6139 results
The American journal of cardiology,
Volume 117, Issue 7, 2 1 2016, Pages 1167-1172
Comparison of Left Ventricular Volume and Ejection Fraction and Frequency and Extent of Aortic Regurgitation After Operative Repair of Type A Aortic Dissection Among Three Different Surgical Techniques.
Regeer MV, Versteegh MI, Klautz RJ, Schalij MJ, Bax JJ, Marsan NA, Delgado V
Differences in recurrence rate of aortic regurgitation (AR) and extent of left ventricular (LV) remodeling across the different surgical options in patients operated for type A aortic dissection remain unknown. The present evaluation compared the AR recurrence rate and changes in LV volumes and systolic function in valve-sparing aorta replacement (VSAR), supracoronary ascending aorta replacement (SCAR), and aortic valve and aorta replacement (AVAR). A total of 97 patients (58 ± 12 years, 62% men...
Abstract
Cited 13 times since 2016 (1.4 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 24, Issue 2, 1 1 2016, Pages 127-133
The extent of the raphe in bicuspid aortic valves is associated with aortic regurgitation and aortic root dilatation.
Koenraadt WM, Grewal N, Gaidoukevitch OY, DeRuiter MC, Gittenberger-de Groot AC, Bartelings MM, Holman ER, Klautz RJ, Schalij MJ, Jongbloed MR
Background: The clinical course of bicuspid aortic valves (BAVs) is variable. Data on predictors of aortopathy and valvular dysfunction mainly focus on valve morphology. Aim: To determine whether the presence and extent of the raphe (fusion site of valve leaflets) is associated with the degree of aortopathy and valvular dysfunction in patients with isolated BAV and associated aortic coarctation (CoA). Methods: Valve morphology and aortic dimensions of 255 BAV patients were evaluated retrospectiv...
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 24, Issue 2, 1 1 2016, Pages 154-155
An anomalous left coronary artery with a malignant course: coronary angiography and myocardial perfusion imaging with computed tomography.
de Graaf MA, van Rosendael AR, Kroft LJ, Vliegen HW, Hazekamp MG, Bax JJ, Scholte AJ
Abstract
Cited 6 times since 2016 (0.7 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 24, Issue 2, 1 1 2016, Pages 143-151
Outcome of stand-alone thoracoscopic epicardial left atrial posterior box isolation with bipolar radiofrequency energy for longstanding persistent atrial fibrillation.
Compier MG, Braun J, Tjon A, Zeppenfeld K, Klautz RJ, Schalij MJ, Trines SA
Introduction: Catheter ablation of longstanding (> 1 year) persistent atrial fibrillation (AF) is associated with poor outcome. This might be due to remodelling and fibrosis formation, mainly located in the posterior left atrial (LA) wall. Therefore, we adopted a thoracoscopic epicardial box isolation of the posterior left atrium using bipolar RF energy with intraoperative testing of conduction block. Methods and results: Bilateral thoracoscopic box isolation was performed with a bipolar RF c...
Abstract
Cited 103 times since 2016 (11.3 per year)
source: EuropePMC
Nature communications,
Volume 7, 1 1 2016, Pages 10494
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.
Kilpeläinen TO, Carli JF, Skowronski AA, Sun Q, Kriebel J, Feitosa MF, Hedman ÅK, Drong AW, Hayes JE, Zhao J, Pers TH, Schick U, Grarup N, Kutalik Z, Trompet S, Mangino M, Kristiansson K, Beekman M, Lyytikäinen LP, Eriksson J, Henneman P, Lahti J, Tanaka T, Luan J, Del Greco M F, Pasko D, Renström F, Willems SM, Mahajan A, Rose LM, Guo X, Liu Y, Kleber ME, Pérusse L, Gaunt T, Ahluwalia TS, Ju Sung Y, Ramos YF, Amin N, Amuzu A, Barroso I, Bellis C, Blangero J, Buckley BM, Böhringer S, I Chen YD, de Craen AJ, Crosslin DR, Dale CE, Dastani Z, Day FR, Deelen J, Delgado GE, Demirkan A, Finucane FM, Ford I, Garcia ME, Gieger C, Gustafsson S, Hallmans G, Hankinson SE, Havulinna AS, Herder C, Hernandez D, Hicks AA, Hunter DJ, Illig T, Ingelsson E, Ioan-Facsinay A, Jansson JO, Jenny NS, Jørgensen ME, Jørgensen T, Karlsson M, Koenig W, Kraft P, Kwekkeboom J, Laatikainen T, Ladwig KH, LeDuc CA, Lowe G, Lu Y, Marques-Vidal P, Meisinger C, Menni C, Morris AP, Myers RH, Männistö S, Nalls MA, Paternoster L, Peters A, Pradha
Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe obesity, no common loci regulating circulating leptin levels have been uncovered. Therefore, we performed a genome-wide association study (GWAS) of circulating leptin levels from 32,161 individuals and followed up loci reaching P
Abstract
Cited 4 times since 2016 (0.4 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 24, Issue 2, 1 1 2016, Pages 110-119
Treatment variation in stent choice in patients with stable or unstable coronary artery disease.
Burgers LT, McClellan EA, Hoefer IE, Pasterkamp G, Jukema JW, Horsman S, Pijls NH, Waltenberger J, Hillaert MA, Stubbs AC, Severens JL, Redekop WK
Aim: Variations in treatment are the result of differences in demographic and clinical factors (e.g. anatomy), but physician and hospital factors may also contribute to treatment variation. The choice of treatment is considered important since it could lead to differences in long-term outcomes. This study explores the associations with stent choice: i.e. drug-eluting stent (DES) versus bare-metal stents (BMS) for Dutch patients diagnosed with stable or unstable coronary artery disease (CAD). Met...
Abstract
Cited 24 times since 2016 (2.6 per year)
source: EuropePMC
Disease models & mechanisms,
Volume 9, Issue 4, 28 4 2016, Pages 413-425
Common arterial trunk and ventricular non-compaction in Lrp2 knockout mice indicate a crucial role of LRP2 in cardiac development.
Baardman ME, Zwier MV, Wisse LJ, Gittenberger-de Groot AC, Kerstjens-Frederikse WS, Hofstra RM, Jurdzinski A, Hierck BP, Jongbloed MR, Berger RM, Plösch T, DeRuiter MC
Lipoprotein-related receptor protein 2 (LRP2) is important for development of the embryonic neural crest and brain in both mice and humans. Although a role in cardiovascular development can be expected, the hearts ofLrp2knockout (KO) mice have not yet been investigated. We studied the cardiovascular development ofLrp2KO mice between embryonic day 10.5 (E10.5) and E15.5, applying morphometry and immunohistochemistry, using antibodies against Tfap2α (neural crest cells), Nkx2.5 (second heart field...
Abstract
Cited 35 times since 2016 (3.8 per year)
source: EuropePMC
European heart journal. Cardiovascular pharmacotherapy,
Volume 2, Issue 3, 27 4 2016, Pages 152-167
Use, patient selection and outcomes of P2Y12 receptor inhibitor treatment in patients with STEMI based on contemporary European registries.
Danchin N, Lettino M, Zeymer U, Widimsky P, Bardaji A, Barrabes JA, Cequier A, Claeys MJ, De Luca L, Dörler J, Erlinge D, Erne P, Goldstein P, Koul SM, Lemesle G, Lüscher TF, Matter CM, Montalescot G, Radovanovic D, Lopez Sendón J, Tousek P, Weidinger F, Weston CF, Zaman A, Andell P, Li J, Jukema JW, PIRAEUS group
Aims: Among acute coronary syndromes (ACS), ST-segment elevation myocardial infarction (STEMI) has the most severe early clinical course. We aimed to describe the effectiveness and safety of P2Y12 receptor inhibitors in patients with STEMI based on the data from contemporary European ACS registries. Methods and results: Twelve registries provided data in a systematic manner on outcomes in STEMI patients overall, and seven of these also provided data for P2Y12 receptor inhibitor-based dual antipl...
Abstract
Cited 10 times since 2016 (1.1 per year)
source: EuropePMC
Radiology,
Volume 279, Issue 2, 26 4 2016, Pages 443-450
Association between Hepatic Triglyceride Content and Left Ventricular Diastolic Function in a Population-based Cohort: The Netherlands Epidemiology of Obesity Study.
Widya RL, de Mutsert R, den Heijer M, le Cessie S, Rosendaal FR, Jukema JW, Smit JW, de Roos A, Lamb HJ, NEO Study Group
Purpose: To investigate the association between hepatic triglyceride content and left ventricular (LV) diastolic function while taking potential confounding factors into account, including the components of the metabolic syndrome. Materials and methods: The study was approved by the institutional review board, and all participants gave informed consent. In this cross-sectional analysis of baseline data from the Netherlands Epidemiology of Obesity study, a population-based, prospective cohort stu...
Abstract
Cited 328 times since 2016 (35.8 per year)
source: EuropePMC
Nature communications,
Volume 7, 21 3 2016, Pages 10023
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.
Pattaro C, Teumer A, Gorski M, Chu AY, Li M, Mijatovic V, Garnaas M, Tin A, Sorice R, Li Y, Taliun D, Olden M, Foster M, Yang Q, Chen MH, Pers TH, Johnson AD, Ko YA, Fuchsberger C, Tayo B, Nalls M, Feitosa MF, Isaacs A, Dehghan A, d'Adamo P, Adeyemo A, Dieffenbach AK, Zonderman AB, Nolte IM, van der Most PJ, Wright AF, Shuldiner AR, Morrison AC, Hofman A, Smith AV, Dreisbach AW, Franke A, Uitterlinden AG, Metspalu A, Tonjes A, Lupo A, Robino A, Johansson Å, Demirkan A, Kollerits B, Freedman BI, Ponte B, Oostra BA, Paulweber B, Krämer BK, Mitchell BD, Buckley BM, Peralta CA, Hayward C, Helmer C, Rotimi CN, Shaffer CM, Müller C, Sala C, van Duijn CM, Saint-Pierre A, Ackermann D, Shriner D, Ruggiero D, Toniolo D, Lu Y, Cusi D, Czamara D, Ellinghaus D, Siscovick DS, Ruderfer D, Gieger C, Grallert H, Rochtchina E, Atkinson EJ, Holliday EG, Boerwinkle E, Salvi E, Bottinger EP, Murgia F, Rivadeneira F, Ernst F, Kronenberg F, Hu FB, Navis GJ, Curhan GC, Ehret GB, Homuth G, Coassin S, Thun GA, Pistis G, Gambaro G, Mal
Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that...
Abstract
Cited 3 times since 2016 (0.3 per year)
source: EuropePMC
Atherosclerosis,
Volume 246, 19 3 2016, Pages 267-273
Serum CETP concentration is not associated with measures of body fat: The NEO study.
Blauw LL, de Mutsert R, Lamb HJ, de Roos A, Rosendaal FR, Jukema JW, Wang Y, van Dijk KW, Rensen PC
Introduction: Adipose tissue has been postulated to contribute substantially to the serum cholesteryl ester transfer protein (CETP) pool. However, in a recent large cohort study waist circumference was not associated with plasma CETP. The aim of the present study was to further examine associations of accurate measures of body fat and body fat distribution with serum CETP concentration. Methods: In this cross-sectional analysis of the Netherlands Epidemiology of Obesity study, we examined in 660...
Abstract
Cited 20 times since 2016 (2.2 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 49, Issue 6, 19 3 2016, Pages 1699-1704
Stentless bioprostheses: a versatile and durable solution in extensive aortic valve endocarditis.
Schneider AW, Hazekamp MG, Versteegh MI, Bruggemans EF, Holman ER, Klautz RJ, Braun J
Objectives: Infective endocarditis of the aortic valve with local aortic root destruction requires radical resection of infected tissues and subsequent reconstruction of periannular structures and the left ventricular outflow tract (LVOT). Homografts or stentless bioprostheses are recommended for use in this specific patient group. The Freestyle stentless bioprosthesis is a porcine aortic root prosthesis, which approaches the surgical versatility of the homograft, but has the advantage of ready...
Abstract
Cited 4 times since 2016 (0.4 per year)
source: EuropePMC
European heart journal,
Volume 37, Issue 28, 18 3 2016, Pages 2272-2275
Does computed tomography detect bioprosthetic aortic valve thrombosis? New findings, new questions?
Bax JJ, Delgado V, Prendergast B
Abstract
Cited 68 times since 2016 (7.4 per year)
source: EuropePMC
European heart journal,
Volume 37, Issue 43, 18 3 2016, Pages 3285-3290
Genotype impacts survival in Marfan syndrome.
Franken R, Groenink M, de Waard V, Feenstra HM, Scholte AJ, van den Berg MP, Pals G, Zwinderman AH, Timmermans J, Mulder BJ
Aims: The aorta in Marfan syndrome (MFS) patients is variably affected. We investigated the assumed genotype-effect on protein production as a risk factor for a severe aortic phenotype in adult MFS patients. Methods and results: We collected clinical and genetic data from all 570 adults with MFS who had been included in the Dutch CONgenital CORvitia registry since the start in 2001. Mean age was 36.5 ± 13.5 years (51.2% male, 28.9% prior aortic surgery, 8.2% prior aortic dissection). Patients we...
Abstract
Cited 2 times since 2016 (0.2 per year)
source: EuropePMC
Journal of electrocardiology,
Volume 49, Issue 3, 13 2 2016, Pages 316-322
Subtraction electrocardiography: Detection of ischemia-induced ST displacement without the need to identify the J point.
Ter Haar CC, Man SC, Maan AC, Schalij MJ, Swenne CA
Background: When triaging a patient with acute chest pain at first medical contact, an electrocardiogram (ECG) is routinely made and inspected for signs of myocardial ischemia. The guidelines recommend comparison of the acute and an earlier-made ECG, when available. No concrete recommendations for this comparison exist, neither is known how to handle J-point identification difficulties. Here we present a J-point independent method for such a comparison. Methods: After conversion to vectorcardiog...
Abstract
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 49, Issue 5, 5 1 2016, Pages 1426-1427
Down-sizing of cryopreserved homografts is a valuable technique, but do not make them too small.
Koolbergen DR
Abstract
Cited 15 times since 2016 (1.6 per year)
source: EuropePMC
European journal of heart failure,
Volume 18, Issue 5, 4 1 2016, Pages 469-481
Diagnosis and management of aortic valve stenosis in patients with heart failure.
Kamperidis V, Delgado V, van Mieghem NM, Kappetein AP, Leon MB, Bax JJ
Aortic stenosis (AS) is the most frequent degenerative valvular heart disease in Western countries and its prevalence increases in parallel with the ageing process of the population. Heart failure (HF), defined by the presence of reduced left ventricular ejection fraction, may be present in up to a quarter of patients with severe AS, posing diagnostic and management challenges. The present article reviews the prevalence of HF in severe AS patients, discusses the diagnostic challenges and the adv...
Abstract
Cited 3 times since 2016 (0.3 per year)
source: EuropePMC
European heart journal,
Volume 37, Issue 8, 3 1 2016, Pages 667-675
The year in cardiology 2015: imaging.
Gaemperli O, Delgado V, Habib G, Kaufmann PA, Bax JJ
Abstract
Cited 9 times since 2016 (1 per year)
source: EuropePMC
Methods in molecular biology (Clifton, N.J.),
Volume 1408, 1 1 2016, Pages 319-331
Optogenetic Engineering of Atrial Cardiomyocytes.
Feola I, Teplenin A, de Vries AA, Pijnappels DA
Optogenetics is emerging in the cardiology field as a new strategy to explore biological functions through the use of light-sensitive proteins and dedicated light sources. For example, this technology allows modification of the electrophysiological properties of cardiac muscle cells with superb spatiotemporal resolution and quantitative control. In this chapter, the optogenetic modification of atrial cardiomyocytes (aCMCs) from 2-day-old Wistar rats using lentiviral vector (LV) technology and th...
Abstract
Cited 60 times since 2016 (6.5 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 67, Issue 3, 1 1 2016, Pages 275-287
Myocardial Infarction Alters Adaptation of the Tethered Mitral Valve.
Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Hjortnaes J, Beaudoin J, Szymanski C, Bartko PE, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Mauskapf A, Titus JS, Wylie-Sears J, Irvin WS, Chaput M, Messas E, Hagège AA, Carpentier A, Levine RA, Leducq Transatlantic Mitral Network
Background: In patients with myocardial infarction (MI), leaflet tethering by displaced papillary muscles induces mitral regurgitation (MR), which doubles mortality. Mitral valves (MVs) are larger in such patients but fibrosis sets in counterproductively. The investigators previously reported that experimental tethering alone increases mitral valve area in association with endothelial-to-mesenchymal transition. Objectives: The aim of this study was to explore the clinically relevant situation of...
Abstract
