Research

Publications

Below you can find a list of our published research.

9618 results

Cited 22 times since 2008 (1.3 per year) source: EuropePMC

Journal of anatomy, Volume 212, Issue 3, 1 1 2008, Pages 286-294 Chronic right ventricular pressure overload results in a hyperplastic rather than a hypertrophic myocardial response. Leeuwenburgh BP, Helbing WA, Wenink AC, Steendijk P, de Jong R, Dreef EJ, Gittenberger-de Groot AC, Baan J, van der Laarse A

Myocardial hyperplasia is generally considered to occur only during fetal development. However, recent evidence suggests that this type of response may also be triggered by cardiac overload after birth. In congenital heart disease, loading conditions are frequently abnormal, thereby affecting ventricular function. We hypothesized that chronic right ventricular pressure overload imposed on neonatal hearts initiates a hyperplastic response in the right ventricular myocardium. To test this, young l... Abstract

Cited 15 times since 2008 (0.9 per year) source: EuropePMC

Current medical research and opinion, Volume 24, Issue 2, 1 1 2008, Pages 359-364 ApoB/A1 and LDL-C/HDL-C and the prediction of cardiovascular risk in statin-treated patients. Liem AH, van de Woestijne AP, Roeters van Lennep HW, Zwinderman AH, van der Steeg WA, Jukema JW

Background: It is generally accepted that low density lipoprotein cholesterol (LDL-C) or calculated ratios such as LDL-C to high density lipoprotein cholesterol (HDL-C) (LDL-C/HDL-C) are useful predictors of risk of cardiovascular disease in the primary as well as in the secondary prevention setting. However, there is accumulating evidence that the ratio of the corresponding apolipoproteins (apoB/A1) might be superior in some populations. Little is known with regard to the prognostic significanc... Abstract

Cited 179 times since 2008 (10.2 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 85, Issue 2, 1 1 2008, Pages 430-6; discussion 436-7 Restrictive mitral annuloplasty cures ischemic mitral regurgitation and heart failure. Braun J, van de Veire NR, Klautz RJ, Versteegh MI, Holman ER, Westenberg JJ, Boersma E, van der Wall EE, Bax JJ, Dion RA

Background: Restrictive mitral annuloplasty with revascularization is considered the best approach to ischemic mitral regurgitation with heart failure, but late results are controversial. We report late outcome in relation to preoperative left ventricular end-diastolic diameter (LVEDD) cutoff values, previously identified to predict intermediate-term left ventricular reverse remodeling. Methods: One hundred consecutive ischemic mitral regurgitation patients underwent restrictive mitral annulopla... Abstract

Cited 15 times since 2008 (0.9 per year) source: EuropePMC

Journal of rehabilitation medicine, Volume 40, Issue 2, 1 1 2008, Pages 132-136 Manual dexterity in hereditary motor and sensory neuropathy type 1a: severity of limitations and feasibility and reliability of two assessment instruments. Videler AJ, Beelen A, van Schaik IN, de Visser M, Nollet F

Objective: To assess the prevalence and significance of impaired manual dexterity in hereditary motor and sensory neuropathy type 1a (HMSN 1a), with the Sollerman hand function and the Functional Dexterity test, and compare the reliability and agreement of the tests. Design: Descriptive cross-sectional study. Subjects: Forty-nine subjects with HMSN 1a. Results: Forty-six (94%) subjects had an abnormal Sollerman sum score (< 80) for the dominant hand. The most difficult subtests required finge... Abstract

Cited 17 times since 2008 (1 per year) source: EuropePMC

Cyberpsychology & behavior : the impact of the Internet, multimedia and virtual reality on behavior and society, Volume 11, Issue 1, 1 1 2008, Pages 103-106 Virtual augmented exercise gaming for older adults. Van Schaik P, Blake J, Pernet F, Spears I, Fencott C

This paper details the design, development, and testing of virtual augmented exercise (VAE) gaming for older adults. Three versions of an underwater VAE environment were tested with a sample of 22 healthy adults aged 50 or over. Participants strongly preferred VAE to traditional physical exercise, and adherence rate was 100%. The findings suggest that VAE with puzzles changes or negates the expected negative associations among exercise outcomes. Fitness level was not associated with performance... Abstract

Cited 10 times since 2008 (0.6 per year) source: EuropePMC

European heart journal, Volume 29, Issue 3, 1 1 2008, Pages 283-284 Preoperative cardiac risk assessment in vascular surgery patients: seeing beyond the perioperative period. Schouten O, Bax JJ, Poldermans D

Abstract

Nederlands tijdschrift voor geneeskunde, Volume 152, Issue 6, 1 1 2008, Pages 297-301 [Differential diagnosis in patients with suspected anoxic-ischaemic coma]. van der Jagt M, Bosman RJ, van Schaik IN, van der Bilt IA, Dekker LR, Zandstra DF

Three case studies illustrate that suspected anoxic-ischaemic coma often requires careful differential diagnosis to detect treatable conditions. A 47-year-old man underwent cardiopulmonary resuscitation for ventricular fibrillation caused by myocardial ischaemia. He exhibited rhythmic eyelid movements while in a coma. Epilepsy was suspected, and the patient regained consciousness after being treated with antiepileptic drugs. A 34-year-old man underwent cardiopulmonary resuscitation for multiple... Abstract

Cited 75 times since 2008 (4.3 per year) source: EuropePMC

Proceedings of the National Academy of Sciences of the United States of America, Volume 105, Issue 5, 30 5 2008, Pages 1692-1697 Interaction between HMGA1a and the origin recognition complex creates site-specific replication origins. Thomae AW, Pich D, Brocher J, Spindler MP, Berens C, Hock R, Hammerschmidt W, Schepers A

In all eukaryotic cells, origins of DNA replication are characterized by the binding of the origin recognition complex (ORC). How ORC is positioned to sites where replication initiates is unknown, because metazoan ORC binds DNA without apparent sequence specificity. Thus, additional factors might be involved in ORC positioning. Our experiments indicate that a family member of the high-mobility group proteins, HMGA1a, can specifically target ORC to DNA. Coimmunoprecipitations and imaging studies... Abstract

Cited 48 times since 2008 (2.7 per year) source: EuropePMC

Journal of affective disorders, Volume 110, Issue 1-2, 30 5 2008, Pages 27-35 Depressive symptoms in peripheral arterial disease: a follow-up study on prevalence, stability, and risk factors. Smolderen KG, Aquarius AE, de Vries J, Smith OR, Hamming JF, Denollet J

Background: Depressive symptoms are associated with poor prognosis in coronary artery disease, but there is a paucity of research on these symptoms in peripheral arterial disease (PAD). We examined the clinical correlates and 18-month course of depressive symptoms in PAD patients. Methods: 166 patients with symptomatic lower-extremity PAD (39% women; M age=64.9 +/- 10 years) completed the 10-item Center for Epidemiological Studies Depression scale. A score > or =4 indicates clinically relevan... Abstract

Cited 60 times since 2008 (3.4 per year) source: EuropePMC

British journal of clinical pharmacology, Volume 65, Issue 5, 30 5 2008, Pages 752-760 Effect of CYP2C19*2 and *17 mutations on pharmacodynamics and kinetics of proton pump inhibitors in Caucasians. Hunfeld NG, Mathot RA, Touw DJ, van Schaik RH, Mulder PG, Franck PF, Kuipers EJ, Geus WP

What is already known about this subject: The influence of CYP2C19 on the kinetics and dynamics of omeprazole, lansoprazole and rabeprazole has been studied in Japanese subjects. * It has been suggested that subjects with *1/*1 genotype might need stronger acid suppression than *1/*2 and *2/*2 subjects. This suggestion comes from data in Japanese subjects and has not been confirmed in Caucasians. * Furthermore, a novel CYP2C19 mutation, *17, which mainly occurs in Caucasians has been discovered.... Abstract

Cited 50 times since 2008 (2.8 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 21, Issue 7, 28 4 2008, Pages 801-807 Real-time three-dimensional echocardiography as a novel approach to quantify left ventricular dyssynchrony: a comparison study with phase analysis of gated myocardial perfusion single photon emission computed tomography. Marsan NA, Henneman MM, Chen J, Ypenburg C, Dibbets P, Ghio S, Bleeker GB, Stokkel MP, van der Wall EE, Tavazzi L, Garcia EV, Bax JJ

Background: Different imaging modalities have been explored for assessment of left ventricular (LV) dyssynchrony. Gated myocardial perfusion single photon emission computed tomography (GMPS) with phase analysis is a reliable technique to quantify LV dyssynchrony and predict response to cardiac resynchronization therapy. Objective: Real-time 3-dimensional echocardiography (RT3DE) is a novel imaging technique that provides a LV systolic dyssynchrony index, based on regional volumetric changes as a... Abstract

Cited 31 times since 2008 (1.8 per year) source: EuropePMC

Current medical research and opinion, Volume 24, Issue 3, 25 4 2008, Pages 685-694 The efficacy of statin monotherapy uptitration versus switching to ezetimibe/simvastatin: results of the EASEGO study. Roeters van Lennep HW, Liem AH, Dunselman PH, Dallinga-Thie GM, Zwinderman AH, Jukema JW

Objective: To assess the incremental low-density lipoprotein-cholesterol (LDL-C) lowering efficacy of doubling the statin dose or switching to the ezetimibe/simvastatin 10/20 mg combination tablet (EZE/SIMVA) in patients on simvastatin 20 mg or atorvastatin 10 mg not at LDL-C target < 2.5 mmol/L. Study design and methods: Patients with documented coronary heart disease (CHD) and/or type 2 diabetes (DM2) with LDL-C > or = 2.5 and < 5.0 mmol/L despite treatment with atorvastatin 10 mg or... Abstract

Cited 8 times since 2008 (0.5 per year) source: EuropePMC

BMC genetics, Volume 9, 25 4 2008, Pages 9 Estimating effects of rare haplotypes on failure time using a penalized Cox proportional hazards regression model. Souverein OW, Zwinderman AH, Jukema JW, Tanck MW

Background: This paper describes a likelihood approach to model the relation between failure time and haplotypes in studies with unrelated individuals where haplotype phase is unknown, while dealing with the problem of unstable estimates due to rare haplotypes by considering a penalized log-likelihood. Results: The Cox model presented here incorporates the uncertainty related to the unknown phase of multiple heterozygous individuals as weights. Estimation is performed with an EM algorithm. In th... Abstract

Cited 25 times since 2008 (1.4 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 28, Issue 4, 24 4 2008, Pages 771-776 Vitamin K epoxide reductase complex subunit 1 (VKORC1) polymorphism and aortic calcification: the Rotterdam Study. Teichert M, Visser LE, van Schaik RH, Hofman A, Uitterlinden AG, De Smet PA, Witteman JC, Stricker BH

Objective: Besides effects on hemostasis, vitamin K-dependent proteins play a role in bone mineralization and arterial calcification. We investigated the association between the VKORC1 1173C>T polymorphism and calcification of the aortic far wall in a large population-based cohort. Methods and results: Aortic calcification was diagnosed by radiographic detection of calcified deposits in the abdominal aorta. In all cohort members for whom DNA was available, the C1173T SNP of VKORC1 (rs9934438)... Abstract

Cited 2 times since 2008 (0.1 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 35, Issue 3, 22 4 2008, Pages 532-534 Can cardiac iodine-123 metaiodobenzylguanidine imaging contribute to risk stratification in heart failure patients? Bax JJ, Boogers M, Henneman MM

Abstract

Cited 45 times since 2008 (2.6 per year) source: EuropePMC

Stem cells (Dayton, Ohio), Volume 26, Issue 4, 17 3 2008, Pages 1083-1093 Forced myocardin expression enhances the therapeutic effect of human mesenchymal stem cells after transplantation in ischemic mouse hearts. Grauss RW, van Tuyn J, Steendijk P, Winter EM, Pijnappels DA, Hogers B, Gittenberger-De Groot AC, van der Geest R, van der Laarse A, de Vries AA, Schalij MJ, Atsma DE

Human mesenchymal stem cells (hMSCs) have only a limited differentiation potential toward cardiomyocytes. Forced expression of the cardiomyogenic transcription factor myocardin may stimulate hMSCs to acquire a cardiomyogenic phenotype, thereby improving their possible therapeutic potential. hMSCs were transduced with green fluorescent protein (GFP) and myocardin (hMSC(myoc)) or GFP and empty vector (hMSC). After coronary ligation in immune-compromised NOD/scid mice, hMSC(myoc) (n = 10), hMSC (n... Abstract

Cited 72 times since 2008 (4.1 per year) source: EuropePMC

European heart journal, Volume 29, Issue 4, 17 3 2008, Pages 557-563 Clinical value, cost-effectiveness, and safety of myocardial perfusion scintigraphy: a position statement. Marcassa C, Bax JJ, Bengel F, Hesse B, Petersen CL, Reyes E, Underwood R, European Council of Nuclear Cardiology (ECNC), European Society of Cardiology Working Group 5 (Nuclear Cardiology and Cardiac CT), European Association of Nuclear Medicine Cardiovascular Committee

Mortality rates due to coronary artery disease (CAD) have declined in recent years as result of improved prevention, diagnosis, and management. Nonetheless, CAD remains the leading cause of death worldwide with most casualties expected to occur in developing nations. Myocardial perfusion scintigraphy (MPS) provides a highly cost-effective tool for the early detection of obstructive CAD in symptomatic individuals and contributes substantially to stratification of patients according to their risk... Abstract

Cited 30 times since 2008 (1.7 per year) source: EuropePMC

Clinical and vaccine immunology : CVI, Volume 15, Issue 3, 16 3 2008, Pages 522-533 Rational combination of peptides derived from different Mycobacterium leprae proteins improves sensitivity for immunodiagnosis of M. leprae infection. Geluk A, van der Ploeg J, Teles RO, Franken KL, Prins C, Drijfhout JW, Sarno EN, Sampaio EP, Ottenhoff TH

The stable incidence of new leprosy cases suggests that transmission of infection is continuing despite the worldwide implementation of multidrug therapy programs. Highly specific tools are required to accurately diagnose asymptomatic and early stage Mycobacterium leprae infections which are the likely sources of transmission and cannot be identified by using the detection of antibodies against phenolic glycolipid I. One of the hurdles hampering T-cell-based diagnostic tests is that M. leprae an... Abstract

Cited 16 times since 2008 (0.9 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 95, Issue 2, 15 3 2008, Pages 119-124 Effect of intramyocardial bone marrow cell injection on left ventricular dyssynchrony and global strain. van Ramshorst J, Atsma DE, Beeres SL, Mollema SA, Ajmone Marsan N, Holman ER, van der Wall EE, Schalij MJ, Bax JJ

Objective: To evaluate the effect of bone marrow cell injection on global strain and left ventricular (LV) dyssynchrony. Methods: In 14 patients with severe postinfarction heart failure, 93 (14) x 10(6) autologous bone marrow cells were percutaneously injected in the infarction border zone. LV ejection fraction (LVEF), LV dyssynchrony and echocardiographic global strain were assessed at baseline and 3 months in patients and in a non-randomised control group of 10 patients with a history of infar... Abstract

Cited 19 times since 2008 (1.1 per year) source: EuropePMC

Archives of gerontology and geriatrics, Volume 48, Issue 1, 4 1 2008, Pages 116-120 Elderly patients undergoing major vascular surgery: risk factors and medication associated with risk reduction. Feringa HH, Bax JJ, Karagiannis SE, Noordzij P, van Domburg R, Klein J, Poldermans D

This study assesses risk factors in elderly vascular surgery patients and to evaluate whether perioperative cardiac medication can reduce postoperative mortality rate. In a cohort study, 1693 consecutive patients > or =65 years undergoing major non-cardiac vascular surgery were preoperatively screened for cardiac risk factors and medication. During follow-up (median: 8.2 years), mortality was noted. Hospital mortality occurred in 8.1% and long-term mortality in 28.5%. In multivariate analysis... Abstract