or sudden cardiac death. Preventive strategies are promising but can only be applied and tested adequately if genetic DCM can be diagnosed at an early stage. Early diagnos... Abstract

Cited 2 times since 2018 (0.3 per year) source: EuropePMC

European heart journal, Volume 39, Issue 21, 1 1 2018, Pages 2000-2002 Left ventricular stroke volume in severe aortic stenosis and preserved left ventricular ejection fraction: prognostic relevance. Delgado V, Bax JJ

Abstract

Cited 323 times since 2018 (47.5 per year) source: EuropePMC

European heart journal, Volume 39, Issue 22, 1 1 2018, Pages 2047-2062 International Expert Consensus Document on Takotsubo Syndrome (Part II): Diagnostic Workup, Outcome, and Management. Ghadri JR, Wittstein IS, Prasad A, Sharkey S, Dote K, Akashi YJ, Cammann VL, Crea F, Galiuto L, Desmet W, Yoshida T, Manfredini R, Eitel I, Kosuge M, Nef HM, Deshmukh A, Lerman A, Bossone E, Citro R, Ueyama T, Corrado D, Kurisu S, Ruschitzka F, Winchester D, Lyon AR, Omerovic E, Bax JJ, Meimoun P, Tarantini G, Rihal C, Y-Hassan S, Migliore F, Horowitz JD, Shimokawa H, Lüscher TF, Templin C

The clinical expert consensus statement on takotsubo syndrome (TTS) part II focuses on the diagnostic workup, outcome, and management. The recommendations are based on interpretation of the limited clinical trial data currently available and experience of international TTS experts. It summarizes the diagnostic approach, which may facilitate correct and timely diagnosis. Furthermore, the document covers areas where controversies still exist in risk stratification and management of TTS. Based on a... Abstract

Cited 627 times since 2018 (92.2 per year) source: EuropePMC

European heart journal, Volume 39, Issue 22, 1 1 2018, Pages 2032-2046 International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology. Ghadri JR, Wittstein IS, Prasad A, Sharkey S, Dote K, Akashi YJ, Cammann VL, Crea F, Galiuto L, Desmet W, Yoshida T, Manfredini R, Eitel I, Kosuge M, Nef HM, Deshmukh A, Lerman A, Bossone E, Citro R, Ueyama T, Corrado D, Kurisu S, Ruschitzka F, Winchester D, Lyon AR, Omerovic E, Bax JJ, Meimoun P, Tarantini G, Rihal C, Y-Hassan S, Migliore F, Horowitz JD, Shimokawa H, Lüscher TF, Templin C

Takotsubo syndrome (TTS) is a poorly recognized heart disease that was initially regarded as a benign condition. Recently, it has been shown that TTS may be associated with severe clinical complications including death and that its prevalence is probably underestimated. Since current guidelines on TTS are lacking, it appears timely and important to provide an expert consensus statement on TTS. The clinical expert consensus document part I summarizes the current state of knowledge on clinical pre... Abstract

Cited 116 times since 2018 (17 per year) source: EuropePMC

European heart journal, Volume 39, Issue 21, 1 1 2018, Pages 1949-1969 European Association of Preventive Cardiology (EAPC) and European Association of Cardiovascular Imaging (EACVI) joint position statement: recommendations for the indication and interpretation of cardiovascular imaging in the evaluation of the athlete's heart. Pelliccia A, Caselli S, Sharma S, Basso C, Bax JJ, Corrado D, D'Andrea A, D'Ascenzi F, Di Paolo FM, Edvardsen T, Gati S, Galderisi M, Heidbuchel H, Nchimi A, Nieman K, Papadakis M, Pisicchio C, Schmied C, Popescu BA, Habib G, Grobbee D, Lancellotti P, Internal reviewers for EAPC and EACVI

Abstract

Cited 9 times since 2018 (1.3 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 53, Issue 6, 1 1 2018, Pages 1272-1278 Twenty-year experience with stentless biological aortic valve and root replacement: informing patients of risks and benefits. Schneider AW, Putter H, Hazekamp MG, Holman ER, Bruggemans EF, Versteegh MIM, Schalij MJ, Varkevisser RRB, Klautz RJM, Braun J

Objectives: The aim of this study was to provide predictive data on the performance of the Freestyle stentless bioprosthesis that can be used to support and improve the shared decision-making process of prosthetic valve choice for aortic valve replacement. Methods: Between 1993 and 2014, 604 patients received the Freestyle stentless bioprosthesis (143 subcoronary, 58 root inclusion and 403 full-root replacement). Perioperative data were collected retrospectively, and follow-up data were collecte... Abstract

Cited 12 times since 2018 (1.8 per year) source: EuropePMC

International journal of cardiology, Volume 260, 1 1 2018, Pages 184-190 The role of CD27-CD70-mediated T cell co-stimulation in vasculogenesis, arteriogenesis and angiogenesis. Simons KH, Aref Z, Peters HAB, Welten SP, Nossent AY, Jukema JW, Hamming JF, Arens R, de Vries MR, Quax PHA

Background: T cells have a distinctive role in neovascularization, which consists of arteriogenesis and angiogenesis under pathological conditions and vasculogenesis under physiological conditions. However, the role of co-stimulation in T cell activation in neovascularization has yet to be established. The aim of this study was to investigate the role T cell co-stimulation and inhibition in angiogenesis, arteriogenesis and vasculogenesis. Methods and results: Hind limb ischemia was induced by do... Abstract

Cited 95 times since 2018 (14 per year) source: EuropePMC

European heart journal, Volume 39, Issue 21, 1 1 2018, Pages 2003-2013 Pacemaker implantation rate after transcatheter aortic valve implantation with early and new-generation devices: a systematic review. van Rosendael PJ, Delgado V, Bax JJ

Aims: The incidence of new-onset conduction abnormalities requiring permanent pacemaker implantation (PPI) after transcatheter aortic valve implantation (TAVI) with new-generation prostheses remains debated. This systematic review analyses the incidence of PPI after TAVI with new-generation devices and evaluates the electrical, anatomical, and procedural factors associated with PPI. In addition, the incidence of PPI after TAVI with early generation prostheses was reviewed for comparison. Methods... Abstract

Cited 1 times since 2018 (0.1 per year) source: EuropePMC

Optics letters, Volume 43, Issue 11, 1 1 2018, Pages 2660-2663 Highly controlled Bloch wave propagation in surfaces with broken symmetry. Yilmaz D, Yeltik A, Kurt H

We propose and demonstrate reduced symmetry photonic surfaces providing highly controlled Bloch wave propagation. The backward and dual directional propagations have been observed in the proposed low-symmetric periodic structures without variation in the unit-cell filling factor. Frequency-domain analyses present group indices up to negative/positive -237/+96 as strong indicators of the observed directional controlled surface waves driven by the orientation angle in the range of 20°-90°. Further... Abstract

Cited 10 times since 2018 (1.5 per year) source: EuropePMC

Journal of cardiology, Volume 72, Issue 6, 31 5 2018, Pages 473-479 Long-term results of mitral valve repair for severe mitral regurgitation in asymptomatic patients. Tomšič A, Hiemstra YL, van Hout FMA, van Brakel TJ, Versteegh MIM, Marsan NA, Klautz RJM, Palmen M

Background: In asymptomatic patients with severe degenerative mitral valve regurgitation (MR), early surgery is often performed in experienced centers. The patient- and valve-related results and the quality of life after surgery in these patients remain insufficiently explored. Methods: Between 1/2000 and 12/2015, 83 asymptomatic patients (mean age 56.6±12.6 years, 21 female) without any complications related to long-lasting MR underwent early surgery. Follow-up clinical and echocardiographic da... Abstract

Cited 334 times since 2018 (49 per year) source: EuropePMC

Nature communications, Volume 9, Issue 1, 29 5 2018, Pages 2098 Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Davies G, Lam M, Harris SE, Trampush JW, Luciano M, Hill WD, Hagenaars SP, Ritchie SJ, Marioni RE, Fawns-Ritchie C, Liewald DCM, Okely JA, Ahola-Olli AV, Barnes CLK, Bertram L, Bis JC, Burdick KE, Christoforou A, DeRosse P, Djurovic S, Espeseth T, Giakoumaki S, Giddaluru S, Gustavson DE, Hayward C, Hofer E, Ikram MA, Karlsson R, Knowles E, Lahti J, Leber M, Li S, Mather KA, Melle I, Morris D, Oldmeadow C, Palviainen T, Payton A, Pazoki R, Petrovic K, Reynolds CA, Sargurupremraj M, Scholz M, Smith JA, Smith AV, Terzikhan N, Thalamuthu A, Trompet S, van der Lee SJ, Ware EB, Windham BG, Wright MJ, Yang J, Yu J, Ames D, Amin N, Amouyel P, Andreassen OA, Armstrong NJ, Assareh AA, Attia JR, Attix D, Avramopoulos D, Bennett DA, Böhmer AC, Boyle PA, Brodaty H, Campbell H, Cannon TD, Cirulli ET, Congdon E, Conley ED, Corley J, Cox SR, Dale AM, Dehghan A, Dick D, Dickinson D, Eriksson JG, Evangelou E, Faul JD, Ford I, Freimer NA, Gao H, Giegling I, Gillespie NA, Gordon SD, Gottesman RF, Griswold ME, Gudnason V, Harris

General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P Abstract

Cited 14 times since 2018 (2.1 per year) source: EuropePMC

Journal of the American Heart Association, Volume 7, Issue 11, 27 4 2018, Pages e009592 Interaction of Left Ventricular Size and Sex on Outcome of Cardiac Resynchronization Therapy Among Patients With a Narrow QRS Duration in the EchoCRT Trial. Varma N, Sogaard P, Bax JJ, Abraham WT, Borer JS, Dickstein K, Singh JP, Gras D, Holzmeister J, Brugada J, Ruschitzka F

Background: Longer QRS duration (QRSd) improves, but increased left ventricular (LV) end-diastolic volume (LVEDV) reduces, efficacy of cardiac resynchronization therapy (CRT). QRSd/LVEDV ratios differ between sexes. We hypothesized that in the EchoCRT (Echocardiography Guided Cardiac Resynchronization Therapy) trial enrolling patients with heart failure with QRSd Abstract

PloS one, Volume 13, Issue 5, 24 4 2018, Pages e0198376 Correction: Latent tuberculosis infection in foreign-born communities: Import vs. transmission in The Netherlands derived through mathematical modelling. Korthals Altes H, Kloet S, Cobelens F, Bootsma M

[This corrects the article DOI: 10.1371/journal.pone.0192282.]. Abstract

Cited 14 times since 2018 (2.1 per year) source: EuropePMC

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, Volume 105, 24 4 2018, Pages 1-10 Chronic sequelae and severe complications of norovirus infection: A systematic review of literature. Petrignani M, Verhoef L, de Graaf M, Richardus JH, Koopmans M

Norovirus causes an estimated 18% of all cases of acute gastroenteritis worldwide and is found to be associated with mortality. To create a first overview of severe complications and chronic sequelae of norovirus infections, a systematic review of literature was performed. Of 3928 individual hits, 176 publications remained for data extraction. Study periods varied between 1974 and 2017, though strongly skewed towards the last decade (n = 122, 70%). Countries of studies were worldwide, though Afr... Abstract

, 23 4 2018 Progerin Expression during Normal Closure of the Human Ductus Arteriosus: A Case of Premature Ageing? Gittenberger-de Groot AC, Bokenkamp R, Raz V, van Munsteren C, Poelmann RE, Grewal N, DeRuiter MC

The ductus arteriosus (DA) is a fetal vessel bypassing the still nonfunctional lungs. Closure of the DA at birth is essential for the transition from a fetal to a neonatal circulation. This closing process begins with a physiological contraction followed by definitive anatomical closure. The latter process starts already before birth by development of intimal thickening followed after birth by degeneration of the inner media, including cytolytic necrosis and apoptosis. The DA will remain patent... Abstract

Cited 3 times since 2018 (0.4 per year) source: EuropePMC

Journal of cardiovascular computed tomography, Volume 12, Issue 3, 19 3 2018, Pages 231-237 Impact of Non-obstructive left main disease on the progression of coronary artery disease: A PARADIGM substudy. Weir-McCall JR, Blanke P, Sellers SL, Ahmadi AA, Andreini D, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Chun EJ, Conte E, Gottlieb I, Hadamitzky M, Kim YJ, Lee BK, Lee SE, Maffei E, Marques H, Pontone G, Raff GL, Shin S, Sung JM, Stone P, Samady H, Virmani R, Narula J, Berman DS, Shaw LJ, Bax JJ, Lin FY, Min JK, Chang HJ, Leipsic JA

Background: The aim of the study is examine the impact of non-obstructive ( Abstract

Cited 24 times since 2018 (3.5 per year) source: EuropePMC

BMC surgery, Volume 18, Issue 1, 18 3 2018, Pages 27 MEDIASTinal staging of non-small cell lung cancer by endobronchial and endoscopic ultrasonography with or without additional surgical mediastinoscopy (MEDIASTrial): study protocol of a multicenter randomised controlled trial. Bousema JE, Dijkgraaf MGW, Papen-Botterhuis NE, Schreurs HW, Maessen JG, van der Heijden EH, Steup WH, Braun J, Noyez VJJM, Hoeijmakers F, Beck N, van Dorp M, Claessens NJM, Hiddinga BI, Daniels JMA, Heineman DJ, Zandbergen HR, Verhagen AFTM, van Schil PE, Annema JT, van den Broek FJC, MEDIASTrial study group

Background: In case of suspicious lymph nodes on computed tomography (CT) or fluorodeoxyglucose positron emission tomography (FDG-PET), advanced tumour size or central tumour location in patients with suspected non-small cell lung cancer (NSCLC), Dutch and European guidelines recommend mediastinal staging by endosonography (endobronchial ultrasound (EBUS) and endoscopic ultrasound (EUS)) with sampling of mediastinal lymph nodes. If biopsy results from endosonography turn out negative, additional... Abstract

Cited 11 times since 2018 (1.6 per year) source: EuropePMC

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, Volume 72, 17 3 2018, Pages 63-68 A novel view on the pathogenesis of complications after intravesical BCG for bladder cancer. Bilsen MP, van Meijgaarden KE, de Jong HK, Joosten SA, Prins C, Kroft LJM, Jonker JT, Crobach S, Pelger RC, Ottenhoff THM, Arend SM

Intravesical bacillus Calmette-Guérin (BCG) is widely used for high-risk, non-muscle-invasive bladder cancer. This report describes four cases that illustrate the spectrum of BCG-induced complications, varying from granulomatous prostatitis to sepsis. There is considerable debate regarding whether inflammation or infection is the predominant mechanism in the pathogenesis of BCG disease. In two patients with a systemic illness, the symptoms first resolved after adding prednisone, indicating a pri... Abstract