Research

Publications

Below you can find a list of our published research.

9543 results

Cited 10 times since 2021 (2.1 per year) source: EuropePMC

Tissue engineering. Part C, Methods, Volume 27, Issue 2, 1 1 2021, Pages 100-114 Advanced In Vitro Modeling to Study the Paradox of Mechanically Induced Cardiac Fibrosis. Bracco Gartner TCL, Stein JM, Muylaert DEP, Bouten CVC, Doevendans PA, Khademhosseini A, Suyker WJL, Sluijter JPG, Hjortnaes J

In heart failure, cardiac fibrosis is the result of an adverse remodeling process. Collagen is continuously synthesized in the myocardium in an ongoing attempt of the heart to repair itself. The resulting collagen depositions act counterproductively, causing diastolic dysfunction and disturbing electrical conduction. Efforts to treat cardiac fibrosis specifically have not been successful and the molecular etiology is only partially understood. The differentiation of quiescent cardiac fibroblasts... Abstract

Cited 1234 times since 2021 (256.4 per year) source: EuropePMC

European heart journal, Volume 42, Issue 6, 1 1 2021, Pages 563-645 2020 ESC Guidelines for the management of adult congenital heart disease. Baumgartner H, De Backer J, Babu-Narayan SV, Budts W, Chessa M, Diller GP, Lung B, Kluin J, Lang IM, Meijboom F, Moons P, Mulder BJM, Oechslin E, Roos-Hesselink JW, Schwerzmann M, Sondergaard L, Zeppenfeld K, ESC Scientific Document Group

Abstract

Pediatric emergency care, Volume 37, Issue 2, 1 1 2021, Pages e77-e78 Unexpected Diagnosis in an Adolescent With Bruises and Ecchymosis: Celiac Disease. Er A, Çağlar A, Kuyum P, Akgül F, Ulusoy E, Çitlenbik H, Aksoy BY, Yilmaz D, Arslan N, Duman M

Abstract: Acquired coagulopathy is a rare but challenging diagnosis for pediatric emergency physicians. Although the coagulopathy usually presents with mild skin and mucosal hemorrhages, it also can lead to life-threatening events. Thus, accurate interpretation of hints obtained from a detailed history, physical examination, and laboratory findings is essential for the prompt diagnosis and management. This case demonstrates an uncommon cause of coagulopathy; celiac disease that presented with sp... Abstract

Cited 7 times since 2021 (1.5 per year) source: EuropePMC

Journal of thoracic disease, Volume 13, Issue 2, 1 1 2021, Pages 592-599 Quality assessment of robot assisted thoracic surgical resection of non-small cell lung cancer: nodal upstaging and mediastinal recurrence. Shahin GM, Topal B, Pouwels S, Markou TL, Boon R, Stigt JA

Background: Robot assisted thoracic surgery (RATS) is the minimally invasive surgical technique of choice for treatment of patients with non-small cell lung cancer (NSCLC), at the Isala Hospital. The aim of this study is to compare clinical and pathological staging results and mediastinal recurrence after RATS for anatomical resections of lung cancer as surrogate markers for quality of mediastinal lymph node dissection (MLND). Methods: This single institute retrospective study was conducted in p... Abstract

Cited 24 times since 2021 (5 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 22, Issue 3, 1 1 2021, Pages 339-347 Left ventricular myocardial work in the culprit vessel territory and impact on left ventricular remodelling in patients with ST-segment elevation myocardial infarction after primary percutaneous coronary intervention. Lustosa RP, Fortuni F, van der Bijl P, Goedemans L, El Mahdiui M, Montero-Cabezas JM, Kostyukevich MV, Ajmone Marsan N, Bax JJ, Delgado V, Knuuti J

Aims: Adverse left ventricular (LV) remodelling after ST-segment elevation myocardial infarction (STEMI) is associated with poor outcome. Global and regional LV myocardial work (LVMW) derived from speckle tracking echocardiographic strain data in combination with non-invasive blood pressure recordings could provide information for prediction of LV remodelling after STEMI. The aim of the study was to assess the predictive value of global and regional LVMW for LV remodelling before discharge in pa... Abstract

Cited 13 times since 2021 (2.7 per year) source: EuropePMC

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, Volume 98, Issue 5, 1 1 2021, Pages E733-E736 Virtual support for remote proctoring in TAVR during COVID-19. Arslan F, Gerckens U

Objectives: The current report describes a single operator's experience of the first use of smartglass technology as a facilitator of virtual support during TAVR proctoring. Background: Restricted gatherings and containment measures during the ongoing COVID-19 pandemic have a major impact on daily clinical practice. Interaction between peers is crucial in science, clinical practice, and education. In addition, there is also a growing importance of proctoring in interventional cardiology for... Abstract

European journal of nutrition, Volume 60, Issue 1, 1 1 2021, Pages 555-556 Correction to: Adherence to a food group-based dietary guideline and incidence of prediabetes and type 2 diabetes. Braver NRD, Rutters F, van der Spek ALJK, Ibi D, Looman M, Geelen A, Elders P, van der Heijden AA, Brug J, Lakerveld J, Soedamah-Muthu SS, Beulens JWJ

Abstract

Cited 38 times since 2021 (7.9 per year) source: EuropePMC

The Journal of infectious diseases, Volume 223, Issue 2, 1 1 2021, Pages 238-246 Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults. Chen S, Pawelec G, Trompet S, Goldeck D, Mortensen LH, Slagboom PE, Christensen K, Gussekloo J, Kearney P, Buckley BM, Ford I, Jukema JW, Westendorp RGJ, Maier AB

Background: Whether latent cytomegalovirus (CMV) infection in older adults has any substantial health consequences is unclear. Here, we sought associations between CMV-seropositivity and IgG titer with all-cause and cardiovascular mortality in 5 longitudinal cohorts. Methods: Leiden Longevity Study, Prospective Study of Pravastatin in the Elderly at Risk, Longitudinal Study of Aging Danish Twins, and Leiden 85-plus Study were assessed at median (2.8-11.4 years) follow-up . Cox regression and ran... Abstract

Cited 3 times since 2021 (0.6 per year) source: EuropePMC

Open heart, Volume 8, Issue 1, 1 1 2021, Pages e001554 Discovery of predictors of sudden cardiac arrest in diabetes: rationale and outline of the RESCUED (REcognition of Sudden Cardiac arrest vUlnErability in Diabetes) project. van Dongen LH, Harms PP, Hoogendoorn M, Zimmerman DS, Lodder EM, 't Hart LM, Herings R, van Weert HCPM, Nijpels G, Swart KMA, van der Heijden AA, Blom MT, Elders PJ, Tan HL

Introduction: Early recognition of individuals with increased risk of sudden cardiac arrest (SCA) remains challenging. SCA research so far has used data from cardiologist care, but missed most SCA victims, since they were only in general practitioner (GP) care prior to SCA. Studying individuals with type 2 diabetes (T2D) in GP care may help solve this problem, as they have increased risk for SCA, and rich clinical datasets, since they regularly visit their GP for check-up measurements. This info... Abstract

Cited 92 times since 2021 (19.1 per year) source: EuropePMC

The Journal of infectious diseases, Volume 223, Issue 2, 1 1 2021, Pages 214-224 Complement Activation in the Disease Course of Coronavirus Disease 2019 and Its Effects on Clinical Outcomes. de Nooijer AH, Grondman I, Janssen NAF, Netea MG, Willems L, van de Veerdonk FL, Giamarellos-Bourboulis EJ, Toonen EJM, Joosten LAB, RCI-COVID-19 study group

Background: Excessive activation of immune responses in coronavirus disease 2019 (COVID-19) is considered to be related to disease severity, complications, and mortality rate. The complement system is an important component of innate immunity and can stimulate inflammation, but its role in COVID-19 is unknown. Methods: A prospective, longitudinal, single center study was performed in hospitalized patients with COVID-19. Plasma concentrations of complement factors C3a, C3c, and terminal complemen... Abstract

Cited 6356 times since 2021 (1320.7 per year) source: EuropePMC

European heart journal, Volume 42, Issue 5, 1 1 2021, Pages 373-498 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Hindricks G, Potpara T, Dagres N, Arbelo E, Bax JJ, Blomström-Lundqvist C, Boriani G, Castella M, Dan GA, Dilaveris PE, Fauchier L, Filippatos G, Kalman JM, La Meir M, Lane DA, Lebeau JP, Lettino M, Lip GYH, Pinto FJ, Thomas GN, Valgimigli M, Van Gelder IC, Van Putte BP, Watkins CL, ESC Scientific Document Group

Abstract

Cited 13 times since 2021 (2.7 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 28, Issue 3, 31 5 2021, Pages 1105-1116 Assessing myocardial perfusion in suspected coronary artery disease: rationale and design of the second phase 3, open-label multi-center study of flurpiridaz (F-18) injection for positron emission tomography (PET) imaging. Bourque JM, Hanson CA, Agostini D, Bateman TM, Bax JJ, Beanlands RSB, Berman DS, Garcia EV, Heller GV, Knuuti J, Tamaki N, Udelson JE, Maddahi J

Background: Positron emission tomography (PET) myocardial perfusion imaging (MPI) with the novel radiopharmaceutical Fluorine-18 Flurpiridaz has been shown in Phase 1, 2, and first Phase 3 clinical studies to be safe and effective in diagnosing coronary artery disease (CAD). We describe the methodology of the second FDA-mandated phase 3 prospective, open-label, international, multi-center trial of F-18 Flurpiridaz PET MPI. Methods: The primary study end point is to assess the diagnostic efficacy... Abstract

Cited 16 times since 2021 (3.3 per year) source: EuropePMC

Evolutionary applications, Volume 14, Issue 4, 29 5 2021, Pages 1124-1144 The ghosts of propagation past: haplotype information clarifies the relative influence of stocking history and phylogeographic processes on contemporary population structure of walleye (Sander vitreus). Bootsma ML, Miller L, Sass GG, Euclide PT, Larson WA

Stocking of fish is an important tool for maintaining fisheries but can also significantly alter population genetic structure and erode the portfolio of within-species diversity that is important for promoting resilience and adaptability. Walleye (Sander vitreus) are a highly valued sportfish in the midwestern United States, a region characterized by postglacial recolonization from multiple lineages and an extensive history of stocking. We leveraged genomic data and recently developed analytical... Abstract

Animals : an open access journal from MDPI, Volume 11, Issue 2, 29 5 2021, Pages 347 Observational Study on Variation of Longitudinal Platelet Counts in Calves over the First 14 Days of Life and Reference Intervals from Cross-Sectional Platelet and Leukocyte Counts in Dairy Calves up to Two Months of Age. Strous E, Vanhoudt A, Smolenaars A, van Schaik G, Schouten M, de Pater H, Roelofs B, Nielen M

Platelet and leukocyte count reference intervals (RIs) for cattle differ by age and while adult RIs are known, RIs for calves are studied less. The aims of this observational study are to evaluate variation of platelet counts of Holstein Friesian calves over the first 14 days of life and to propose RIs for platelet and leukocyte counts of Holstein Friesian calves aged 0-60 days. In a longitudinal study, 19 calves were blood sampled 17 times, in the first 14 days of their lives. Blood was collect... Abstract

Cited 33 times since 2021 (6.8 per year) source: Scopus

EClinicalMedicine, Volume 32, 28 4 2021, Pages 100731 Short-term outpatient follow-up of COVID-19 patients: A multidisciplinary approach. de Graaf MA, Antoni ML, Ter Kuile MM, Arbous MS, Duinisveld AJF, Feltkamp MCW, Groeneveld GH, Hinnen SCH, Janssen VR, Lijfering WM, Omara S, Postmus PE, Ramai SRS, Rius-Ottenheim N, Schalij MJ, Schiemanck SK, Smid L, Stöger JL, Visser LG, de Vries JJC, Wijngaarden MA, Geelhoed JJM, Roukens AHE

Background: Short-term follow-up of COVID-19 patients reveals pulmonary dysfunction, myocardial damage and severe psychological distress. Little is known of the burden of these sequelae, and there are no clear recommendations for follow-up of COVID-19 patients.In this multi-disciplinary evaluation, cardiopulmonary function and psychological impairment after hospitalization for COVID-19 are mapped. Methods: We evaluated patients at our outpatient clinic 6 weeks after discharge. Cardiopulmonary fu... Abstract

Cited 15 times since 2021 (3.1 per year) source: EuropePMC

Journal of medical microbiology, Volume 70, Issue 3, 28 4 2021 Emergence of carbapenem-resistant Klebsiella pneumoniae harbouring bla OXA-48-like genes in China. Chen Y, Fang L, Yang Y, Yan R, Fu Y, Shen P, Zhao D, Chen Y, Hua X, Jiang Y, Moran RA, van Schaik W, Yu Y

Klebsiella pneumoniae strains carrying OXA-48-like carbapenemases are increasingly prevalent across the globe. There is thus an urgent need to better understand the mechanisms that underpin the dissemination of bla OXA-48-like carbapenemases. To this end, four ertapenem-resistant K. pneumoniae isolates producing OXA-48-like carbapenemases were isolated from two patients. Genome sequencing revealed that one sequence type (ST) 17 isolate carried bla OXA-181, whilst three isolates from a single pat... Abstract

Cited 1 times since 2021 (0.2 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 37, Issue 5, 27 4 2021, Pages 1563-1565 Pacemaker lead-induced tricuspid regurgitation: consider leaflet remodeling. Fortuni F, van der Kley F, Delgado V, Ajmone Marsan N

Abstract

Cited 20 times since 2021 (4.1 per year) source: EuropePMC

Journal of cardiovascular development and disease, Volume 8, Issue 2, 27 4 2021, Pages 12 A Systematic Histopathologic Evaluation of Type-A Aortic Dissections Implies a Uniform Multiple-Hit Causation. Grewal N, Velders BJJ, Gittenberger-de Groot AC, Poelmann R, Klautz RJM, Van Brakel TJ, Lindeman JHN

(1) Background: The pathophysiologic basis of an acute type A aortic dissection (TAAD) is largely unknown. In an effort to evaluate vessel wall defects, we systematically studied aortic specimens in TAAD patients. (2) Methods: Ascending aortic wall specimens (n = 58, mean age 63 years) with TAAD were collected. Autopsy tissues (n = 17, mean age 63 years) served as controls. All sections were studied histopathologically. (3) Results: Pathomorphology in TAAD showed predominantly moderate elastic f... Abstract

Cited 6 times since 2021 (1.2 per year) source: EuropePMC

Pediatric pulmonology, Volume 56, Issue 5, 26 4 2021, Pages 1053-1059 Point of care diaphragm ultrasound in acute bronchiolitis: A measurable tool to predict the clinical, sonographic severity of the disease, and outcomes. Şık N, Çitlenbik H, Öztürk A, Yılmaz D, Duman M

Background: The aim of this study was to evaluate diaphragmatic parameters in bronchiolitis patients and identify correlations between clinical and sonographic severity scores and outcomes to develop a more objective and useful tool in the emergency department. Methods: Children aged between 1 and 24 months and diagnosed with acute bronchiolitis were included in the study. The Modified Respiratory Distress Assessment Instrument (mRDAI) score was used to quantify the clinical severity of the dise... Abstract

Cited 32 times since 2021 (6.6 per year) source: EuropePMC

International journal of obesity (2005), Volume 45, Issue 3, 25 4 2021, Pages 687-694 A higher BMI is not associated with a different immune response and disease course in critically ill COVID-19 patients. Kooistra EJ, de Nooijer AH, Claassen WJ, Grondman I, Janssen NAF, Netea MG, van de Veerdonk FL, van der Hoeven JG, Kox M, Pickkers P, RCI-COVID-19 study group

Background/objectives: Obesity appears to be an independent risk factor for ICU admission and a severe disease course in COVID-19 patients. An aberrant inflammatory response and impaired respiratory function have been suggested as underlying mechanisms. We investigated whether obesity is associated with differences in inflammatory, respiratory, and clinical outcome parameters in critically ill COVID-19 patients. Subjects/methods: Sixty-seven COVID-19 ICU patients were divided into obese (BMI ≥ 3... Abstract