Research

Publications

Below you can find a list of our published research.

9543 results

Cited 61 times since 2022 (18.4 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 80, Issue 5, 1 1 2022, Pages 545-561 Standardized Definitions for Bioprosthetic Valve Dysfunction Following Aortic or Mitral Valve Replacement: JACC State-of-the-Art Review. Pibarot P, Herrmann HC, Wu C, Hahn RT, Otto CM, Abbas AE, Chambers J, Dweck MR, Leipsic JA, Simonato M, Rogers T, Sathananthan J, Guerrero M, Ternacle J, Wijeysundera HC, Sondergaard L, Barbanti M, Salaun E, Généreux P, Kaneko T, Landes U, Wood DA, Deeb GM, Sellers SL, Lewis J, Madhavan M, Gillam L, Reardon M, Bleiziffer S, O'Gara PT, Rodés-Cabau J, Grayburn PA, Lancellotti P, Thourani VH, Bax JJ, Mack MJ, Leon MB, Heart Valve Collaboratory

Bioprosthetic valve dysfunction (BVD) and bioprosthetic valve failure (BVF) may be caused by structural or nonstructural valve dysfunction. Both surgical and transcatheter bioprosthetic valves have limited durability because of structural valve deterioration. The main objective of this summary of experts participating in a virtual workshop was to propose standardized definitions for nonstructural and structural BVD and BVF following aortic or mitral biological valve replacement with the goal of... Abstract

Cited 35 times since 2022 (10.6 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 80, Issue 5, 1 1 2022, Pages 527-544 Bioprosthetic Aortic Valve Hemodynamics: Definitions, Outcomes, and Evidence Gaps: JACC State-of-the-Art Review. Herrmann HC, Pibarot P, Wu C, Hahn RT, Tang GHL, Abbas AE, Playford D, Ruel M, Jilaihawi H, Sathananthan J, Wood DA, De Paulis R, Bax JJ, Rodes-Cabau J, Cameron DE, Chen T, Del Nido PJ, Dweck MR, Kaneko T, Latib A, Moat N, Modine T, Popma JJ, Raben J, Smith RL, Tchetche D, Thomas MR, Vincent F, Yoganathan A, Zuckerman B, Mack MJ, Leon MB, Heart Valve Collaboratory

A virtual workshop was organized by the Heart Valve Collaboratory to identify areas of expert consensus, areas of disagreement, and evidence gaps related to bioprosthetic aortic valve hemodynamics. Impaired functional performance of bioprosthetic aortic valve replacement is associated with adverse patient outcomes; however, this assessment is complicated by the lack of standardization for labelling, definitions, and measurement techniques, both after surgical and transcatheter valve replacement.... Abstract

Cited 19 times since 2022 (5.7 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 80, Issue 7, 1 1 2022, Pages 666-676 Prevalence and Prognostic Implications of Discordant Grading and Flow-Gradient Patterns in Moderate Aortic Stenosis. Stassen J, Ewe SH, Singh GK, Butcher SC, Hirasawa K, Amanullah MR, Pio SM, Sin KYK, Ding ZP, Sia CH, Chew NWS, Kong WKF, Poh KK, Leon MB, Pibarot P, Delgado V, Marsan NA, Bax JJ

Background: The prognostic implications of discordant grading in severe aortic stenosis (AS) are well known. However, the prevalence of different flow-gradient patterns and their prognostic implications in moderate AS are unknown. Objectives: The purpose of this study was to investigate the occurrence and prognostic implications of different flow-gradient patterns in patients with moderate AS. Methods: Patients with moderate AS (aortic valve area >1.0 and ≤1.5 cm2) were identified and divided... Abstract

Cited 11 times since 2022 (3.3 per year) source: EuropePMC

Research and practice in thrombosis and haemostasis, Volume 6, Issue 6, 1 1 2022, Pages e12809 Lupus anticoagulant associates with thrombosis in patients with COVID-19 admitted to intensive care units: A retrospective cohort study. Noordermeer T, Schutgens REG, Visser C, Rademaker E, de Maat MPM, Jansen AJG, Limper M, Cremer OL, Kruip MJHA, Endeman H, Maas C, de Laat B, Urbanus RT, Dutch COVID & Thrombosis Coalition (DCTC)

Background: Thrombosis is a frequent and severe complication in patients with coronavirus disease 2019 (COVID-19) admitted to the intensive care unit (ICU). Lupus anticoagulant (LA) is a strong acquired risk factor for thrombosis in various diseases and is frequently observed in patients with COVID-19. Whether LA is associated with thrombosis in patients with severe COVID-19 is currently unclear. Objective: To investigate if LA is associated with thrombosis in critically ill patients with COVID-... Abstract

Cited 16 times since 2022 (4.8 per year) source: EuropePMC

International journal of molecular sciences, Volume 23, Issue 15, 29 5 2022, Pages 8418 Targeting Fibronectin to Overcome Remyelination Failure in Multiple Sclerosis: The Need for Brain- and Lesion-Targeted Drug Delivery. van Schaik PEM, Zuhorn IS, Baron W

Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease with unknown etiology that can be characterized by the presence of demyelinated lesions. Prevailing treatment protocols in MS rely on the modulation of the inflammatory process but do not impact disease progression. Remyelination is an essential factor for both axonal survival and functional neurological recovery but is often insufficient. The extracellular matrix protein fibronectin contributes to the inhibitory enviro... Abstract

Cited 5 times since 2022 (1.5 per year) source: EuropePMC

Infant behavior & development, Volume 68, 29 5 2022, Pages 101751 Infants' sensitivity to emotional expressions in actions: The contributions of parental expressivity and motor experience. Schröer L, Çetin D, Vacaru SV, Addabbo M, van Schaik JE, Hunnius S

Actions can convey information about the affective state of an actor. By the end of the first year, infants show sensitivity to such emotional information in actions. Here, we examined the mechanisms contributing to infants' developing sensitivity to emotional action kinematics. We hypothesized that this sensitivity might rely on two factors: a stable motor representation of the observed action to be able to detect deviations from how it would typically be performed and experience with emot... Abstract

Cited 41 times since 2022 (12.4 per year) source: EuropePMC

Allergy, Volume 77, Issue 11, 29 5 2022, Pages 3398-3407 Patient-centered dupilumab dosing regimen leads to successful dose reduction in persistently controlled atopic dermatitis. Spekhorst LS, Bakker D, Drylewicz J, Rispens T, Loeff F, Boesjes CM, Thijs J, Romeijn GLE, Loman L, Schuttelaar ML, van Wijk F, de Graaf M, de Bruin-Weller MS

Background: At present, no real-world studies are available on different dupilumab dosing regimens in controlled atopic dermatitis (AD). The aim of this study was to clinically evaluate a patient-centered dupilumab dosing regimen in patients with controlled AD and to relate this to serum drug levels and serum biomarkers. Methods: Ninety adult AD patients from the prospective BioDay registry were included based on their dupilumab administration interval according to a predefined patient-centered... Abstract

Cited 5 times since 2022 (1.5 per year) source: EuropePMC

JMIR formative research, Volume 6, Issue 7, 28 4 2022, Pages e38263 COVID-box Experiences of Patients and Health Care Professionals (COVID-box Project): Single-Center, Retrospective, Observational Study. Dirikgil E, Brons K, Duindam M, Groeneveld GH, Geelhoed JJM, Heringhaus C, van der Boog PJM, Rabelink TJ, Bos WJW, Chavannes NH, Atsma DE, Teng YKO

Background: During the COVID-19 pandemic, several home monitoring programs have described the success of reducing hospital admissions, but only a few studies have investigated the experiences of patients and health care professionals. Objective: The objective of our study was to determine patients' and health care professionals' experiences and satisfaction with employing the COVID-box. Methods: In this single-center, retrospective, observational study, patients and health care profess... Abstract

Cited 3 times since 2022 (0.9 per year) source: EuropePMC

Journal of internal medicine, Volume 292, Issue 6, 27 4 2022, Pages 892-903 Thyroid antibodies and levothyroxine effects in subclinical hypothyroidism: A pooled analysis of two randomized controlled trials. Lyko C, Blum MR, Abolhassani N, Stuber MJ, Del Giovane C, Feller M, Moutzouri E, Oberle J, Jungo KT, Collet TH, den Elzen WPJ, Poortvliet RKE, Du Puy RS, Dekkers OM, Trompet S, Jukema JW, Aujesky D, Quinn T, Westendorp R, Kearney PM, Gussekloo J, Van Heemst D, Mooijaart SP, Bauer DC, Rodondi N

Background: Antithyroid antibodies increase the likelihood of developing overt hypothyroidism, but their clinical utility remains unclear. No large randomized controlled trial (RCT) has assessed whether older adults with subclinical hypothyroidism (SHypo) caused by autoimmune thyroid disease derive more benefits from levothyroxine treatment (LT4). Objective: To determine whether older adults with SHypo and positive antibodies derive more clinical benefits from LT4 than those with negative antibo... Abstract

Cited 7 times since 2022 (2.1 per year) source: EuropePMC

Frontiers in immunology, Volume 13, 27 4 2022, Pages 915687 In rheumatoid arthritis inflamed joints share dominant patient-specific B-cell clones. Musters A, Balzaretti G, van Schaik BDC, Jongejan A, van der Weele L, Tas SW, van Kampen AHC, de Vries N

Background: In patients with rheumatoid arthritis (RA) different joints were shown to share the same dominant T-cell clones, suggesting shared characteristics of the inflammatory process and indicating that strategies to selectively target the antigen receptor might be feasible. Since T- and B-lymphocytes closely interact in adaptive responses, we analysed to what extent different joints also share dominant B-cell clones. Methods: In 11 RA patients, quantitative B-cell receptor (BCR) repertoire... Abstract

Cited 4 times since 2022 (1.2 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 31, Issue 1, 27 4 2022, Pages 16-20 The Netherlands Heart Tissue Bank : Strengthening the cardiovascular research infrastructure with an open access Cardiac Tissue Repository. Henkens MTHM, van Ast JF, Te Riele ASJM, Houweling AC, Amin AS, Nijveldt R, Antoni ML, Li X, Wehrens SMT, von der Thüsen JH, Damman K, Ter Horst EN, Manintveld OC, Abma-Schouten RY, Niessen HWM, Silljé HHW, Jukema JW, Doevendans PA

Aim: Cardiac diseases remain a leading cause of cardiovascular disease (CVD) related hospitalisation and mortality. That is why research to improve our understanding of pathophysiological processes underlying cardiac diseases is of great importance. There is a strong need for healthy and diseased human cardiac tissue and related clinical data to accomplish this, since currently used animal and in vitro disease models do not fully grasp the pathophysiological processes observed in humans. This de... Abstract

Cited 5 times since 2022 (1.5 per year) source: EuropePMC

Current heart failure reports, Volume 19, Issue 5, 25 4 2022, Pages 255-266 Change of Heart: the Epitranscriptome of Small Non-coding RNAs in Heart Failure. Woudenberg T, Kruyt ND, Quax PHA, Nossent AY

Purpose of review: Small non-coding RNAs regulate gene expression and are highly implicated in heart failure. Recently, an additional level of post-transcriptional regulation has been identified, referred to as the epitranscriptome, which encompasses the body of post-transcriptional modifications that are placed on RNA molecules. In this review, we summarize the current knowledge on the small non-coding RNA epitranscriptome in heart failure. Recent findings: With the rise of new methods to study... Abstract

Cited 17 times since 2022 (5.1 per year) source: EuropePMC

Philosophical transactions of the Royal Society of London. Series B, Biological sciences, Volume 377, Issue 1859, 25 4 2022, Pages 20210098 A convergent interaction engine: vocal communication among marmoset monkeys. Burkart JM, Adriaense JEC, Brügger RK, Miss FM, Wierucka K, van Schaik CP

To understand the primate origins of the human interaction engine, it is worthwhile to focus not only on great apes but also on callitrichid monkeys (marmosets and tamarins). Like humans, but unlike great apes, callitrichids are cooperative breeders, and thus habitually engage in coordinated joint actions, for instance when an infant is handed over from one group member to another. We first explore the hypothesis that these habitual cooperative interactions, the marmoset interactional ethology,... Abstract

Cited 5 times since 2022 (1.5 per year) source: EuropePMC

Philosophical transactions of the Royal Society of London. Series B, Biological sciences, Volume 377, Issue 1859, 25 4 2022, Pages 20210106 Social tolerance and interactional opportunities as drivers of gestural redoings in orang-utans. Fröhlich M, van Schaik CP

Communicative repair is a fundamental and universal element of interactive language use. It has been suggested that the persistence and elaboration after communicative breakdown in nonhuman primates constitute two evolutionary building blocks of this capacity, but the conditions favouring it are poorly understood. Because zoo-housed individuals of some species are more social and more terrestrial than in the wild, they should be more likely to show gestural redoings (i.e. both repetition and ela... Abstract

Cited 3 times since 2022 (0.9 per year) source: EuropePMC

International journal of environmental research and public health, Volume 19, Issue 15, 25 4 2022, Pages 9062 Posterior Tibial Nerve Stimulation in Children with Lower Urinary Tract Dysfunction: A Mixed-Methods Analysis of Experiences, Quality of Life and Treatment Effect. De Wall LL, Bekker AP, Oomen L, Janssen VACT, Kortmann BBM, Heesakkers JPFA, Oerlemans AJM

Background: Posterior tibial nerve stimulation (PTNS) is one of the treatment modalities for children with therapy-refractory lower urinary tract dysfunction (LUTD). This study used a mixed-methods analysis to gain insight into the experiences of children treated with PTNS and their parents, the effect of treatment on quality of life (QOL) and the effect of PTNS on urinary symptoms. Methods: Quantitative outcomes were assessed through a single-centre retrospective chart analysis of all children... Abstract

Cited 27 times since 2022 (8.1 per year) source: EuropePMC

Alimentary pharmacology & therapeutics, Volume 56, Issue 6, 23 4 2022, Pages 1044-1054 Real-world experience of switching from intravenous to subcutaneous vedolizumab maintenance treatment for inflammatory bowel diseases. Volkers A, Straatmijer T, Duijvestein M, Sales A, Levran A, van Schaik F, Maljaars J, Gecse K, Ponsioen C, Grootjans J, Hanzel J, Tack G, Jansen J, Hoentjen F, de Boer N, van der Marel S, Dijkstra G, Oldenburg B, Löwenberg M, van der Meulen A, D Haens G, IBD center Amsterdam and the Dutch Initiative on Crohn and Colitis

Background: Subcutaneous (SC) vedolizumab is effective in inflammatory bowel diseases (IBD) when administered after induction with two infusions. Aim: To assess the effectiveness, safety and pharmacokinetics of a switch from intravenous (IV) to SC maintenance vedolizumab in patients with IBD METHODS: In this prospective cohort study, patients with IBD who had ≥4 months IV vedolizumab were switched to SC vedolizumab. We studied the time to discontinuation of SC vedolizumab, adverse events (AEs),... Abstract

Cited 5 times since 2022 (1.5 per year) source: EuropePMC

Archives of psychiatric nursing, Volume 41, 23 4 2022, Pages 96-102 Examination of individuals' depression, anxiety, and stress levels during the COVID-19 pandemic in Turkey. Erdoğan S, Can AA, Abiç A, Yilmaz DV

Purpose: This research was conducted to determine the depression, anxiety, and stress levels of individuals during the COVID-19 epidemic. In addition, the compatibility of the Depression-Anxiety-Stress Scale (DASS-21) scale results with the participants' feeling depressed, anxious, and stressed were examined. Design and methods: The sample of the study consisted of 870 individuals over the age of 18 between May-August 2021. The data of the study were collected online, using the personal inf... Abstract

Cited 7 times since 2022 (2.1 per year) source: EuropePMC

Endocrine connections, Volume 11, Issue 8, 21 3 2022, Pages e220276 Resting energy expenditure in children at risk of hypothalamic dysfunction. Van Schaik J, Burghard M, Lequin MH, van Maren EA, van Dijk AM, Takken T, Rehorst-Kleinlugtenbelt LB, Bakker B, Meijer L, Hoving EW, Fiocco M, Schouten-van Meeteren AYN, Tissing WJE, van Santen HM

Objective: Children with suprasellar brain damage are at risk of hypothalamic dysfunction (HD). HD may lead to decreased resting energy expenditure (REE). Decreased REE, however, is not present in all children with HD. Our aim was to assess which children suspect for HD have low REE, and its association with clinical severity of HD or radiological hypothalamic damage. Patients and methods: A retrospective cohort study was performed. Measured REE (mREE) of children at risk of HD was compared to p... Abstract

Cited 8 times since 2022 (2.4 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 115, Issue 6, 21 3 2022, Pages 1396-1402 The Aortic Root in Acute Type A Dissection: Repair or Replace? Arabkhani B, Verhoef J, Tomšič A, van Brakel TJ, Hjortnaes J, Klautz RJM

Background: The effect of an "aggressive" approach on the aortic root in acute type A aortic dissection (ATAAD) remains insufficiently explored. Methods: Retrospective analysis was conducted between 1992 and 2020 of a single-center, prospective cohort of consecutive patients aged ≥18 years diagnosed with ATAAD. Patients were divided into 2 groups: aortic root replacement (ARR; prosthetic or valve-sparing root replacement, n = 141) and conservative root approach (CRA; root sparing of pa... Abstract

Cited 11 times since 2022 (3.3 per year) source: EuropePMC

International journal of cardiology. Heart & vasculature, Volume 42, 19 3 2022, Pages 101086 Dyspnea in patients with atrial fibrillation: Mechanisms, assessment and an interdisciplinary and integrated care approach. van der Velden RMJ, Hermans ANL, Pluymaekers NAHA, Gawalko M, Elliott A, Hendriks JM, Franssen FME, Slats AM, van Empel VPM, Van Gelder IC, Thijssen DHJ, Eijsvogels TMH, Leue C, Crijns HJGM, Linz D, Simons SO

Atrial fibrillation (AF) is the most common sustained heart rhythm disorder and is often associated with symptoms that can significantly impact quality of life and daily functioning. Palpitations are the cardinal symptom of AF and many AF therapies are targeted towards relieving this symptom. However, up to two-third of patients also complain of dyspnea as a predominant self-reported symptom. In clinical practice it is often challenging to ascertain whether dyspnea represents an AF-related sympt... Abstract