Research

Publications

Below you can find a list of our published research.

9543 results

Cited 4 times since 2021 (0.9 per year) source: EuropePMC

The Journal of antimicrobial chemotherapy, Volume 76, Issue 6, 1 1 2021, Pages 1604-1613 National point prevalence study on carriage of multidrug-resistant microorganisms in Dutch long-term care facilities in 2018. van Kleef E, Wielders CCH, Schouls LM, Feenstra SG, Hertogh CMPM, Bonten MJM, van Weert Y, Tostmann A, van der Lubben M, de Greeff SC, PPO study group

Objectives: Long-term care facilities (LTCFs) may act as a reservoir of ESBL-producing Enterobacterales (ESBL-E) and carbapenemase-producing Enterobacterales (CPE) for hospitals and the general population. In this study, we estimated the prevalence and molecular epidemiology of rectal carriage with ESBL-E and CPE in residents of Dutch LTCFs between March 2018 and December 2018. Methods: LTCFs were geographically selected across the country. For each LTCF, a random sample of residents were tested... Abstract

Cited 5 times since 2021 (1.1 per year) source: EuropePMC

RMD open, Volume 7, Issue 2, 1 1 2021, Pages e001524 New risk model is able to identify patients with a low risk of progression in systemic sclerosis. van Leeuwen NM, Maurits M, Liem S, Ciaffi J, Ajmone Marsan N, Ninaber M, Allaart C, Gillet van Dongen H, Goekoop R, Huizinga T, Knevel R, De Vries-Bouwstra J

Objectives: To develop a prediction model to guide annual assessment of systemic sclerosis (SSc) patients tailored in accordance to disease activity. Methods: A machine learning approach was used to develop a model that can identify patients without disease progression. SSc patients included in the prospective Leiden SSc cohort and fulfilling the ACR/EULAR 2013 criteria were included. Disease progression was defined as progression in ≥1 organ system, and/or start of immunosuppression or death. U... Abstract

Cited 1 times since 2021 (0.2 per year) source: EuropePMC

Interactive cardiovascular and thoracic surgery, Volume 32, Issue 5, 1 1 2021, Pages 834-836 Repair of traumatic avulsion of the right bronchus in children using extracorporeal membrane oxygenation support. Ricciardi G, Putman LM, Hazekamp MG

Traumatic avulsion of the right main bronchus in children is usually caused by blunt trauma or traffic accidents. Primary repair by suturing is the preferred treatment. Lesions are life threatening and urgent or emergency surgical repair is indicated. We report our experience with 2 cases of traumatic avulsion of right bronchus in children successfully suture repaired with the use of extracorporeal membrane oxygenation. Abstract

Cited 44 times since 2021 (9.6 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 59, Issue 5, 1 1 2021, Pages 968-977 Long-term outcome after the arterial switch operation: 43 years of experience. van der Palen RLF, Blom NA, Kuipers IM, Rammeloo LAJ, Jongbloed MRM, Konings TC, Bouma BJ, Koolbergen DR, Hazekamp MG

Objectives: The objective of this study was to assess our 43-year experience with arterial switch operation (ASO) for transposition of the great arteries (TGA) by analysing cardiac outcome measures (hospital and late mortality, reoperations and catheter interventions, significant coronary artery obstruction) and to identify risk factors for reoperation and catheter interventions. Methods: A total of 490 patients who underwent ASO for TGA from 1977 to 2020 were included in this retrospective, sin... Abstract

European heart journal, Volume 42, Issue 18, 1 1 2021, Pages 1811 A case of tortuous anatomy: cervical aortic arch. van Driest FY, Stöger JL, Scholte AJHA, Jukema JW, Egorova AD

Abstract

Cited 195 times since 2021 (42.7 per year) source: EuropePMC

Science (New York, N.Y.), Volume 372, Issue 6545, 1 1 2021, Pages 984-989 3D genomics across the tree of life reveals condensin II as a determinant of architecture type. Hoencamp C, Dudchenko O, Elbatsh AMO, Brahmachari S, Raaijmakers JA, van Schaik T, Sedeño Cacciatore Á, Contessoto VG, van Heesbeen RGHP, van den Broek B, Mhaskar AN, Teunissen H, St Hilaire BG, Weisz D, Omer AD, Pham M, Colaric Z, Yang Z, Rao SSP, Mitra N, Lui C, Yao W, Khan R, Moroz LL, Kohn A, St Leger J, Mena A, Holcroft K, Gambetta MC, Lim F, Farley E, Stein N, Haddad A, Chauss D, Mutlu AS, Wang MC, Young ND, Hildebrandt E, Cheng HH, Knight CJ, Burnham TLU, Hovel KA, Beel AJ, Mattei PJ, Kornberg RD, Warren WC, Cary G, Gómez-Skarmeta JL, Hinman V, Lindblad-Toh K, Di Palma F, Maeshima K, Multani AS, Pathak S, Nel-Themaat L, Behringer RR, Kaur P, Medema RH, van Steensel B, de Wit E, Onuchic JN, Di Pierro M, Lieberman Aiden E, Rowland BD

We investigated genome folding across the eukaryotic tree of life. We find two types of three-dimensional (3D) genome architectures at the chromosome scale. Each type appears and disappears repeatedly during eukaryotic evolution. The type of genome architecture that an organism exhibits correlates with the absence of condensin II subunits. Moreover, condensin II depletion converts the architecture of the human genome to a state resembling that seen in organisms such as fungi or mosquitoes. In th... Abstract

Cited 9 times since 2021 (2 per year) source: EuropePMC

Journal of vascular surgery, Volume 74, Issue 3, 1 1 2021, Pages 1024-1032 Systematic review of embolization of type I endoleaks using liquid embolic agents. van Schaik TG, Meekel JP, Hoksbergen AWJ, de Vries R, Blankensteijn JD, Yeung KK

Objective: The long-term success of endovascular aneurysm repair (EVAR) is limited by complications, most importantly endoleaks. In case of (persistent) type I endoleak (T1EL), secondary intervention is indicated to prevent secondary aneurysm rupture. Different treatment options are suggested for T1ELs, such as endo anchors, (fenestrated) cuffs, embolization, or open conversion. Currently, the treatment of T1EL with liquid embolic agents is available; however, results are not yet addressed. This... Abstract

Cited 9 times since 2021 (2 per year) source: EuropePMC

Ultrastructural pathology, Volume 45, Issue 3, 1 1 2021, Pages 167-181 Effects of Theranekron and alpha-lipoic acid combined treatment on GAP-43 and Krox-20 gene expressions and inflammation markers in peripheral nerve injury. Sencar L, Coşkun G, Şaker D, Sapmaz T, Kara S, Çelenk A, Polat S, Yılmaz DM, Dağlıoğlu YK, Polat S

Peripheral nerve injury (PNI) is a major health problem that results in loss of motor and sensory functions. In treatment of PNI, various methods such as anastomosis, nerve grafts, nonneural tissue grafts, and nerve conduits are applied. In the present study, it was aimed to investigate the effects of Theranekron and Alpha-lipoic acid (ALA) combined treatment on nerve healing in experimental PNI by using histomorphometric, electron microscopic, immunohistochemical and molecular biological method... Abstract

Cited 159 times since 2021 (34.8 per year) source: EuropePMC

Emerging infectious diseases, Volume 27, Issue 5, 1 1 2021, Pages 1405-1415 Monitoring SARS-CoV-2 Circulation and Diversity through Community Wastewater Sequencing, the Netherlands and Belgium. Izquierdo-Lara R, Elsinga G, Heijnen L, Munnink BBO, Schapendonk CME, Nieuwenhuijse D, Kon M, Lu L, Aarestrup FM, Lycett S, Medema G, Koopmans MPG, de Graaf M

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly become a major global health problem, and public health surveillance is crucial to monitor and prevent virus spread. Wastewater-based epidemiology has been proposed as an addition to disease-based surveillance because virus is shed in the feces of ≈40% of infected persons. We used next-generation sequencing of sewage samples to evaluate the diversity of SARS-CoV-2 at the community level in the Netherlands and Belgium. Phylo... Abstract

Cited 2 times since 2021 (0.4 per year) source: EuropePMC

BJS open, Volume 5, Issue 3, 1 1 2021, Pages zraa065 Effects of hospital preference for endovascular repair on postoperative mortality after elective abdominal aortic aneurysm repair: analysis of the Dutch Surgical Aneurysm Audit. Lijftogt N, Vahl AC, Karthaus EG, van der Willik EM, Amodio S, van Zwet EW, Hamming JF, Dutch Society of Vascular Surgery, the Steering Committee of the Dutch Surgical Aneurysm Audit, and the Dutch Institute for Clinical Auditing

Background: Increased use of endovascular aneurysm repair (EVAR) and reduced open surgical repair (OSR), has decreased postoperative mortality after elective repair of abdominal aortic aneurysms (AAAs). The choice between EVAR or OSR depends on aneurysm anatomy, and the experience and preference of the vascular surgeon, and therefore differs between hospitals. The aim of this study was to investigate the current mortality risk difference (RD) between EVAR and OSR, and the effect of hospital pref... Abstract

Cited 6 times since 2021 (1.3 per year) source: EuropePMC

Lupus science & medicine, Volume 8, Issue 1, 1 1 2021, Pages e000472 Effectiveness of a multidisciplinary clinical pathway for women with systemic lupus erythematosus and/or antiphospholipid syndrome. Wind M, Hendriks M, van Brussel BTJ, Eikenboom J, Allaart CF, Lamb HJ, Siebelink HJ, Ninaber MK, van Geloven N, van Lith JMM, Huizinga TWJ, Rabelink TJ, Sueters M, Teng YKO

Objectives: SLE and/or antiphospholipid syndrome (SLE/APS) are complex and rare systemic autoimmune diseases that predominantly affect women of childbearing age. Women with SLE/APS are at high risk of developing complications during pregnancy. Therefore, clinical practice guidelines recommend that patients with SLE/APS should receive multidisciplinary counselling before getting pregnant. We investigated the clinical effectiveness of implementing a multidisciplinary clinical pathway including pre... Abstract

Cited 64 times since 2021 (14 per year) source: EuropePMC

European heart journal, Volume 42, Issue 18, 1 1 2021, Pages 1742-1756 Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality. Schunk SJ, Kleber ME, März W, Pang S, Zewinger S, Triem S, Ege P, Reichert MC, Krawczyk M, Weber SN, Jaumann I, Schmit D, Sarakpi T, Wagenpfeil S, Kramann R, Boerwinkle E, Ballantyne CM, Grove ML, Tragante V, Pilbrow AP, Richards AM, Cameron VA, Doughty RN, Dubé MP, Tardif JC, Feroz-Zada Y, Sun M, Liu C, Ko YA, Quyyumi AA, Hartiala JA, Tang WHW, Hazen SL, Allayee H, McDonough CW, Gong Y, Cooper-DeHoff RM, Johnson JA, Scholz M, Teren A, Burkhardt R, Martinsson A, Smith JG, Wallentin L, James SK, Eriksson N, White H, Held C, Waterworth D, Trompet S, Jukema JW, Ford I, Stott DJ, Sattar N, Cresci S, Spertus JA, Campbell H, Tierling S, Walter J, Ampofo E, Niemeyer BA, Lipp P, Schunkert H, Böhm M, Koenig W, Fliser D, Laufs U, Speer T, eQTLGen consortium, BIOS consortium

Aims: Inflammation plays an important role in cardiovascular disease (CVD) development. The NOD-like receptor protein-3 (NLRP3) inflammasome contributes to the development of atherosclerosis in animal models. Components of the NLRP3 inflammasome pathway such as interleukin-1β can therapeutically be targeted. Associations of genetically determined inflammasome-mediated systemic inflammation with CVD and mortality in humans are unknown. Methods and results: We explored the association of genetic N... Abstract

Nature genetics, Volume 53, Issue 5, 1 1 2021, Pages 762 Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B, Yao C, Kraja AT, Cartwright JH, Hellwege JN, Giri A, Tragante V, Thorleifsson G, Liu DJ, Prins BP, Stewart ID, Cabrera CP, Eales JM, Akbarov A, Auer PL, Bielak LF, Bis JC, Braithwaite VS, Brody JA, Daw EW, Warren HR, Drenos F, Nielsen SF, Faul JD, Fauman EB, Fava C, Ferreira T, Foley CN, Franceschini N, Gao H, Giannakopoulou O, Giulianini F, Gudbjartsson DF, Guo X, Harris SE, Havulinna AS, Helgadottir A, Huffman JE, Hwang SJ, Kanoni S, Kontto J, Larson MG, Li-Gao R, Lindström J, Lotta LA, Lu Y, Luan J, Mahajan A, Malerba G, Masca NGD, Mei H, Menni C, Mook-Kanamori DO, Mosen-Ansorena D, Müller-Nurasyid M, Paré G, Paul DS, Perola M, Poveda A, Rauramaa R, Richard M, Richardson TG, Sepúlveda N, Sim X, Smith AV, Smith JA, Staley JR, Stanáková A, Sulem P, Thériault S, Thorsteinsdottir U, Trompet S, Varga TV, Velez Edwards DR, Veronesi G, Weiss S, Willems SM, Yao J, Young R, Yu B, Zhang W, Zhao JH, Zhao W, Zhao W, Evangelou E,

Abstract

Cited 16 times since 2021 (3.5 per year) source: EuropePMC

International journal of molecular sciences, Volume 22, Issue 9, 30 5 2021, Pages 4804 Endoglin/CD105-Based Imaging of Cancer and Cardiovascular Diseases: A Systematic Review. Sier VQ, van der Vorst JR, Quax PHA, de Vries MR, Zonoobi E, Vahrmeijer AL, Dekkers IA, de Geus-Oei LF, Smits AM, Cai W, Sier CFM, Goumans MJTH, Hawinkels LJAC

Molecular imaging of pathologic lesions can improve efficient detection of cancer and cardiovascular diseases. A shared pathophysiological feature is angiogenesis, the formation of new blood vessels. Endoglin (CD105) is a coreceptor for ligands of the Transforming Growth Factor-β (TGF-β) family and is highly expressed on angiogenic endothelial cells. Therefore, endoglin-based imaging has been explored to visualize lesions of the aforementioned diseases. This systematic review highlights the prog... Abstract

Cited 6 times since 2021 (1.3 per year) source: EuropePMC

New directions for child and adolescent development, Volume 2021, Issue 177, 30 5 2021, Pages 199-217 Family cohesion and school belongingness: Protective factors for immigrant youth against bias-based bullying. Shah S, Choi M, Miller M, Halgunseth LC, van Schaik SDM, Brenick A

This study explores the protective effects of family cohesion and school belongingness against the negative consequences of bullying. 481 immigrant and nonimmigrant US middle-school students (Mage = 13.28(0.87), 49% female; 36% ethnic minority) self-reported their experiences being bullied, school belongingness, family cohesion, and socioemotional well-being measured as externalizing, internalizing, and prosocial behaviors. First- or second-generation immigrant youth (n = 72) came from 30 countr... Abstract

Cited 43 times since 2021 (9.4 per year) source: EuropePMC

Frontiers in cardiovascular medicine, Volume 8, 28 4 2021, Pages 647785 Post-ischemic Myocardial Inflammatory Response: A Complex and Dynamic Process Susceptible to Immunomodulatory Therapies. Pluijmert NJ, Atsma DE, Quax PHA

Following acute occlusion of a coronary artery causing myocardial ischemia and implementing first-line treatment involving rapid reperfusion, a dynamic and balanced inflammatory response is initiated to repair and remove damaged cells. Paradoxically, restoration of myocardial blood flow exacerbates cell damage as a result of myocardial ischemia-reperfusion (MI-R) injury, which eventually provokes accelerated apoptosis. In the end, the infarct size still corresponds to the subsequent risk of deve... Abstract

Cited 14 times since 2021 (3.1 per year) source: EuropePMC

JMIR mHealth and uHealth, Volume 9, Issue 4, 28 4 2021, Pages e26161 Impact of Mobile Health Devices for the Detection of Atrial Fibrillation: Systematic Review. Biersteker TE, Schalij MJ, Treskes RW

Background: Atrial fibrillation (AF) is the most common arrhythmia, and its prevalence is increasing. Early diagnosis is important to reduce the risk of stroke. Mobile health (mHealth) devices, such as single-lead electrocardiogram (ECG) devices, have been introduced to the worldwide consumer market over the past decade. Recent studies have assessed the usability of these devices for detection of AF, but it remains unclear if the use of mHealth devices leads to a higher AF detection rate. Object... Abstract

Preventive veterinary medicine, Volume 191, 28 4 2021, Pages 105368 SVEPM 2020 - Resilience and community support in the first year of the COVID-19 pandemic: The Society for Veterinary Epidemiology and Preventive Medicine Annual Conference, extraordinarily held online. Dórea FC, Vergne T, Brennan M, van Schaik G, Barrett D, Carmo LP, Robinson PA, Brodbelt DC, McIntyre KM

Abstract

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, Volume 174, 28 4 2021, Pages 109756 Albedo factors of some boron compounds at 59.54 keV. Yılmaz D, Akkuş T

In this study, the albedo factors (number, energy, and dose) of some boron compounds were investigated at a scattering angle of 180°. Eight boron compounds were tested in the mean atomic number range of 4.571 ≤ Z‾ ≤ 19.00. The samples were irradiated by gamma rays emitted at 59.54 keV from an Am-241-point source with an activity of 0.43 MBq. The scattered gamma rays were counted by an ultra-low energy germanium detector with a resolution of 140 eV at 5.9 keV. The results showed that the albedo f... Abstract

Cited 9 times since 2021 (2 per year) source: EuropePMC

International journal of colorectal disease, Volume 36, Issue 7, 27 4 2021, Pages 1507-1513 Normal inflammatory markers and acute appendicitis: a national multicentre prospective cohort analysis. de Jonge J, Scheijmans JCG, van Rossem CC, van Geloven AAW, Boermeester MA, Bemelman WA, Snapshot Appendicitis Collaborative Study group

Purpose: For the diagnosis of acute appendicitis, the combination of clinical and laboratory variables achieves high diagnostic accuracy. Nevertheless, appendicitis can present with normal laboratory tests of inflammation. The aim of this study was to investigate the incidence of normal inflammatory markers in patients operated for acute appendicitis. Methods: This is an analysis of data from a prospective, multicentre SNAPSHOT cohort study of patients with suspected acute appendicitis. Only pat... Abstract