Research

Publications

Below you can find a list of our published research.

7365 results

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology, Volume 80, 31 5 2025, Pages 107789 Aortic wall lamellar structure in phylogeny and in humans: insights from bicuspid and tricuspid aortic valve morphology. Bacour N, Zafar M, Kargin N, Zinganshin B, Poelmann R, Klautz RJM, Elefteriades J, Grewal N

Objective: Despite a voluminous literature on aortopathy, comparatively little attention has been paid to the lamellar architecture of the aortic wall, including the number and distribution of these layers. This study compares the lamellar organization of the developing aorta in individuals with a bicuspid (BAV) versus tricuspid aortic valve (TAV) and includes a literature review on aortic lamellae in mammals and adult humans. Methods: Non-dilated ascending aortic wall samples (n = 83) were anal... Abstract

American heart journal, 31 5 2025, Pages 107296 Routine versus selective protamine administration to reduce bleeding after TAVI: Rationale and Design of the POPular ACE TAVI trial. Overduin DC, van Ginkel DJ, Dubois C, Lesizza P, Broeze GM, Montero-Cabezas JM, Rosseel L, van der Kley F, van Nuland PJ, Smits TP, Hemelrijk KI, Aarts HM, Rensing BJWM, Timmers L, Swaans MJ, Sonker U, Veenstra L, van 't Hof AWJ, Peper J, Tijssen JGP, Delewi R, Vriesendorp PA, Ten Berg JM

Background: Unfractionated heparin is routinely used during transcatheter aortic valve implantation (TAVI) to reduce catheter thrombosis and thromboembolism. Protamine reverses the effect of heparin and may lower bleeding risk, but it can also trigger severe allergic reactions. Robust data on the safety and efficacy of routine protamine administration after TAVI is lacking. Methods: The 'Routine Versus Selective Protamine Administration to Reduce Bleeding Complications After Transcatheter A... Abstract

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 31 5 2025, Pages S0894-7317(25)00608-X Reply to "Optimizing clinical applicability of left atrial strain index in patients with heart failure with preserved ejection fraction". Chua AP, Marsan NA

Abstract

Annals of vascular surgery, 31 5 2025, Pages S0890-5096(25)00695-8 Rupture risk of large abdominal aortic aneurysms: a scoping review. Paping JHM, Bulder RMA, Lancaster E, Chang RW, Putter H, Hamming JF, Lindeman JH

Objectives: Abdominal Aortic Aneurysm (AAA) management is currently dictated by the 55 mm intervention threshold. Whilst it has been suggested that this intervention threshold is too conservative, the rupture risk of AAAs larger than 55 mm is discussed differently. This scoping review aims to critically summarize and review the available evidence with respect to the rupture risk of larger AAA. Methods: A quantitative and qualitative evaluation of the available literature on the rupture risk of l... Abstract

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 30 5 2025, Pages euaf276 The Sidecar 2.0 (S-ICD Registry in European Paediatric and Young Adult Patients with Congenital Heart Defects 2.0): An Analysis of European S-ICD Clinical Practice and its Evolution in Paediatric Patients. Silvetti MS, Bruyndonckx L, Waldmann V, Gebauer R, Környei L, Ksiazczyk T, Illikova V, Tavacova T, Noguer FR, Kwiatkowska J, Pazzano V, Wilkin M, Paech C, Fésüs G, Egorova AD, Wieniawski P, Gandara NR, Kempa M, Battipaglia I, Klehs S, Chalupka M, Maltret A, Knops RE, Janousek J, Blom NA, Lovecchio M, Valsecchi S, Drago F

Background: Subcutaneous implantable cardioverter-defibrillators (S-ICD) are effective in patients who require protection from sudden cardiac death while avoiding the long-term risks associated with transvenous leads. However, data on their real-world performance in paediatric and young patients remain limited. Objective: To evaluate the safety and efficacy of S-ICDs in a large, multicentre cohort of paediatric and young patients across Europe, with a focus on contemporary implantation practices... Abstract

JACC. Cardiovascular imaging, 30 5 2025, Pages S1936-878X(25)00549-2 Can Cardiac Computed Tomography Refine Prognosis in Tricuspid Regurgitation? Ajmone Marsan N

Abstract

Scientific reports, Volume 15, Issue 1, 30 5 2025, Pages 38074 Safety trial assessing 1.77 cm2 H2O2 producing electrochemical bandages on healthy human skin. Kies PJ, Kim WJ, Fleming D, Bozyel I, Holtegaard S, Shrivastava S, Schwartz K, Schwieder S, Beyenal H, Patel R

Mammalian skin maintains complex repair mechanisms after barrier disruption. Chronic wounds develop when these events are not efficiently completed, increasing infection risk. With ~2% of the population afflicted yearly, chronic wound care needs new technologies. Here, a Phase 0/1 study of one such therapeutic intervention is presented- H2O2 (hydrogen peroxide)-producing electrochemical bandages (e-bandages) controlled by wearable micropotentiostats. The e-bandages generate H2O2 in precise, micr... Abstract

Journal of cardiovascular translational research, 30 5 2025 RNA Therapeutics in Heart Failure. Deiman FE, de Graaf MM, Sillje HHW, Grote Beverborg N, Bomer N, van der Meer P

RNA-based therapeutics, such as small interfering RNAs (siRNAs), antisense oligonucleotides (ASOs) and messenger RNAs (mRNAs) are promising therapeutics that offer new avenues for targeting molecular pathways underlying heart failure (HF) pathogenesis. This review provides an overview of RNA therapeutics, detailing their mechanisms and potential applications in the treatment of HF. Key pathological processes in HF, including dysregulated calcium handling, myocardial fibrosis, oxidative stress, i... Abstract

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 29 5 2025, Pages 101975 3D distensibility of the aorta derived from 4D CMR in young and middle-aged adults with Marfan syndrome. Bosshardt D, Merton R, Schreurs BA, van Kimmenade RRJ, Nederveen AJ, Cox MGPJ, Scholte AJHA, Schrauben EM, Strijkers GJ, de Waard V, Robbers-Visser D, Groenink M, van Ooij P

Background: Acute aortic syndromes in Marfan syndrome (MFS) often occur before reaching the surgical diameter threshold, highlighting the need for new imaging biomarkers. Objectives: Aim was to compare CMR-derived aortic three-dimensional (3D) distensibility and displacement in MFS patients with or without a history of aortic root surgery (RR or native) and healthy volunteers. Methods: The participants underwent 3T CMR of the thoracic aorta using an accelerated non-contrast-enhanced, free breath... Abstract

European journal of pediatrics, Volume 184, Issue 11, 29 5 2025, Pages 719 Resurgent measles in Türkiye: predictors of severe disease in a nationwide paediatric cohort, 2023. Bursal B, Çelik T, Bingöl İ, Tosun D, Tuncay SA, Dağtekin ZK, Kaçmaz BB, Somer A, Dinleyici EÇ, Tezer H, Kara A, Türkiye Measles Study Group

Measles remains among the most important global health threats worldwide. A global increase has been reported since 2022, peaking in 2024, which heightens the risk of imported infections, particularly from unvaccinated children and adults, and measles outbreaks persist where immunity gaps remain. The aim of this study was to assess the clinical severity, complications, and outcomes of measles in hospitalised children as well as the effect of vaccination status on measles in Türkiye in 2023. We p... Abstract

Cited 1 times since 2025 (18.8 per year) source: EuropePMC

Lancet (London, England), 27 4 2025, Pages S0140-6736(25)02073-2 Percutaneous transcatheter valve replacement in individuals with mitral regurgitation unsuitable for surgery or transcatheter edge-to-edge repair: a prospective, multicountry, single-arm trial. Guerrero ME, Daniels DV, Makkar RR, Thourani VH, Asch FM, Pham M, Muhammad KI, Greenbaum AB, Vasquez A, Oldemeyer JB, Dahle TG, Rihal C, Morse MA, Rodriguez E, O'Neill BP, Russo M, Whisenant B, Yadav P, Yu X, Wang DD, Makar M, Baran DA, Mahoney P, Reddy G, Blanke P, Webb J, ENCIRCLE Trial Executive Committee and Study Investigators

Background: Patients with severe mitral regurgitation are frequently not candidates for surgery or transcatheter edge-to-edge repair (TEER). We aimed to evaluate 1-year outcomes of a novel percutaneous transseptal transcatheter mitral valve replacement (TMVR) system in patients unsuitable for surgery or TEER. Methods: In this prospective, multicentre, single-arm, pivotal trial, adult patients (aged ≥18 years) with symptomatic moderate-to-severe or severe mitral regurgitation who were not suitabl... Abstract

International journal of paediatric dentistry, 25 4 2025 Is Digital Anesthesia a Viable Alternative for Pain and Anxiety Control in Pediatric Dentistry? Atesci AA, Korkut Isik B, Yılmaz DO, Gergit B, Kılıc MÇ, Oncag RO

Background: Pain and anxiety during dental procedures remain major challenges in pediatric dentistry, particularly during local anesthesia administration. Aim: This study compared the effectiveness of digital anesthesia systems versus conventional infiltration and mandibular block techniques in managing pain, anxiety, and behavioral responses in pediatric dental patients. Design: Seventy-nine children aged 6-12 were randomly assigned to receive anesthesia via digital anesthesia system (DAS), inf... Abstract

Science advances, Volume 11, Issue 43, 24 4 2025, Pages eadx3794 The designer cytokine IC7Fc attenuates atherosclerosis development by targeting hyperlipidemia in mice. In Het Panhuis W, Thiemann E, van Dijk DMAH, Been B, Jarrett KE, Meurs A, Kooijman S, Hovingh MV, Modder M, van Os BW, Sluiter TJ, Blomberg N, Pronk ACM, Afkir S, Streefland TCM, Lalai RA, Taveras MO, Zhang S, Adams TE, Terry LV, Turpin-Nolan SM, de Vries MR, Giera M, Rose-John S, Zelcer N, de Boer JF, de Aguiar Vallim TQ, Febbraio MA, Rensen PCN, Schönke M

The chimeric cytokine IC7Fc conveys the metabolic signaling properties of the glycoprotein 130 receptor cytokines interleukin-6 and ciliary neurotrophic factor via membrane-bound signaling. IC7Fc was previously shown to slow the progression of type 2 diabetes mellitus, and here, we demonstrate its effect on atherosclerotic development. In APOE*3-Leiden.CETP mice, an atherosclerosis-prone model with a humanized lipoprotein metabolism, IC7Fc markedly lowered plasma triglyceride and total cholester... Abstract

Langenbeck's archives of surgery, Volume 410, Issue 1, 23 4 2025, Pages 309 Cut from the same cloth? investigating the personality of interventional and surgical cardiovascular specialists. Sier VQ, Verhagen MJ, Zegel M, Schmitz RF, van Rijswijk CSP, van Schaik J, Schmidt EJET, Hamming JF, Schepers A, Wijdh-den Hamer IJ, Burgmans MC, Hjortnaes J, van der Vorst JR, SUPER Consortium

Purpose: Considering that the treatment of patients with complex vascular disease requires multidisciplinary collaboration in teams and personality traits can impact team dynamics, we investigated the personality structures of vascular surgeons, cardiothoracic surgeons, and interventional radiologists using the validated big five model. Methods: A cross-sectional study utilizing the validated Big Five Inventory-2 (BFI-2) questionnaire. Corrected one-way analyses of variance were performed to com... Abstract

European heart journal, 23 4 2025, Pages ehaf835 Early outcomes of children with univentricular circulation undergoing Fontan surgery: the EuroFontan registry. Padalino MA, Constantine A, Bergonzoni E, Cao I, Horer J, Ono M, Staehler H, Sames-Dolzer E, Gierlinger G, Hazekamp M, Rijnberg FM, Galletti L, Butera G, Panebianco M, Meyns B, Van Puyvelde J, Yemets I, Bairamov E, Kansy A, Nosal M, Lenoir M, Angeli E, Careddu L, Martens T, Bove T, Napoleone CP, Lo Rito M, Giamberti A, Montanaro C, Marianeschi S, Agati S, Sarris GK, Protopapas E, Rocafort AG, Scrascia G, Meliota G, Vairo U, Michielon G, Gozzi A, Biffanti R, Castaldi B, Gregori D, Vedovelli L, Di Salvo G, Vida V, Dimopoulos K

Background and aims: The Fontan operation and its modifications have transformed the management of children with functional single ventricle physiology. While outcomes have improved, peri-operative complications remain common. This study aimed to assess early outcomes and complications following Fontan completion in a large international European cohort. Methods: The EuroFontan registry is a multicentre retrospective study involving 21 congenital heart disease and transplant centres across Europ... Abstract

JACC. Advances, Volume 4, Issue 11 Pt 1, 23 4 2025, Pages 102250 Drug-Coated Balloon After Intravascular Lithotripsy: Procedural and Clinical Outcome of the "Crack and Drug" Strategy. Oliveri F, van Oort MJH, Phagu AAS, Al Amri I, Bingen BO, Paradies V, Mincione G, Claessen BEPM, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, Mandurino-Mirizzi A, Van der Kley F, Jukema JW, Montero-Cabezas J

Background: Drug-eluting stents (DESs) after intravascular lithotripsy (IVL) have proven effective in calcified coronary lesions. However, evidence supporting drug-coated balloons (DCBs) after IVL remains limited. Objectives: We aimed to compare the technical success and 1-year clinical outcomes of IVL + DES vs IVL + DCB strategies for the treatment of balloon-crossable calcified coronary lesions. Methods: Patients undergoing percutaneous coronary intervention with IVL from the prospective BENEL... Abstract

Annals of surgical oncology, 23 4 2025 Accuracy of Predicting Residual Disease and Disease Progression During Active Surveillance for Esophageal Cancer. Gangaram Panday SSG, van Klaveren D, Lagarde SM, Lingsma HF, Mostert B, Coene PLO, Dekker JWT, Hartgrink HH, Heisterkamp J, Hutteman M, Kouwenhoven EA, Nieuwenhuijzen GAP, Pierie JP, van Sandick JW, Sosef MN, van der Zaag ES, van Lanschot JJB, Wijnhoven BPL, SANO Study Group

Background: To date, active surveillance has been non-inferior to standard surgery for patients with esophageal cancer, achieving a clinical complete response (CCR) after neoadjuvant chemoradiotherapy (nCRT). However, two thirds of patients have residual disease detected 12 weeks after nCRT and undergo surgery. At 12 weeks, nearly half of the patients with CCR will experience locoregional regrowth. This study aimed to identify routine predictive factors for achieving (sustained) CCR to improve p... Abstract

The American journal of cardiology, 22 4 2025, Pages S0002-9149(25)00656-3 Clinical and Technical Predictors of Adverse Cardiovascular Events Following Coronary Lithotripsy in the BENELUX-IVL Registry. van Oort MJH, Phagu AAS, Oliveri F, Bingen BO, Mincione G, Paradies V, Claessen BEPM, Dimitriu-Leen AC, Vossenberg TN, Kefer J, Mandurino-Mirizzi A, van der Kley F, Jukema JW, Amri IA, Montero-Cabezas JM

Intravascular lithotripsy (IVL) has emerged as a viable treatment option for calcified coronary lesions. This study aimed to identify clinical and procedural factors associated with major adverse cardiovascular events (MACE) following IVL. This retrospective analysis included 583 patients (72.9 ± 9 years, 74% male) treated with IVL for 612 lesions from the multicenter BENELUX-IVL registry (May 2019-December 2024). Kaplan-Meier analysis was performed to evaluate survival probability. Binary logis... Abstract

Heart (British Cardiac Society), 20 3 2025, Pages heartjnl-2025-326395 Ventricular arrhythmias during exercise in patients with mitral valve prolapse. van Wijngaarden AL, de Riva M, Sabbag A, El-Am E, Essayagh B, Michelena HI, Rahme SJ, Medina Inojosa J, Enriquez-Sarano M, Bax JJ, Ajmone Marsan N

Background: Mitral valve prolapse (MVP) can be associated with ventricular arrhythmias (VA), but little is known about the relationship between VA and exercise in these patients. The aim of this study was to assess the occurrence and severity of VA during exercise tests in patients with MVP, and to explore the association between VA during exercise and the occurrence of arrhythmic events during follow-up. Methods: In this multicentre study, 375 patients with MVP (58 (48-69) years, 53% male) who... Abstract

European heart journal, 17 3 2025, Pages ehaf791 Outcomes of moderate mixed aortic valve stenosis and regurgitation. Lopez Santi P, Bernard J, Chua A, Laenens D, Powers A, Abdoun K, Velders BJJ, Sarrazyn C, Springhetti P, Zhang J, Amanullah MR, Ewe SH, Yiu KH, Palmen M, Hjortnaes J, Pibarot P, Clavel MA, Bax JJ, Ajmone Marsan N

Background and aims: There are limited data on mortality in patients with moderate mixed aortic valve disease (MAVD), defined as the combination of moderate aortic stenosis (AS) and moderate aortic regurgitation (AR). Consequently, current guidelines lack specific recommendations for aortic valve replacement (AVR) in this population. This study aims to compare survival between moderate MAVD and isolated severe AS or severe AR, and to evaluate the impact of symptoms or left ventricular ejection f... Abstract