Research

Publications

Below you can find a list of our published research.

6177 results

Cited 28 times since 2008 (1.6 per year) source: EuropePMC

Molecular therapy : the journal of the American Society of Gene Therapy, Volume 16, Issue 4, 4 1 2008, Pages 741-748 Genetic complementation of human muscle cells via directed stem cell fusion. Gonçalves MA, Swildens J, Holkers M, Narain A, van Nierop GP, van de Watering MJ, Knaän-Shanzer S, de Vries AA

Duchenne muscular dystrophy (DMD) is caused by mutations in the X chromosome-linked DMD gene, which encodes the sarcolemma-stabilizing protein-dystrophin. Initial attempts at DMD therapy deployed muscle progenitor cells from healthy donors. The utilization of these cells is, however, hampered by their immunogenicity, while those from DMD patients are scarce and display limited ex vivo replication. Nonmuscle cells with myogenic capacity may offer valuable alternatives especially if, to allow auto... Abstract

Cited 36 times since 2008 (2.1 per year) source: EuropePMC

TheScientificWorldJournal, Volume 8, 3 1 2008, Pages 239-269 Development of the cardiac conduction system and the possible relation to predilection sites of arrhythmogenesis. Jongbloed MR, Mahtab EA, Blom NA, Schalij MJ, Gittenberger-de Groot AC

The cardiac conduction system (CCS) encompasses a complex system responsible for the coordinated contraction of the heart. In the developing heart, as well as in the adult heart, tissues of the (putative) CCS are characterized by different properties than the surrounding working myocardium, which can be observed on a histological level, as well as by the expression patterns of several immunohistological and molecular markers. In recent years, many markers have been studied that have helped to el... Abstract

Cited 2 times since 2008 (0.1 per year) source: EuropePMC

Vascular, Volume 16, Issue 2, 1 1 2008, Pages 116-119 Inflammatory aneurysm of the common iliac artery mimicking appendicitis. Mieog JS, Stoot JH, Bosch JJ, Koning OH, Hamming JF

Isolated inflammatory aneurysm of the common iliac artery is a rare condition. Previously reported cases presented with urologic complications owing to entrapment of the ureter in the perianeurysmal fibrosis. We report a case of a healthy young man who presented with acute abdominal pain in the right lower quadrant without urologic complications mimicking acute appendicitis. The pain was caused by an isolated inflammatory aneurysm of the right common iliac artery measuring 4 cm in diameter. Thre... Abstract

Annals of surgery, Volume 247, Issue 3, 1 1 2008, Pages 555; author reply 555-6 Re: Laparoscopic Versus Open Appendectomy in Children: A Meta-analysis. Aziz MI, van der Burg BL, Hamming JF

Abstract

Cited 9 times since 2008 (0.5 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 1, Issue 2, 1 1 2008, Pages 190-199 Invasive versus noninvasive evaluation of coronary artery disease. Schuijf JD, van Werkhoven JM, Pundziute G, Jukema JW, Decramer I, Stokkel MP, Dibbets-Schneider P, Schalij MJ, Reiber JH, van der Wall EE, Wijns W, Bax JJ

Objectives: We sought to compare the diagnostic information obtained from noninvasive characterization of coronary artery disease by using multidetector computed tomography (MDCT) and myocardial perfusion imaging (MPI) and to compare findings with the use of invasive coronary angiography and intravascular ultrasound (IVUS). Background: Preliminary comparisons have suggested that abnormal myocardial perfusion studies correlate well with significant luminal stenosis on MDCT coronary angiography. H... Abstract

Cited 94 times since 2008 (5.5 per year) source: EuropePMC

Developmental dynamics : an official publication of the American Association of Anatomists, Volume 237, Issue 3, 1 1 2008, Pages 847-857 Cardiac malformations and myocardial abnormalities in podoplanin knockout mouse embryos: Correlation with abnormal epicardial development. Mahtab EA, Wijffels MC, Van Den Akker NM, Hahurij ND, Lie-Venema H, Wisse LJ, Deruiter MC, Uhrin P, Zaujec J, Binder BR, Schalij MJ, Poelmann RE, Gittenberger-De Groot AC

Epicardium and epicardium-derived cells have been shown to be necessary for myocardial differentiation. To elucidate the function of podoplanin in epicardial development and myocardial differentiation, we analyzed podoplanin knockout mouse embryos between embryonic day (E) 9.5 and E15.5 using immunohistochemical differentiation markers, morphometry, and three-dimensional reconstructions. Podoplanin null mice have an increased embryonic lethality, possibly of cardiac origin. Our study reveals imp... Abstract

Cited 57 times since 2008 (3.3 per year) source: EuropePMC

Diabetic medicine : a journal of the British Diabetic Association, Volume 25, Issue 3, 1 1 2008, Pages 277-281 Sulphonylurea therapy improves cognition in a patient with the V59M KCNJ11 mutation. Slingerland AS, Hurkx W, Noordam K, Flanagan SE, Jukema JW, Meiners LC, Bruining GJ, Hattersley AT, Hadders-Algra M

Background: KCNJ11 mutations are a common cause of diabetes diagnosed in the first 6 months of life, and approximately 25% of patients have neurological features. Sulphonylureas have been shown to improve glycaemic control and also motor function, but the impact on cognitive function has not been extensively addressed previously. Methods: The patient had a low birth weight and was found to have diabetes at the age of 2 days. The patient was treated with insulin from diagnosis. The child also had... Abstract

Cited 24 times since 2008 (1.4 per year) source: EuropePMC

Pacing and clinical electrophysiology : PACE, Volume 31, Issue 3, 1 1 2008, Pages 358-374 Ablation of ventricular tachycardia in patients with structural heart disease. Zeppenfeld K, Stevenson WG

Catheter ablation is an important therapeutic option for controlling recurrent ventricular arrhythmias in patients with heart disease. Although implantable defibrillators are generally first line therapy in this patient population, a substantial number of patients require additional therapy with either antiarrhythmic drugs, ablation, or both. Studies of mapping and ablation have produced further insights into pathophysiologic mechanisms of these arrhythmias, which are now well characterized. The... Abstract

Cited 331 times since 2008 (19.3 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 21, Issue 3, 1 1 2008, Pages 191-213 Echocardiography for cardiac resynchronization therapy: recommendations for performance and reporting--a report from the American Society of Echocardiography Dyssynchrony Writing Group endorsed by the Heart Rhythm Society. Gorcsan J, Abraham T, Agler DA, Bax JJ, Derumeaux G, Grimm RA, Martin R, Steinberg JS, Sutton MS, Yu CM, American Society of Echocardiography Dyssynchrony Writing Group, American Society of Echocardiography Dyssynchrony Writing Group, Heart Rhythm Society

Echocardiography plays an evolving and important role in the care of heart failure patients treated with biventricular pacing, or cardiac resynchronization therapy (CRT). Numerous recent published reports have utilized echocardiographic techniques to potentially aide in patient selection for CRT prior to implantation and to optimized device settings afterwards. However, no ideal approach has yet been found. This consensus report evaluates the contemporary applications of echocardiography for CRT... Abstract

Cited 26 times since 2008 (1.5 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 94, Issue 3, 1 1 2008, Pages 255-257 CT angiography: an alternative to nuclear perfusion imaging? Schuijf JD, Bax JJ

Abstract

Cited 3 times since 2008 (0.2 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 15, Issue 2, 1 1 2008, Pages 218-224 Stroke volume measurements with first-pass dynamic positron emission tomography: comparison with cardiovascular magnetic resonance. Knaapen P, Lubberink M, Rijzewijk LJ, van der Meer RW, Unger M, Germans T, Bax JJ, Smit JW, Lamb HJ, van Rossum AC, Diamant M, Visser FC, Lammertsma AA

Background: The assessment of forward stroke volume (SV) using dynamic, first-pass cardiac positron emission tomography (PET) was shown to be feasible in a limited number of studies with small numbers of subjects. The aim of this study was to compare first-pass derived SV with cardiovascular magnetic resonance imaging (CMR)-obtained values in a larger population of subjects. Methods and results: Fifty-nine subjects with varying degrees of cardiac function were studied. Stroke volume was assessed... Abstract

Cited 32 times since 2008 (1.9 per year) source: EuropePMC

American journal of physiology. Heart and circulatory physiology, Volume 294, Issue 5, 29 5 2008, Pages H2150-7 Improved ECG detection of presence and severity of right ventricular pressure load validated with cardiac magnetic resonance imaging. Henkens IR, Mouchaers KT, Vonk-Noordegraaf A, Boonstra A, Swenne CA, Maan AC, Man SC, Twisk JW, van der Wall EE, Schalij MJ, Vliegen HW

The study aimed to assess whether the 12-lead ECG-derived ventricular gradient, a vectorial representation of ventricular action potential duration heterogeneity directed toward the area of shortest action potential duration, can improve ECG diagnosis of chronic right ventricular (RV) pressure load. ECGs from 72 pulmonary arterial hypertension patients recorded 1 with R > 0.5 mV in V1, and QRS axis >90 degrees ) had a sensitivity of 89% and a specificity of 93% for presence of chronic RV... Abstract

Cited 3 times since 2008 (0.2 per year) source: EuropePMC

Current medical research and opinion, Volume 24, Issue 4, 28 4 2008, Pages 1065-1068 Determinants of CRP level in statin-treated patients. Liem AH, van de Woestijne AP, Zwinderman AH, Visseren FL, Jukema JW

Objective: All factors of the metabolic syndrome (MetS) are reported to be associated with elevated C-reactive protein (CRP) levels. As CRP levels have been found to decrease as a result of statin treatment, the present study was intended to explore the relationship between CRP and the MetS in statin treated patients. Methods: In this study, the relationship between the components of the MetS and CRP level were analysed and factors determining CRP were identified in patients with longstanding in... Abstract

Cited 81 times since 2008 (4.7 per year) source: EuropePMC

European heart journal, Volume 29, Issue 6, 27 4 2008, Pages 757-765 Mechanism of improvement in mitral regurgitation after cardiac resynchronization therapy. Ypenburg C, Lancellotti P, Tops LF, Boersma E, Bleeker GB, Holman ER, Thomas JD, Schalij MJ, Piérard LA, Bax JJ

Aims: The aim of the current study was to evaluate the relationship between the presence of left ventricular (LV) dyssynchrony at baseline and acute vs. late improvement in mitral regurgitation (MR) after cardiac resynchronization therapy (CRT). Methods and results: Sixty eight patients consecutive (LV ejection fraction 23 +/- 8%) with at least moderate MR (>or=grade 2+) were included. Echocardiography was performed at baseline, 1 day after CRT initiation and at 6 months follow-up. Speckle tr... Abstract

Cited 50 times since 2008 (2.9 per year) source: EuropePMC

Brain : a journal of neurology, Volume 131, Issue Pt 4, 26 4 2008, Pages 1069-1077 Genetic variation in the interleukin-1 beta-converting enzyme associates with cognitive function. The PROSPER study. Trompet S, de Craen AJ, Slagboom P, Shepherd J, Blauw GJ, Murphy MB, Bollen EL, Buckley BM, Ford I, Gaw A, Macfarlane PW, Packard CJ, Stott DJ, Jukema JW, Westendorp RG, PROSPER Group

Inflammation is thought to play an important role in the development of cognitive decline and dementia in old age. The interleukin-1 signalling pathway may play a prominent role in this process. The gene encoding for interleukin-1 beta-converting enzyme (ICE) is likely to influence IL-1 beta levels. Inhibition of ICE decreases the age-related increase in IL-1 beta levels and may therefore improve memory function. We assessed whether genetic variation in the ICE gene associates with cognitive fun... Abstract

Cited 35 times since 2008 (2 per year) source: EuropePMC

Differentiation; research in biological diversity, Volume 76, Issue 7, 21 3 2008, Pages 809-819 Periostin expression by epicardium-derived cells is involved in the development of the atrioventricular valves and fibrous heart skeleton. Lie-Venema H, Eralp I, Markwald RR, van den Akker NM, Wijffels MC, Kolditz DP, van der Laarse A, Schalij MJ, Poelmann RE, Bogers AJ, Gittenberger-de Groot AC

The epicardium is embryologically formed by outgrowth of proepicardial cells over the naked heart tube. Epicardium-derived cells (EPDCs) migrate into the myocardium, contributing to myocardial architecture, valve development, and the coronary vasculature. Defective EPDC formation causes valve malformations, myocardial thinning, and coronary defects. In the atrioventricular (AV) valves and the fibrous heart skeleton isolating atrial from ventricular myocardium, EPDCs colocalize with periostin, a... Abstract

Cited 3 times since 2008 (0.2 per year) source: EuropePMC

International journal of oral and maxillofacial surgery, Volume 37, Issue 5, 12 2 2008, Pages 448-452 Biomechanical evaluation of the consolidation period of alveolar distraction osteogenesis with three-dimensional finite element analysis. Veziroglu F, Yilmaz D

In this study, three-dimensional (3D) modeling and finite element analysis were used to determine the optimum consolidation period for implant loading under forces of different directions and amounts after alveolar distraction osteogenesis. A 3D model of an atrophic edentulous alveolar crest was prepared. Distraction osteogenesis with the required bone height was simulated. After a consolidation period of 4, 8, 12 and 16 weeks, horizontal, vertical and oblique forces were applied to the conical... Abstract

Cited 47 times since 2008 (2.7 per year) source: EuropePMC

Atherosclerosis, Volume 200, Issue 1, 8 2 2008, Pages 95-101 Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population. Polisecki E, Peter I, Robertson M, McMahon AD, Ford I, Packard C, Shepherd J, Jukema JW, Blauw GJ, Westendorp RG, de Craen AJ, Trompet S, Buckley BM, Murphy MB, Ordovas JM, Schaefer EJ, PROSPER Study Group

Caucasian carriers of the T allele at R46L in the proprotein convertase subtilisin/kexin type 9 (PCSK9) locus have been reported to have 15% lower low-density lipoprotein (LDL) cholesterol (C) levels and 47% lower coronary heart disease (CHD) risk. Our objective was to examine two PCSK9 single nucleotide polymorphisms (SNPs), R46L and E670G, in 5783 elderly participants in Prospective Study of Pravastatin in the Elderly at Risk (PROSPER), of whom 43% had a history of vascular disease at baseline... Abstract

Cited 47 times since 2008 (2.7 per year) source: EuropePMC

Atherosclerosis, Volume 200, Issue 1, 7 1 2008, Pages 109-114 Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER. Polisecki E, Muallem H, Maeda N, Peter I, Robertson M, McMahon AD, Ford I, Packard C, Shepherd J, Jukema JW, Westendorp RG, de Craen AJ, Buckley BM, Ordovas JM, Schaefer EJ, Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) Investigators

Our purpose was to evaluate associations of single nucleotide polymorphisms (SNPs) at the low density lipoprotein (LDL) receptor (LDLR C44857T, minor allele frequency (MAF) 0.26, and A44964G, MAF 0.25, both in the untranslated region) and HMG-CoA reductase (HMGCR i18 T>G, MAF 0.019) gene loci with baseline lipid values, statin-induced LDL-cholesterol (C) lowering response, and incident coronary heart disease (CHD) and cardiovascular disease (CVD) on trial. Our population consisted of 5804 eld... Abstract

Cited 49 times since 2008 (2.8 per year) source: EuropePMC

The American journal of cardiology, Volume 101, Issue 8, 7 1 2008, Pages 1196-1200 Anemia as an independent predictor of perioperative and long-term cardiovascular outcome in patients scheduled for elective vascular surgery. Dunkelgrun M, Hoeks SE, Welten GM, Vidakovic R, Winkel TA, Schouten O, van Domburg RT, Bax JJ, Kuijper R, Chonchol M, Verhagen HJ, Poldermans D

Anemia is common in patients scheduled for vascular surgery and is a risk factor for adverse cardiac outcome. However, it is unclear whether this is an independent risk factor or an expression of underlying co-morbidities. In total, 1,211 patients (77% men, 68 +/- 11 years of age) were enrolled. Anemia was defined as serum hemoglobin levels Abstract