9543 results
Cited 9 times since 2019 (1.3 per year)
source: EuropePMC
Journal of Alzheimer's disease : JAD,
Volume 67, Issue 1, 1 1 2019, Pages 279-289
Spatial QRS-T Angle and Cognitive Decline in Older Subjects.
Mahinrad S, Ferguson I, Macfarlane PW, Clark EN, Stott DJ, Ford I, Mooijaart SP, Trompet S, van Heemst D, Jukema JW, Sabayan B
Background: An abnormally wide spatial QRS-T angle on an ECG is a marker of heterogeneity in electrical activity of cardiac ventricles and is linked with cardiovascular events. Growing evidence suggests that cardiac dysfunction might signal future cognitive decline. Objective: In this study, we investigated whether spatial QRS-T angle associates with future cognitive decline in older subjects at high cardiovascular risk. Methods: We included 4,172 men and women (mean age 75.2±3.3 years) free of...
Abstract
Cited 6 times since 2019 (0.9 per year)
source: EuropePMC
Travel medicine and infectious disease,
Volume 31, 1 1 2019, Pages 101362
Risk of acquisition of human diarrhoeagenic Escherichia coli virulence genes in intercontinental travellers: A prospective, multi-centre study.
van Hattem JM, Cabal A, Arcilla MS, Alvarez J, de Jong MD, Melles DC, Penders J, COMBAT consortium, Schmidt CG, Schultsz C
Background: We studied geographic distribution of diarrhoeagenic Escherichia coli virulence genes (DEC VGs) acquisition in travellers and investigated if they acquired highly virulent EAEC/STEC hybrid strains. Methods: From the prospective, multicentre COMBAT study among 2001 Dutch travellers, 491 travellers were selected based on travel destination to 7 subregions. Faecal samples taken directly before and after travel were screened for nine DEC VGs with real-time PCR. Incidence proportions and...
Abstract
Cited 1533 times since 2019 (222.3 per year)
source: EuropePMC
European heart journal,
Volume 40, Issue 3, 1 1 2019, Pages 237-269
Fourth universal definition of myocardial infarction (2018).
Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, White HD, ESC Scientific Document Group
Abstract
Cited 20 times since 2019 (2.9 per year)
source: EuropePMC
Endocrine-related cancer,
Volume 26, Issue 1, 1 1 2019, Pages 1-12
Hotspot DAXX, PTCH2 and CYFIP2 mutations in pancreatic neuroendocrine neoplasms.
Vandamme T, Beyens M, Boons G, Schepers A, Kamp K, Biermann K, Pauwels P, De Herder WW, Hofland LJ, Peeters M, Van Camp G, Op de Beeck K
Mutations in DAXX/ATRX, MEN1 and genes involved in the phosphoinositide-3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway have been implicated in pancreatic neuroendocrine neoplasms (pNENs). However, mainly mutations present in the majority of tumor cells have been identified, while proliferation-driving mutations could be present only in small fractions of the tumor. This study aims to identify high- and low-abundance mutations in pNENs using ultra-deep targeted resequencing. F...
Abstract
Cited 168 times since 2019 (24.4 per year)
source: EuropePMC
JACC. Cardiovascular interventions,
Volume 12, Issue 2, 1 1 2019, Pages 182-193
Predictors of Left Ventricular Outflow Tract Obstruction After Transcatheter Mitral Valve Replacement.
Yoon SH, Bleiziffer S, Latib A, Eschenbach L, Ancona M, Vincent F, Kim WK, Unbehaum A, Asami M, Dhoble A, Silaschi M, Frangieh AH, Veulemans V, Tang GHL, Kuwata S, Rampat R, Schmidt T, Patel AJ, Nicz PFG, Nombela-Franco L, Kini A, Kitamura M, Sharma R, Chakravarty T, Hildick-Smith D, Arnold M, de Brito FS, Jensen C, Jung C, Jilaihawi H, Smalling RW, Maisano F, Kasel AM, Treede H, Kempfert J, Pilgrim T, Kar S, Bapat V, Whisenant BK, Van Belle E, Delgado V, Modine T, Bax JJ, Makkar RR
Objectives: The aim of this study was to evaluate the predictors of left ventricular outflow tract (LVOT) obstruction after transcatheter mitral valve replacement (TMVR). Background: LVOT obstruction is a major concern with TMVR, but limited data exist regarding its predictors and impact on outcomes. Methods: Patients with pre-procedural multidetector row computed tomography (MDCT) undergoing TMVR for failed mitral bioprosthetic valves (valve-in-valve), annuloplasty rings (valve-in-ring), and mi...
Abstract
Cited 79 times since 2019 (11.5 per year)
source: EuropePMC
Circulation,
Volume 139, Issue 3, 1 1 2019, Pages 413-415
Outcomes Associated With Cardiogenic Shock in Takotsubo Syndrome.
Di Vece D, Citro R, Cammann VL, Kato K, Gili S, Szawan KA, Micek J, Jurisic S, Ding KJ, Bacchi B, Schwyzer M, Candreva A, Bossone E, D'Ascenzo F, Sarcon A, Franke J, Napp LC, Jaguszewski M, Noutsias M, Münzel T, Knorr M, Heiner S, Katus HA, Burgdorf C, Schunkert H, Thiele H, Bauersachs J, Tschöpe C, Pieske BM, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Hasenfuβ G, Karakas M, Koenig W, Rottbauer W, Said SM, Braun-Dullaeus RC, Banning A, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Opolski G, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Crea F, Dichtl W, Empen K, Felix SB, Delmas C, Lairez O, El-Battrawy I, Akin I, Borggrefe M, Gilyarova E, Shilova A, Gilyarov M, Horowitz J, Kozel M, Tousek P, Widimský P, Winchester DE, Ukena C, Di Mario C, Prasad A, Böhm M, Bax JJ, Lüscher TF, Ruschitzka F, Ghadri JR, Templin C
Abstract
Cited 21 times since 2019 (3 per year)
source: EuropePMC
Circulation,
Volume 139, Issue 1, 1 1 2019, Pages 134-136
High-Frequency Biomarker Measurements of Troponin, NT-proBNP, and C-Reactive Protein for Prediction of New Coronary Events After Acute Coronary Syndrome.
Oemrawsingh RM, Akkerhuis KM, de Mulder M, Umans VA, Kietselaer B, Schotborgh C, Ronner E, Lenderink T, Liem A, Haitsma D, van der Harst P, Asselbergs FW, Maas A, Oude Ophuis AJ, Ilmer B, Dijkgraaf R, de Winter RJ, Kie The SH, Wardeh AJ, Hermans W, Cramer E, van Schaik RH, Hoefer IE, Doevendans PA, Simoons ML, Boersma E, BIOMArCS Investigators
Abstract
Cited 41 times since 2019 (5.9 per year)
source: EuropePMC
Brain : a journal of neurology,
Volume 142, Issue 1, 1 1 2019, Pages 35-49
Integrated clinical and omics approach to rare diseases: novel genes and oligogenic inheritance in holoprosencephaly.
Kim A, Savary C, Dubourg C, Carré W, Mouden C, Hamdi-Rozé H, Guyodo H, Douce JL, FREX Consortium, GoNL Consortium, Pasquier L, Flori E, Gonzales M, Bénéteau C, Boute O, Attié-Bitach T, Roume J, Goujon L, Akloul L, Odent S, Watrin E, Watrin E, Dupé V, de Tayrac M, David V
Holoprosencephaly is a pathology of forebrain development characterized by high phenotypic heterogeneity. The disease presents with various clinical manifestations at the cerebral or facial levels. Several genes have been implicated in holoprosencephaly but its genetic basis remains unclear: different transmission patterns have been described including autosomal dominant, recessive and digenic inheritance. Conventional molecular testing approaches result in a very low diagnostic yield and most c...
Abstract
Cited 5 times since 2019 (0.7 per year)
source: EuropePMC
Annals of translational medicine,
Volume 7, Issue 1, 1 1 2019, Pages 9
Muscle weakness in a <i>S. pneumoniae</i> sepsis mouse model.
Witteveen E, Wieske L, Manders E, Verhamme C, Ottenheijm CAC, Schultz MJ, van Schaik IN, Horn J
Background: The pathophysiology of intensive care unit-acquired weakness (ICU-AW), which affects peripheral nerves, limb muscles and respiratory muscles, is complex and incompletely understood. This illustrates the need for an ICU-AW animal model. However, a translatable and easily applicable ICU-AW animal model does not exist. The objective of this study was to investigate whether induction of a S. pneumoniae sepsis could serve as a model for ICU-AW. Methods: A total of 24 C57BL/6J mice were in...
Abstract
Cited 3 times since 2019 (0.4 per year)
source: EuropePMC
Tijdschrift voor psychiatrie,
Volume 61, Issue 10, 1 1 2019, Pages 683-691
[Guided web-based intervention for sleeping problems (I-Sleep) in depressed patients within outpatient specialist mental health care: a pilot study].
Dozeman E, van Straten A, van Genugten CR, van Schaik DJF
Background: Insomnia in depressed patients is usually targeted by medication, while cognitive behavioural treatment for insomnia (CBT-I) is the treatment of first choice. Effective online CBT-I is available but is not frequently offered in regular care. AIM: To determine the feasibility and indications for effectiveness of I-Sleep, an online CBT-I module, for uni- and bipolar depressed patients in specialised mental health care settings. METHOD: In a pilot study I-Sleep (5 sessions) was offered...
Abstract
Tijdschrift voor psychiatrie,
Volume 61, Issue 10, 1 1 2019, Pages 678-680
[Too early for pharmacogenetics in psychiatric practice? Implementation is in full swing].
van Westrhenen R, Bet PM, van Weelden M, van Schaik RHN
Abstract
Cited 12 times since 2019 (1.7 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 20, Issue 1, 1 1 2019, Pages 56-65
Left ventricular global longitudinal strain and long-term prognosis in patients with chronic obstructive pulmonary disease after acute myocardial infarction.
Goedemans L, Abou R, Hoogslag GE, Ajmone Marsan N, Delgado V, Bax JJ
Aims: Left ventricular (LV) systolic function is a known prognostic factor after ST-segment elevation myocardial infarction (STEMI). We evaluated the prognostic value of LV global longitudinal strain (GLS) in patients with chronic obstructive pulmonary disease (COPD) after STEMI. Methods and results: One hundred and forty-three STEMI patients with COPD (mean age 70 ± 11 years, 71% male), were retrospectively analysed. Left ventricular ejection fraction (LVEF) and LV GLS were measured on transtho...
Abstract
Cited 2 times since 2019 (0.3 per year)
source: EuropePMC
Turkish neurosurgery,
Volume 29, Issue 5, 1 1 2019, Pages 671-676
Immunohistochemical Evaluation of Hemostatic Changes in Glioblastoma Multiforme and Low-Grade Astrocytoma.
Haciyakupoglu E, Yilmaz DM, Walter J, Erdogan S, Haciyakupoglu S, Kuhn SA
Aim: To compare glioblastoma multiforme with astrocytoma grade II by subjectively evaluating the levels of prothrombin and biotinylation thrombin, and G protein serum protease activatin receptors, as tissue factors causing hypercoagulation and affecting coagulation. Material and methods: Specimens from 35 cases with glioblastoma multiforme and 23 cases with astrocytoma grade II were evaluated immunohistochemically. The specimens were stained with hematoxylen-eosin and immunohistochemically for p...
Abstract
Cited 3 times since 2019 (0.4 per year)
source: EuropePMC
Turkish neurosurgery,
Volume 29, Issue 3, 1 1 2019, Pages 340-348
Analysis of Cavernous Malformations: Experience with 18 Cases.
Haciyakupoglu E, Yilmaz DM, Kinali B, Akbas T, Haciyakupoglu S
Aim: To analyze the results of stereotactic radiosurgery (SRS) or surgical treatment of 18 cases with cavernous malformation and report 2 cases with unusual localization and size. Material and methods: We present 11 and 8 patients who underwent surgery and SRS between 2010 and 2018 respectively. The operated group comprised six men and five women (mean age, 33.6 years). SRS was performed in five men and three women (mean age, 33.3 years). All patients were diagnosed and followed-up with magnetic...
Abstract
Cited 4 times since 2019 (0.6 per year)
source: EuropePMC
Advances in experimental medicine and biology,
Volume 1144, 1 1 2019, Pages 101-121
Stem Cells for the Oromaxillofacial Area: Could they be a promising source for regeneration in dentistry?
Mendi A, Ulutürk H, Ataç MS, Yılmaz D
Oromaxillofacial tissues (OMT) are composed of tooth and bone, together with nerves and blood vessels. Such a composite material is a huge source for mesenchymal stem cells (MSCs) that can be obtained with ease from extracted teeth, teeth structures and socket blood, flapped gingiva tissue, and mandibular/maxillar bone marrow. They offer a biological answer for restoring damaged dental tissues such as the regeneration of alveolar bone, prevention of pulp tissue defects, and dental structures. De...
Abstract
Cited 10 times since 2019 (1.5 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 27, Issue 1, 1 1 2019, Pages 18-23
Expectations and perceived barriers to widespread implementation of e‑Health in cardiology practice: Results from a national survey in the Netherlands.
Treskes RW, Wildbergh TX, Schalij MJ, Scherptong RWC
Introduction: Expectations of physicians concerning e‑Health and perceived barriers to implementation in clinical practice are scarcely reported in the literature. The purpose of this study was to assess these aspects of cardiovascular e‑Health. Methods: A survey was sent to members of the Netherlands Society of Cardiology. In total, the questionnaire contained 30 questions about five topics: personal use of smartphones, digital communication between respondents and patients, current e‑Health im...
Abstract
Cited 121 times since 2019 (17.5 per year)
source: EuropePMC
Circulation,
Volume 139, Issue 5, 1 1 2019, Pages 620-635
Genome-Wide Association Transethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels.
Sabater-Lleal M, Huffman JE, de Vries PS, Marten J, Mastrangelo MA, Song C, Pankratz N, Ward-Caviness CK, Yanek LR, Trompet S, Delgado GE, Guo X, Bartz TM, Martinez-Perez A, Germain M, de Haan HG, Ozel AB, Polasek O, Smith AV, Eicher JD, Reiner AP, Tang W, Davies NM, Stott DJ, Rotter JI, Tofler GH, Boerwinkle E, de Maat MPM, Kleber ME, Welsh P, Brody JA, Chen MH, Vaidya D, Soria JM, Suchon P, van Hylckama Vlieg A, Desch KC, Kolcic I, Joshi PK, Launer LJ, Harris TB, Campbell H, Rudan I, Becker DM, Li JZ, Rivadeneira F, Uitterlinden AG, Hofman A, Franco OH, Cushman M, Psaty BM, Morange PE, McKnight B, Chong MR, Fernandez-Cadenas I, Rosand J, Lindgren A, INVENT Consortium; MEGASTROKE Consortium of the International Stroke Genetics Consortium (ISGC), Gudnason V, Wilson JF, Hayward C, Ginsburg D, Fornage M, Rosendaal FR, Souto JC, Becker LC, Jenny NS, März W, Jukema JW, Dehghan A, Trégouët DA, Morrison AC, Johnson AD, O'Donnell CJ, Strachan DP, Lowenstein CJ, Smith NL
Background: Factor VIII (FVIII) and its carrier protein von Willebrand factor (VWF) are associated with risk of arterial and venous thrombosis and with hemorrhagic disorders. We aimed to identify and functionally test novel genetic associations regulating plasma FVIII and VWF. Methods: We meta-analyzed genome-wide association results from 46 354 individuals of European, African, East Asian, and Hispanic ancestry. All studies performed linear regression analysis using an additive genetic model an...
Abstract
Cited 2 times since 2018 (0.3 per year)
source: EuropePMC
International journal of integrated care,
Volume 18, Issue 4, 31 5 2019, Pages 15
The Integrated Dyspnea Clinic: An Evaluation of Efficiency.
Rietbroek MV, Slats AM, Kiès P, de Grooth GJ, Chavannes NH, Taube C, Bonten TN
Introduction: Dyspnea is a common complaint and in 70 to 90% the origin is pulmonary or cardiovascular. However, referral to the "wrong" specialism could result in diagnostic- and treatment delay. Integrated care by a cardiologist and a pulmonologist could improve this. The aim of the present study was to evaluate whether integrated care for patients with dyspnea is more efficient and effective than regular care. Methods: Consecutive patients (n = 235) seen at our dyspnea clinic after...
Abstract
Cited 9 times since 2018 (1.3 per year)
source: EuropePMC
Journal of the neurological sciences,
Volume 397, 31 5 2019, Pages 141-145
Intravenous immunoglobulins in patients with clinically suspected chronic immune-mediated neuropathy.
Lucke IM, Adrichem ME, Wieske L, van der Kooi AJ, Verhamme C, van Schaik IN, Eftimov F
Intravenous immunoglobulins (IVIg) are an efficacious treatment for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal motor neuropathy (MMN). IVIg is considered in patients who have a high suspicion of an inflammatory neuropathy, but do not meet diagnostic criteria. The objective of this retrospective study was to assess which diagnostic results led to the decision to administer IVIg and to determine the rate of improvement. We included consecutive patients suspecte...
Abstract
Cited 49 times since 2018 (7.1 per year)
source: EuropePMC
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine,
Volume 38, Issue 8, 28 4 2018, Pages 2133-2140
Point-of-Care Ultrasonography (POCUS) in a Community Emergency Department: An Analysis of Decision Making and Cost Savings Associated With POCUS.
Van Schaik GWW, Van Schaik KD, Murphy MC
Objectives: Point-of-care ultrasonography (POCUS) is an increasingly integral part of emergency medicine. This study investigated community emergency department physicians' choices regarding ultrasonography as a branch point in clinical decision making. Methods: During shifts covering all days of the week and all time-spans over a 3-month period, emergency department physicians were interviewed whenever POCUS was used. Questions focused on the role of POCUS in clinical management and on tes...
Abstract
