7365 results
Clinical cancer research : an official journal of the American Association for Cancer Research,
4 1 2025
Prognosis and biological characteristics of ER-low metastatic breast cancer: results from a multicenter cohort and the TONIC trial.
Miglietta F, De Graaf M, Vernieri C, Piacentini F, Cacciatore M, Botticelli A, Vingiani A, Fotia G, Nicolè L, Griguolo G, Giarratano T, Massa D, Pellegrini V, Schiavi F, Porra F, Fassan M, Pruneri G, Dei Tos AP, Guarneri V, Kok M, Dieci MV
Purpose: To assess prognosis of ER-low expression and its dynamics in HER2- metastatic breast cancer (BC) and to compare sensitivity to nivolumab between ER-low and triple-negative (TN) BC. Experimental design: Two cohorts were analyzed: a multicenter cohort of 982 patients with HER2- metastatic BC, and one prospective cohort of 110 patients with ER
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 33, Issue 10, 3 1 2025, Pages 299-306
ENDOCOR: a nationwide consortium of endocarditis teams-initiating a registry for infective endocarditis within the Netherlands Heart Registration.
Peijster AJL, Heinen FJ, Douiyeb S, van der Stoel MD, Selder JL, Watson-de Lepper AGW, Houthuizen P, Meijs MFL, Kampschreur LM, Schalla S, Sinha BNM, Bakker ALM, Kouijzer IJE, Nijland F, Boel CHE, Riezebos RK, Duffels MGJ, Hjortnaes J, Klautz RJM, Verkaik NJ, Post MC, Chamuleau SAJ, Kamp O, Tanis W
Background: Despite advancements in diagnostics and treatment strategies, infective endocarditis continues to carry a substantial morbidity and mortality risk. In addition, the field of infective endocarditis contains many gaps in evidence, as international guidelines are predominantly based on low-level evidence. To improve infective endocarditis care and survival rates in the Netherlands, adequate evaluation of diagnostics, treatment strategies and outcomes is essential. Methods: To address th...
Abstract
Atherosclerosis,
Volume 409, 2 1 2025, Pages 120509
Immunopeptidomics analysis of human atherosclerosis plaques identifies antigenic drivers of atherosclerosis.
Lozano Vigario F, Molenaar J, Simó Vesperinas I, van der Zon M, Crone NSA, de Jong MJM, Hemme E, Depuydt MAC, Delfos L, de Mol J, Bernabé Kleijn MN, Peeters JAHM, Wezel A, Smeets HJ, Tjokrodirijo RTN, de Ru AH, Kros A, Quax PHA, de Vries MR, Kuiper J, Bot I, van Veelen P, Slütter B
Background and aim: Atherosclerosis has an auto-immune component driven by self-reactive T and B cells. Identifying their antigenic drivers may lead to new diagnosis and treatment approaches. Here, we aim to identify immunogenic T cell epitopes derived from atherosclerosis-relevant proteins such as ApoB100 by studying the repertoire of peptides presented by HLA in human plaques. Methods: We used immunopeptidomics to identify peptides presented by HLA-DR molecules from plaques of patients that un...
Abstract
Cited 1 times since 2025 (4.8 per year)
source: EuropePMC
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society,
Volume 33, Issue 5, 1 1 2025, Pages e70092
H<sub>2</sub>O<sub>2</sub>-Producing Electrochemical Bandages Are Active Using Off-the-Shelf Hydrogels.
Dagsuyu E, Kies P, Patel R, Beyenal H
An electrochemical bandage (e-bandage) that generates hydrogen peroxide (H2O2) through a combination of working, counter and reference electrodes used with an electrolyte-providing hydrogel is being developed for wound infection management. e-Bandage biocidal activity was previously demonstrated using Xanthan gum hydrogel. For clinical use, clinically used hydrogels would be ideal, but their use with the described e-bandage has not been shown. The goal of this work was to evaluate the biocidal a...
Abstract
Cited 1 times since 2025 (4.8 per year)
source: EuropePMC
American journal of primatology,
Volume 87, Issue 9, 1 1 2025, Pages e70072
Slowly but Surely: Larger Brains Improve Immature Survival in Primates.
Song Z, van Schaik CP
The high energy costs of brains suggest that a species' current brain size is adaptive. However, although the comparative data for mammals suggest a positive effect on fitness in larger-brained species because of higher adult survival and thus longer lifespan, it also reveals two negative effects, namely later age at first reproduction owing to slower development and a tendency towards reduced reproductive allocation owing to larger newborns. Here we suggest that what is missing is the posi...
Abstract
Nucleic acids research,
Volume 53, Issue 18, 1 1 2025, Pages gkaf964
Coordinated control of genome-nuclear lamina interactions by topoisomerase 2B and lamin B receptor.
van Schaik T, Magnitov M, de Haas M, Breda J, de Wit E, Manjon AG, Medema RH, Gothe HJ, Roukos V, Buckle AJ, Naughton C, Gilbert N, van Steensel B, Manzo SG
Lamina-associated domains (LADs) are megabase-sized genomic regions anchored to the nuclear lamina (NL). Factors controlling the interactions of the genome with the NL have largely remained elusive. Here, we identified DNA topoisomerase 2 beta (TOP2B) as a regulator of these interactions. TOP2B binds predominantly to inter-LAD (iLAD) chromatin and its depletion results in a partial loss of genomic partitioning between LADs and iLADs, suggesting that this enzyme might protect specific iLADs from...
Abstract
Cited 1 times since 2025 (4.8 per year)
source: EuropePMC
Nature structural & molecular biology,
1 1 2025
Interactions between the genome and the nuclear lamina are multivalent and cooperative.
Dauban L, Eder M, de Haas M, Franceschini-Santos VH, Yañez-Cuna JO, Martinovic M, van Schaik T, Leemans C, Teunissen H, Rademaker K, Martinez Ara M, Verkuilen M, de Wit E, van Steensel B
Lamina-associated domains (LADs) are megabase-sized genomic regions that interact with the nuclear lamina (NL). It is not yet understood how their interactions with the NL are encoded in their DNA. Here we designed an efficient LAD 'scrambling' approach, based on transposon-mediated local hopping of loxP recombination sites, to generate series of large deletions and inversions that span LADs and flanking sequences. Mapping of NL interactions in these rearrangements revealed that, in mo...
Abstract
Evolutionary anthropology,
Volume 34, Issue 3, 1 1 2025, Pages e70016
Cooperative Breeding as a Likely Early Catalyst of Human Evolution.
Burkart JM, Cerrito P, Natalucci G, van Schaik CP
Unlike any other great ape, humans give birth to large, secondarily altricial babies, show precocial social development, have bigger brains that require a long maturation period, and engage in cooperative breeding (CB). These traits, which characterize the human adaptive complex, are intricately linked and must have mutually reinforced each other over evolutionary time. Here, we use recent evidence from paleontology, developmental psychology, and pediatrics, complemented with comparative analyse...
Abstract
Cited 1 times since 2025 (4.8 per year)
source: EuropePMC
Allergy and asthma proceedings,
Volume 46, Issue 6, 1 1 2025, Pages 471-477
Evaluation of diagnostic tests for suspected hypersensitivity reactions to proton pump inhibitors in children.
Yilmaz D, Yilmaz Topal O, Sengul Emeksiz Z, Dibek Misirlioglu E
Background: Proton-pump inhibitors (PPI) are widely used in pediatric populations, although hypersensitivity reactions (HSR) to these agents are rare and not well characterized in children. Objective: This study aimed to evaluate the clinical characteristics and diagnostic findings of pediatric patients with suspected HSRs to PPIs. Methods: Pediatric patients referred to our allergy clinic with suspected PPI-related HSRs between January 2012 and October 2023 were retrospectively analyzed. Data o...
Abstract
Cited 2 times since 2025 (9.7 per year)
source: EuropePMC
JAMA cardiology,
Volume 10, Issue 9, 1 1 2025, Pages 896-903
Location of LMNA Variants and Clinical Outcomes in Cardiomyopathy.
Bhaskaran A, Ben Yaou R, Helms AS, Fayssoil A, Richard P, Stojkovic T, Anselme F, Labombarda F, Chikhaoui C, De Sandre-Giovannoli A, Jeru I, Leturcq F, Vigouroux C, Dembele M, Elliott P, Savvatis K, Zeppenfeld K, Bouguerra H, Charron P, Kumar S, Bonne G, Wahbi K, Lakdawala NK
Importance: Prior studies have suggested that patients with nonmissense (ie, truncating) variants causing LMNA cardiomyopathy have worse arrhythmic outcomes compared to those with missense variants. However, the effect of the spatial distribution of missense and truncating variants on clinical outcomes remains poorly understood. Objective: To determine the association of the spatial distribution of missense and truncating LMNA variants with cardiac outcomes. Design, setting, and participants: Th...
Abstract
Clinical cancer research : an official journal of the American Association for Cancer Research,
Volume 31, Issue 18, 1 1 2025, Pages 3897-3906
Biomarker Analysis and Treatment Dynamics Following Preoperative Ipilimumab plus Nivolumab in Locally Advanced Urothelial Cancer from the Phase IB NABUCCO Study.
Stockem CF, Gil-Jimenez A, Ali H, van Dorp J, van Dijk N, van Montfoort ML, Alkemade M, Broeks A, Seignette IM, Hooijberg E, Brugman W, Voogd R, van Rhijn BWG, Mertens LS, de Feijter JM, Mehra N, van der Heijden AG, Meijer RP, Suelmann BBM, Scheper W, Wessels LFA, Vis DJ, van der Heijden MS
Purpose: In NABUCCO, the safety and efficacy of preoperative ipilimumab plus nivolumab were assessed in stage III urothelial cancer. Encouraging responses were achieved, and ipilimumab 3 mg/kg (ipilimumab-high) seemed more effective than ipilimumab 1 mg/kg (ipilimumab-low). We explored ipilimumab plus nivolumab response biomarkers and tumor microenvironment (TME) treatment dynamics. Patients and methods: Baseline formalin-fixed, paraffin-embedded tumor tissue was analyzed using PD-L1 IHC (n = 51...
Abstract
Nursing in critical care,
Volume 30, Issue 5, 1 1 2025, Pages e70141
Investigation of Fluorescent Concretisation Intervention on Intensive Care Nurses' Hand Hygiene Training According to the Kirkpatrick Model: A Cluster Randomised Controlled Study.
Yılmaz H, Ayhan D, Yılmaz D, Özen Y
Background: The predominant fomite responsible for the transmission of healthcare-associated infections via the hands of healthcare professionals is ineffective handwashing within critical care. Aim: The fundamental aim was to evaluate the impact of fluorescent concretisation intervention on handwashing efficiency, skill performance, duration scores and educational programmes on hand hygiene (HH). A secondary aim was to determine the level of HH knowledge in intensive care nurses. Study design:...
Abstract
Cells,
Volume 14, Issue 17, 31 5 2025, Pages 1357
Heart Failure Impacts Endothelial Cell Responses to Cardiac Surgery on Cardiopulmonary Bypass.
Papazisi O, Postma RJ, Dirven RJ, Beeres SLMA, Berendsen RR, Arbous SM, Klautz RJM, van Vessem ME, Bijkerk R, Lindeman JHN, Palmen M, van Zonneveld AJ
Patients with heart failure with a reduced ejection fraction (HFrEF) are at an increased risk of developing postoperative hemodynamic instability and vasoplegia after surgery on cardiopulmonary bypass (CPB). Potentially pre-existing endothelial cell (EC) alterations due to chronic HF influence EC responses to cardiac surgery and might be responsible for the altered vascular responsiveness observed postoperatively. In this study, well-described EC activation markers were measured in blood samples...
Abstract
Cited 1 times since 2025 (4.7 per year)
source: EuropePMC
European journal of heart failure,
30 5 2025
Left ventricular ejection fraction and benefit of tricuspid valve interventions - insights from the international TRIGISTRY.
Heitzinger G, Dreyfus J, Dannenberg V, Topilsky Y, Benfari G, Marsan NA, Taramasso M, Russo G, Bohbot Y, Iliadis C, Weber M, Nombela-Franco L, Eixerés-Esteve A, Bazire B, Iung B, Obadia JF, Loureiro RE, Riant E, Donal E, Habib G, Lavie-Badie Y, Hausleiter J, Stolz L, Badano L, Le Tourneau T, Coisne A, Modine T, Praz F, Zamorano JL, von Bardeleben RS, Hahn RT, Fam N, Sievert H, Muraru D, Adamo M, Heuts S, Nejjari M, Chan V, De Bonis M, Carnero-Alcazar M, Rudolph V, Crestanello J, Lurz P, Bax J, Gauda R, Bernick J, Wells GA, Maisano F, Enriquez-Sarano M, Bartko P, Messika-Zeitoun D, TRIGISTRY Investigators
Aims: The impact of treatment for tricuspid regurgitation (TR) across different levels of left ventricular ejection fraction (LVEF) remains uncertain. This study aimed to compare the outcomes of surgical and transcatheter tricuspid valve interventions (TTVI) to conservative (medical) management across LVEF categories. Methods and results: Patients with severe isolated TR from the TRIGISTRY, a multicentre international registry, were categorized based on LVEF (preserved ejection fraction [pEF]: ≥...
Abstract
European heart journal,
30 5 2025, Pages ehaf660
AAV9-mediated KCNH2 suppression-replacement gene therapy in a transgenic rabbit model of type 1 short QT syndrome.
Nimani S, Bains S, Alerni N, Ördög B, Horváth A, Matas L, Louradour J, Giammarino L, Tester DJ, Beslac O, Lopez R, Meier S, Egle M, Christoforou N, Barbieri M, Vashanthakumar V, Perez-Feliz S, Parodi C, Garcia Casalta LG, Kim CSJ, Zhou W, Ye D, Jurgensen J, Barry MA, Bego M, Keyes L, Owens J, Pinkstaff J, Christoph J, Zehender M, Brunner M, Heijman J, Casoni D, Praz F, Haeberlin A, Brooks G, Ackerman MJ, Odening KE
Background and aims: Type 1 short QT syndrome (SQT1) is a genetic channelopathy caused by gain-of-function variants in KCNH2. This shortens cardiac repolarization and QT intervals, predisposing patients to ventricular arrhythmias and sudden cardiac death. This study aimed to investigate the therapeutic efficacy of KCNH2-specific suppression-and-replacement (KCNH2-SupRep) gene therapy in a transgenic rabbit model of SQT1. Methods: KCNH2-SupRep was developed by combining a KCNH2-shRNA with its cor...
Abstract
Cited 16 times since 2025 (74.3 per year)
source: EuropePMC
European heart journal,
29 5 2025, Pages ehaf194
2025 ESC/EACTS Guidelines for the management of valvular heart disease.
Praz F, Borger MA, Lanz J, Marin-Cuartas M, Abreu A, Adamo M, Ajmone Marsan N, Barili F, Bonaros N, Cosyns B, De Paulis R, Gamra H, Jahangiri M, Jeppsson A, Klautz RJM, Mores B, Pérez-David E, Pöss J, Prendergast BD, Rocca B, Rossello X, Suzuki M, Thiele H, Tribouilloy CM, Wojakowski W, ESC/EACTS Scientific Document Group
Abstract
The Annals of thoracic surgery,
29 5 2025, Pages S0003-4975(25)00805-7
Mitral Valve Repair in Infective Endocarditis: A Patient-Tailored Approach.
Tomšič A, Palmen M
Abstract
Cited 1 times since 2025 (4.6 per year)
source: EuropePMC
European heart journal,
29 5 2025, Pages ehaf193
2025 ESC Guidelines for the management of cardiovascular disease and pregnancy.
De Backer J, Haugaa KH, Hasselberg NE, de Hosson M, Brida M, Castelletti S, Cauldwell M, Cerbai E, Crotti L, de Groot NMS, Estensen ME, Goossens ES, Haring B, Kurpas D, McEniery CM, Peters SAE, Rakisheva A, Sambola A, Schlager O, Schoenhoff FS, Simoncini T, Steinbach F, Sudano I, Swan L, Valente AM, ESC Scientific Document Group
Abstract
European heart journal,
29 5 2025, Pages ehaf560
Surgical myectomy for hypertrophic cardiomyopathy: procedural volume and outcomes.
Heeringa TJP, Hegeman RMJJ, Koop Y, El Mathari S, Hoogewerf M, Roefs MM, Smits KC, Laenens D, De Zan G, Cramer MJ, Guglielmo M, van der Harst P, Vaartjes I, Mokhles MM, Klein P, van der Kaaij NP, SAM-Registry Study Investigators, Cardiothoracic Surgery Registration Committee of the Netherlands
Background and aims: Outcomes after surgical myectomy in hypertrophic obstructive cardiomyopathy (HOCM) patients have not been investigated in a multicentre registry with detailed clinical data. Hence, the objectives of this multicentre Dutch study are to describe the 30-day clinical outcomes after surgical myectomy, and to assess factors associated with increased 30-day complication rates. Methods: All HOCM patients (n = 335) who underwent surgery between 2012 and 2020 across 12 Dutch hospitals...
Abstract
Communications biology,
Volume 8, Issue 1, 28 4 2025, Pages 1293
Publisher Correction: Observational social learning of "know-how" and "know-what" in wild orangutans: evidence from nest-building skill acquisition.
Permana AL, Permana JJ, Nellissen L, Prayogi ES, Prasetyo D, Wich SA, van Schaik CP, Schuppli C
Abstract
