7365 results
Cited 1 times since 2025 (1.7 per year)
source: EuropePMC
Cardiovascular drugs and therapy,
14 2 2025
Geranylgeranylacetone as Prevention for Postoperative Atrial Fibrillation (GENIALITY).
S Ramos K, Nassiri S, Wijdeveld LFJ, van der Palen RL, Kuipers MF, Hills MT, Slijkerman P, van Raalte DH, Handoko ML, de Groot NMS, Grewal N, Klautz RJM, Eringa EC, Brundel BJJM
Purpose: Interestingly, 30-50% of patients undergoing elective cardiothoracic surgery develop postoperative AF (PoAF). Unfortunately, preventive PoAF therapy is still suboptimal. In our previous studies, we showed that oral Geranylgeranylacetone (GGA) administration increased cardioprotective heat shock protein (HSP) protecting against AF onset and progression in clinically relevant animal model studies. Methods: The GENIALITY study is a phase II single-center, double-blind, placebo-controlled r...
Abstract
Cited 1 times since 2025 (1.7 per year)
source: EuropePMC
International journal of cardiology,
Volume 432, 11 2 2025, Pages 133269
Early aortic valve replacement versus conservative management in asymptomatic severe aortic stenosis: Meta-analysis of time-to-event data of randomized controlled trials.
Jacquemyn X, Sá MP, Marín-Cuartas M, Bax JJ, Borger MA, Clavel MA, Pibarot P, Généreux P, Sultan I
Background: Current guidelines recommend aortic valve replacement (AVR) for symptomatic patients with severe aortic stenosis (AS), but the optimal timing for intervention in asymptomatic patients is still debated. Recent randomized controlled trials (RCTs) have offered new insights, prompting a reevaluation of the potential benefits of early AVR. Methods: A systematic review and pooled meta-analysis of Kaplan-Meier-derived reconstructed time-to-event data of RCTs published by November 2024 was c...
Abstract
European journal of preventive cardiology,
9 2 2025, Pages zwaf193
Lifestyle behaviour change of patients following cardiac rehabilitation: the BENEFIT intervention study with one-year follow-up.
Breeman LD, Janssen VR, Kraaijenhagen RA, Al-Dhahir I, IJzerman RVH, Wolstencroft K, Kraaij W, Bonten TN, Atsma DE, Chavannes NH, van Gemert-Pijnen L, Kemps HMC, Scholte Op Reimer W, Evers AWM
Background: The majority of people with cardiovascular disease (CVD) do not maintain a healthy lifestyle. To help patients implement behaviour change at home, the BENEFIT programme was developed as an addition to cardiac rehabilitation (CR) care. Methods: Using a cluster non-randomised controlled trial design involving 7 CR centres, we examined whether intervention group patients (n=587) showed increased improvements in health behaviour change compared to control group patients (n=298) who (only...
Abstract
World journal of surgical oncology,
Volume 23, Issue 1, 8 2 2025, Pages 128
Re-do robot-assisted salvage lobectomy after esophagectomy with gastric pull-up reconstruction: a case report.
Shahin G, Kharbanda R, Tummers Q, Braun J
Background: Robot-assisted Thoracic Surgery (RATS) is well-established for complex minimally invasive thoracic surgery. Despite the available literature, robotics for complex advanced NSCLC for re-do surgery remains underexplored. Case presentation: We present a 55-year-old female who underwent esophagectomy with gastric pull-up reconstruction for squamous cell carcinoma (SCC) of the esophagus (cT3N2M0, stage IIIB) after neo-adjuvant concurrent chemoradiation therapy (ypT2N1 stage IIB disease)....
Abstract
Cited 6 times since 2025 (9.8 per year)
source: EuropePMC
Circulation,
Volume 151, Issue 14, 7 1 2025, Pages 1047-1050
Relation of Low-Density Lipoprotein Cholesterol, High-Sensitivity C-Reactive Protein, and Lipoprotein(a) Each to Future Cardiovascular Events and Death After Acute Coronary Syndrome on High-Intensity Statin Therapy: An Analysis of the Placebo Arm of ODYSSEY OUTCOMES.
Steg PG, Szarek M, Jukema JW, Bhatt DL, Bittner VA, Diaz R, Fazio S, Garon G, Goodman SG, Harrington RA, White HD, Zeiher AM, Schwartz GG, ODYSSEY OUTCOMES Investigators
Abstract
Cited 1 times since 2025 (1.6 per year)
source: EuropePMC
Journal of cardiovascular development and disease,
Volume 12, Issue 4, 7 1 2025, Pages 140
Brief Review: Racial Disparities in the Presentation and Outcomes of Patients with Thoracic Aortic Aneurysms.
Bacour N, Theijsse RT, Grewal S, Klautz RJM, Grewal N
(1) Background: Thoracic aortic aneurysms (TAAs) pose critical health risks and are often asymptomatic until a rupture or dissection occurs. Guidelines recommend surgical repair based on specific aortic diameters and risk factors, emphasizing the importance of early detection and intervention. Despite established clinical risk factors for the early detection of TAAs, the influence of racial disparities on TAAs remains underexplored. This study aims to provide a comprehensive summary of existing...
Abstract
Cited 1 times since 2025 (1.6 per year)
source: EuropePMC
Journal of hazardous materials,
Volume 492, 4 1 2025, Pages 138170
Estimating the emission of microplastics from urban surfaces into the atmosphere using the PI-SWERL.
Leitão IA, van Schaik L, Goossens D, Ferreira AJD, Geissen V
Microplastics (MPs) are a global concern, with the atmosphere being a key pathway for their transport. Understanding their sources is crucial for controlling MP dispersion. This study examines MPs on urban surfaces and their transport through wind erosion using a Portable In Situ Wind Erosion Laboratory (PI-SWERL) under two wind shear conditions. Material was collected in Coimbra, Portugal, from fourteen locations associated with different land uses. MPs number and types were determined with a s...
Abstract
Cited 4 times since 2025 (6.4 per year)
source: EuropePMC
Journal of the European Academy of Dermatology and Venereology : JEADV,
3 1 2025
Infection risk in atopic dermatitis patients treated with biologics and JAK inhibitors: BioDay results.
van der Gang LF, Atash K, Zuithoff NPA, Haeck I, Boesjes CM, Bacoş-Cosma OI, Loman L, Kamsteeg M, Stadhouders-Keet S, Oosting AJ, van Lynden-van Nes AMT, Politiek K, Gostynksi A, Berntsen-Zandbergen L, Christoffers WA, Flinterman A, Touwslager WRH, Velstra B, Stewart SM, van Erp FC, de Graaf M, Schuttelaar MA, de Bruin-Weller MS
Background: Limited data exist on the comparative risk of infections during biologic and Janus kinase inhibitor (JAKi) treatment for atopic dermatitis (AD) in daily practice. Objective: To assess the differential infection risk of biologic and JAKi treatment in patients with moderate-to-severe AD in a real-world setting. Methods: This prospective, multicentre study evaluated treatment-emergent infections in patients (age ≥ 12 years) using biologics or JAKi from the BioDay registry from October 2...
Abstract
BMJ nutrition, prevention & health,
Volume 8, Issue 1, 3 1 2025, Pages e001059
In-hospital nudging intervention increases patients' healthy dietary choices: a quasi-experimental study.
de Frel DL, Janssen VR, Wicks H, Bakk Z, van Keulen N, Kleinsmann MS, Assendelft WJ, Atsma D
Aims: Most hospitals still lag behind in their policies to stimulate healthier dietary choices by their patients. This study investigates whether a multicomponent nudging intervention, designed to prompt healthy food choices, can influence dietary choices of hospitalised patients. Methods: This pre-postintervention study included a baseline phase and an intervention phase (7+7 months) and was carried out at the cardiology ward of a large hospital. All 2419 cardiac patients admitted to the ward d...
Abstract
International journal of cardiology. Congenital heart disease,
Volume 20, 3 1 2025, Pages 100580
A 2:1 atrioventricular block in an adult patient with a Fontan circulation: from transesophageal pacing to echocardiographic guidance of epicardial pacemaker lead placement.
Smit JM, Regeer MV, Wijnmaalen AP, Jongbloed MRM, Hazekamp MG, Egorova AD
Background: The diagnosis and management of atrioventricular (AV)-conduction disorders in patients with a Fontan circulation can be challenging. Little is known about the effects of various pacing strategies in single-ventricle patients. Here we report 1) the feasibility of transesophageal electrophysiological study (EPS) to assess AV-conduction in a patient with limited venous access and 2) the potential of echocardiography to guide epicardial systemic right ventricular (sRV) lead positioning a...
Abstract
Cited 1 times since 2025 (1.6 per year)
source: EuropePMC
Atherosclerosis,
Volume 404, 3 1 2025, Pages 119184
Sex related coronary plaque progression patterns among patients with family history as the sole cardiovascular risk factor: A PARADIGM sub-study.
Conte E, Lee SE, Chang HJ, Hadamitzky M, Kim YJ, Pontone G, Budoff MJ, Gottlieb I, Lee BK, Chun EJ, Cademartiri F, Maffei E, Marques H, Di Lenarda F, Guarnieri G, Leipsic JA, Shin S, Choi JH, Mouaz AM, Chinnaiyan K, Pedro AG, Sung JM, Virmani R, Samady H, Lin FY, Stone PH, Narula J, Shaw L, Bax JJ, Andreini D
Background and aims: How sex may influence the prevalence and progression of coronary atherosclerosis in patients with positive family history for CAD is still unclear. Aim of the present study was to explore the role of family history of CAD in coronary atherosclerosis expression and progression in male and female subjects. Methods: A total of 2252 patients who underwent clinically indicated serial CCTAs at an interscan interval of more than 2 years were enrolled in the PARADIGM Study. For the...
Abstract
North American Spine Society journal,
Volume 22, 2 1 2025, Pages 100609
Sexual health and chronic low back pain: A qualitative study.
van Schaik D, Channa H, Fobelets M, Moens M, Scheerlinck T, Goudman L
Background: Chronic low back pain presents a major challenge to society and healthcare systems, with significant financial and personal consequences. Beyond physical limitations, it affects relationships and sexual well-being-an often-overlooked aspect. Reduced sexual activity and satisfaction can strain intimacy, heighten psychological stress, and amplify pain perception. Despite its importance, sexual health remains underdiscussed in clinical care, and research on this topic is limited. A holi...
Abstract
Cited 1 times since 2025 (1.6 per year)
source: EuropePMC
EJVES vascular forum,
Volume 64, 2 1 2025, Pages 8-15
Strategies for Antithrombotic Management During Non-cardiac Arterial Procedures: Results of the International ACTION Survey.
Hoebink M, Jongkind V, European Vascular Research Collaborative, ACTION-1 Research Collaborative
Objective: Peri-procedural antithrombotics are used extensively to prevent thromboembolic complications during non-cardiac arterial procedures (NCAP) worldwide. However, there is a lack of evidence to support recommendations on antithrombotic strategies, possibly leading to substantial variation in local practices. A comprehensive overview of antithrombotic strategies is needed to identify the most widely accepted protocols employed during NCAP, highlight variations in local practices, and ident...
Abstract
Cited 4 times since 2025 (6.4 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 85, Issue 14, 1 1 2025, Pages 1471-1484
Cardiac Troponins and Cardiovascular Disease Risk Prediction: An Individual-Participant-Data Meta-Analysis.
Shah ASV, Keene SJ, Pennells L, Kaptoge S, Kimenai DM, Walker M, Halley JD, Rocha S, Hoogeveen RC, Gudnason V, Bakker SJL, Wannamethee SG, Pareek M, Eggers KM, Jukema JW, Hankey GJ, deLemos JA, Ford I, Omland T, Lyngbakken MN, Psaty BM, deFilippi CR, Wood AM, Danesh J, Welsh P, Sattar N, Mills NL, Di Angelantonio E, CAPRICE Co-Investigators
Background: The extent to which high-sensitivity cardiac troponin can predict cardiovascular disease (CVD) is uncertain. Objectives: We aimed to quantify the potential advantage of adding information on cardiac troponins to conventional risk factors in the prevention of CVD. Methods: We meta-analyzed individual-participant data from 15 cohorts, comprising 62,150 participants without prior CVD. We calculated HRs, measures of risk discrimination, and reclassification after adding cardiac troponin...
Abstract
Cited 6 times since 2025 (9.6 per year)
source: EuropePMC
Diabetes care,
Volume 48, Issue 4, 1 1 2025, Pages 596-604
Risk of Incident Diabetes Related to Lipoprotein(a), LDL Cholesterol, and Their Changes With Alirocumab: Post Hoc Analyses of the ODYSSEY OUTCOMES Randomized Trial.
Schwartz GG, Szarek M, Jukema JW, Cobbaert CM, Reijnders E, Bittner VA, Schwertfeger M, Bhatt DL, Fazio S, Garon G, Goodman SG, Harrington RA, White HD, Steg PG
Objective: Previous genetic and clinical analyses have associated lower lipoprotein(a) and LDL cholesterol (LDL-C) with greater risk of new-onset type 2 diabetes (NOD). However, PCSK9 inhibitors such as alirocumab lower both lipoprotein(a) and LDL-C without effect on NOD. Research design and methods: In a post hoc analysis of the ODYSSEY OUTCOMES trial (NCT01663402), we examined the joint prediction of NOD by baseline lipoprotein(a), LDL-C, and insulin (or HOMA-insulin resistance [HOMA-IR]) and...
Abstract
Multiple sclerosis journal - experimental, translational and clinical,
Volume 11, Issue 2, 1 1 2025, Pages 20552173251335625
Allele-specific vitamin D receptor binding is associated with pediatric-onset multiple sclerosis.
Yilmaz D, Adams C, Horton MK, Graves JS, Francisco C, Edwards A, Quach H, Quach D, Aaen G, Lotze T, Mar S, Ness J, Wheeler Y, Gorman MP, Benson L, Weinstock-Guttman B, Waldman A, Schreiner T, Tillema JM, Chitnis T, Rose J, Casper TC, Rensel M, Waubant E, Barcellos LF, Network of Pediatric Multiple Sclerosis Centers
Background and objectives: The genetic basis of adult-onset multiple sclerosis (MS) is well-studied, but less is known about pediatric-onset MS (pedMS), comprising approximately 5% of all MS onsets. Mendelian randomization (MR) studies have demonstrated evidence for a causal association between MS and both 25-hydroxyvitamin D [25(OH)D] serum levels and genetic variation related to vitamin D receptor (VDR) binding. The objective was to identify whether VDR binding variants (VDR-BVs) previously im...
Abstract
European heart journal. Cardiovascular Imaging,
Volume 26, Issue 5, 1 1 2025, Pages 918-927
The reversibility of cardiac damage after transcatheter aortic valve implantation and short-term outcomes in a real-world setting.
Myagmardorj R, Fortuni F, Généreux P, Nabeta T, Stassen J, Galloo X, Meucci MC, Butcher S, van der Kley F, Cohen DJ, Clavel MA, Pibarot P, Leon MB, Regeer MV, Delgado V, Ajmone Marsan N, Bax JJ
Aims: This study aims to assess the changes in cardiac damage stage in a real-world cohort of patients undergoing transcatheter aortic valve implantation (TAVI), and to investigate the prognostic value of cardiac damage stage evolution. Methods and results: Patients with severe aortic stenosis (AS) undergoing TAVI were retrospectively analysed. A five-stage system based on the presence and extent of cardiac damage assessed by echocardiography was applied before and 6 months after TAVI. Multivari...
Abstract
Proceedings. IEEE International Symposium on Biomedical Imaging,
Volume 2025, 1 1 2025
CT CONTRAST PHASE IDENTIFICATION BY PREDICTING THE TEMPORAL ANGLE USING CIRCULAR REGRESSION.
Su D, Van Schaik KD, Remedios LW, Li T, Maldonado F, Sandler KL, Dawant BM, Landman BA
Contrast enhancement is widely used in computed tomography (CT) scans, where radiocontrast agents circulate through the bloodstream and accumulate in the vasculature, creating visual contrast between blood vessels and surrounding tissues. This work introduces a technique to predict the timing of contrast in a CT scan, a key factor influencing the contrast effect, using circular regression models. Specifically, we represent the contrast timing as unit vectors on a circle and employ 2D convolution...
Abstract
Cited 1 times since 2025 (1.6 per year)
source: EuropePMC
Acta anaesthesiologica Scandinavica,
Volume 69, Issue 4, 1 1 2025, Pages e70021
Characteristics and outcomes of older patients undergoing out- versus inpatient surgery in Europe. A secondary analysis of the Peri-interventional Outcome Study in the Elderly (POSE).
Grüßer L, Coburn M, Schmid M, Rossaint R, Ziemann S, Kowark A, POSE Study group
Background: The number of older patients undergoing surgical procedures with anaesthesia care is projected to rise. In order to cope with the increased demand, the expansion of outpatient surgery may play a decisive role. We aim to investigate the characteristics and outcomes of the older outpatient population. Patients and methods: The Peri-interventional Outcome Study in the Elderly in Europe (POSE) was a prospective multicenter study investigating characteristics and outcomes in 9497 patients...
Abstract
Neural computation,
Volume 37, Issue 5, 1 1 2025, Pages 926-956
The Leaky Integrate-and-Fire Neuron Is a Change-Point Detector for Compound Poisson Processes.
Mani S, Hurley P, van Schaik A, Monk T
Animal nervous systems can detect changes in their environments within hundredths of a second. They do so by discerning abrupt shifts in sensory neural activity. Many neuroscience studies have employed change-point detection (CPD) algorithms to estimate such abrupt shifts in neural activity. But very few studies have suggested that spiking neurons themselves are online change-point detectors. We show that a leaky integrate-and-fire (LIF) neuron implements an online CPD algorithm for a compound P...
Abstract
