9543 results
Cited 22 times since 2020 (4.4 per year)
source: EuropePMC
British journal of clinical pharmacology,
Volume 87, Issue 4, 24 4 2020, Pages 1918-1929
Monitoring the tacrolimus concentration in peripheral blood mononuclear cells of kidney transplant recipients.
Francke MI, Hesselink DA, Li Y, Koch BCP, de Wit LEA, van Schaik RHN, Yang L, Baan CC, van Gelder T, de Winter BCM
Aims: Tacrolimus is a critical dose drug and to avoid under- and overexposure, therapeutic drug monitoring is standard practice. However, rejection and drug-related toxicity occur despite whole-blood tacrolimus pre-dose concentrations ([Tac]blood ) being on target. Monitoring tacrolimus concentrations at the target site (within peripheral blood mononuclear cells; [Tac]cells ) may better correlate with drug-efficacy. The aim of this study was to (1) investigate the relationship between [Tac]blood...
Abstract
Cited 127 times since 2020 (25.4 per year)
source: EuropePMC
Nature genetics,
Volume 52, Issue 12, 23 4 2020, Pages 1314-1332
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.
Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B, Yao C, Kraja AT, Cartwright JH, Hellwege JN, Giri A, Tragante V, Thorleifsson G, Liu DJ, Prins BP, Stewart ID, Cabrera CP, Eales JM, Akbarov A, Auer PL, Bielak LF, Bis JC, Braithwaite VS, Brody JA, Daw EW, Warren HR, Drenos F, Nielsen SF, Faul JD, Fauman EB, Fava C, Ferreira T, Foley CN, Franceschini N, Gao H, Giannakopoulou O, Giulianini F, Gudbjartsson DF, Guo X, Harris SE, Havulinna AS, Helgadottir A, Huffman JE, Hwang SJ, Kanoni S, Kontto J, Larson MG, Li-Gao R, Lindström J, Lotta LA, Lu Y, Luan J, Mahajan A, Malerba G, Masca NGD, Mei H, Menni C, Mook-Kanamori DO, Mosen-Ansorena D, Müller-Nurasyid M, Paré G, Paul DS, Perola M, Poveda A, Rauramaa R, Richard M, Richardson TG, Sepúlveda N, Sim X, Smith AV, Smith JA, Staley JR, Stanáková A, Sulem P, Thériault S, Thorsteinsdottir U, Trompet S, Varga TV, Velez Edwards DR, Veronesi G, Weiss S, Willems SM, Yao J, Young R, Yu B, Zhang W, Zhao JH, Zhao W, Zhao W, Evangelou E,
Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to ~1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency ≤ 0.01) variant BP associations (P
Abstract
Cited 37 times since 2020 (7.4 per year)
source: EuropePMC
ESC heart failure,
Volume 8, Issue 1, 23 4 2020, Pages 566-576
Meta-analysis of echocardiographic quantification of left ventricular filling pressure.
Jones R, Varian F, Alabed S, Morris P, Rothman A, Swift AJ, Lewis N, Kyriacou A, Wild JM, Al-Mohammad A, Zhong L, Dastidar A, Storey RF, Swoboda PP, Bax JJ, Garg P
Aims: The clinical reliability of echocardiographic surrogate markers of left ventricular filling pressures (LVFPs) across different cardiovascular pathologies remains unanswered. The main objective was to evaluate the evidence of how effectively different echocardiographic indices estimate true LVFP. Methods and results: Design: this is a systematic review and meta-analysis. Data source: Scopus, PubMed and Embase. Eligibility criteria for selecting studies were those that used echocardiography...
Abstract
Cited 33 times since 2020 (6.6 per year)
source: EuropePMC
The Annals of thoracic surgery,
Volume 112, Issue 4, 19 3 2020, Pages 1150-1159
Multiinstitutional Phase 2 Clinical Trial of Intraoperative Molecular Imaging of Lung Cancer.
Gangadharan S, Sarkaria IN, Rice D, Murthy S, Braun J, Kucharczuk J, Predina J, Singhal S
Background: Intraoperative molecular imaging (IMI) may improve surgical outcomes during pulmonary resection for lung cancer. A multiinstitutional phase 2 IMI clinical trial was conducted using a near-infrared, folate receptor-targeted contrast agent for lung adenocarcinomas, OTL38. The primary goal was to determine whether OTL38 improved surgeons' ability to identify difficult to find nodules, occult cancers, and positive margins. Methods: Patients with lung nodules received OTL38 (0.025 mg...
Abstract
Cited 57 times since 2020 (11.4 per year)
source: EuropePMC
Frontiers in nutrition,
Volume 7, 19 3 2020, Pages 597600
The Impact of Obesity and Lifestyle on the Immune System and Susceptibility to Infections Such as COVID-19.
de Frel DL, Atsma DE, Pijl H, Seidell JC, Leenen PJM, Dik WA, van Rossum EFC
Background: COVID-19 is a global challenge to healthcare. Obesity is common in patients with COVID-19 and seems to aggravate disease prognosis. In this review we explore the link between obesity, chronic disease, lifestyle factors and the immune system, and propose societal interventions to enhance global immunity. Search Strategy and Selection Criteria: We performed three literature searches using the keywords (1) coronavirus AND comorbidities, (2) comorbidities AND immune system, and (3) lifes...
Abstract
Cited 56 times since 2020 (11.2 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 14, Issue 1, 18 3 2020, Pages 233-242
The Relationship Between Coronary Calcification and the Natural History of Coronary Artery Disease.
Jin HY, Weir-McCall JR, Leipsic JA, Son JW, Sellers SL, Shao M, Blanke P, Ahmadi A, Hadamitzky M, Kim YJ, Conte E, Andreini D, Pontone G, Budoff MJ, Gottlieb I, Lee BK, Chun EJ, Cademartiri F, Maffei E, Marques H, de Araujo Goncalves P, Shin S, Choi JH, Virmani R, Samady H, Stone PH, Berman DS, Narula J, Shaw LJ, Bax JJ, Chinnaiyan K, Raff G, Al-Mallah MH, Lin FY, Min JK, Sung JM, Lee SE, Chang HJ
Objectives: The aim of the current study was to explore the impact of plaque calcification in terms of absolute calcified plaque volume (CPV) and in the context of its percentage of the total plaque volume at a lesion and patient level on the progression of coronary artery disease. Background: Coronary artery calcification is an established marker of risk of future cardiovascular events. Despite this, plaque calcification is also considered a marker of plaque stability, and it increases in respo...
Abstract
Cited 20 times since 2020 (4 per year)
source: EuropePMC
Journal of the American Heart Association,
Volume 9, Issue 23, 16 3 2020, Pages e017094
Extreme Diversity of the Human Vascular Mesenchymal Cell Landscape.
Bruijn LE, van den Akker BEWM, van Rhijn CM, Hamming JF, Lindeman JHN
Background Human mesenchymal cells are culprit factors in vascular (patho)physiology and are hallmarked by phenotypic and functional heterogeneity. At present, they are subdivided by classic umbrella terms, such as "fibroblasts," "myofibroblasts," "smooth muscle cells," "fibrocytes," "mesangial cells," and "pericytes." However, a discriminative marker-based subclassification has to date not been established. Methods and Results As a fir...
Abstract
Cited 8 times since 2020 (1.6 per year)
source: EuropePMC
American journal of physiology. Renal physiology,
Volume 320, Issue 1, 16 3 2020, Pages F17-F30
Connexin43 is differentially distributed within renal vasculature and mediates profibrotic differentiation in medullary fibroblasts.
Xu Y, Hu J, Yilmaz DE, Bachmann S
Connexins (Cxs) form gap junctions for intercellular exchange of inorganic ions and messenger molecules. In the kidney, Cxs play essential roles within its compartments, but data on the precise cellular localization and cell type-related function of their isoforms are scarce. We tested whether Cx43 distribution is restricted to vascular and interstitial cells and whether medullary fibroblasts express Cx43 to coordinate profibrotic signaling. Confocal immunofluorescence techniques, ultrastructura...
Abstract
Cited 20 times since 2020 (4 per year)
source: EuropePMC
Biomaterials,
Volume 268, 14 2 2020, Pages 120498
Fibronectin-functionalization of 3D collagen networks supports immune tolerance and inflammation suppression in human monocyte-derived macrophages.
Logie C, van Schaik T, Pompe T, Pietsch K
The extracellular matrix (ECM) is dynamically reorganized during wound healing. Concomitantly, recruited monocytes differentiate into macrophages. However, the role of the wound's ECM during this transition remain to be fully understood. Fibronectin is a multifunctional glycoprotein present in early wound ECM with a potential immunomodulatory role during monocyte-to-macrophage differentiation. Hence, to investigate the impact of fibronectin during this differentiation step, 3D fibrillar col...
Abstract
Drug metabolism and personalized therapy,
13 2 2020
The need of the clinical implementation of pharmacogenetics in European health services for routine drug prescription. What's next? An urgent clinical unmet need for patients.
Taron M, Llerena A, Manolopoulos VG, Rodriguez-Antona C, Stankovic S, van Schaik RHN
Abstract
Cited 2 times since 2020 (0.4 per year)
source: EuropePMC
Drug metabolism and personalized therapy,
Volume 35, Issue 4, 13 2 2020
The need of the clinical implementation of pharmacogenetics in European health services for routine drug prescription. What's next? An urgent clinical unmet need for patients.
Taron M, Llerena A, Manolopoulos VG, Rodriguez-Antona C, Stankovic S, van Schaik RHN
Abstract
Cited 204 times since 2020 (40.5 per year)
source: EuropePMC
Nature reviews. Cardiology,
Volume 18, Issue 4, 13 2 2020, Pages 291-304
Diabesity: the combined burden of obesity and diabetes on heart disease and the role of imaging.
Ng ACT, Delgado V, Borlaug BA, Bax JJ
Diabesity is a term used to describe the combined adverse health effects of obesity and diabetes mellitus. The worldwide dual epidemic of obesity and type 2 diabetes is an important public health issue. Projections estimate a sixfold increase in the number of adults with obesity in 40 years and an increase in the number of individuals with diabetes to 642 million by 2040. Increased adiposity is the strongest risk factor for developing diabetes. Early detection of the effects of diabesity on the...
Abstract
Cited 5 times since 2020 (1 per year)
source: EuropePMC
Pacing and clinical electrophysiology : PACE,
Volume 44, Issue 1, 12 2 2020, Pages 120-128
Mechanical extraction of cardiac implantable electronic devices leads with long dwell time: Efficacy and safety of the step up approach.
Lensvelt LMH, Egorova AD, Schalij MJ, Yilmaz D, Kennergren C, Bootsma M, van Erven L
The aim of this study was to evaluate the efficacy and safety of the stepwise mechanical transvenous lead extraction approach in a patient population with chronically implanted transvenous leads with a long dwell time. From January 2014 till December 2018, all lead extractions with lead dwell time ≥5 years performed at our tertiary centre were retrospectively analysed. A total of 173 leads, from 78 patients (median age 68 years; 81% male) with a median dwell time of 9 years (interquartile range...
Abstract
Cited 12 times since 2020 (2.4 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 164, Issue 3, 12 2 2020, Pages 822-829.e6
Why the categorization of indexed effective orifice area is not justified for the classification of prosthesis-patient mismatch.
Vriesendorp MD, Deeb GM, Reardon MJ, Kiaii B, Bapat V, Labrousse L, Rao V, Sabik JF, Gearhart E, Klautz RJM
Objectives: Although the impact of prosthesis-patient mismatch (PPM) on survival has been widely studied, there has been little debate about whether the current definition of PPM truly reflects hemodynamic obstruction. This study aimed to validate the categorization of indexed effective orifice area (EOAi) for the classification of PPM. Methods: In total, 2171 patients who underwent aortic valve replacement with a surgical stented bioprosthesis in 5 trials (CoreValve US High-Risk, SURTAVI [Surgi...
Abstract
Trends in cardiovascular medicine,
Volume 31, Issue 8, 11 2 2020, Pages 495-496
Editorial commentary: Future of transcatheter mitral valve interventions for secondary mitral regurgitation.
Vo NM, Bax JJ, Delgado V
Abstract
Cited 9 times since 2020 (1.8 per year)
source: EuropePMC
European journal of nuclear medicine and molecular imaging,
Volume 48, Issue 5, 11 2 2020, Pages 1434-1444
Global and segmental absolute stress myocardial blood flow in prediction of cardiac events: [<sup>15</sup>O] water positron emission tomography study.
Harjulahti E, Maaniitty T, Nammas W, Stenström I, Biancari F, Bax JJ, Knuuti J, Saraste A
Purpose: We evaluated the value of reduced global and segmental absolute stress myocardial blood flow (sMBF) quantified by [15O] water positron emission tomography (PET) for predicting cardiac events in patients with suspected obstructive coronary artery disease (CAD). Methods: Global and segmental sMBF during adenosine stress were retrospectively quantified in 530 symptomatic patients who underwent [15O] water PET for evaluation of coronary stenosis detected by coronary computed tomography angi...
Abstract
Cited 11 times since 2020 (2.2 per year)
source: EuropePMC
Scientific reports,
Volume 10, Issue 1, 11 2 2020, Pages 19596
Increased Ca<sup>2+</sup> content of the sarcoplasmic reticulum provides arrhythmogenic trigger source in swimming-induced rat athlete's heart model.
Gazdag P, Oravecz K, Acsai K, Demeter-Haludka V, Ördög B, Szlovák J, Kohajda Z, Polyák A, Barta BA, Oláh A, Radovits T, Merkely B, Papp JG, Baczkó I, Varró A, Nagy N, Prorok J
Sudden cardiac death among top athletes is very rare, however, it is 2-4 times more frequent than in the age-matched control population. In the present study, the electrophysiological consequences of long-term exercise training were investigated on Ca2+ homeostasis and ventricular repolarization, together with the underlying alterations of ion channel expression, in a rat athlete's heart model. 12-week swimming exercise-trained and control Wistar rats were used. Electrophysiological data we...
Abstract
Cited 32 times since 2020 (6.3 per year)
source: EuropePMC
Cell reports. Medicine,
Volume 1, Issue 9, 10 2 2020, Pages 100146
Hydroxychloroquine Inhibits the Trained Innate Immune Response to Interferons.
Rother N, Yanginlar C, Lindeboom RGH, Bekkering S, van Leent MMT, Buijsers B, Jonkman I, de Graaf M, Baltissen M, Lamers LA, Riksen NP, Fayad ZA, Mulder WJM, Hilbrands LB, Joosten LAB, Netea MG, Vermeulen M, van der Vlag J, Duivenvoorden R
Hydroxychloroquine is being investigated for a potential prophylactic effect in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but its mechanism of action is poorly understood. Circulating leukocytes from the blood of coronavirus disease 2019 (COVID-19) patients show increased responses to Toll-like receptor ligands, suggestive of trained immunity. By analyzing interferon responses of peripheral blood mononuclear cells from healthy donors conditioned with heat-killed Can...
Abstract
Cited 8 times since 2020 (1.6 per year)
source: EuropePMC
Scientific reports,
Volume 10, Issue 1, 9 2 2020, Pages 19312
From remote sensing and machine learning to the history of the Silk Road: large scale material identification on wall paintings.
Kogou S, Shahtahmassebi G, Lucian A, Liang H, Shui B, Zhang W, Su B, van Schaik S
Automatic remote reflectance spectral imaging of large painted areas in high resolution, from distances of tens of meters, has made the imaging of entire architectural interior feasible. However, it has significantly increased the volume of data. Here we present a machine learning based method to automatically detect 'hidden' writings and map material variations. Clustering of reflectance spectra allowed materials at inaccessible heights to be properly identified by performing non-inva...
Abstract
Cited 20 times since 2020 (4 per year)
source: Scopus
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 34, Issue 3, 9 2 2020, Pages 257-266
Left Ventricular Myocardial Work in Patients with Severe Aortic Stenosis.
Fortuni F, Butcher SC, van der Kley F, Lustosa RP, Karalis I, de Weger A, Priori SG, van der Bijl P, Bax JJ, Delgado V, Ajmone Marsan N
Background: Left ventricular myocardial work (LVMW) is a novel method to assess left ventricular (LV) function using pressure-strain loops that takes into consideration LV afterload. The estimation of LV afterload in patients with severe aortic stenosis (AS) may be challenging, and no study so far has investigated LVMW in this setting. The aim of this study was to develop a method to calculate LVMW in patients with severe AS and to analyze its relationship with heart failure symptoms. Methods: I...
Abstract
