Research

Publications

Below you can find a list of our published research.

9543 results

Cited 1 times since 2022 (0.3 per year) source: EuropePMC

Methods in molecular biology (Clifton, N.J.), Volume 2478, 1 1 2022, Pages 677-700 Mechanics of Single Vimentin Intermediate Filaments Under Load. Schepers AV, Kraxner J, Lorenz C, Köster S

The eukaryotic cytoskeleton consists of three different types of biopolymers - microtubules, actin filaments, and intermediate filaments - and provides cells with versatile mechanical properties, combining stability and flexibility. The unique molecular structure of intermediate filaments leads to high extensibility and stability under load. With high laser power dual optical tweezers, the mechanical properties of intermediate filaments may be investigated, while monitoring the extension with fl... Abstract

Cited 17 times since 2022 (4.4 per year) source: EuropePMC

The Journal of clinical endocrinology and metabolism, Volume 107, Issue 2, 1 1 2022, Pages 512-524 The Cortisol Response of Male and Female Choroidal Endothelial Cells: Implications for Central Serous Chorioretinopathy. Brinks J, van Dijk EHC, Kiełbasa SM, Mei H, van der Veen I, Peters HAB, Sips HCM, Notenboom RGE, Quax PHA, Boon CJF, Meijer OC

Context: Central serous chorioretinopathy (CSC) is a severe ocular disease characterized by fluid accumulation under the retina and abnormalities in the underlying vascular layer, the choroid. CSC has a striking prevalence in males of 80% to 90% of total patients. Corticosteroids are the most pronounced extrinsic risk factor for CSC. Choroidal endothelial cells (CECs) are important for the vascular integrity of the choroid, but the effects of corticosteroid effects in these cells are unknown. Ob... Abstract

Cited 2 times since 2022 (0.5 per year) source: EuropePMC

Methods in molecular biology (Clifton, N.J.), Volume 2478, 1 1 2022, Pages 701-723 Quantifying the Interaction Strength Between Biopolymers. Lorenz C, Schepers AV, Köster S

The cytoskeleton consists of three types of biopolymers-actin filaments, microtubules, and intermediate filaments-and the interplay between these components is essential for many cellular functions such as cell migration, mitosis, and the mechanical response to external cues. In the cell, the interactions between the filaments are mediated by a myriad of cross-linkers and motor proteins; however, direct forces, mediated by electrostatics or hydrophobicity, may also play an important role. Here,... Abstract

Tijdschrift voor psychiatrie, Volume 64, Issue 9, 1 1 2022, Pages 574-579 [Guided discontinuation of antidepressants: approach and first results of a Dutch multidisciplinary outpatient clinic]. Dozeman E, van der Lande HJ, Bet PM, Fransen K, Jager I, Jonker J, Philippo E, Reisman-Dolman J, van Schaik DJF, Scholten W, van de Velde I, Verheijen V, van der Wart M, van Zon M, Batelaan N, Vinkers CH

Background: Discontinuation of antidepressant medication can be difficult due to withdrawal symptoms and relapse risk. Scientific evidence on the questions of who, when, and how to stop antidepressants is limited. In Amsterdam a multidisciplinary outpatient clinic was started to provide advice and guidance. Aim: To substantiate the design of the clinic. Central questions relate to knowing which patients are referred, the background of their request, and their experiences with the outpatient clin... Abstract

Tijdschrift voor psychiatrie, Volume 64, Issue 2, 1 1 2022, Pages 108-111 [Plea for a work policy aiming autonomy and recovery in child and adolescent psychiatry]. van Schaik HJ, Pelzer ACM

When a child or adolescent is admitted to a High & Intensive Care (HIC) unit for adolescents, this implies that they find themselves in a severe psychiatric crisis. The work policy aiming autonomy and recovery is a vision that has been implemented in the treatment method at the HIC unit for adolescents. This policy focuses on the recovery of young people, in which learning to understand their own story and learning taking responsibility, are essential components. Sharing these experience... Abstract

Cited 16 times since 2022 (4.1 per year) source: EuropePMC

Gut microbes, Volume 14, Issue 1, 1 1 2022, Pages 2060676 Enterobacteriaceae and Bacteroidaceae provide resistance to travel-associated intestinal colonization by multi-drug resistant Escherichia coli. Davies M, Galazzo G, van Hattem JM, Arcilla MS, Melles DC, de Jong MD, Schultsz C, Wolffs P, McNally A, Schaik WV, Penders J

Previous studies have shown high acquisition risks of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) among international travelers visiting antimicrobial resistance (AMR) hotspots. Although antibiotic use and travelers' diarrhea have shown to influence the ESBL-E acquisition risk, it remains largely unknown whether successful colonization of ESBL-E during travel is associated with the composition, functional capacity and resilience of the traveler's microbiome.... Abstract

Cited 19 times since 2022 (4.9 per year) source: EuropePMC

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, Volume 23, Issue 1, 1 1 2022, Pages 54-59 Establishing Entrustable Professional Activities in Pediatric Cardiac Critical Care. Werho DK, DeWitt AG, Owens ST, McBride ME, van Schaik S, Roth SJ

Objectives: Define a set of entrustable professional activities for pediatric cardiac critical care that are recognized as the core activities of the subspecialty by a diverse group of pediatric cardiac critical care physicians and that can be broadly and consistently applied irrespective of training pathway. Design: Mixed methods study with sequential integration of qualitative and quantitative data. Setting: Structured telephone interviews of pediatric cardiac critical care medical directors a... Abstract

Cited 127 times since 2022 (32.7 per year) source: EuropePMC

Proceedings of the National Academy of Sciences of the United States of America, Volume 119, Issue 1, 1 1 2022, Pages e2110877119 Coxiella burnetii inhibits host immunity by a protein phosphatase adapted from glycolysis. Zhang Y, Fu J, Liu S, Wang L, Qiu J, van Schaik EJ, Samuel JE, Song L, Luo ZQ

Coxiella burnetii is a bacterial pathogen that replicates within host cells by establishing a membrane-bound niche called the Coxiella-containing vacuole. Biogenesis of this compartment requires effectors of its Dot/Icm type IV secretion system. A large cohort of such effectors has been identified, but the function of most of them remain elusive. Here, by a cell-based functional screening, we identified the effector Cbu0513 (designated as CinF) as an inhibitor of NF-κB signaling. CinF is highly... Abstract

Cited 5 times since 2022 (1.3 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 23, Issue 2, 1 1 2022, Pages 266-274 Associations between dyspnoea, coronary atherosclerosis, and cardiovascular outcomes: results from the long-term follow-up CONFIRM registry. van Rosendael AR, Bax AM, van den Hoogen IJ, Smit JM, Al'Aref SJ, Achenbach S, Al-Mallah MH, Andreini D, Berman DS, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan K, Chow BJW, Cury RC, DeLago A, Feuchtner G, Hadamitzky M, Hausleiter J, Kaufmann PA, Kim YJ, Leipsic JA, Maffei E, Marques H, de Araújo Gonçalves P, Pontone G, Raff GL, Rubinshtein R, Villines TC, Gransar H, Lu Y, Peña JM, Lin FY, Shaw LJ, Narula J, Min JK, Bax JJ

Aims: The relationship between dyspnoea, coronary artery disease (CAD), and major cardiovascular events (MACE) is poorly understood. This study evaluated (i) the association of dyspnoea with the severity of anatomical CAD by coronary computed tomography angiography (CCTA) and (ii) to which extent CAD explains MACE in patients with dyspnoea. Methods and results: From the international COronary CT Angiography EvaluatioN for Clinical Outcomes: An InteRnational Multicenter (CONFIRM) registry, 4425 p... Abstract

Cited 2 times since 2022 (0.5 per year) source: EuropePMC

Methods in molecular biology (Clifton, N.J.), Volume 2458, 1 1 2022, Pages 215-229 Genome-Wide Mapping and Microscopy Visualization of Protein-DNA Interactions by pA-DamID. van Schaik T, Manzo SG, van Steensel B

Several methods have been developed to map protein-DNA interactions genome-wide in the last decades. Protein A-DamID (pA-DamID) is a recent addition to this list with distinct advantages. pA-DamID relies on antibody-based targeting of the bacterial Dam enzyme, resulting in adenine methylation of DNA in contact with the protein of interest. This m6A can then be visualized by microscopy, or mapped genome-wide. The main advantages of pA-DamID are an easy and direct visualization of DNA that is in c... Abstract

Cited 1 times since 2022 (0.3 per year) source: EuropePMC

The Journal of the Acoustical Society of America, Volume 151, Issue 1, 1 1 2022, Pages 500 Noise-robust text-dependent speaker identification using cochlear models. Islam MA, Xu Y, Monk T, Afshar S, van Schaik A

One challenging issue in speaker identification (SID) is to achieve noise-robust performance. Humans can accurately identify speakers, even in noisy environments. We can leverage our knowledge of the function and anatomy of the human auditory pathway to design SID systems that achieve better noise-robust performance than conventional approaches. We propose a text-dependent SID system based on a real-time cochlear model called cascade of asymmetric resonators with fast-acting compression (CARFAC)... Abstract

Cited 4 times since 2021 (1 per year) source: EuropePMC

Pediatric nephrology (Berlin, Germany), Volume 37, Issue 8, 31 5 2022, Pages 1867-1875 Impact of coronavirus disease-2019 on pediatric nephrology practice and education: an ESPN survey. Yazıcıoğlu B, Bakkaloğlu SA, European Society for Pediatric Nephrology

Background: Coronavirus disease-2019 (COVID-19) has been challenging for patients and medical staff. Radical changes have been needed to prevent disruptions in patient care and medical education. Methods: A web-based survey was sent to European Society for Pediatric Nephrology (ESPN) members via the ESPN mailing list to evaluate the effects of the COVID-19 pandemic on delivery of pediatric nephrology (PN) care and educational activities. There were ten questions with subheadings. Results: Sevent... Abstract

Cited 13 times since 2021 (3.3 per year) source: EuropePMC

Micromachines, Volume 13, Issue 1, 29 5 2022, Pages 49 Rapid Prototyping of Organ-on-a-Chip Devices Using Maskless Photolithography. Kasi DG, de Graaf MNS, Motreuil-Ragot PA, Frimat JMS, Ferrari MD, Sarro PM, Mastrangeli M, van den Maagdenberg AMJM, Mummery CL, Orlova VV

Organ-on-a-chip (OoC) and microfluidic devices are conventionally produced using microfabrication procedures that require cleanrooms, silicon wafers, and photomasks. The prototyping stage often requires multiple iterations of design steps. A simplified prototyping process could therefore offer major advantages. Here, we describe a rapid and cleanroom-free microfabrication method using maskless photolithography. The approach utilizes a commercial digital micromirror device (DMD)-based setup using... Abstract

Cited 14 times since 2021 (3.6 per year) source: EuropePMC

Annals of surgery, Volume 276, Issue 1, 28 4 2022, Pages 38-45 Pelvic Floor Rehabilitation After Rectal Cancer Surgery: A Multicenter Randomized Clinical Trial (FORCE Trial). van der Heijden JAG, Kalkdijk-Dijkstra AJ, Pierie JPEN, van Westreenen HL, Broens PMA, Klarenbeek BR, FORCE trial group

Objective: To investigate the effects of PFR after LAR compared to usual care without PFR. Summary of background data: Functional complaints, including fecal incontinence, often occur after LAR for rectal cancer. Controversy exists about the effectiveness of PFR in improving such postoperative functional outcomes. Methods: This was a multicenter, randomized controlled trial involving 17 Dutch centers. Patients after LAR for rectal cancer were randomly assigned (1:1) to usual care or PFR and stra... Abstract

Cited 2 times since 2021 (0.5 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 15, Issue 1, 23 4 2021, Pages e009886 Ultrasound-Guided Optogenetic Gene Delivery for Shock-Free Ventricular Rhythm Restoration. Nyns ECA, Jin T, Bart CI, Bax WH, Zhang G, Poelma RH, de Vries AAF, Pijnappels DA

Abstract

Cited 14 times since 2021 (3.6 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 35, Issue 5, 23 4 2021, Pages 486-494.e2 Left Atrial Deformation Imaging and Atrial Fibrillation in Patients with Rheumatic Mitral Stenosis. Stassen J, Butcher SC, Namazi F, Ajmone Marsan N, Bax JJ, Delgado V

Background: Atrial fibrillation (AF) is a frequent complication of rheumatic mitral stenosis (MS) and is associated with worse outcomes. Prediction of new-onset AF by assessing left atrial (LA) mechanics with speckle-tracking echocardiography might be useful for risk stratification and guiding therapeutic strategies. Therefore, the aim of this study was to assess the association of LA reservoir strain (LASr) and strain rate (LASRr) with AF at follow-up in patients with rheumatic MS. Methods: Lef... Abstract

Cited 9 times since 2021 (2.3 per year) source: EuropePMC

Seminars in musculoskeletal radiology, Volume 25, Issue 6, 22 4 2021, Pages 735-744 Orthobiologics: Diagnosis and Treatment of Common Tendinopathies. Van Schaik KD, Lee KS

Orthobiologics, including platelet-rich plasma, prolotherapy, and mesenchymal stem cells, are seeing increasing use in the treatment of osteoarthritis (OA), muscle injury, and tendinopathy. This article reviews the biology and applications of orthobiologics in tendons, muscles, and joints, and focuses on platelet-rich plasma (PRP). Clinical evidence-based literature related to the use of PRP in the treatment of rotator cuff injury, lateral epicondylosis, Achilles tendinopathy, plantar fasciitis,... Abstract

Cited 98 times since 2021 (25 per year) source: EuropePMC

Nature immunology, Volume 23, Issue 1, 22 4 2021, Pages 23-32 Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-19. Roukens AHE, Pothast CR, König M, Huisman W, Dalebout T, Tak T, Azimi S, Kruize Y, Hagedoorn RS, Zlei M, Staal FJT, de Bie FJ, van Dongen JJM, Arbous SM, Zhang JLH, Verheij M, Prins C, van der Does AM, Hiemstra PS, de Vries JJC, Janse JJ, Roestenberg M, Myeni SK, Kikkert M, Yazdanbakhsh M, Heemskerk MHM, Smits HH, Jochems SP, in collaboration with BEAT-COVID group, in collaboration with COVID-19 LUMC group

Systemic immune cell dynamics during coronavirus disease 2019 (COVID-19) are extensively documented, but these are less well studied in the (upper) respiratory tract, where severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates1-6. Here, we characterized nasal and systemic immune cells in individuals with COVID-19 who were hospitalized or convalescent and compared the immune cells to those seen in healthy donors. We observed increased nasal granulocytes, monocytes, CD11c+ natura... Abstract

Cited 3 times since 2021 (0.8 per year) source: EuropePMC

Acta chirurgica Belgica, Volume 122, Issue 2, 22 4 2021, Pages 77-84 Peri-operative nutrition in cardiovascular surgery: current pitfalls and future directions. Vinck EE, van Ierland KM, Rendón JC, Escobar JJ, Quintero Gómez A, Saldarriaga CI, van Brakel T, Klautz RJM, Cárdenas D

In the field of cardiovascular surgery, many areas are frequently evaluated to improve patient outcomes. Even though cardiac surgery has advanced significantly, peri-operative nutrition remains an area needing special attention and is under-considered in patient results. The three portions of cardiac surgical nutrition optimization are pre-operative, intra-operative and post-operative. All these, merit important clinical intervention which when done properly can significantly improve patient rec... Abstract

Cited 60 times since 2021 (15.3 per year) source: EuropePMC

Journal of advanced research, Volume 40, 22 4 2021, Pages 1-15 The microbiota of the grapevine holobiont: A key component of plant health. Bettenfeld P, Cadena I Canals J, Jacquens L, Fernandez O, Fontaine F, van Schaik E, Courty PE, Trouvelot S

Background: Grapevine is a woody, perennial plant of high economic importance worldwide. Like other plants, it lives in close association with large numbers of microorganisms. Bacteria, fungi and viruses are structured in communities, and each individual can be beneficial, neutral or harmful to the plant. In this sense, microorganisms can interact with each other and regulate plant functions (including immunity) and even provide new ones. Thus, the grapevine associated with its microbial communi... Abstract