9543 results
Cited 2 times since 2018 (0.3 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 12, Issue 4, 15 3 2018, Pages 759-760
Comparison of Insonation-Augmented Physical Examination With Standard Physical Examination in Detecting Severe Left-Sided Valve Disease.
Argulian E, Ramirez R, Hobson S, Bavishi C, Casso Dominguez A, Selby A, Talebi S, Moreno P, Ahmadi AA, Bax JJ, Narula J
Abstract
Cited 92 times since 2018 (13.1 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 12, Issue 1, 15 3 2018, Pages 135-145
Transcatheter Aortic Heart Valves: Histological Analysis Providing Insight to Leaflet Thickening and Structural Valve Degeneration.
Sellers SL, Turner CT, Sathananthan J, Cartlidge TRG, Sin F, Bouchareb R, Mooney J, Nørgaard BL, Bax JJ, Bernatchez PN, Dweck MR, Granville DJ, Newby DE, Lauck S, Webb JG, Payne GW, Pibarot P, Blanke P, Seidman MA, Leipsic JA
Objectives: This study investigated processes causing leaflet thickening and structural valve degeneration (SVD). Background: Although transcatheter aortic valve replacement (TAVR) has changed the treatment of aortic stenosis, concerns remain regarding SVD, potentially related to valve thrombosis and thickening, based on studies using computed tomography (CT). Detailed histological analyses are provided to help attain insights into these processes. Methods: Explanted transcatheter heart valves (...
Abstract
Cited 6 times since 2018 (0.9 per year)
source: Scopus
JACC. Cardiovascular imaging,
Volume 12, Issue 1, 15 3 2018, Pages 216-217
Prognostic Value of Thoracic Aorta Calcification Burden in Patients Treated With TAVR.
Gegenava T, Vollema EM, Abou R, Goedemans L, van Rosendael A, van der Kley F, de Weger A, Ajmone Marsan N, Bax JJ, Delgado V
Abstract
Cited 28 times since 2018 (4 per year)
source: EuropePMC
European journal of human genetics : EJHG,
Volume 27, Issue 3, 12 2 2018, Pages 422-431
Mendelian randomization reveals unexpected effects of CETP on the lipoprotein profile.
Blauw LL, Noordam R, Soidinsalo S, Blauw CA, Li-Gao R, de Mutsert R, Berbée JFP, Wang Y, van Heemst D, Rosendaal FR, Jukema JW, Mook-Kanamori DO, Würtz P, Willems van Dijk K, Rensen PCN
According to the current dogma, cholesteryl ester transfer protein (CETP) decreases high-density lipoprotein (HDL)-cholesterol (C) and increases low-density lipoprotein (LDL)-C. However, detailed insight into the effects of CETP on lipoprotein subclasses is lacking. Therefore, we used a Mendelian randomization approach based on a genetic score for serum CETP concentration (rs247616, rs12720922 and rs1968905) to estimate causal effects per unit (µg/mL) increase in CETP on 159 standardized metabol...
Abstract
Cited 22 times since 2018 (3.1 per year)
source: EuropePMC
International journal of colorectal disease,
Volume 34, Issue 2, 12 2 2018, Pages 269-276
Sex- and site-specific differences in colorectal cancer risk among people with type 2 diabetes.
Overbeek JA, Kuiper JG, van der Heijden AAWA, Labots M, Haug U, Herings RMC, Nijpels G
Purpose: The prevalence of colorectal cancer is higher among patients with type 2 diabetes mellitus (T2D) than among patients without diabetes. Furthermore, men are at higher risk for developing colorectal cancer than women in the general population and also subsite-specific risks differ per sex. The aim was to evaluate the impact of T2D on these associations. Methods: A population-based matched cohort study was performed using data from the PHARMO Database Network. Patients with T2D were select...
Abstract
Cited 105 times since 2018 (14.9 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 73, Issue 4, 11 2 2018, Pages 387-396
Alirocumab Reduces Total Nonfatal Cardiovascular and Fatal Events: The ODYSSEY OUTCOMES Trial.
Szarek M, White HD, Schwartz GG, Alings M, Bhatt DL, Bittner VA, Chiang CE, Diaz R, Edelberg JM, Goodman SG, Hanotin C, Harrington RA, Jukema JW, Kimura T, Kiss RG, Lecorps G, Mahaffey KW, Moryusef A, Pordy R, Roe MT, Tricoci P, Xavier D, Zeiher AM, Steg PG, ODYSSEY OUTCOMES Committees and Investigators
Background: The ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) trial compared alirocumab with placebo, added to high-intensity or maximum-tolerated statin treatment, after acute coronary syndrome (ACS) in 18,924 patients. Alirocumab reduced the first occurrence of the primary composite endpoint and was associated with fewer all-cause deaths. Objectives: This pre-specified analysis determined the extent to which alirocuma...
Abstract
Cited 25 times since 2018 (3.6 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 105, Issue 10, 10 2 2018, Pages 790-796
Long-term outcome after atrial correction for transposition of the great arteries.
Couperus LE, Vliegen HW, Zandstra TE, Kiès P, Jongbloed MRM, Holman ER, Zeppenfeld K, Hazekamp MG, Schalij MJ, Scherptong RWC
Objective: This study assessed adult survival and morbidity patterns in patients who underwent atrial correction according to Mustard or Senning for transposition of the great arteries (TGA). Methods: In 76 adult patients with TGA (59% male) after atrial correction, long-term survival and morbidity were investigated in three periods: early (30 years postoperatively). Results: The Mustard technique was performed in 41 (54%) patients, and the Senning technique was performed in 35 (46%) patients ag...
Abstract
Cited 17 times since 2018 (2.4 per year)
source: EuropePMC
Langenbeck's archives of surgery,
Volume 403, Issue 8, 10 2 2018, Pages 999-1005
Safety and efficacy of subtotal or total parathyroidectomy for patients with secondary or tertiary hyperparathyroidism in four academic centers in the Netherlands.
van der Plas WY, Dulfer RR, Koh EY, Vogt L, Appelman-Dijkstra NM, Schepers A, Rotmans JI, Pol RA, van Ginhoven TM, Hoorn EJ, Nieveen van Dijkum EJM, Engelsman AF, de Borst MH, Kruijff S, Dutch Hyperparathyroidism Study Group (DHSG)
Purpose: Hyperparathyroidism (HPT) is a common abnormality in patients with end-stage renal disease (ESRD). Since the introduction of cinacalcet in 2004, a shift from surgery toward predominantly medical treatment has occurred. Surgery is thought to be associated with more complications than oral medication. The aim of this retrospective study was to evaluate 30-day outcomes and effectiveness of parathyroidectomy (PTx) in ESRD patients in the Netherlands. Methods: A national database containing...
Abstract
Cited 29 times since 2018 (4.1 per year)
source: EuropePMC
International journal of cardiology,
Volume 278, 10 2 2018, Pages 84-87
Long-term clinical outcomes of valsartan in patients with a systemic right ventricle: Follow-up of a multicenter randomized controlled trial.
van Dissel AC, Winter MM, van der Bom T, Vliegen HW, van Dijk APJ, Pieper PG, Sieswerda GT, Roos-Hesselink JW, Zwinderman AH, Mulder BJM, Bouma BJ
Objectives: In the VAL-SERVE (Valsartan in Systemic Right Ventricle) trial, three-year valsartan treatment improved systemic ventricular function only in symptomatic patients with congenitally or with an atrial switch corrected transposition of the great arteries. The aim of the current study was to investigate the longer-term clinical outcomes after valsartan treatment. Methods: From 2006 to 2009, 88 adults were randomly allocated 1:1 to either valsartan or placebo for three consecutive years....
Abstract
Cited 3 times since 2018 (0.4 per year)
source: EuropePMC
Anatomical record (Hoboken, N.J. : 2007),
Volume 302, Issue 1, 9 2 2018, Pages 83-92
Disruption of RHOA-ROCK Signaling Results in Atrioventricular Block and Disturbed Development of the Putative Atrioventricular Node.
Kelder TP, Vicente-Steijn R, Poelmann RE, Schalij MJ, Deruiter MC, Jongbloed MRM, Gittenberger-de Groot AC
The RHOA-ROCK signaling pathway is involved in numerous developmental processes, including cell proliferation, differentiation and migration. RHOA is expressed in the atrioventricular node (AVN) and altered expression of RHOA results in atrioventricular (AV) conduction disorders in mice. The current study aims to detect functional AVN disorders after disturbing RHOA-ROCK signaling in chicken embryos. RHOA-ROCK signaling was inhibited chemically by using the Rho-kinase inhibitor compound Y-27632...
Abstract
Cited 2130 times since 2018 (302.3 per year)
source: EuropePMC
The New England journal of medicine,
Volume 379, Issue 22, 7 1 2018, Pages 2097-2107
Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome.
Schwartz GG, Steg PG, Szarek M, Bhatt DL, Bittner VA, Diaz R, Edelberg JM, Goodman SG, Hanotin C, Harrington RA, Jukema JW, Lecorps G, Mahaffey KW, Moryusef A, Pordy R, Quintero K, Roe MT, Sasiela WJ, Tamby JF, Tricoci P, White HD, Zeiher AM, ODYSSEY OUTCOMES Committees and Investigators
Background: Patients who have had an acute coronary syndrome are at high risk for recurrent ischemic cardiovascular events. We sought to determine whether alirocumab, a human monoclonal antibody to proprotein convertase subtilisin-kexin type 9 (PCSK9), would improve cardiovascular outcomes after an acute coronary syndrome in patients receiving high-intensity statin therapy. Methods: We conducted a multicenter, randomized, double-blind, placebo-controlled trial involving 18,924 patients who had a...
Abstract
Cited 11 times since 2018 (1.6 per year)
source: EuropePMC
The American journal of cardiology,
Volume 123, Issue 3, 6 1 2018, Pages 474-481
Frequency, Predictors, and Prognostic Impact of Pulmonary Artery Aneurysms in Patients With Pulmonary Arterial Hypertension.
Nuche J, Montero Cabezas JM, Jiménez López-Guarch C, Velázquez Martín M, Alonso Charterina S, Revilla Ostolaza Y, Arribas Ynsaurriaga F, Escribano Subías P
Detection of pulmonary artery aneurysms (PAA) in pulmonary arterial hypertension (PAH) is increasing. We sought to determine the frequency of PAA in a PAH cohort, variables related to its development and its prognostic impact. We conducted a retrospective analysis of PAH patients who underwent a computed tomography or magnetic resonance. PAA was defined as a pulmonary artery >40 mm. Baseline, echocardiographic, and hemodynamic findings at PAH diagnosis were compared. Freedom from death or lun...
Abstract
Cited 45 times since 2018 (6.4 per year)
source: EuropePMC
Nature communications,
Volume 9, Issue 1, 5 1 2018, Pages 4616
Germline variation at 8q24 and prostate cancer risk in men of European ancestry.
Matejcic M, Saunders EJ, Dadaev T, Brook MN, Wang K, Sheng X, Olama AAA, Schumacher FR, Ingles SA, Govindasami K, Benlloch S, Berndt SI, Albanes D, Koutros S, Muir K, Stevens VL, Gapstur SM, Tangen CM, Batra J, Clements J, Gronberg H, Pashayan N, Schleutker J, Wolk A, West C, Mucci L, Kraft P, Cancel-Tassin G, Sorensen KD, Maehle L, Grindedal EM, Strom SS, Neal DE, Hamdy FC, Donovan JL, Travis RC, Hamilton RJ, Rosenstein B, Lu YJ, Giles GG, Kibel AS, Vega A, Bensen JT, Kogevinas M, Penney KL, Park JY, Stanford JL, Cybulski C, Nordestgaard BG, Brenner H, Maier C, Kim J, Teixeira MR, Neuhausen SL, De Ruyck K, Razack A, Newcomb LF, Lessel D, Kaneva R, Usmani N, Claessens F, Townsend PA, Gago-Dominguez M, Roobol MJ, Menegaux F, Khaw KT, Cannon-Albright LA, Pandha H, Thibodeau SN, Schaid DJ, PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, Wiklund F, Chanock SJ, Easton DF, Eeles RA, Kote-Jarai Z, Conti DV, Haiman CA
Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p
Abstract
Cited 19 times since 2018 (2.7 per year)
source: EuropePMC
Expert opinion on biological therapy,
Volume 18, Issue 12, 2 1 2018, Pages 1223-1233
The immune microenvironment in vulvar (pre)cancer: review of literature and implications for immunotherapy.
Abdulrahman Z, Kortekaas KE, De Vos Van Steenwijk PJ, Van Der Burg SH, Van Poelgeest MI
Introduction: Vulvar squamous cell carcinoma (VSCC) develops via two different pathways: TP53 mutations in a background of lichen sclerosus or a persistent infection with high-risk human papilloma virus (HPV). The latter group of tumor responds better to treatment than the non-virally induced VSCC. This may be explained by a difference in the tumor immune microenvironment (TME). Areas covered: This review summarizes literature on TME of VSCC and its precursors, and extrapolates this to foster th...
Abstract
European heart journal,
Volume 39, Issue 44, 1 1 2018, Pages 3915-3917
Biological defibrillation.
Nyns ECA, de Vries AAF, Pijnappels DA
Abstract
Cited 17 times since 2018 (2.4 per year)
source: EuropePMC
Journal of thrombosis and thrombolysis,
Volume 46, Issue 4, 1 1 2018, Pages 473-481
Antithrombotic therapy after mitral valve repair: VKA or aspirin?
van der Wall SJ, Olsthoorn JR, Heuts S, Klautz RJM, Tomsic A, Jansen EK, Vonk ABA, Sardari Nia P, Klok FA, Huisman MV
The optimal antithrombotic therapy following mitral valve repair (MVr) is still a matter of debate. Therefore, we evaluated the rate of thromboembolic and bleeding complications of two antithrombotic prevention strategies: vitamin K antagonists (VKA) versus aspirin. Consecutive patients who underwent MVr between 2004 and 2016 at three Dutch hospitals were evaluated for thromboembolic and bleeding complications during three postoperative months. The primary endpoint was the combined incidence of...
Abstract
Cited 20 times since 2018 (2.8 per year)
source: EuropePMC
Investigative ophthalmology & visual science,
Volume 59, Issue 13, 1 1 2018, Pages 5682-5692
The Effect of Corticosteroids on Human Choroidal Endothelial Cells: A Model to Study Central Serous Chorioretinopathy.
Brinks J, van Dijk EHC, Habeeb M, Nikolaou A, Tsonaka R, Peters HAB, Sips HCM, van de Merbel AF, de Jong EK, Notenboom RGE, Kielbasa SM, van der Maarel SM, Quax PHA, Meijer OC, Boon CJF
Purpose: To isolate, culture, and characterize primary human choroidal endothelial cells, and to assess their responsiveness to corticosteroids, in order to enable knowledge gain on the pathogenesis of central serous chorioretinopathy. Methods: Choroidal endothelial cells were isolated from cadaveric human donors. Magnetic-activated cell sorting with anti-human CD31 was performed for choroidal endothelial cell isolation. Primary cultures of purified choroidal endothelial cells were treated with...
Abstract
Cited 1 times since 2018 (0.1 per year)
source: EuropePMC
Journal of thrombosis and thrombolysis,
Volume 46, Issue 4, 1 1 2018, Pages 482
Correction to: Antithrombotic therapy after mitral valve repair: VKA or aspirin?
van der Wall SJ, Olsthoorn JR, Heuts S, Klautz RJM, Tomsic A, Jansen EK, Vonk ABA, Sardari Nia P, Klok FA, Huisman MV
The original version of this article unfortunately contained a mistake in the author name. The co-author name should be Frederikus A. Klok instead of Frederik A. Klok. The original article has been corrected.
Abstract
Cited 3 times since 2018 (0.4 per year)
source: EuropePMC
Annals of surgery,
Volume 268, Issue 5, 1 1 2018, Pages 756-761
No Clinical Benefit of Intramuscular Delivery of Bone Marrow-derived Mononuclear Cells in Nonreconstructable Peripheral Arterial Disease: Results of a Phase-III Randomized-controlled Trial.
Lindeman JHN, Zwaginga JJ, Kallenberg-Lantrua G, van Wissen RC, Schepers A, van Bockel HJ, Fibbe WE, Hamming JF
Background and aims: Prospects for no-option, end-stage peripheral artery disease (PAD) patients remain poor. Although results from open and semiblinded studies fuel hope for cell-based strategies in no-option patients, so far conclusions from the available placebo-controlled studies are not supportive. With the intention to end the remaining controversy with regard to cell therapy for PAD we conducted a confirmatory, double-blinded randomized placebo-controlled phase 3 trial. Study design: This...
Abstract
Cited 330 times since 2018 (46.7 per year)
source: EuropePMC
American journal of human genetics,
Volume 103, Issue 5, 1 1 2018, Pages 691-706
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.
Ligthart S, Vaez A, Võsa U, Stathopoulou MG, de Vries PS, Prins BP, Van der Most PJ, Tanaka T, Naderi E, Rose LM, Wu Y, Karlsson R, Barbalic M, Lin H, Pool R, Zhu G, Macé A, Sidore C, Trompet S, Mangino M, Sabater-Lleal M, Kemp JP, Abbasi A, Kacprowski T, Verweij N, Smith AV, Huang T, Marzi C, Feitosa MF, Lohman KK, Kleber ME, Milaneschi Y, Mueller C, Huq M, Vlachopoulou E, Lyytikäinen LP, Oldmeadow C, Deelen J, Perola M, Zhao JH, Feenstra B, LifeLines Cohort Study, Amini M, CHARGE Inflammation Working Group, Lahti J, Schraut KE, Fornage M, Suktitipat B, Chen WM, Li X, Nutile T, Malerba G, Luan J, Bak T, Schork N, Del Greco M F, Thiering E, Mahajan A, Marioni RE, Mihailov E, Eriksson J, Ozel AB, Zhang W, Nethander M, Cheng YC, Aslibekyan S, Ang W, Gandin I, Yengo L, Portas L, Kooperberg C, Hofer E, Rajan KB, Schurmann C, den Hollander W, Ahluwalia TS, Zhao J, Draisma HHM, Ford I, Timpson N, Teumer A, Huang H, Wahl S, Liu Y, Huang J, Uh HW, Geller F, Joshi PK, Yanek LR, Trabetti E, Lehne B, Vozzi D, Verbanck M
C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is associated with multiple complex diseases. The genetic determinants of chronic inflammation remain largely unknown, and the causal role of CRP in several clinical outcomes is debated. We performed two genome-wide association studies (GWASs), on HapMap and 1000 Genomes imputed data, of circulating amounts of CRP by using data from 88 studies comprising 204,402 European individuals. Additionally, we performe...
Abstract
