7365 results
The Journal of dermatological treatment,
Volume 36, Issue 1, 30 5 2025, Pages 2539282
Upadacitinib in daily practice for refractory atopic dermatitis in adolescents: a case series of the BioDay registry.
Vroman F, van der Rijst LP, Bacoş-Cosma OI, Zuithoff NPA, Kamsteeg M, van Lumig PPM, Loman L, Schuttelaar MLA, de Bruin-Weller MS, de Graaf M
Purpose: Upadacitinib is approved for treating moderate-to-severe atopic dermatitis (AD) aged ≥12 years. We evaluated upadacitinib's effectiveness and safety in AD adolescents in daily practice. Materials and methods: Fifteen adolescent AD patients from the BioDay registry, treated with upadacitinib 15 mg once daily were evaluated at baseline and after 4, 8, 16, and 28 weeks. Effectiveness was assessed using Eczema Area and Severity Index (EASI) score and Investigator Global Assessment (IGA...
Abstract
Immuno-oncology technology,
Volume 27, 29 5 2025, Pages 101065
Comprehensive analysis of the systemic immune landscape across breast cancer subtypes and disease stages.
Bakker NAM, Garner H, Geurts VCM, Champanhet E, Klaver C, Duijst M, Nederlof I, Gielen RCAM, de Graaf M, Voorthuis R, Liefaard MC, Lips EH, Oosterkamp HM, Kok M, de Visser KE
Background: Breast cancer is a systemic disease, yet the impact of tumor molecular subtype and disease stage on the systemic immune landscape remains poorly understood. In this study, we comprehensively analyzed the systemic immune landscape in a large cohort of breast cancer patients, encompassing all molecular subtypes and disease stages, alongside a control group of healthy donors. Materials and methods: Using multi-parameter flow cytometry, we assessed the abundance, phenotype, and activatio...
Abstract
Journal of orthopaedics,
Volume 68, 29 5 2025, Pages 283-286
Indomethacin versus Ketorolac for the prevention of heterotopic ossification in hip arthroscopy patients.
Frey CS, Spears TM, Puczko D, Hymel AM, Mathews CG, Luchini PM, Van Schaik KD, Leschied JR, Sullivan J
Background: Nonsteroidal anti-inflammatory drugs are commonly utilized to reduce the risk of developing heterotopic ossification (HO) after hip arthroscopy. However, it is not known which regimen is optimal. Purpose: The purpose of this study is to determine the rate of HO formation after hip arthroscopy in response to different NSAID protocols. Methods: Consecutive cases of a single fellowship-trained surgeon at a tertiary referral center were retrospectively reviewed. Patients received a regim...
Abstract
JACC. Basic to translational science,
Volume 10, Issue 8, 29 5 2025, Pages 101323
CD137 Signaling Modulates Vein Graft Atherosclerosis by Driving T-Cell Activation and Regulating Intraplaque Angiogenesis.
de Jong A, Sluiter TJ, Peters HAB, Lamens A, Jukema JW, Arens R, Quax PHA, de Vries MR
Atherosclerotic vein graft failure still presents a major problem. T-cells have been identified as one of the most abundant immune cell subset in atherosclerotic plaques. Their role, however, remains only partly understood. Using a murine vein graft model for advanced, unstable atherosclerotic lesions, we find that T-cells accumulate over time in atherosclerotic vein grafts, and appear to be activated rapidly after engraftment, demonstrated by increased expression of CD137 on plaque T-cells. Tar...
Abstract
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association,
28 4 2025, Pages S1542-3565(25)00636-6
Preoperative Body Composition Parameters Are Associated With Postoperative Outcomes in Patients With Crohn's Disease.
Bak MTJ, Demers K, van Ruler O, Pierik MJ, van Dijk DPJ, van der Bilt JDW, Romberg-Camps M, Dijkstra G, Duijvestein M, van der Marel S, Maljaars PWJ, Buskens CJ, Bakers FCH, Brecheisen R, Bongers BC, de Witte D, Jansen SV, Jharap B, Horjus CS, van Schaik FDM, West RL, de Boer NKH, Hansen BE, van der Woude CJ, van Rossum EFC, Stassen LPS, de Vries AC, RAP-CD study group, Dutch Initiative on Crohn and Colitis (ICC) and Dutch Initiative on Crohn and Colitis – Surgery (ICC-S)
Background & aims: Preoperative body composition is a potential modifiable risk factor for poor postoperative outcomes in Crohn's disease (CD). This study aimed to investigate the association of preoperative body composition parameters with postoperative complications and endoscopic postoperative recurrence (ePOR) in patients with CD following ileocolic (re-)resection (ICR). Methods: Patients with CD (≥16 years) scheduled for ICR with preoperative abdominal imaging (
Abstract
European heart journal,
25 4 2025, Pages ehaf456
Arrhythmia ablation in patients with congenital heart disease: challenges and opportunities in using complex spectrum data to guide individual care.
Kimura Y, Zeppenfeld K
Abstract
Cited 1 times since 2025 (3.2 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 38, Issue 11, 25 4 2025, Pages 1099-1101
Left Atrial Strain Index in Patients With Heart Failure With Preserved Ejection Fraction.
Chua APA, Weerts J, Achten A, Nabeta T, Sarrazyn C, Lopez-Santi P, Mourmans SGJ, Su JL, Bax JJ, Knackstedt C, van Empel VPM, Ajmone-Marsan N
Abstract
Circulation. Arrhythmia and electrophysiology,
Volume 18, Issue 8, 25 4 2025, Pages e013150
Regional Cardiac Denervation Predicts Sustained Ventricular Arrhythmias in Nonischemic Cardiomyopathy Patients Without LGE on CMR Imaging.
Jungen C, Chen HS, Wijnmaalen AP, Dibbets-Schneider P, Meretta A, Piers SR, Kimura Y, Androulakis AFA, van der Geest RJ, de Geus-Oei LF, Mertens BJA, Scholte AJHA, Lamb HJ, Jongbloed MRM, Zeppenfeld K
Background: In patients with nonischemic cardiomyopathy and no late gadolinium enhancement (LGE) on cardiac magnetic resonance, risk prediction for the occurrence of sustained ventricular arrhythmias (VA) is challenging. Global and regional sympathetic denervation has been associated with VA in patients with ischemic cardiomyopathy. Its prognostic relevance in nonischemic cardiomyopathy is unknown. Methods: Consecutive patients from the Leiden Nonischemic Cardiomyopathy Study who underwent progr...
Abstract
Cited 1 times since 2025 (3.2 per year)
source: EuropePMC
Veterinary microbiology,
Volume 309, 24 4 2025, Pages 110652
Evaluating the effect of vaccination on the impact of BTV-3 in Dutch sheep flocks in 2024.
Dijkstra E, Santman-Berends IMGA, Stegeman A, van den Brink KMJA, van Schaik G, van den Brom R
Bluetongue virus serotype 3 (BTV-3) emerged in the Netherlands in 2023 and re-emerged in 2024, causing a substantial impact on the sheep population. In 2024, inactivated BTV-3 vaccines became available, yet clinical cases and excess mortality were still reported, including among vaccinated flocks. This study aimed to quantify the effect of BTV-3 vaccination on excess mortality in sheep and lambs during the 2024 epidemic, using data from twenty veterinary practises, and to evaluate whether a prot...
Abstract
Advances in radiation oncology,
Volume 10, Issue 10, 24 4 2025, Pages 101871
Predicting Radionecrosis After Stereotactic Radiation Therapy for Solitary Brain Metastases: External Validation of a Univariable Model and Development of a Multivariable Model.
van Schaik EEMW, Crouzen JA, Mast ME, Broekman MLD, Hakstege MP, Mertens BJA, Kiderlen M, van der Voort van Zyp NCMG, Petoukhova AL, Zindler JD
Purpose: Stereotactic radiation therapy (SRT) is a frequently used and effective treatment for patients who received diagnosis for brain metastases (BMs). Radionecrosis (RN) is a severe complication of SRT which may cause neurologic symptoms. A normal tissue complication probability (NTCP) model has previously been established to predict the risk of RN based on the volume of healthy brain receiving ≥12 Gy. The aim of this study is to externally validate this prediction model. Methods and materia...
Abstract
Frontiers in cardiovascular medicine,
Volume 12, 24 4 2025, Pages 1649558
Editorial: New trends in vascular biology 2024.
Chelvanambi S, Chen H, De Vries MR, Fang Y, Fredman G, Gomez D, Iwata H, Uchida S, Yanagisawa H, Aikawa M
Abstract
Frontiers in medicine,
Volume 12, 23 4 2025, Pages 1587912
Immersion to impact: does one or three years of rural immersion influence graduate clinical practice intentions and locations?
Harvey W, Ali Z, Van Schaik L, Develyn T, Wright J
Background: Addressing rural healthcare workforce shortages requires evidence-based strategies in medical education. Extended rural immersion programs offer a potential solution, but the optimal duration for fostering long-term regional and rural practice remains unclear. Methods: This retrospective study evaluates the impact of one-year versus three-year rural immersion experiences at the University of Melbourne's Rural Clinical School (RCS) on graduate clinical practice locations of the 2...
Abstract
Cited 1 times since 2025 (3.2 per year)
source: EuropePMC
Biological reviews of the Cambridge Philosophical Society,
Volume 100, Issue 6, 23 4 2025, Pages 2471-2481
Assessing flexibility in meaning and context in non-human communication.
Fröhlich M, Aychet J, Clark PR, Crockford C, Dezecache G, Rebout N, van Schaik CP, Graham KE
The concept of flexibility in communication is central to reconstructing the evolutionary history of language, and grappling with "contextual flexibility" in particular is pivotal to address implications for pragmatics-first accounts of language evolution. Despite significant advances in the field, research is hindered by definitional inconsistencies and methodological gaps across modalities. We build on recent frameworks to propose further, detailed methods for studying contextual and...
Abstract
Journal of the Society for Cardiovascular Angiography & Interventions,
Volume 4, Issue 8, 23 4 2025, Pages 103706
Incidence of Complications Following Coronary Intravascular Lithotripsy, Clinical Outcomes, and Predictors of Complications.
van Oort MJH, Phagu AAS, Oliveri F, Bingen BO, Paradies V, Mincione G, Claessen BEPM, Dimitriu-Leen AC, Vossenberg TN, Kefer J, Girgis H, van der Kley F, Jukema JW, Al Amri I, Montero-Cabezas JM
Background: This study aimed to evaluate the incidence of complications associated with intravascular lithotripsy (IVL) therapy, assess clinical outcomes, and identify predictors of complications in a real-world patient cohort. Methods: Patients undergoing IVL between May 2019 and September 2024 were enrolled from the BENELUX-IVL registry and categorized based on the occurrence of complications following IVL and concomitant therapy. End points were achievement of residual diameter stenosis
Abstract
British journal of anaesthesia,
Volume 135, Issue 4, 22 4 2025, Pages 1075-1077
Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the perioperative period: withdraw or continue? A multicentre randomised controlled trial.
Miggelbrink LA, van Klei WA, Verhaar MC, Asselbergs FW, Spiering W, Buhre WFFA, Hollmann MW, van Lier F, van Dongen EHPA, Schober P, Rettig TCD, Reitsma HJB, van Schaik EPC, Vernooij LM, van Waes JAR
Abstract
The American journal of cardiology,
Volume 256, 22 4 2025, Pages 72-80
Procedural and Clinical Outcomes of Coronary Intravascular Lithotripsy in Patients With Impaired Renal Function: A Multicenter Retrospective Study.
Phagu AAS, van Oort MJH, Oliveri F, Bingen BO, Paradies V, Mincione G, Claessen BEPM, Dimitriu-Leen AC, Vossenberg TN, Kefer J, Mandurino-Mirizzi A, van der Kley F, Jukema JW, Amri IA, Montero-Cabezas JM
Chronic kidney disease (CKD) is a prevalent comorbidity in patients undergoing percutaneous coronary intervention (PCI), yet its impact on outcomes following intravascular lithotripsy (IVL) remains insufficiently studied. This study evaluated procedural and long-term outcomes of IVL-assisted PCI in patients with renal insufficiency compared to those with normal renal function. From the BENELUX-IVL registry (May 2019-September 2024), 558 patients were included in a retrospective multicenter analy...
Abstract
Cited 7 times since 2025 (21.7 per year)
source: EuropePMC
Nature medicine,
Volume 31, Issue 9, 21 3 2025, Pages 3151-3168
Polygenic prediction of body mass index and obesity through the life course and across ancestries.
Smit RAJ, Wade KH, Hui Q, Arias JD, Yin X, Christiansen MR, Yengo L, Preuss MH, Nakabuye M, Rocheleau G, Graham SE, Buchanan VL, Chittoor G, Graff M, Guindo-Martínez M, Lu Y, Marouli E, Sakaue S, Spracklen CN, Vedantam S, Wilson EP, Chen SH, Ferreira T, Ji Y, Karaderi T, Lüll K, Machado M, Malden DE, Medina-Gomez C, Moore A, Rüeger S, Akiyama M, Allison MA, Alvarez M, Andersen MK, Appadurai V, Arbeeva L, Bartell E, Bhaskar S, Bielak LF, Bis JC, Bollepalli S, Bork-Jensen J, Bradfield JP, Bradford Y, Brandl C, Braund PS, Brody JA, Broeckel U, Burgdorf KS, Cade BE, Cai Q, Camarda S, Campbell A, Cañadas-Garre M, Chai JF, Chesi A, Choi SH, Christofidou P, Couture C, Cuellar-Partida G, Danning R, Degenhardt F, Delgado GE, Delitala A, Demirkan A, Deng X, Dietl A, Dimitriou M, Dimitrov L, Dorajoo R, Eichelmann F, Eliasen AU, Engmann JE, Erdos MR, Fairhurst-Hunter Z, Farmaki AE, Faul JD, Fernandez-Lopez JC, Forer L, Frank M, Freitag-Wolf S, Fritsche LG, Fuchsberger C, Galesloot TE, Gao Y, Geller F, Giannakopoulou O, G
Polygenic scores (PGSs) for body mass index (BMI) may guide early prevention and targeted treatment of obesity. Using genetic data from up to 5.1 million people (4.6% African ancestry, 14.4% American ancestry, 8.4% East Asian ancestry, 71.1% European ancestry and 1.5% South Asian ancestry) from the GIANT consortium and 23andMe, Inc., we developed ancestry-specific and multi-ancestry PGSs. The multi-ancestry score explained 17.6% of BMI variation among UK Biobank participants of European ancestry...
Abstract
Frontiers in medicine,
Volume 12, 21 3 2025, Pages 1585017
Support from start to finish-a collaborative primary medical program in rural Victoria, Australia.
Harvey W, Van Schaik L, Develyn T, Ali Z, Hogarth C, Wright J
Australia faces a persistent shortage of doctors in rural and regional areas, exacerbating health disparities between urban and rural communities. Traditional medical education models, which have been largely centralized in metropolitan areas, often result in rural-origin students needing to relocate to cities for training, thus disrupting community connections and reducing the likelihood of their return to rural practice. To address this challenge, the University of Melbourne and La Trobe Unive...
Abstract
Open heart,
Volume 12, Issue 2, 21 3 2025, Pages e003445
Effect of sodium-glucose cotransporter 2 inhibitors on ventricular function in systemic right ventricular failure.
Neijenhuis RM, Regeer MV, Walker NL, Mertens BJ, Hunter A, Kiès P, Swan L, Vliegen HW, MacDonald ST, Zemrak F, Zaidi AN, Cedars AM, Jongbloed MR, Jukema JW, Veldtman GR, Egorova AD
Background: Systemic right ventricle (sRV) patients are at an increased risk of developing heart failure. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) could be a valuable treatment option. This study investigated the changes in ventricular function in sRV failure patients in the first year after starting SGLT2i. Methods: Adult sRV patients from the international, real-world ACHIEVE-SGLT2i registry were included if they had a clinical diagnosis of sRV failure, a transthoracic echocardiogram...
Abstract
Cited 1 times since 2025 (3 per year)
source: EuropePMC
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery,
Volume 70, Issue 3, 18 3 2025, Pages 295-305
Editor's Choice - Activated Clotting Time Guided Heparinisation during Open Abdominal Aortic Aneurysm Repair (ACTION-1): A Randomised, Multicentre, Single Blind, Superiority Trial.
Jongkind V, Steunenberg TAH, Roosendaal LC, Hoebink M, Blankensteijn JD, Koelemay MJW, Kropman RHJ, Zeebregts CJ, van Schaik J, Heyligers JMM, Geelkerken RH, Pierie MEN, Reijnen MMPJ, Lemson SM, Hoencamp R, Teijink JAW, Steinbauer MG, Hissink RJ, Debus S, Buscher HCJL, Fioole B, van Dieren S, Wiersema AM, ACTION-1 Investigators
Objective: The optimal dosage of intravenous unfractionated heparin and the role of monitoring its effect using activated clotting time (ACT) to prevent thromboembolic complications (TECs) during open abdominal aortic aneurysm (AAA) repair are uncertain. This trial aimed to compare ACT guided heparinisation with a single dose of 5 000 international units (IU) of heparin. Methods: This was a multicentre, randomised controlled, single blinded, superiority trial (NCT04061798). Patients undergoing e...
Abstract
