Research

Publications

Below you can find a list of our published research.

9543 results

Cited 7 times since 2021 (1.5 per year) source: EuropePMC

Sensors (Basel, Switzerland), Volume 21, Issue 4, 15 3 2021, Pages 1361 Early Detection of Fluid Retention in Patients with Advanced Heart Failure: A Review of a Novel Multisensory Algorithm, HeartLogicTM. Feijen M, Egorova AD, Beeres SLMA, Treskes RW

Heart failure (HF) hospitalisations due to decompensation are associated with shorter life expectancy and lower quality of life. These hospitalisations pose a significant burden on the patients, doctors and healthcare resources. Early detection of an upcoming episode of decompensation may facilitate timely optimisation of the ambulatory medical treatment and thereby prevent heart-failure-related hospitalisations. The HeartLogicTM algorithm combines data from five sensors of cardiac implantable e... Abstract

Cited 6 times since 2021 (1.3 per year) source: EuropePMC

Forensic science international, Volume 321, 13 2 2021, Pages 110722 Measuring calibration of likelihood-ratio systems: A comparison of four metrics, including a new metric devPAV. Vergeer P, van Schaik Y, Sjerps M

Numerical likelihood-ratio (LR) systems aim to calculate evidential strength for forensic evidence evaluation. Calibration of such LR-systems is essential: one does not want to over- or understate the strength of the evidence. Metrics that measure calibration differ in sensitivity to errors in calibration of such systems. In this paper we compare four calibration metrics by a simulation study based on Gaussian Log LR-distributions. Three calibration metrics are taken from the literature (Good, 1... Abstract

Cited 2 times since 2021 (0.4 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 112, Issue 4, 13 2 2021, Pages e237-e239 Pneumothorax Due to a Nontraumatic Thoracic Wall Rupture Due to Steroid-Induced Muscle Wasting. van Schaik E, Ramnarain D, Pouwels S

Spontaneous pneumothorax can be classified into primary and secondary variants. A 58-year-old patient presented with a 7-week history of severe coughing and chest pain. He noticed progressive swelling of the face and the upper part of the body. His medical history revealed osteoporosis and severe rheumatoid arthritis treated with steroids and disease-modifying antirheumatic drugs. Computed tomography of the thorax revealed complete rupture of the thoracic wall through costae 9 and 10 with lung h... Abstract

Cited 24 times since 2021 (5 per year) source: EuropePMC

Frontiers in cardiovascular medicine, Volume 8, 12 2 2021, Pages 631985 Myocardial Disease and Long-Distance Space Travel: Solving the Radiation Problem. Meerman M, Bracco Gartner TCL, Buikema JW, Wu SM, Siddiqi S, Bouten CVC, Grande-Allen KJ, Suyker WJL, Hjortnaes J

Radiation-induced cardiovascular disease is a well-known complication of radiation exposure. Over the last few years, planning for deep space missions has increased interest in the effects of space radiation on the cardiovascular system, as an increasing number of astronauts will be exposed to space radiation for longer periods of time. Research has shown that exposure to different types of particles found in space radiation can lead to the development of diverse cardiovascular disease via fibro... Abstract

Cited 26 times since 2021 (5.4 per year) source: EuropePMC

Cancers, Volume 13, Issue 4, 12 2 2021, Pages 771 Clinical CYP2D6 Genotyping to Personalize Adjuvant Tamoxifen Treatment in ER-Positive Breast Cancer Patients: Current Status of a Controversy. Mulder TAM, de With M, Del Re M, Danesi R, Mathijssen RHJ, van Schaik RHN

Tamoxifen is a major option for adjuvant endocrine treatment in estrogen receptor (ER) positive breast cancer patients. The conversion of the prodrug tamoxifen into the most active metabolite endoxifen is mainly catalyzed by the enzyme cytochrome P450 2D6 (CYP2D6). Genetic variation in the CYP2D6 gene leads to altered enzyme activity, which influences endoxifen formation and thereby potentially therapy outcome. The association between genetically compromised CYP2D6 activity and low endoxifen pla... Abstract

Cited 10 times since 2021 (2.1 per year) source: EuropePMC

BMJ open, Volume 11, Issue 2, 12 2 2021, Pages e041553 Prehospital triage of patients with acute cardiac complaints: study protocol of HART-c, a multicentre prospective study. de Koning E, Biersteker TE, Beeres S, Bosch J, Backus BE, Kirchhof CJ, Alizadeh Dehnavi R, Silvius HA, Schalij M, Boogers MJ

Introduction: Emergency department (ED) overcrowding is a major healthcare problem associated with worse patient outcomes and increased costs. Attempts to reduce ED overcrowding of patients with cardiac complaints have so far focused on in-hospital triage and rapid risk stratification of patients with chest pain at the ED. The Hollands-Midden Acute Regional Triage-Cardiology (HART-c) study aimed to assess the amount of patients left at home in usual ambulance care as compared with the new prehos... Abstract

Cited 12 times since 2021 (2.5 per year) source: EuropePMC

Journal of magnetic resonance imaging : JMRI, Volume 54, Issue 2, 10 2 2021, Pages 411-420 Quantification of Myocardial Creatine and Triglyceride Content in the Human Heart: Precision and Accuracy of in vivo Proton Magnetic Resonance Spectroscopy. Bakermans AJ, Boekholdt SM, de Vries DK, Reckman YJ, Farag ES, de Heer P, Uthman L, Denis SW, Zuurbier CJ, Houtkooper RH, Koolbergen DR, Kluin J, Planken RN, Lamb HJ, Webb AG, Strijkers GJ, Beard DA, Jeneson JAL, Nederveen AJ

Background: Proton magnetic resonance spectroscopy (1 H-MRS) of the human heart is deemed to be a quantitative method to investigate myocardial metabolite content, but thorough validations of in vivo measurements against invasive techniques are lacking. Purpose: To determine measurement precision and accuracy for quantifications of myocardial total creatine and triglyceride content with localized 1 H-MRS. Study type: Test-retest repeatability and measurement validation study. Subjects: Sixteen v... Abstract

Cited 47 times since 2021 (9.8 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 14, Issue 6, 10 2 2021, Pages 1085-1095 Prognostic Implications of a Novel Algorithm to Grade Secondary Tricuspid Regurgitation. Fortuni F, Dietz MF, Prihadi EA, van der Bijl P, De Ferrari GM, Knuuti J, Bax JJ, Delgado V, Marsan NA

Objectives: A novel tricuspid regurgitation (TR) grading system, using vena contracta (VC) width and effective regurgitant orifice area (EROA), was proposed and validated based on its prognostic usefulness. Background: The clinical need of a new grading system for TR has recently been emphasized to depict the whole spectrum of TR severity, particularly beyond severe TR (massive or torrential). Methods: TR severity was characterized in 1,129 patients with moderate or severe secondary TR (STR). Re... Abstract

Cited 12 times since 2021 (2.5 per year) source: EuropePMC

Frontiers in cardiovascular medicine, Volume 8, 9 2 2021, Pages 638487 Multi-Modality Imaging for Interventions in Tricuspid Valve Disease. Fortuni F, Hirasawa K, Bax JJ, Delgado V, Ajmone Marsan N

Several studies have demonstrated that severe tricuspid regurgitation (TR) has a significant negative impact on morbidity and mortality. Nowadays, several therapeutic options to treat TR are available and patients at high surgical risk can also be treated with transcatheter procedures. For the management of patients with TR, an accurate assessment of the tricuspid valve and its surrounding structures is therefore of crucial importance and has gained significant interest in the medical community.... Abstract

Cited 42 times since 2021 (8.8 per year) source: EuropePMC

STAR protocols, Volume 2, Issue 1, 9 2 2021, Pages 100334 Massive expansion and cryopreservation of functional human induced pluripotent stem cell-derived cardiomyocytes. Maas RGC, Lee S, Harakalova M, Snijders Blok CJB, Goodyer WR, Hjortnaes J, Doevendans PAFM, Van Laake LW, van der Velden J, Asselbergs FW, Wu JC, Sluijter JPG, Wu SM, Buikema JW

Since the discovery of human induced pluripotent stem cells (hiPSCs), numerous strategies have been established to efficiently derive cardiomyocytes from hiPSCs (hiPSC-CMs). Here, we describe a cost-effective strategy for the subsequent massive expansion (>250-fold) of high-purity hiPSC-CMs relying on two aspects: removal of cell-cell contacts and small-molecule inhibition with CHIR99021. The protocol maintains CM functionality, allows cryopreservation, and the cells can be used in downstream... Abstract

Cited 2 times since 2021 (0.4 per year) source: EuropePMC

Der Urologe. Ausg. A, Volume 60, Issue 3, 9 2 2021, Pages 318-330 [Urological care in practices and clinics during the corona virus pandemic in Germany]. Kriegmair MC, Speck T, Schneider AW, Volkmer B, Michel MS

The coronavirus pandemic has had an immediate and far-reaching effect on the care of urological patients. The pandemic monitor of the German Society for Urology was able to record the restrictions on patient care in urological practices and clinics by means of regular surveys of the members. A total of 689 responses at four survey time points were included. In April there was a reduction in urological inpatients to 44% and the number of patients in practices dropped to 50%. Available operating t... Abstract

Cited 2 times since 2021 (0.4 per year) source: EuropePMC

Journal of clinical medicine, Volume 10, Issue 4, 8 2 2021, Pages 649 Mitral Valve Annulus Dimensions Assessment with Three-Dimensional Echocardiography Versus Computed Tomography: Implications for Transcatheter Interventions. Hirasawa K, Vo NM, Gegenava T, Pio SM, van Wijngaarden SE, Ajmone Marsan N, Bax JJ, Delgado V

The aim of this study is to evaluate the agreement between three-dimensional (3D) transesophageal echocardiography (TEE) and multidetector computed tomography (MDCT) for assessing mitral annular (MA) dimensions. A total of 105 patients (79 ± 9 years old, 52% male) who underwent clinically indicated 3D TEE and MDCT feasible for MA geometrical assessment were included. Using dedicated semi-automated postprocessing software, MA geometry, including mitral annular area (MAA), perimeter, septal-latera... Abstract

Cited 6 times since 2021 (1.3 per year) source: EuropePMC

Nature communications, Volume 12, Issue 1, 8 2 2021, Pages 995 Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability. Lagou V, Mägi R, Hottenga JJ, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D, Jansen R, Min JL, Dimas AS, Ulrich A, Zudina L, Gådin JR, Jiang L, Faggian A, Bonnefond A, Fadista J, Stathopoulou MG, Isaacs A, Willems SM, Navarro P, Tanaka T, Jackson AU, Montasser ME, O'Connell JR, Bielak LF, Webster RJ, Saxena R, Stafford JM, Pourcain BS, Timpson NJ, Salo P, Shin SY, Amin N, Smith AV, Li G, Verweij N, Goel A, Ford I, Johnson PCD, Johnson T, Kapur K, Thorleifsson G, Strawbridge RJ, Rasmussen-Torvik LJ, Esko T, Mihailov E, Fall T, Fraser RM, Mahajan A, Kanoni S, Giedraitis V, Kleber ME, Silbernagel G, Meyer J, Müller-Nurasyid M, Ganna A, Sarin AP, Yengo L, Shungin D, Luan J, Horikoshi M, An P, Sanna S, Boettcher Y, Rayner NW, Nolte IM, Zemunik T, Iperen EV, Kovacs P, Hastie ND, Wild SH, McLachlan S, Campbell S, Polasek O, Carlson O, Egan J, Kiess W, Willemsen G, Kuusisto J, Laakso M, Dimitriou M, Hicks AA, Rauramaa R, Bandinelli S, Thorand B, Liu Y, Miljkovic I, Lind L, Doney A, Perola M, Hingorani A,

Abstract

Cited 23 times since 2021 (4.8 per year) source: EuropePMC

Angiogenesis, Volume 24, Issue 3, 7 1 2021, Pages 567-581 Atorvastatin pleiotropically decreases intraplaque angiogenesis and intraplaque haemorrhage by inhibiting ANGPT2 release and VE-Cadherin internalization. Baganha F, de Jong RCM, Peters EA, Voorham W, Jukema JW, Delibegovic M, de Vries MR, Quax PHA

Objective: Statins pleiotropically provide additional benefits in reducing atherosclerosis, but their effects on intraplaque angiogenesis (IPA) and hemorrhage (IPH) remain unclear. Therefore, we discriminated statin's lipid-lowering dependent and independent effects on IPA and IPH. Approach and results: ApoE3*Leiden mice are statin-responsive due to ApoE and LDLR presence, but also allow to titrate plasma cholesterol levels by diet. Therefore, ApoE3*Leiden mice were fed a high-cholesterol-i... Abstract

Cited 23 times since 2021 (4.8 per year) source: EuropePMC

Frontiers in neuroscience, Volume 15, 4 1 2021, Pages 621356 Effects of Caffeine on Brown Adipose Tissue Thermogenesis and Metabolic Homeostasis: A Review. Van Schaik L, Kettle C, Green R, Irving HR, Rathner JA

The impact of brown adipose tissue (BAT) metabolism on understanding energy balance in humans is a relatively new and exciting field of research. The pathogenesis of obesity can be largely explained by an imbalance between caloric intake and energy expenditure, but the underlying mechanisms are far more complex. Traditional non-selective sympathetic activators have been used to artificially elevate energy utilization, or suppress appetite, however undesirable side effects are apparent with the u... Abstract

Cited 25 times since 2021 (5.2 per year) source: EuropePMC

International journal of cardiology, Volume 331, 3 1 2021, Pages 316-321 Standard and emerging CMR methods for mitral regurgitation quantification. Fidock B, Archer G, Barker N, Elhawaz A, Al-Mohammad A, Rothman A, Hose R, Hall IR, Grech E, Briffa N, Lewis N, van der Geest RJ, Zhang JM, Zhong L, Swift AJ, Wild JM, De Gárate E, Bucciarelli-Ducci C, Bax JJ, Plein S, Myerson S, Garg P

Background: There are several methods to quantify mitral regurgitation (MR) by cardiovascular magnetic resonance (CMR). The interoperability of these methods and their reproducibility remains undetermined. Objective: To determine the agreement and reproducibility of different MR quantification methods by CMR across all aetiologies. Methods: Thirty-five patients with MR were recruited (primary MR = 12, secondary MR = 10 and MVR = 13). Patients underwent CMR, including cines and four-dimensional f... Abstract

Cited 12 times since 2021 (2.5 per year) source: EuropePMC

Journal of internal medicine, Volume 290, Issue 1, 2 1 2021, Pages 141-156 Identification of IgG1 isotype phosphorylcholine antibodies for the treatment of inflammatory cardiovascular diseases. de Vries MR, Ewing MM, de Jong RCM, MacArthur MR, Karper JC, Peters EAB, Nordzell M, Karabina SAP, Sexton D, Dahlbom I, Bergman A, Mitchell JR, Frostegård J, Kuiper J, Ninio E, Jukema JW, Pettersson K, Quax PHA

Background: Phosphorylcholine (PC) is an important pro-inflammatory damage-associated molecular pattern. Previous data have shown that natural IgM anti-PC protects against cardiovascular disease. We aimed to develop a monoclonal PC IgG antibody with anti-inflammatory and anti-atherosclerotic properties. Methods: Using various techniques PC antibodies were validated and optimized. In vivo testing was performed in a femoral artery cuff model in ApoE3*Leiden mice. Safety studies are performed in ra... Abstract

Cited 2 times since 2021 (0.4 per year) source: EuropePMC

Journal of religion and health, Volume 60, Issue 1, 1 1 2021, Pages 188-201 Cultural Viewpoints of Nursing Students on Patient Privacy: A Qualitative Study. Ak B, Tanrıkulu F, Gündoğdu H, Yılmaz D, Öner Ö, Ziyai NY, Erol F, Dikmen Y

The purpose of this study was to determine the feelings, thoughts, perceptions and cultural standpoint of nursing students concerning patient privacy. This study was conducted as a qualitative descriptive design. The homogeneous sampling method, purposive sampling method for qualitative research samples, was used to determine the study group. Data were collected from 17 nursing students at a state university in Turkey. Individual semi-structured interviews were conducted, and content analysis wa... Abstract

Cited 22 times since 2021 (4.6 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 77, Issue 6, 1 1 2021, Pages 761-771 Preventing Arrhythmic Death in Patients With Tetralogy of Fallot: JACC Review Topic of the Week. Cohen MI, Khairy P, Zeppenfeld K, Van Hare GF, Lakkireddy DR, Triedman JK

Patients with tetralogy of Fallot are at risk for ventricular arrhythmias and sudden cardiac death. These abnormalities are associated with pulmonary regurgitation, right ventricular enlargement, and a substrate of discrete, slowly-conducting isthmuses. Although these arrhythmic events are rare, their prediction is challenging. This review will address contemporary risk assessment and prevention strategies. Numerous variables have been proposed to predict who would benefit from an implantable ca... Abstract

Cited 5 times since 2021 (1 per year) source: EuropePMC

Pediatric cardiology, Volume 42, Issue 4, 1 1 2021, Pages 866-874 Oxygen Uptake Efficiency Slope is Strongly Correlated to VO2peak Long-Term After Arterial Switch Operation. Terol Espinosa de Los Monteros C, Van der Palen RLF, Hazekamp MG, Rammeloo L, Jongbloed MRM, Blom NA, Harkel ADJT

After the arterial switch operation (ASO) for transposition of the great arteries (TGA), many patients have an impaired exercise tolerance. Exercise tolerance is determined with cardiopulmonary exercise testing by peak oxygen uptake (VO2peak). Unlike VO2peak, the oxygen uptake efficiency slope (OUES) does not require a maximal effort for interpretation. The value of OUES has not been assessed in a large group of patients after ASO. The purpose of this study was to determine OUES and VO2peak, eva... Abstract