Research

Publications

Below you can find a list of our published research.

9618 results

Cited 9 times since 2005 (0.5 per year) source: EuropePMC

Sexually transmitted diseases, Volume 32, Issue 10, 1 1 2005, Pages 625-629 Management of Chlamydia cases and their partners: results from a home-based screening program organized by municipal public health services with referral to regular health care. Götz HM, Hoebe CJ, Van Bergen JE, Veldhuijzen IK, Broer J, De Groot F, Verhooren MJ, Van Schaik DT, Coenen AJ, Richardus JH

Background: We evaluated the management of Chlamydia trachomatis cases and partners found in a systematic home-based chlamydia screening project in the Netherlands among 15- to 29-year-old women and men, organized by the Municipal Public Health Services (MHS). Methods: Infected participants (165/8339 = 2%) were referred to regular curative services. The treating physician provided feedback on treatment and partner notification. Results: Including the effect of a reminder, the treatment rate of a... Abstract

Cited 48 times since 2005 (2.4 per year) source: EuropePMC

Clinical cancer research : an official journal of the American Association for Cancer Research, Volume 11, Issue 20, 1 1 2005, Pages 7398-7404 Effect of common CYP3A4 and CYP3A5 variants on the pharmacokinetics of the cytochrome P450 3A phenotyping probe midazolam in cancer patients. Lepper ER, Baker SD, Permenter M, Ries N, van Schaik RH, Schenk PW, Price DK, Ahn D, Smith NF, Cusatis G, Ingersoll RG, Bates SE, Mathijssen RH, Verweij J, Figg WD, Sparreboom A

Purpose: To evaluate the effect of naturally occurring variants in genes encoding the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5 in patients with cancer receiving midazolam as a phenotyping probe. Experimental design: Five variants in CYP3A4 and CYP3A5 were evaluated in 58 patients (21 women and 37 men) receiving a short i.v. bolus of midazolam (dose, 0.0145 or 0.025 mg/kg). Midazolam concentrations in plasma were determined using liquid chromatography-mass spectrometry, and pharmacokineti... Abstract

Cited 12 times since 2005 (0.6 per year) source: EuropePMC

Applied and environmental microbiology, Volume 71, Issue 10, 1 1 2005, Pages 6427-6430 Deletion of the sigB gene in Bacillus cereus ATCC 14579 leads to hydrogen peroxide hyperresistance. van Schaik W, Zwietering MH, de Vos WM, Abee T

The sigB gene of Bacillus cereus ATCC 14579 encodes the alternative sigma factor sigma(B). Deletion of sigB in B. cereus leads to hyperresistance to hydrogen peroxide. The expression of katA, which encodes one of the catalases of B. cereus, is upregulated in the sigB deletion mutant, and this may contribute to the hydrogen peroxide-resistant phenotype. Abstract

Nederlands tijdschrift voor geneeskunde, Volume 149, Issue 42, 1 1 2005, Pages 2377; author reply 2377-8 [Metabolic syndrome]. Alizadeh Dehnavi R, Tamsma JT

Abstract

Cited 2 times since 2005 (0.1 per year) source: EuropePMC

Journal of vascular surgery, Volume 42, Issue 4, 1 1 2005, Pages 825; author reply 826 Regarding "Perioperative beta-blockade (POBBLE) for patients undergoing infrarenal vascular surgery: results of a randomized double-blind controlled trial". Schouten O, van Urk H, Feringa HH, Bax JJ, Poldermans D

Abstract

Cited 4 times since 2005 (0.2 per year) source: EuropePMC

World journal of gastroenterology, Volume 11, Issue 38, 1 1 2005, Pages 5997-6002 Effect of herpesvirus infection on pancreatic duct cell secretion. Hegyi P, Ordog B, Rakonczai Z, Takács T, Lonovics J, Szabolcs A, Sári R, Tóth A, Papp JG, Varró A, Kovács MK, Gray MA, Argent BE, Boldogköi Z

Aim: To examine the effect of acute infection caused by herpesvirus (pseudorabies virus, PRV) on pancreatic ductal secretion. Methods: The virulent Ba-DupGreen (BDG) and non-virulent Ka-RREp0lacgfp (KEG) genetically modified strains of PRV were used in this study and both of them contain the gene for green fluorescent protein (GFP). Small intra/interlobular ducts were infected with BDG virus (10(7) PFU/mL for 6 h) or with KEG virus (10(10) PFU/mL for 6 h), while non-infected ducts were incubated... Abstract

Cited 29 times since 2005 (1.5 per year) source: EuropePMC

Bone marrow transplantation, Volume 36, Issue 7, 1 1 2005, Pages 605-610 Long-term renal function after hemopoietic stem cell transplantation in children. Kist-van Holthe JE, Bresters D, Ahmed-Ousenkova YM, Goedvolk CA, Abbink FC, Wolterbeek R, Bredius RG, Pauwels EK, van der Heijden AJ

Glomerular function of all long-term survivors who underwent hemopoietic stem cell transplantation (HSCT) from 1991 to 1998 (study I, n=121) was studied retrospectively. In addition, we prospectively analyzed glomerular and tubular function of all long-term surviving children who received an HSCT between 1998 and 2000 (study II, n=41). We found a lower prevalence of children with chronic renal failure (CRF) post-HSCT in our more recent cohort (study II: 10%) as compared to the older cohort (stud... Abstract

Cited 33 times since 2005 (1.7 per year) source: EuropePMC

Cancer research, Volume 65, Issue 20, 1 1 2005, Pages 9398-9405 Tissue inhibitor of metalloproteinase-3 expression from an oncolytic adenovirus inhibits matrix metalloproteinase activity in vivo without affecting antitumor efficacy in malignant glioma. Lamfers ML, Gianni D, Tung CH, Idema S, Schagen FH, Carette JE, Quax PH, Van Beusechem VW, Vandertop WP, Dirven CM, Chiocca EA, Gerritsen WR

Oncolytic adenoviruses exhibiting tumor-selective replication are promising anticancer agents. Insertion and expression of a transgene encoding tissue inhibitor of metalloproteinase-3 (TIMP-3), which has been reported to inhibit angiogenesis and tumor cell infiltration and induce apoptosis, may improve the antitumor activity of these agents. To assess the effects of TIMP-3 gene transfer to glioma cells, a replication-defective adenovirus encoding TIMP-3 (Ad.TIMP-3) was employed. Ad.TIMP-3 infect... Abstract

Cited 52 times since 2005 (2.6 per year) source: EuropePMC

American heart journal, Volume 150, Issue 4, 1 1 2005, Pages 775-781 Comprehensive assessment of patients after coronary artery bypass grafting by 16-detector-row computed tomography. Salm LP, Bax JJ, Jukema JW, Schuijf JD, Vliegen HW, Lamb HJ, van der Wall EE, de Roos A

Background: Multidetector-row computed tomography (MDCT) is a versatile modality to evaluate stenoses in native coronary arteries and bypass grafts. Acquired MDCT data can additionally be used to assess left ventricular ejection fraction (LVEF). The purpose was to use MDCT for the assessment of bypass graft and coronary artery disease combined with evaluation of LVEF. Methods: Twenty-five patients underwent 16-detector-row CT examination and coronary angiography. Bypass grafts and nongrafted cor... Abstract

Cited 1 times since 2005 (0.1 per year) source: EuropePMC

Thrombosis and haemostasis, Volume 94, Issue 4, 1 1 2005, Pages 892-894 Pre-procedural levels of erythrocyte sedimentation rate (ESR) and risk of clinical restenosis in patients with percutaneous coronary intervention and coronary stent placement. Rana JS, Monraats PS, Zwinderman AH, de Maat MP, Kastelein JJ, Agema WR, Doevendans PA, de Winter RJ, Tio RA, Waltenberger J, Frants RR, van der Laarse A, van der Wall EE, Jukema JW

Abstract

Cited 52 times since 2005 (2.6 per year) source: EuropePMC

Circulation, Volume 112, Issue 16, 1 1 2005, Pages 2417-2425 Genetic inflammatory factors predict restenosis after percutaneous coronary interventions. Monraats PS, Pires NM, Agema WR, Zwinderman AH, Schepers A, de Maat MP, Doevendans PA, de Winter RJ, Tio RA, Waltenberger J, Frants RR, Quax PH, van Vlijmen BJ, Atsma DE, van der Laarse A, van der Wall EE, Jukema JW

Background: Restenosis is a negative effect of percutaneous coronary intervention (PCI). No clinical factors are available that allow good risk stratification. However, evidence exists that genetic factors are important in the restenotic process as well as in the process of inflammation, a pivotal factor in restenosis. Association studies have identified genes that may predispose to restenosis, but confirmation by large prospective studies is lacking. Our aim was to identify polymorphisms and ha... Abstract

Neuropediatrics, Volume 36, Issue 5, 1 1 2005, Pages 324-327 An unexpected cause of a recurrent cerebral hemorrhage. Thijs RD, Hazekamp MG, Rijlaarsdam ME, Willems SM, Schutte PJ, Laan LA

A 4-year-old previously healthy boy presented with a non-traumatic right parietal hemorrhage. A second life-threatening left cerebral hemorrhage occurred three weeks later and was decompressed with a craniotomy. Transthoracic echocardiography revealed a hypermobile elongated tumor of the mitral valve. The cardiac tumor was successfully resected three weeks after the craniotomy. Histological examination of the cardiac tumor revealed a papillary lesion of spindle cells with smooth muscle cell diff... Abstract

Cited 36 times since 2005 (1.8 per year) source: EuropePMC

Journal of cardiovascular electrophysiology, Volume 16, Issue 10, 1 1 2005, Pages 1097-1103 Validation of ECG indices of ventricular repolarization heterogeneity: a computer simulation study. Van Huysduynen BH, Swenne CA, Draisma HH, Antoni ML, Van De Vooren H, Van Der Wall EE, Schalij MJ

Introduction: Repolarization heterogeneity (RH) is functionally linked to dispersion in refractoriness and to arrhythmogenicity. In the current study, we validate several proposed electrocardiogram (ECG) indices for RH: T-wave amplitude, -area, -complexity, and -symmetry ratio, QT dispersion, and the Tapex-end interval (the latter being an index of transmural dispersion of the repolarization (TDR)). Methods and results: We used ECGSIM, a mathematical simulation model of ECG genesis in a human th... Abstract

Cited 4 times since 2005 (0.2 per year) source: EuropePMC

European journal of heart failure, Volume 8, Issue 3, 26 4 2005, Pages 314-320 Benefits of coronary revascularisation in diabetic and non-diabetic patients with ischaemic cardiomyopathy: role of myocardial viability. Rizzello V, Poldermans D, Biagini E, Schinkel AF, Boersma E, Elhendy A, Sozzi FB, Maat A, Roelandt JR, Bax JJ

Background: Diabetes mellitus in patients with coronary artery disease is associated with poor outcome. In this study, the relation between myocardial viability, diabetes, coronary revascularisation and outcome was evaluated. Methods: 129 patients (31 diabetic, 98 non-diabetic) with ischaemic cardiomyopathy underwent dobutamine stress echocardiography to assess myocardial viability. Patients with >or=4 viable segments were defined as viable and patients with or=5% in 44% of diabetic and in 40... Abstract

Cited 38 times since 2005 (1.9 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 46, Issue 8, 23 4 2005, Pages 1559-1564 Time course of diastolic and systolic function improvement after pulmonary valve replacement in adult patients with tetralogy of Fallot. van Straten A, Vliegen HW, Lamb HJ, Roes SD, van der Wall EE, Hazekamp MG, de Roos A

Objectives: The aim of this research was to assess right ventricular diastolic and systolic function before and after pulmonary valve replacement (PVR) in adult patients after repair of tetralogy of Fallot. Background: Pulmonary valve replacement (PVR) in adult patients late after repair of tetralogy of Fallot leads to rapid improvement of right ventricular (RV) systolic function. Methods: A total of 16 patients and 8 healthy subjects were included. Median age at initial repair was 4.9 (0.9 to 1... Abstract

Cited 18 times since 2005 (0.9 per year) source: EuropePMC

Nucleic acids research, Volume 33, Issue 17, 22 4 2005, Pages 5426-5436 Mutational analysis of BTAF1-TBP interaction: BTAF1 can rescue DNA-binding defective TBP mutants. Klejman MP, Zhao X, van Schaik FM, Herr W, Timmers HT

The BTAF1 transcription factor interacts with TATA-binding protein (TBP) to form the B-TFIID complex, which is involved in RNA polymerase II transcription. Here, we present an extensive mapping study of TBP residues involved in BTAF1 interaction. This shows that residues in the concave, DNA-binding surface of TBP are important for BTAF1 binding. In addition, BTAF1 interacts with residues in helix 2 on the convex side of TBP as assayed in protein-protein and in DNA-binding assays. BTAF1 drastical... Abstract

Cited 13 times since 2005 (0.7 per year) source: EuropePMC

Preventive veterinary medicine, Volume 72, Issue 3-4, 19 3 2005, Pages 221-236 Cow-level evaluation of a kinetics ELISA with multiple cutoff values to detect fecal shedding of Mycobacterium avium subspecies paratuberculosis in New York State dairy cows. van Schaik G, Stehman SM, Jacobson RH, Schukken YH, Shin SJ, Lein DH

In control programs for Mycobacterium avium subsp. paratuberculosis (Map), the infection status of the cows in a herd is often obtained by testing (a sample of) the herd with an ELISA that may lack some sensitivity and specificity but that is fast and inexpensive. In New York State (NYS), an unabsorbed kinetics ELISA (KELA) has been used extensively for Map control. The objective of this study was to determine the relative sensitivity and specificity of the KELA for detection of fecal shedding o... Abstract

Cited 20 times since 2005 (1 per year) source: EuropePMC

Intensive care medicine, Volume 31, Issue 10, 16 3 2005, Pages 1420-1426 Effect of dexamethasone on postoperative cardiac troponin T production in pediatric cardiac surgery. Malagon I, Hogenbirk K, van Pelt J, Hazekamp MG, Bovill JG

Objective: Pediatric cardiac surgery is associated with a temporary rise in cardiac troponin T (cTnT) during the postoperative period. We examined whether dexamethasone given before cardiopulmonary bypass has myocardial protective effects as assessed by the postoperative production of cTnT. Design and setting: Prospective randomized interventional study in the pediatric intensive care unit in a university hospital. Interventions: Patients were randomly allocated to act as controls or receive a s... Abstract

Cited 39 times since 2005 (2 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 92, Issue 4, 13 2 2005, Pages 490-494 Cardiac resynchronisation therapy in chronic atrial fibrillation: impact on left atrial size and reversal to sinus rhythm. Kiès P, Leclercq C, Bleeker GB, Crocq C, Molhoek SG, Poulain C, van Erven L, Bootsma M, Zeppenfeld K, van der Wall EE, Daubert JC, Schalij MJ, Bax JJ

Objective: To evaluate the impact of long term cardiac resynchronisation therapy (CRT) on left atrial and left ventricular (LV) reverse remodelling and reversal to sinus rhythm (SR) in patients with heart failure with atrial fibrillation (AF). Patients: 74 consecutive patients (age 68 (8) years; 67 men) with advanced heart failure and AF (20 persistent and 54 permanent) were implanted with a CRT device. Main outcome measures: Patients were evaluated clinically (New York Heart Association (NYHA)... Abstract

Cited 463 times since 2005 (23.2 per year) source: EuropePMC

Circulation, Volume 112, Issue 11, 6 1 2005, Pages 1580-1586 Left ventricular reverse remodeling but not clinical improvement predicts long-term survival after cardiac resynchronization therapy. Yu CM, Bleeker GB, Fung JW, Schalij MJ, Zhang Q, van der Wall EE, Chan YS, Kong SL, Bax JJ

Background: In patients with severe heart failure and dilated cardiomyopathy, cardiac resynchronization therapy (CRT) improves left ventricular (LV) systolic function associated with LV reverse remodeling and favorable 1-year survival. However, it is unknown whether LV reverse remodeling translates into a better long-term prognosis and what extent of reverse remodeling is clinically relevant, which were investigated in this study. Methods and results: Patients (n=141) with advanced heart failure... Abstract