Research

Publications

Below you can find a list of our published research.

7365 results

Water research, Volume 287, Issue Pt A, 18 3 2025, Pages 124257 Tracking norovirus diversity at a global scale through wastewater metagenomics. Izquierdo-Lara RW, Worp N, Olthof M, Oude Munnink BB, Schapendonk CME, Prasad DK, Aarestrup FM, Koopmans MPG, de Graaf M

Norovirus is a leading cause of gastroenteritis globally. Understanding the emergence, evolution, and trends in norovirus genotype/strain diversity is essential to develop sustainable strategies to guide the development of interventions. Here, we used urban wastewater samples to assess and compare the diversity of noroviruses worldwide. By using a metagenomics approach, we analyzed 327 sewage samples, collected from 62 cities across 6 continents, collected over the course of two years between 20... Abstract

Journal of the American Heart Association, Volume 14, Issue 15, 17 3 2025, Pages e040868 Disproportionate Left Ventricular Enlargement in Mitral Valve Prolapse: Prevalence, Predictors, and Association With Outcomes. Topilsky Y, Essayagh B, Benfari G, Le Tourneau T, Antoine C, Grigioni F, Roussel JC, Bax JJ, Marsan NA, van Wijngaarden A, Tribouilloy C, Loewenstein I, Hochstadt A, Thapa P, Michelena HI, Enriquez-Sarano M

Background: Left ventricular (LV) end-systolic enlargement in severe degenerative mitral-regurgitation (MR) is a class I surgical trigger. Whether it occurs disproportionately to less-than-severe MR due to mitral valve prolapse and is associated with mortality are unknown. We aimed to analyze prevalence and association with survival of disproportionate LV enlargement in less-than-severe MR. Methods: A multicenter cohort international study enrolled 2848 consecutive patients (52% women, 69±16 yea... Abstract

American heart journal, Volume 290, 16 3 2025, Pages 359-370 Design and rationale of the HARTc 2.0 trial: A multicenter randomized controlled study on the impact of point-of-care high-sensitivity cardiac troponin-I testing in prehospital acute coronary syndrome triage on diagnosis and cost-effectiveness. van der Lande ACMH, Diederiks NM, de Koning ER, Bosch J, Romijn FPHTM, van der Loo WPM, van den Akker-van Marle ME, Dehnavi RA, Tietge WJ, Mertens BJA, Jukema JW, Cobbaert CM, Schalij MJ, Boogers MJ

Introduction: Chest pain accounts for ∼10% of emergency department visits, though most cases are not acute coronary syndrome (ACS), underscoring the need for effective prehospital triage. The HARTc 2.0 study evaluates the modified History, Electrocardiogram, Age, Risk Factors, and Troponin (HEART) score incorporating point-of-care (POC) high-sensitivity cardiac troponin-I (hs-cTnI) capillary fingerprick testing with sex-specific cut-offs to improve ACS risk stratification. The randomized control... Abstract

BMC nursing, Volume 24, Issue 1, 15 3 2025, Pages 918 Development and validation of paternal breastfeeding attitude scale. Buldum A, Alıcı D, Yılmaz DV

Objective: The aim of this study is to develop a valid and reliable instrument for the measurement of fathers' attitudes towards breastfeeding. Methods: This basic research-designed study included two independent participant groups of fathers who resided with their wives and had children aged 0-24 months who were exclusively breastfed. The final draft of the Paternal Breastfeeding Attitude Scale consisted of 32 items, which were scored on a five-point Likert scale. Results: Exploratory Fact... Abstract

American journal of physiology. Renal physiology, Volume 329, Issue 2, 15 3 2025, Pages F300-F310 Valosin-containing protein in ciliary morphology: a novel target in ADPKD. Pioppini C, Bhardwaj R, Schönauer R, Halbritter J, Hassan F, Eckardt KU, Fedeles SV, Yilmaz DE, Krappitz M

Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disorder leading to kidney cyst formation and loss of kidney function. The major causative genes Pkd1 and Pkd2 encode for the ciliary proteins polycystin-1 (PC1) and polycystin-2 (PC2), respectively, which are involved in ciliary functions. Within PKD1-defective cells, the accumulation of misfolded PC1 proteins triggers the unfolded protein response (UPR). Among the pathways activated, the ER-associated degradation (ERAD), medi... Abstract

Molecular therapy. Methods & clinical development, Volume 33, Issue 3, 15 3 2025, Pages 101532 AAV6 vectors provide superior gene transfer compared to AAV9 vectors following intramyocardial administration. Wang J, Jonker T, Cervera-Barea A, Dong Z, Visser RN, Birza EE, Boender AR, Klerk M, Yang Y, Visser J, Jansen MS, Grootswagers TC, Bart CI, de Jager SCA, Schrödel S, Thirion C, Kirzner OF, Tan HL, de Vries AAF, Sluijter JPG, Neef K, de Groot JR, Christoffels VM, Boink GJJ

Cardiac gene therapy using adeno-associated viral (AAV) vectors holds great promise for treating heart diseases but would benefit from more potent AAV vectors. Vectors based on the AAV serotypes 6 and 9 have been used in pre-clinical gene therapy studies, yet the therapeutic outcomes varied depending on the experimental model and delivery route used. Here, we evaluated the transduction efficiency of AAV6, AAV9, and AAV9-derived MyoAAVs for local cardiac delivery. Vectors were tested in neonatal... Abstract

European journal of pediatrics, Volume 184, Issue 8, 14 2 2025, Pages 481 ''Unraveling the effects of smoking in asthmatic adolescents: clinical outcomes, spirometry findings, and risk analysis''. Genis C, Tas D, Yılmaz D, Kuzucu FN, Selmanoglu A, Sengul Emeksiz Z, Dibek Mısırlıoglu E

Adolescent smoking and asthma are major global public health concerns. This study aims to comprehensively assess the impact of smoking on asthma control, pulmonary function, and risk factors for uncontrolled asthma in adolescents. A total of 126 adolescents aged 10 to 18 years were categorized into three groups: (1) smoking asthmatics, (2) non-smoking asthmatics, and (3) smoking non-asthmatics. Asthma symptom control was determined according to the Global Initiative for Asthma (GINA). Demographi... Abstract

JBMR plus, Volume 9, Issue 10, 13 2 2025, Pages ziaf118 Comparison between dietary, parenteral, and genetic iron overload on bone health reveals secondary iron overload as a driver of cortical bone loss and fracture risk in mice. Steele-Perkins P, Yilmaz D, Walther Y, Wagner A, Paganoni R, Rauner M, Baschant U, Vujić Spasić M

More than 18% of the global population suffers from osteoporosis and its associated fracture risk each year. Among the many factors implicated in osteoporosis development, high iron levels have been implicated in bone loss in mice and patients. Here, we performed a comparative analysis of the effect of iron overload induced via diet, injections, or genetic factors, on overall bone health and mechanical bone strength. We used female mice, given the higher risk of osteoporosis and associated fract... Abstract

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 12 2 2025, Pages S1078-5884(25)00678-1 Factors Influencing Vascular Surgeons' Compliance with Elective Repair Guidelines for Abdominal Aortic Aneurysm: A Qualitative Study. Brust M, van Gestel LC, Vriens PWHE, Hamming JF, Adriaanse MA, Lindeman JH

Objective: Despite guideline recommendations to delay elective abdominal aortic aneurysm (AAA) repair until the diameter exceeds the intervention threshold, a notable proportion of repairs occur earlier. This study aimed to explore factors influencing vascular surgeons' compliance with the intervention threshold regarding AAA repair, adopting a behavioural science perspective. Methods: This qualitative study employed semi-structured interviews with vascular surgeons. Twelve vascular surgeon... Abstract

Scientific reports, Volume 15, Issue 1, 11 2 2025, Pages 25022 Joint contact forces during barefoot, minimal and conventional shod running are highly individual. Kloock L, Arensmann A, de Graaf ML, Gerlach M, Boström KJ, Wagner H

The supposed benefits of barefoot running are an often debated topic, with many studies investigating footwear influences on the kinematics and kinetics of running. Few studies, however, have analysed the effect on joint contact forces (JCFs). In this study, we investigated the influence of different footwear on the JCFs of the hip, knee, and ankle during running using a 3D musculoskeletal model. Kinematics were recorded from 16 volunteers while running on a treadmill at two speeds (2.0 m/s and... Abstract

Cited 1 times since 2025 (2.8 per year) source: EuropePMC

Royal Society open science, Volume 12, Issue 7, 9 2 2025, Pages 241754 An integrated baseline assessment of reef-associated sharks around Saba (Dutch Caribbean), combining three methods: stereo-BRUVs, telemetry and citizen science. Leurs G, de Graaf M, Hassell-Knijff D, Izioka LAK, van Looijengoed W, Meijer Zu Schlochtern MP, Bervoets T, Nagelkerke LAJ, Winter HV

The Exclusive Economic Zone of Saba (Dutch Windward Islands) has been designated Yarari Marine Mammal and Shark Sanctuary. However, to effectively conserve sharks, a baseline on their diversity and spatiotemporal distribution is required. We used three methods: telemetry, stereo-baited remote underwater video systems (stereo-BRUVs) and a citizen science program to study reef-associated sharks, mainly Caribbean reef sharks (Carcharhinus perezi) and nurse sharks (Ginglymostoma cirratum) around Sab... Abstract

Heart (British Cardiac Society), 8 2 2025, Pages heartjnl-2025-326162 Representativeness of surgical controls in aortic valve replacement trials: comparison with routine surgical cohorts. Tomsic A, Velders BJJ, Kawczynski MJ, Schoones JW, Klautz RJM, Palmen M, Sardari Nia P, Owais T, Girdauskas E, Heuts S

Background: Randomised controlled trials (RCTs) comparing transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) have significantly influenced treatment guidelines for aortic stenosis, expanding the use of TAVI into lower risk populations. However, the patients enrolled in the SAVR arms of these trials may differ from those typically undergoing SAVR in routine clinical practice. This study aims to critically assess the representativeness of SAVR patients in t... Abstract

The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland, 8 2 2025, Pages S1479-666X(25)00123-4 Bridging generational gaps in Surgery: A narrative review on values, well-being, and training preferences. Huizing F, Sier VQ, Sark AD, Snijders HS, van der Vorst JR, Schmitz RF, Schepers A, Blok JJ, Future Surgeon Initiative

Background and purpose: Intergenerational differences in surgery create both challenges and opportunities. While differening perspectives and expectations may deter younger generations from pursuing surgical careers, it is crucial to balance these with the core values that define the surgical profession. This narrative review was conducted to better understand how the profession needs to evolve. Methods: A structured literature search on generational changes in surgery was conducted using PubMed... Abstract

The international journal of cardiovascular imaging, Volume 41, Issue 8, 5 1 2025, Pages 1577-1587 Incremental prognostic value of left atrial reservoir strain after ST-segment elevation myocardial infarction for the prediction of new-onset atrial fibrillation. Caunite L, Myagmardorj R, Galloo X, Laenens D, Stassen J, Nabeta T, Yedidya I, Meucci MC, Kuneman JH, van den Hoogen IJ, van Rosendael SE, Wu HW, van den Brand VM, Giuca A, Trusinskis K, Marsan NA, Bax JJ, van der Bijl P

New-onset atrial fibrillation (AF) affects up to 21% of ST-segment elevation myocardial infarction (STEMI) patients. The value of LA reservoir strain to predict new-onset AF in a STEMI population has not been thoroughly investigated. We aimed to explore the incremental value of LA reservoir strain for predicting new-onset AF post-STEMI. Data were analyzed retrospectively from an ongoing STEMI registry. LA reservoir strain Abstract

Waste management (New York, N.Y.), Volume 205, 4 1 2025, Pages 115003 Coupling of chemical deconstruction and pyrolysis to upcycle metallized multilayer plastic films. Kulas D, Aloba S, Noecker A, Putman L, Meinholz C, Garland K, Henry J, Flores H, Chipkar S, Zolghadr A, Techtmann S, Ong R, Shonnard D

Multilayer metallized plastic films are popular packaging materials that are not currently recycled due to their complex multi-material make-up. In this study, a sequential pathway combining chemical, thermal and biological techniques was introduced to recycle military multilayer packaging made up of Polyethylene Terephthalate (PET), Polyethylene (PE), and aluminum. Chemical deconstruction using 10 wt% aqueous ammonia was able to selectively depolymerize the PET layer at a conversion close to 10... Abstract

EClinicalMedicine, Volume 85, 4 1 2025, Pages 103342 Intravascular lithotripsy for the treatment of calcified coronary lesions in individuals of advanced age: a post-hoc analysis of the multicentre, prospective BENELUX-IVL study. Oliveri F, García PV, van Oort MJH, Phagu A, Al Amri I, Bingen BO, Paradies V, Mincione G, Claessen BE, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, Mandurino-Mirizzi A, Van der Kley F, Jukema JW, Montero-Cabezas JM

Background: Patients of advanced age are frequently underrepresented or excluded from major clinical trials, leading to limited evidence in this population and a reliance on data extrapolated from younger populations. The present study aims to compare and evaluate the safety and efficacy of intravascular lithotripsy (IVL) for the treatment of calcified coronary lesions in individuals of advanced age and in younger populations. Methods: In this post-hoc analysis, from the ongoing prospective, mul... Abstract

International journal of radiation oncology, biology, physics, Volume 123, Issue 4, 3 1 2025, Pages 1004-1017 Health-Related Quality of Life in Patients Treated for Nonmetastatic Muscle-Invasive Bladder Cancer: Radical Cystectomy Versus Bladder-Preserving Therapy. Brück K, Atema V, Leliveld AM, Franckena M, Meijer RP, van der Heijden MS, Donders AR, Witjes JA, Uyl-de Groot CA, van Hoogstraten LMC, Kiemeney LA, Boormans JL, Aben KKH, Hulshof MCCM, CRAC study group and the BlaZIB study group

Purpose: Patients with nonmetastatic muscle-invasive bladder cancer (MIBC) can be treated with either radical cystectomy (RC) or bladder-preserving therapy (BPT). Contemporary data on the impact of these treatments on health-related quality of life (HRQOL) are lacking. Methods and materials: In our prospective national cohort study, patients were invited to complete HRQOL questionnaires at baseline, 12 and 24 months after diagnosis. We included patients with nonmetastatic MIBC, treated with eith... Abstract

Cited 1 times since 2025 (2.7 per year) source: EuropePMC

Arthritis & rheumatology (Hoboken, N.J.), Volume 77, Issue 11, 2 1 2025, Pages 1560-1572 Differences in Dynamics of Specific Antinuclear Antibodies and Their Susceptibility to B Cell-Targeting Treatment in Patients With Systemic Lupus Erythematosus. van Dooren HJ, van Schaik M, Dorjée AL, Arends EJ, Mackay M, Cooney L, Fox DA, Wofsy D, Smilek D, Aranow C, Dall'Era M, Huizinga TWJ, van Kooten C, Toes REM, Diamond B, Teng YKO, Suurmond J

Objective: The presence of antinuclear antibodies (ANAs) is characteristic for systemic lupus erythematosus (SLE). Antibody dynamics over time are thought to reflect the cellular source of ANAs and their therapeutic targetability. Anti-double-stranded DNA (anti-dsDNA) is the most prevalent and well-studied of all ANAs, and fluctuations in anti-dsDNA serum levels are associated with disease activity. Antibody dynamics of other ANAs, such as antibodies targeting RNA-binding proteins (RBPs), are of... Abstract

The Prostate, Volume 85, Issue 13, 2 1 2025, Pages 1168-1180 Transcriptomic Signatures of Monocyte-Derived Macrophages Associate With Androgen Receptor Pathway Inhibitor Progression in Prostate Cancer. Sharifi MN, Heninger E, Bootsma ML, Recchia EE, Breneman MT, Taylor AK, Zhao SG, LeBeau AM, Kosoff D

Background: Androgen receptor pathway inhibitors (ARPIs) have significantly improved clinical outcomes for patients with metastatic prostate cancer (PC) but acquired ARPI resistance remains universal. Maximizing ARPI treatment duration is crucial to optimal clinical outcomes, but current clinical tools to detect acquired ARPI resistance, including serum Prostate Specific Antigen (PSA) and radiographic disease monitoring, are limited in both sensitivity and specificity. Since prostate cancer dise... Abstract

European heart journal. Cardiovascular Imaging, Volume 26, Issue 8, 1 1 2025, Pages 1466-1474 Left ventricular dilatation in patients with significant aortic regurgitation: association with outcome. Lopez Santi P, Bernard J, Fortuni F, Butcher SC, Meucci MC, Sarrazyn C, Chua AP, Nabeta T, Zhang J, Popescu BA, Tay ELW, Yiu KH, Clavel MA, Pibarot P, Bax JJ, Ajmone Marsan N

Aims: Left ventricular (LV) dilatation is an important prognostic factor in patients with aortic regurgitation (AR). Although current guidelines recommend the use of LV end-systolic diameter index (LVESDi) to indicate the need for intervention, recent studies suggested that LV end-systolic volume index (LVESVi) may more accurately characterize LV remodelling.The present study aims to evaluate, in a multi-centre setting, whether combining LV linear and volumetric measures could improve risk strat... Abstract