9543 results
Cited 3 times since 2020 (0.6 per year)
source: EuropePMC
Journal of pediatric hematology/oncology,
Volume 42, Issue 8, 1 1 2020, Pages e712-e717
High-mobility Group Box 1 Protein in Pediatric Trauma Patients With Acute Traumatic Coagulopathy or Disseminated Intravascular Coagulation.
Ulusoy E, Duman M, Çağlar A, Küme T, Er A, Akgül F, Çitlenbik H, Yilmaz D, Ören H
Objectives: Trauma can induce the release of high-mobility group box 1 (HMGB1), which plays an important role in the activation of coagulation. In this study, we aimed to evaluate the role of HMGB1 in the early diagnosis of acute traumatic coagulopathy (ATC), disseminated intravascular coagulation, and clinical course. Materials and methods: One hundred pediatric trauma patients and 50 healthy controls were enrolled. Demographic data, physical examination results, trauma scores, International So...
Abstract
Cited 5 times since 2020 (1 per year)
source: EuropePMC
Journal of orthopaedic trauma,
Volume 34 Suppl 3, 1 1 2020, Pages S22-S28
Predictors of Loss to Follow-up in Hip Fracture Trials: A Secondary Analysis of the FAITH and HEALTH Trials.
Sivaratnam S, Comeau-Gauthier M, Sprague S, Schemitsch EH, Poolman RW, Frihagen F, Bhandari M, Swiontkowski M, Bzovsky S, FAITH Investigators, HEALTH Investigators
Background: Hip fracture trials often suffer substantial loss to follow-up due to difficulties locating and communicating with participants or when participants, or their family members, withdraw their consent. We aimed to determine which factors were associated with being unable to contact FAITH and HEALTH participants for their 24-month follow-up and to also determine which factors were associated with their withdrawal of consent. Methods: We conducted 2 multivariable logistic regression analy...
Abstract
Cited 11 times since 2020 (2.2 per year)
source: EuropePMC
Journal of orthopaedic trauma,
Volume 34 Suppl 3, 1 1 2020, Pages S9-S14
Arthroplasty Versus Internal Fixation for the Treatment of Undisplaced Femoral Neck Fractures: A Retrospective Cohort Study.
Afaq S, OʼHara NN, Schemitsch EH, Bzovsky S, Sprague S, Poolman RW, Frihagen F, Heels-Ansdell D, Bhandari M, Swiontkowski M, Slobogean GP, FAITH Investigators, HEALTH Investigators
Objective: To compare the 24-month risk of mortality between arthroplasty and internal fixation for undisplaced femoral neck fractures (FNFs). Design: Retrospective cohort study. Setting: Secondary data analysis of 2 multinational randomized controlled trials. Participants: Patients aged 50 years or older with a FNF. Intervention: Arthroplasty (n = 1441), including total hip arthroplasty and hemiarthroplasty, performed for a displaced FNF versus internal fixation (n = 734), including sliding hip...
Abstract
Cited 3 times since 2020 (0.6 per year)
source: EuropePMC
Journal of orthopaedic trauma,
Volume 34 Suppl 3, 1 1 2020, Pages S1-S8
The FAITH and HEALTH Trials: Are We Studying Different Hip Fracture Patient Populations?
Blankstein M, Schemitsch EH, Bzovsky S, Axelrod D, Poolman RW, Frihagen F, Bhandari M, Swiontkowski M, Sprague S, Schottel PC, FAITH Investigators, HEALTH Investigators
Background: Over the past decade, 2 randomized controlled trials were performed to evaluate 2 surgical strategies (internal fixation and arthroplasty) for the treatment of low-energy femoral neck fractures in patients aged ≥50 years. We evaluated whether patient populations in both the FAITH and HEALTH trials had different baseline characteristics and compared the displaced femoral neck fracture cohort from the FAITH trial to HEALTH trial patients. Methods: Patient demographics, medical comorbid...
Abstract
Cited 16 times since 2020 (3.2 per year)
source: EuropePMC
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
Volume 71, Issue 8, 1 1 2020, Pages 1847-1855
Dynamics of Intestinal Carriage of Extended-Spectrum Beta-lactamase-Producing Enterobacteriaceae in the Dutch General Population, 2014-2016.
van den Bunt G, Fluit AC, Bootsma MCJ, van Duijkeren E, Scharringa J, van Pelt W, Bonten MJM
Background: In the Netherlands, the prevalence of intestinal extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) carriage in community-dwelling subjects is ~5%. Little is known about the dynamics of ESBL-E carriage. Methods: In a nationwide, population-based study (2014-2016) with 4177 community-dwelling subjects, fecal samples from 656 subjects were collected after 1 (time point [T] = 1) and 6 (T = 2) months. The growth of ESBL-E was quantified and a whole-genome sequence ana...
Abstract
Cited 7 times since 2020 (1.4 per year)
source: EuropePMC
American journal of respiratory cell and molecular biology,
Volume 63, Issue 5, 1 1 2020, Pages 710-713
Decreased Glycolysis as Metabolic Fingerprint of Endothelial Cells in Chronic Thromboembolic Pulmonary Hypertension.
Smolders VFED, Rodríguez C, Morén C, Blanco I, Osorio J, Piccari L, Bonjoch C, Quax PHA, Peinado VI, Castellà M, Barberà JA, Cascante M, Tura-Ceide O
Abstract
Cited 3 times since 2020 (0.6 per year)
source: EuropePMC
World journal for pediatric & congenital heart surgery,
Volume 11, Issue 6, 1 1 2020, Pages 742-747
Long-Term Follow-Up of Pericardium for the Ventricular Component in Atrioventricular Septal Defect Repair.
IJsselhof RJ, Duchateau SDR, Schouten RM, Slieker MG, Hazekamp MG, Schoof PH
Background: Despite the improved outcome in complete atrioventricular septal defect (AVSD) repair, reoperations for left atrioventricular valve (LAVV) dysfunction are common. The aim of this study was to evaluate the effect of fresh untreated autologous pericardium for ventricular septal defect (VSD) closure on atrioventricular valve function and compare the results with the use of treated bovine pericardial patch material. Methods: Clinical and echocardiographic data were collected of patients...
Abstract
Cited 17 times since 2020 (3.4 per year)
source: EuropePMC
Journal of orthopaedic trauma,
Volume 34 Suppl 3, 1 1 2020, Pages S15-S21
Factors Associated With Mortality After Surgical Management of Femoral Neck Fractures.
Bzovsky S, Comeau-Gauthier M, Schemitsch EH, Swiontkowski M, Heels-Ansdell D, Frihagen F, Bhandari M, Sprague S, FAITH Investigators, HEALTH Investigators
Background: Hip fractures are recognized as one of the most devastating injuries impacting older adults because of the complications that follow. Mortality rates postsurgery can range from 14% to 58% within one year of fracture. We aimed to identify factors associated with increased risk of mortality within 24 months of a femoral neck fracture in patients aged ≥50 years enrolled in the FAITH and HEALTH trials. Methods: Two multivariable Cox proportional hazards regressions were used to investiga...
Abstract
Cited 55 times since 2020 (10.9 per year)
source: EuropePMC
European heart journal,
Volume 41, Issue 43, 1 1 2020, Pages 4181-4187
Long-term clinical outcomes of losartan in patients with Marfan syndrome: follow-up of the multicentre randomized controlled COMPARE trial.
van Andel MM, Indrakusuma R, Jalalzadeh H, Balm R, Timmermans J, Scholte AJ, van den Berg MP, Zwinderman AH, Mulder BJM, de Waard V, Groenink M
Aims: The COMPARE trial showed a small but significant beneficial effect of 3-year losartan treatment on aortic root dilatation rate in adults with Marfan syndrome (MFS). However, no significant effect was found on clinical endpoints, possibly due to a short follow-up period. The aim of the current study was therefore to investigate the long-term clinical outcomes after losartan treatment. Methods and results: In the original COMPARE study (inclusion 2008-2009), adult patients with MFS (n = 233)...
Abstract
Cited 1 times since 2020 (0.2 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 58, Issue 5, 1 1 2020, Pages 1105
What we see depends on what we look for.
Tomšič A, Klautz RJM
Abstract
Cited 28 times since 2020 (5.5 per year)
source: EuropePMC
Molecular oncology,
Volume 15, Issue 1, 31 5 2020, Pages 57-66
Comparison of variant allele frequency and number of mutant molecules as units of measurement for circulating tumor DNA.
Bos MK, Nasserinejad K, Jansen MPHM, Angus L, Atmodimedjo PN, de Jonge E, Dinjens WNM, van Schaik RHN, Del Re M, Dubbink HJ, Sleijfer S, Martens JWM
Quantification of tumor-specific variants (TSVs) in cell-free DNA is rapidly evolving as a prognostic and predictive tool in patients with cancer. Currently, both variant allele frequency (VAF) and number of mutant molecules per mL plasma are used as units of measurement to report those TSVs. However, it is unknown to what extent both units of measurement agree and what are the factors underlying an existing disagreement. To study the agreement between VAF and mutant molecules in current clinica...
Abstract
Cited 10 times since 2020 (2 per year)
source: EuropePMC
Pediatric nephrology (Berlin, Germany),
Volume 36, Issue 5, 31 5 2020, Pages 1195-1205
Predictors of poor kidney outcome in children with C3 glomerulopathy.
Pınarbaşı AS, Dursun I, Gokce I, Çomak E, Saygılı S, Bayram MT, Donmez O, Melek E, Tekcan D, Çiçek N, Yılmaz D, Tabel Y, Yıldırım ZY, Bahat E, Koyun M, Soylu A, Canpolat N, Aksu B, Çelakıl ME, Taşdemir M, Benzer M, Özçelik G, Bakkaloğlu SA, Düşünsel R
Background: C3 glomerulopathy (C3G) is characterized by heterogeneous clinical presentation, outcome, and predominant C3 accumulation in glomeruli without significant IgG. There is scarce outcome data regarding childhood C3G. We describe clinical and pathological features, treatment and outcomes, and risk factors for progression to chronic kidney disease stage 5 (CKD5) in the largest pediatric series with biopsy-proven C3G. Methods: Sixty pediatric patients with C3G from 21 referral centers in T...
Abstract
Cited 11 times since 2020 (2.2 per year)
source: EuropePMC
Cancers,
Volume 12, Issue 11, 29 5 2020, Pages E3179
Plasma Predictive Features in Treating EGFR-Mutated Non-Small Cell Lung Cancer.
Steendam CMJ, Veerman GDM, Pruis MA, Atmodimedjo P, Paats MS, van der Leest C, von der Thüsen JH, Yick DCY, Oomen-de Hoop E, Koolen SLW, Dinjens WNM, van Schaik RHN, Mathijssen RHJ, Aerts JGJV, Dubbink HJ, Dingemans AC
Although epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are the preferred treatment for patients with EGFR-mutated non-small cell lung cancer (NSCLC), not all patients benefit. We therefore explored the impact of the presence of mutations found in cell-free DNA (cfDNA) and TKI plasma concentrations during treatment on progression-free survival (PFS). In the prospective START-TKI study blood samples from 41 patients with EGFR-mutated NSCLC treated with EGFR-TKIs were av...
Abstract
Cited 13 times since 2020 (2.6 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 14, Issue 4, 28 4 2020, Pages 756-765
Insufficient Mitral Leaflet Remodeling in Relation to Annular Dilation and Risk of Residual Mitral Regurgitation After MitraClip Implantation.
Hirasawa K, Namazi F, Milhorini Pio S, Vo NM, Ajmone Marsan N, Bax JJ, Delgado V
Objectives: The purpose of this study was to determine whether the mitral valve (MV) total leaflet area (TLA)-to-mitral annular area (MAA) (TLA/MAA) ratio measured using 3-dimensional (3D) transesophageal echocardiography (TEE) was associated with residual mitral regurgitation (MR) after MitraClip implantation in patients with secondary MR. Background: The factors influencing the results of MitraClip implantation for secondary MR are controversial. This study hypothesized that insufficient remod...
Abstract
Cited 19 times since 2020 (3.7 per year)
source: EuropePMC
JACC. Clinical electrophysiology,
Volume 7, Issue 2, 28 4 2020, Pages 197-205
Mini-, Micro-, and Conventional Electrodes: An in Vivo Electrophysiology and Ex Vivo Histology Head-to-Head Comparison.
Glashan CA, Beukers HKC, Tofig BJ, Tao Q, Blom S, Mertens B, Kristiansen SB, Zeppenfeld K
Objectives: This study sought to assess the relative effect of catheter, tissue, and catheter-tissue parameters, on the ability to determine the amount of viable myocardium in vivo. Background: Although multiple variables impact bipolar voltages (BVs), electrode size, interelectrode spacing, and directional dependency are of particular interest with the development of catheters incorporating mini and microelectrodes. Methods: Nine swine with early reperfusion myocardial infarctions were mapped u...
Abstract
Cited 4 times since 2020 (0.8 per year)
source: EuropePMC
Journal of gastrointestinal and liver diseases : JGLD,
Volume 29, Issue 4, 27 4 2020, Pages 617-622
Evaluation of the Association between Programmed Cell Death-1 Gene Polymorphisms and Hepatocellular Carcinoma Susceptibility in Turkish Subjects. A Pilot Study.
Demirci AF, Demirtas CO, Eren F, Yilmaz D, Keklikkiran C, Ozdogan OC, Gunduz F
Background and aims: Programmed cell death-1 (PD-1) has a vital role in regulating T-cell function, and immune escape mechanism of cancer cells. It was shown that there could be a relationship between single nucleotide polymorphisms (SNPs) in the PD-1 gene and susceptibility to hepatocellular carcinoma (HCC) based on various studies. We aimed to investigate the role of three SNPs within the PD-1 gene in susceptibility to HCC in the Turkish population. Methods: Single nucleotide polymorphisms of...
Abstract
Cited 20 times since 2020 (3.9 per year)
source: EuropePMC
Cardiovascular drugs and therapy,
Volume 36, Issue 4, 21 3 2020, Pages 739-748
The Use of Angiotensin II for the Treatment of Post-cardiopulmonary Bypass Vasoplegia.
Papazisi O, Palmen M, Danser AHJ
Purpose: Vasoplegia is a common complication after cardiac surgery and is related to the use of cardiopulmonary bypass (CPB). Despite its association with increased morbidity and mortality, no consensus exists in terms of its treatment. In December 2017, angiotensin II (AII) was approved by the Food and Drug Administration (FDA) for use in vasodilatory shock; however, except for the ATHOS-3 trial, its use in vasoplegic patients that underwent cardiac surgery on CPB has mainly been reported in ca...
Abstract
Cited 2 times since 2020 (0.4 per year)
source: EuropePMC
Journal of cardiac surgery,
Volume 35, Issue 12, 21 3 2020, Pages 3477-3485
Prosthesis-patient mismatch after mitral valve replacement: A pooled meta-analysis of Kaplan-Meier-derived individual patient data.
Tomšič A, Arabkhani B, Schoones JW, Etnel JRG, Marsan NA, Klautz RJM, Palmen M
Objective: The hemodynamic effect and early and late survival impact of prosthesis-patient mismatch (PPM) after mitral valve replacement remains insufficiently explored. Methods: Pubmed, Embase, Web of Science, and Cochrane Library databases were searched for English language original publications. The search yielded 791 potentially relevant studies. The final review and analysis included 19 studies compromising 11,675 patients. Results: Prosthetic effective orifice area was calculated with the...
Abstract
Cited 6 times since 2020 (1.2 per year)
source: EuropePMC
International journal of cardiology,
Volume 326, 21 3 2020, Pages 88-91
The aortic root in repaired tetralogy of Fallot: Serial measurements and impact of losartan treatment.
Woudstra OI, Ghanam A, Vliegen HW, van Dijk APJ, van Melle JP, Groenink M, Meijboom FJ, Post MC, Mulder BJM, Bouma BJ, Bokma JP
Background: Aortic root dilatation is common in adults with repaired tetralogy of Fallot (rTOF) and might lead to aortic dissection. However, little is known on progression of aortic dilatation and the effect of pharmaceutical treatment. This study aims to determine factors associated with aortic growth and investigate effects of losartan. Methods and results: We performed a prespecified analysis from the 1:1 randomized, double-blind REDEFINE trial. Aortic root diameters were measured at baselin...
Abstract
Cited 6 times since 2020 (1.2 per year)
source: EuropePMC
The Annals of pharmacotherapy,
Volume 55, Issue 6, 17 3 2020, Pages 697-704
Impact of Extended-Interval Versus Standard Dosing of Zoledronic Acid on Skeletal Events in Non-Small-Cell Lung Cancer and Small-Cell Lung Cancer Patients With Bone Metastases.
Tam AH, Schepers AJ, Qin A, Nachar VR
Background: Zoledronic acid every 4 weeks (Q4wk) reduces the incidence of skeletal-related events (SREs) in patients with metastatic lung cancer. Lung cancer patients were excluded from extended-interval dosing trials (every 12 weeks [Q12wk]) that demonstrated noninferiority of the 2 dosing schemes. To date, the optimal dosing of zoledronic acid in metastatic lung cancer remains unknown. Objective: To determine whether zoledronic acid dosed Q12wk is similar to Q4wk dosing for prevention of SRE i...
Abstract
