Research

Publications

Below you can find a list of our published research.

9543 results

Cited 25 times since 2019 (3.9 per year) source: EuropePMC

Alimentary pharmacology & therapeutics, Volume 50, Issue 4, 16 3 2019, Pages 386-396 Earlier discontinuation of TNF-α inhibitor therapy in female patients with inflammatory bowel disease is related to a greater risk of side effects. Schultheiss JPD, Brand EC, Lamers E, van den Berg WCM, van Schaik FDM, Oldenburg B, Fidder HH

Background: In rheumatoid arthritis and psoriasis female sex has been shown to be associated with discontinuation of anti-tumour necrosis factor-α (TNF-α) therapy. Aim: To retrospectively assess the association between sex and TNF-α drug persistence in patients with inflammatory bowel disease (IBD). Methods: All IBD patients on anti-TNF-α therapy with a minimum follow-up of 12 months in a single tertiary centre were identified. Patient and treatment characteristics and reasons for anti-TNF-α dis... Abstract

Cited 5 times since 2019 (0.8 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 32, Issue 10, 13 2 2019, Pages 1277-1285 ST-Segment Elevation Myocardial Infarction in Patients With Chronic Obstructive Pulmonary Disease: Prognostic Implications of Right Ventricular Systolic Dysfunction as Assessed with Two-Dimensional Speckle-Tracking Echocardiography. Goedemans L, Hoogslag GE, Abou R, Schalij MJ, Marsan NA, Bax JJ, Delgado V

Background: Right ventricular (RV) systolic function in patients admitted with ST-segment elevation myocardial infarction (STEMI) with chronic obstructive pulmonary disease (COPD) and its impact on prognosis have not been characterized. The present study aims to compare the prevalence of RV systolic dysfunction in COPD versus non-COPD patients with STEMI and evaluate the prognostic implications. Methods: One hundred seventeen STEMI patients with COPD with transthoracic echocardiography performed... Abstract

Cited 5 times since 2019 (0.8 per year) source: Scopus

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 32, Issue 9, 13 2 2019, Pages 1058-1066.e2 Changes in Left Ventricular Global Longitudinal Strain after Transcatheter Aortic Valve Implantation according to Calcification Burden of the Thoracic Aorta. Gegenava T, Vollema EM, van Rosendael A, Abou R, Goedemans L, van der Kley F, de Weger A, Ajmone Marsan N, Bax JJ, Delgado V

Background: After transcatheter aortic valve replacement (TAVR), changes in left ventricular (LV) function are partly influenced by the vascular afterload. The burden of thoracic aorta calcification is a component of vascular afterload. Objective: To assess changes in LV systolic function measured with global longitudinal strain (GLS) in relation to the burden of thoracic aorta calcification in patients with severe aortic stenosis treated with TAVR. Methods: Calcification of the thoracic aorta w... Abstract

Cited 27 times since 2019 (4.2 per year) source: EuropePMC

Journal for immunotherapy of cancer, Volume 7, Issue 1, 12 2 2019, Pages 182 Donor-derived cell-free DNA detects kidney transplant rejection during nivolumab treatment. Hurkmans DP, Verhoeven JGHP, de Leur K, Boer K, Joosse A, Baan CC, von der Thüsen JH, van Schaik RHN, Mathijssen RHJ, van der Veldt AAM, Hesselink DA

Background: In solid organ transplant (SOT) recipients, transplant rejection during immune checkpoint inhibitor (ICI) treatment for cancer is a clinical problem. Donor-derived cell-free DNA (dd-cfDNA) can be detected in blood and is a sensitive biomarker for diagnosis of acute rejection in SOT recipients. To our best knowledge, this is the first case report of a kidney transplant recipient with advanced cancer treated with ICI who was monitored with dd-cfDNA. Case presentation: A 72-year old fem... Abstract

Cited 41 times since 2019 (6.4 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 105, Issue 22, 10 2 2019, Pages 1732-1740 Progression of aortic root dilatation and aortic valve regurgitation after the arterial switch operation. van der Palen RLF, van der Bom T, Dekker A, Tsonaka R, van Geloven N, Kuipers IM, Konings TC, Rammeloo LAJ, Ten Harkel ADJ, Jongbloed MRM, Koolbergen DR, Mulder BJM, Hazekamp MG, Blom NA

Objective: To study neo-aortic growth and the evolution of neo-aortic valve regurgitation (AR) in patients with transposition of the great arteries (TGA) after arterial switch operation (ASO) from newborn to adulthood and to identify patients at risk. Methods: Neo-aortic dimensions (annulus/root/sinotubular junction) and neo-aortic valve regurgitation were assessed serially in 345 patients with TGA who underwent ASO between 1977 and 2015. Linear mixed-effect models were used to assess increase o... Abstract

Cited 19 times since 2019 (3 per year) source: EuropePMC

Medical teacher, Volume 42, Issue 8, 8 2 2019, Pages 880-885 Twelve tips for assessing medical knowledge with open-ended questions: Designing constructed response examinations in medical education. Hauer KE, Boscardin C, Brenner JM, van Schaik SM, Papp KK

Medical knowledge examinations employing open-ended (constructed response) items can be useful to assess medical students' factual and conceptual understanding. Modern day curricula that emphasize active learning in small groups and other interactive formats lend themselves to an assessment format that prompts students to share conceptual understanding, explain, and elaborate. The open-ended question examination format can provide faculty with insights into learners' abilities to apply... Abstract

Cited 8 times since 2019 (1.3 per year) source: EuropePMC

Australian veterinary journal, Volume 97, Issue 10, 8 2 2019, Pages 404-413 Bovine digital dermatitis in Victoria, Australia. Hesseling J, Legione AR, Stevenson MA, McCowan CI, Pyman MF, Finochio C, Nguyen D, Roic CL, Thiris OL, Zhang AJ, van Schaik G, Coombe JE

Aims: The objectives of this study were to estimate the prevalence of digital dermatitis (DD) in Victoria, Australia, and to investigate which organisms are consistent with typical DD lesions. The prevalence and causative pathogens of DD are not clear yet in Australia and this paper is one of the first to explore these questions in this country. Methods: Examination and sampling of limbs was undertaken at three knackeries in Victoria, Australia. Limbs were classified as normal (N), active DD-les... Abstract

Cited 10 times since 2019 (1.6 per year) source: EuropePMC

Metabolic brain disease, Volume 34, Issue 5, 5 1 2019, Pages 1487-1491 Exon 2 deletion represents a common mutation in Turkish patients with fructose-1,6-bisphosphatase deficiency. Kılıç M, Kasapkara ÇS, Yılmaz DY, Özgül RK

Fructose-1,6-bisphosphatase (FBPase) deficiency is an autosomal recessive inborn error of gluconeogenesis. We aimed to investigate clinical and biochemical findings and molecular genetic data in ten Turkish patients with fructose-1,6-bisphosphatase deficiency. Ten Turkish patients who were diagnosed with fructose-1,6-biphosphatase deficiency in a single center from 2013 to 2019 were included in this study. Their clinical and laboratory data were collected retrospectively. All patients were hospi... Abstract

Cited 32 times since 2019 (5 per year) source: EuropePMC

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Volume 33, Issue 9, 5 1 2019, Pages 10453-10468 Cardiomyocyte-myofibroblast contact dynamism is modulated by connexin-43. Schultz F, Swiatlowska P, Alvarez-Laviada A, Sanchez-Alonso JL, Song Q, de Vries AAF, Pijnappels DA, Ongstad E, Braga VMM, Entcheva E, Gourdie RG, Miragoli M, Gorelik J

Healthy cardiomyocytes are electrically coupled at the intercalated discs by gap junctions. In infarcted hearts, adverse gap-junctional remodeling occurs in the border zone, where cardiomyocytes are chemically and electrically influenced by myofibroblasts. The physical movement of these contacts remains unquantified. Using scanning ion conductance microscopy, we show that intercellular contacts between cardiomyocytes and myofibroblasts are highly dynamic, mainly owing to the edge dynamics (lamel... Abstract

Cited 14 times since 2019 (2.2 per year) source: EuropePMC

ChemistryOpen, Volume 8, Issue 7, 4 1 2019, Pages 888-895 Creation of Conductive Graphene Materials by Bacterial Reduction Using <i>Shewanella Oneidensis</i>. Lehner BAE, Janssen VAEC, Spiesz EM, Benz D, Brouns SJJ, Meyer AS, van der Zant HSJ

Graphene's maximized surface-to-volume ratio, high conductance, mechanical strength, and flexibility make it a promising nanomaterial. However, large-scale graphene production is typically cost-intensive. This manuscript describes a microbial reduction approach for producing graphene that utilizes the bacterium Shewanella oneidensis in combination with modern nanotechnology to enable a low-cost, large-scale production method. The bacterial reduction approach presented in this paper increase... Abstract

Cited 1 times since 2019 (0.2 per year) source: EuropePMC

Journal of affective disorders, Volume 257, 4 1 2019, Pages 180-186 Supported self-help to prevent relapse or recurrence of depression: Who benefits most? Dijkstra-Kersten SM, Biesheuvel-Leliefeld KE, van der Wouden JC, van Schaik DJ, Bosmans JE, van Marwijk HW, van der Horst HE

Background: This study aimed to identify subgroups for whom supported self-help preventive cognitive therapy (S-PCT) is more (cost)effective than treatment as usual (TAU) in preventing relapse and recurrence of major depression. Methods: We conducted a randomized controlled trial in which 248 remitted, recurrently depressed participants were randomized to S-PCT (n = 124) or TAU (n = 124). Clinical outcome was relapse or recurrence of major depressive disorder (SCID-I). We tested the moderating e... Abstract

Cited 36 times since 2019 (5.6 per year) source: EuropePMC

Neurology(R) neuroimmunology & neuroinflammation, Volume 6, Issue 5, 3 1 2019, Pages e590 Long-term safety and efficacy of subcutaneous immunoglobulin IgPro20 in CIDP: PATH extension study. van Schaik IN, Mielke O, Bril V, van Geloven N, Hartung HP, Lewis RA, Sobue G, Lawo JP, Praus M, Durn BL, Cornblath DR, Merkies ISJ, PATH study group

Objective: To investigate the long-term safety and efficacy of weekly subcutaneous IgPro20 (Hizentra, CSL Behring) in chronic inflammatory demyelinating polyneuropathy (CIDP). Methods: In a 48-week open-label prospective extension study to the PATH study, patients were initially started on 0.2 g/kg or on 0.4 g/kg weekly and-if clinically stable-switched to 0.2 g/kg weekly after 24 weeks. Upon CIDP relapse on the 0.2 g/kg dose, 0.4 g/kg was (re)initiated. CIDP relapse was defined as a deteriorati... Abstract

Cited 70 times since 2019 (10.9 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 32, Issue 9, 3 1 2019, Pages 1120-1127 Global Left Ventricular Myocardial Work Efficiency in Healthy Individuals and Patients with Cardiovascular Disease. El Mahdiui M, van der Bijl P, Abou R, Ajmone Marsan N, Delgado V, Bax JJ

Background: Global left ventricular (LV) myocardial work efficiency, the ratio of constructive to wasted work in all LV segments, reflects the efficiency by which mechanical energy is expended during the cardiac cycle. Global LV myocardial work efficiency can be derived from LV pressure-strain loop analysis incorporating both noninvasively estimated blood pressure recordings and echocardiographic strain data. The aim of this study was to characterize global LV myocardial work efficiency in healt... Abstract

The Annals of thoracic surgery, Volume 109, Issue 1, 3 1 2019, Pages 308-309 Reply. Petrus AHJ, Klautz RJM, Braun J

Abstract

Cited 8 times since 2019 (1.3 per year) source: EuropePMC

International journal of molecular sciences, Volume 20, Issue 13, 2 1 2019, Pages E3251 Endothelial Colony Forming Cells as an Autologous Model to Study Endothelial Dysfunction in Patients with a Bicuspid Aortic Valve. van de Pol V, Bons LR, Lodder K, Kurakula KB, Sanchez-Duffhues G, Siebelink HJ, Roos-Hesselink JW, DeRuiter MC, Goumans MJ

Bicuspid aortic valve (BAV), the most common congenital heart defect, is associated with an increased prevalence of aortic dilation, aortic rupture and aortic valve calcification. Endothelial cells (ECs) play a major role in vessel wall integrity. Little is known regarding EC function in BAV patients due to lack of patient derived primary ECs. Endothelial colony forming cells (ECFCs) have been reported to be a valid surrogate model for several cardiovascular pathologies, thereby facilitating an... Abstract

Cited 11 times since 2019 (1.7 per year) source: EuropePMC

European heart journal, Volume 40, Issue 26, 1 1 2019, Pages 2170 Tornado-like flow in the Fontan circulation: insights from quantification and visualization of viscous energy loss rate using 4D flow MRI. Rijnberg FM, van Assen HC, Hazekamp MG, Roest AAW

Abstract

Cited 10 times since 2019 (1.6 per year) source: EuropePMC

PloS one, Volume 14, Issue 7, 1 1 2019, Pages e0218676 The modulation of facial mimicry by attachment tendencies and their underlying affiliation motives in 3-year-olds: An EMG study. Vacaru SV, van Schaik JE, Hunnius S

From early in life, facial mimicry represents an important example of implicit non-verbal communication. Facial mimicry is conceived of as the automatic tendency to mimic another person's facial expressions and is thought to serve as a social glue among interaction partners. Although in adults mimicry has been shown to be moderated by the social context and one's needs to affiliate with others, evidence from behavioural mimicry studies suggest that 3-year-olds do not yet show sensitivi... Abstract

Cited 47 times since 2019 (7.3 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 21, Issue 7, 1 1 2019, Pages 993-994 EHRA White Paper: knowledge gaps in arrhythmia management-status 2019. Goette A, Auricchio A, Boriani G, Braunschweig F, Terradellas JB, Burri H, Camm AJ, Crijns H, Dagres N, Deharo JC, Dobrev D, Hatala R, Hindricks G, Hohnloser SH, Leclercq C, Lewalter T, Lip GYH, Merino JL, Mont L, Prinzen F, Proclemer A, Pürerfellner H, Savelieva I, Schilling R, Steffel J, van Gelder IC, Zeppenfeld K, Zupan I, Heidbüchel H, ESC Scientific Document Group

Clinicians accept that there are many unknowns when we make diagnostic and therapeutic decisions. Acceptance of uncertainty is essential for the pursuit of the profession: bedside decisions must often be made on the basis of incomplete evidence. Over the years, physicians sometimes even do not realize anymore which the fundamental gaps in our knowledge are. As clinical scientists, however, we have to halt and consider what we do not know yet, and how we can move forward addressing those unknowns... Abstract

Cited 6 times since 2019 (0.9 per year) source: EuropePMC

The Journal of infectious diseases, Volume 220, Issue 4, 1 1 2019, Pages 624-634 Chemokine Receptor 7 Is Essential for Coxiella burnetii Whole-Cell Vaccine-Induced Cellular Immunity but Dispensable for Vaccine-Mediated Protective Immunity. Chen C, van Schaik EJ, Gregory AE, Vigil A, Felgner PL, Hendrix LR, Faris R, Samuel JE

Background: Protective immunity against Coxiella burnetii infection is conferred by vaccination with virulent (PI-WCV), but not avirulent (PII-WCV) whole-cell inactivated bacterium. The only well-characterized antigenic difference between virulent and avirulent C. burnetii is they have smooth and rough lipopolysaccharide (LPS), respectively. Methods: Mice were vaccinated with PI-WCV and PII-WCV. Humoral and cellular responses were evaluated using protein chip microarrays and ELISpots, respective... Abstract

Cited 13 times since 2019 (2 per year) source: EuropePMC

Nature genetics, Volume 51, Issue 7, 1 1 2019, Pages 1192-1193 Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, Brown RD, Butterworth AS, Carrera C, Carty CL, Chasman DI, Chen WM, Cole JW, Correa A, Cotlarciuc I, Cruchaga C, Danesh J, de Bakker PIW, DeStefano AL, den Hoed M, Duan Q, Engelter ST, Falcone GJ, Gottesman RF, Grewal RP, Gudnason V, Gustafsson S, Haessler J, Harris TB, Hassan A, Havulinna AS, Heckbert SR, Holliday EG, Howard G, Hsu FC, Hyacinth HI, Ikram MA, Ingelsson E, Irvin MR, Jian X, Jiménez-Conde J, Johnson JA, Jukema JW, Kanai M, Keene KL, Kissela BM, Kleindorfer DO, Kooperberg C, Kubo M, Lange LA, Langefeld CD, Langenberg C, Launer LJ, Lee JM, Lemmens R, Leys D, Lewis CM, Lin WY, Lindgren AG, Lorentzen E, Magnusson PK, Maguire J, Manichaikul A, McArdle PF, Meschia JF, Mitchell BD, Mosley TH, Nalls MA, Ninomiya T, O'Donnell MJ, Psaty BM, Pulit SL, Rannikmäe K,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. Abstract