Research

Publications

Below you can find a list of our published research.

9543 results

Cited 11 times since 2018 (1.5 per year) source: EuropePMC

Frontiers in physiology, Volume 9, 4 1 2018, Pages 1381 Myocyte Remodeling Due to Fibro-Fatty Infiltrations Influences Arrhythmogenicity. De Coster T, Claus P, Seemann G, Willems R, Sipido KR, Panfilov AV

The onset of cardiac arrhythmias depends on the electrophysiological and structural properties of cardiac tissue. Electrophysiological remodeling of myocytes due to the presence of adipocytes constitutes a possibly important pathway in the pathogenesis of atrial fibrillation. In this paper we perform an in-silico study of the effect of such myocyte remodeling on the onset of atrial arrhythmias and study the dynamics of arrhythmia sources-spiral waves. We use the Courtemanche model for atrial myo... Abstract

Cited 5 times since 2018 (0.7 per year) source: EuropePMC

International journal of cardiology, Volume 280, 1 1 2018, Pages 19-28 Chest pain in the absence of obstructive coronary artery disease: A critical review of current concepts focusing on sex specificity, microcirculatory function, and clinical implications. Zijlstra LE, Bootsma M, Jukema JW, Schalij MJ, Vliegen HW, Bruschke AVG

Patients presenting with chest pain suggestive of coronary artery disease (CAD) who at coronary arteriography appear to be free of obstructive disease have presented a diagnostic and therapeutic challenge since the 1970's. Studies in female patient populations have suggested that this is predominantly a women's syndrome usually caused by microvascular endothelial dependent and independent dysfunction. A critical review of the literature focusing on studies including both women and men... Abstract

Cited 13 times since 2018 (1.8 per year) source: EuropePMC

European heart journal. Quality of care & clinical outcomes, Volume 4, Issue 4, 1 1 2018, Pages 239-245 Privacy of patient data in quality-of-care registries in cardiology and cardiothoracic surgery: the impact of the new general data protection regulation EU-law. Wierda E, Eindhoven DC, Schalij MJ, Borleffs CJW, Amoroso G, van Veghel D, Mitchell CR, de Mol BAJM, Hirsch A, Ploem MC

Quality-of-care registries have been shown to improve quality of healthcare and should be facilitated and encouraged. The data of these registries are also very valuable for medical data research. While fully acknowledging the importance of re-using already available data for research purposes, there are concerns about how the applicable privacy legislation is dealt with. These concerns are also articulated in the new European law on privacy, the 'General Data Protection Regulation' (G... Abstract

Cited 34 times since 2018 (4.8 per year) source: EuropePMC

Therapeutic drug monitoring, Volume 40, Issue 5, 1 1 2018, Pages 515-525 Liquid Biopsies to Monitor Solid Organ Transplant Function: A Review of New Biomarkers. Verhoeven JGHP, Boer K, Van Schaik RHN, Manintveld OC, Huibers MMH, Baan CC, Hesselink DA

Despite modern immunosuppressive therapy, allograft rejection remains a major cause of solid organ transplant dysfunction. For clinical care, organ transplant function is routinely monitored by measuring biomarkers that, depending on the organ transplanted, include serum creatinine, N-terminal pro-hormone of brain natriuretic peptide (NT-proBNP), and aspartate aminotransferase. All can be measured easily in clinical chemistry laboratories. The main problem with these biomarkers is that they have... Abstract

Cited 254 times since 2018 (35.5 per year) source: EuropePMC

Clinical pharmacokinetics, Volume 57, Issue 10, 1 1 2018, Pages 1229-1254 Individualization of Irinotecan Treatment: A Review of Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics. de Man FM, Goey AKL, van Schaik RHN, Mathijssen RHJ, Bins S

Since its clinical introduction in 1998, the topoisomerase I inhibitor irinotecan has been widely used in the treatment of solid tumors, including colorectal, pancreatic, and lung cancer. Irinotecan therapy is characterized by several dose-limiting toxicities and large interindividual pharmacokinetic variability. Irinotecan has a highly complex metabolism, including hydrolyzation by carboxylesterases to its active metabolite SN-38, which is 100- to 1000-fold more active compared with irinotecan... Abstract

Cited 6 times since 2018 (0.8 per year) source: EuropePMC

Journal of graduate medical education, Volume 10, Issue 5, 1 1 2018, Pages 573-582 Leadership Observation and Feedback Tool: A Novel Instrument for Assessment of Clinical Leadership Skills. Oza SK, van Schaik S, Boscardin CK, Pierce R, Miao E, Lockspeiser T, Tad-Y D, Aagaard E, Kuo AK

Background: While leadership training is increasingly incorporated into residency education, existing assessment tools to provide feedback on leadership skills are only applicable in limited contexts. Objective: We developed an instrument, the Leadership Observation and Feedback Tool (LOFT), for assessing clinical leadership. Methods: We used an iterative process to develop the tool, beginning with adapting the Leadership Practices Inventory to create an open-ended survey for identification of c... Abstract

Cited 4 times since 2018 (0.6 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 26, Issue 10, 1 1 2018, Pages 473-483 Appropriate use criteria for optical coherence tomography guidance in percutaneous coronary interventions : Recommendations of the working group of interventional cardiology of the Netherlands Society of Cardiology. IJsselmuiden AJJ, Zwaan EM, Oemrawsingh RM, Bom MJ, Dankers FJWM, de Boer MJ, Camaro C, van Geuns RJM, Daemen J, van der Heijden DJ, Jukema JW, Kraaijeveld AO, Meuwissen M, Schölzel BE, Pundziute G, van der Harst P, van Ramshorst J, Dirksen MT, Zivelonghi C, Agostoni P, van der Heyden JAS, Wykrzykowska JJ, Scholte MJ, Nef HM, Kofflard MJM, van Royen N, Alings M, Kedhi E

Introduction: Optical coherence tomography (OCT) enables detailed imaging of the coronary wall, lumen and intracoronary implanted devices. Responding to the lack of specific appropriate use criteria (AUC) for this technique, we conducted a literature review and a procedure for appropriate use criteria. Methods: Twenty-one of all 184 members of the Dutch Working Group on Interventional Cardiology agreed to evaluate 49 pre-specified cases. During a meeting, factual indications were established whe... Abstract

Cited 41 times since 2018 (5.7 per year) source: EuropePMC

The Journal of clinical endocrinology and metabolism, Volume 103, Issue 10, 1 1 2018, Pages 3658-3667 The Relation Between Thyroid Function and Anemia: A Pooled Analysis of Individual Participant Data. Wopereis DM, Du Puy RS, van Heemst D, Walsh JP, Bremner A, Bakker SJL, Bauer DC, Cappola AR, Ceresini G, Degryse J, Dullaart RPF, Feller M, Ferrucci L, Floriani C, Franco OH, Iacoviello M, Iervasi G, Imaizumi M, Jukema JW, Khaw KT, Luben RN, Molinaro S, Nauck M, Patel KV, Peeters RP, Psaty BM, Razvi S, Schindhelm RK, van Schoor NM, Stott DJ, Vaes B, Vanderpump MPJ, Völzke H, Westendorp RGJ, Rodondi N, Cobbaert CM, Gussekloo J, den Elzen WPJ, Thyroid Studies Collaboration

Context: Anemia and thyroid dysfunction often co-occur, and both increase with age. Human data on relationships between thyroid disease and anemia are scarce. Objective: To investigate the cross-sectional and longitudinal associations between clinical thyroid status and anemia. Design: Individual participant data meta-analysis. Setting: Sixteen cohorts participating in the Thyroid Studies Collaboration (n = 42,162). Main outcome measures: Primary outcome measure was anemia (hemoglobin Abstract

Cited 148 times since 2018 (20.7 per year) source: EuropePMC

European heart journal, Volume 39, Issue 39, 1 1 2018, Pages 3574-3581 Development of significant tricuspid regurgitation over time and prognostic implications: new insights into natural history. Prihadi EA, van der Bijl P, Gursoy E, Abou R, Mara Vollema E, Hahn RT, Stone GW, Leon MB, Ajmone Marsan N, Delgado V, Bax JJ

Aims: To evaluate the risk factors influencing the development of significant (moderate and severe) tricuspid regurgitation (TR), and its impact on all-cause mortality in large registry of referral centre. Methods and results: In 1000 patients (mean age 68 ± 13 years; 50.9% male) with documented significant TR, clinical, and echocardiographic data were retrospectively analysed when the echocardiogram showed none/mild TR. Patients with congenital heart disease were excluded. The study population... Abstract

Cited 22 times since 2018 (3.1 per year) source: EuropePMC

Environmental science & technology, Volume 52, Issue 20, 27 4 2018, Pages 11500-11509 Patterns of Host-Associated Fecal Indicators Driven by Hydrology, Precipitation, and Land Use Attributes in Great Lakes Watersheds. Dila DK, Corsi SR, Lenaker PL, Baldwin AK, Bootsma MJ, McLellan SL

Fecal contamination from sewage and agricultural runoff is a pervasive problem in Great Lakes watersheds. Most work examining fecal pollution loads relies on discrete samples of fecal indicators and modeling land use. In this study, we made empirical measurements of human and ruminant-associated fecal indicator bacteria and combined these with hydrological measurements in eight watersheds ranging from predominantly forested to highly urbanized. Flow composited river samples were collected over l... Abstract

Cited 34 times since 2018 (4.7 per year) source: EuropePMC

eLife, Volume 7, 27 4 2018, Pages e41076 Optogenetics enables real-time spatiotemporal control over spiral wave dynamics in an excitable cardiac system. Majumder R, Feola I, Teplenin AS, de Vries AA, Panfilov AV, Pijnappels DA

Propagation of non-linear waves is key to the functioning of diverse biological systems. Such waves can organize into spirals, rotating around a core, whose properties determine the overall wave dynamics. Theoretically, manipulation of a spiral wave core should lead to full spatiotemporal control over its dynamics. However, this theory lacks supportive evidence (even at a conceptual level), making it thus a long-standing hypothesis. Here, we propose a new phenomenological concept that involves a... Abstract

Cited 42 times since 2018 (5.9 per year) source: EuropePMC

Nature communications, Volume 9, Issue 1, 26 4 2018, Pages 3945 Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume. Vojinovic D, Adams HH, Jian X, Yang Q, Smith AV, Bis JC, Teumer A, Scholz M, Armstrong NJ, Hofer E, Saba Y, Luciano M, Bernard M, Trompet S, Yang J, Gillespie NA, van der Lee SJ, Neumann A, Ahmad S, Andreassen OA, Ames D, Amin N, Arfanakis K, Bastin ME, Becker DM, Beiser AS, Beyer F, Brodaty H, Bryan RN, Bülow R, Dale AM, De Jager PL, Deary IJ, DeCarli C, Fleischman DA, Gottesman RF, van der Grond J, Gudnason V, Harris TB, Homuth G, Knopman DS, Kwok JB, Lewis CE, Li S, Loeffler M, Lopez OL, Maillard P, El Marroun H, Mather KA, Mosley TH, Muetzel RL, Nauck M, Nyquist PA, Panizzon MS, Pausova Z, Psaty BM, Rice K, Rotter JI, Royle N, Satizabal CL, Schmidt R, Schofield PR, Schreiner PJ, Sidney S, Stott DJ, Thalamuthu A, Uitterlinden AG, Valdés Hernández MC, Vernooij MW, Wen W, White T, Witte AV, Wittfeld K, Wright MJ, Yanek LR, Tiemeier H, Kremen WS, Bennett DA, Jukema JW, Paus T, Wardlaw JM, Schmidt H, Sachdev PS, Villringer A, Grabe HJ, Longstreth WT, van Duijn CM, Launer LJ, Seshadri S, Ikram MA, Fornage M

The volume of the lateral ventricles (LV) increases with age and their abnormal enlargement is a key feature of several neurological and psychiatric diseases. Although lateral ventricular volume is heritable, a comprehensive investigation of its genetic determinants is lacking. In this meta-analysis of genome-wide association studies of 23,533 healthy middle-aged to elderly individuals from 26 population-based cohorts, we identify 7 genetic loci associated with LV volume. These loci map to chrom... Abstract

Cited 20 times since 2018 (2.8 per year) source: EuropePMC

The American journal of cardiology, Volume 123, Issue 1, 26 4 2018, Pages 75-83 Effect of Functional Mitral Regurgitation on Outcome in Patients Receiving Cardiac Resynchronization Therapy for Heart Failure. van der Bijl P, Khidir M, Ajmone Marsan N, Delgado V, Leon MB, Stone GW, Bax JJ

Functional mitral regurgitation (FMR) is common in heart failure (HF), and negatively impacts prognosis. Cardiac resynchronization therapy (CRT) can improve FMR, but the long-term changes in and impact of FMR after CRT are still unclear. The present study investigated the prevalence, evolution and impact on mortality of FMR before and after CRT in patients with HF. A total of 1,313 patients (66 ± 11 years, 77% male, 59% ischemic heart disease) treated with CRT were evaluated. Patients were divid... Abstract

Cited 1 times since 2018 (0.1 per year) source: EuropePMC

Healthcare (Basel, Switzerland), Volume 6, Issue 3, 19 3 2018, Pages E118 The Applicability of N: Ancient Debates and Modern Experimental Design. Van Schaik KD

Medicine has always been characterized by a tension between the particular and the general. A clinician is obligated to treat the individual in front of her, yet she accomplishes this task by applying generalized knowledge that describes an abstract average but not necessarily a specific person. Efforts to systematize this process of moving between the particular and the general have led to the development of randomized controlled trials and large observational studies. Inclusion of tens of thou... Abstract

Cited 12 times since 2018 (1.7 per year) source: EuropePMC

BMC endocrine disorders, Volume 18, Issue 1, 19 3 2018, Pages 67 Study protocol: a randomised controlled trial on the clinical effects of levothyroxine treatment for subclinical hypothyroidism in people aged 80 years and over. Du Puy RS, Postmus I, Stott DJ, Blum MR, Poortvliet RKE, Den Elzen WPJ, Peeters RP, van Munster BC, Wolffenbuttel BHR, Westendorp RGJ, Kearney PM, Ford I, Kean S, Messow CM, Watt T, Jukema JW, Dekkers OM, Smit JWA, Rodondi N, Gussekloo J, Mooijaart SP

Background: Subclinical hypothyroidism is common in older people and its contribution to health and disease needs to be elucidated further. Observational and clinical trial data on the clinical effects of subclinical hypothyroidism in persons aged 80 years and over is inconclusive, with some studies suggesting harm and some suggesting benefits, translating into equipoise whether levothyroxine therapy provides clinical benefits. This manuscript describes the study protocol for the Institute for E... Abstract

Cited 16 times since 2018 (2.2 per year) source: EuropePMC

Journal of the Royal Army Medical Corps, Volume 165, Issue 3, 17 3 2018, Pages 147-151 Vascular access training for REBOA placement: a feasibility study in a live tissue-simulator hybrid porcine model. Borger van der Burg BLS, Hörer TM, Eefting D, van Dongen TTCF, Hamming JF, DuBose JJ, Bowyer M, Hoencamp R

Background: The use of resuscitative endovascular balloon occlusion of the aorta (REBOA) in patients with severe haemorrhagic shock is increasing. Obtaining vascular access is a necessary prerequisite for REBOA placement in these situations. Methods: During the EVTM workshop (September 2017, Örebro, Sweden), 21 individuals participated in this study, 16 participants and five instructors. A formalised curriculum was constructed including basic anatomy of the femoral region and basic training in a... Abstract

Cited 21 times since 2018 (2.9 per year) source: EuropePMC

European journal of heart failure, Volume 20, Issue 11, 17 3 2018, Pages 1601-1610 Rationale and design of the phase 2b clinical trials to study the effects of the partial adenosine A1-receptor agonist neladenoson bialanate in patients with chronic heart failure with reduced (PANTHEON) and preserved (PANACHE) ejection fraction. Voors AA, Shah SJ, Bax JJ, Butler J, Gheorghiade M, Hernandez AF, Kitzman DW, McMurray JJV, Wirtz AB, Lanius V, van der Laan M, Solomon SD

Despite major advances in the treatment of chronic heart failure (HF) with reduced ejection fraction (HFrEF), morbidity and mortality associated with the condition remain high, suggesting the need for additional treatment options, particularly haemodynamically neutral treatments that do not alter blood pressure, heart rate, or renal function. HF with preserved ejection fraction (HFpEF) is also associated with high morbidity and mortality and adequate treatment options are limited; thus there is... Abstract

Cited 17 times since 2018 (2.4 per year) source: EuropePMC

Environmental pollution (Barking, Essex : 1987), Volume 243, Issue Pt B, 17 3 2018, Pages 1923-1929 Effects of broadband sound exposure on the interaction between foraging crab and shrimp - A field study. Hubert J, Campbell J, van der Beek JG, den Haan MF, Verhave R, Verkade LS, Slabbekoorn H

Aquatic animals live in an acoustic world in which they often rely on sound detection and recognition for various aspects of life that may affect survival and reproduction. Human exploitation of marine resources leads to increasing amounts of anthropogenic sound underwater, which may affect marine life negatively. Marine mammals and fishes are known to use sounds and to be affected by anthropogenic noise, but relatively little is known about invertebrates such as decapod crustaceans. We conducte... Abstract

Cited 1025 times since 2018 (142.6 per year) source: EuropePMC

Nature genetics, Volume 50, Issue 10, 17 3 2018, Pages 1412-1425 Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N, Cabrera CP, Karaman I, Ng FL, Evangelou M, Witkowska K, Tzanis E, Hellwege JN, Giri A, Velez Edwards DR, Sun YV, Cho K, Gaziano JM, Wilson PWF, Tsao PS, Kovesdy CP, Esko T, Mägi R, Milani L, Almgren P, Boutin T, Debette S, Ding J, Giulianini F, Holliday EG, Jackson AU, Li-Gao R, Lin WY, Luan J, Mangino M, Oldmeadow C, Prins BP, Qian Y, Sargurupremraj M, Shah N, Surendran P, Thériault S, Verweij N, Willems SM, Zhao JH, Amouyel P, Connell J, de Mutsert R, Doney ASF, Farrall M, Menni C, Morris AD, Noordam R, Paré G, Poulter NR, Shields DC, Stanton A, Thom S, Abecasis G, Amin N, Arking DE, Ayers KL, Barbieri CM, Batini C, Bis JC, Blake T, Bochud M, Boehnke M, Boerwinkle E, Boomsma DI, Bottinger EP, Braund PS, Brumat M, Campbell A, Campbell H, Chakravarti A, Chambers JC, Chauhan G, Ciullo M, Cocca M, Collins F, Cordell HJ, Davies G, de Borst MH, de Geus EJ, Deary IJ, Deelen J, Del Greco M F, Demirkale CY, Dörr M, Ehret GB, El

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify... Abstract

Cited 48 times since 2018 (6.7 per year) source: EuropePMC

Clinical cancer research : an official journal of the American Association for Cancer Research, Volume 25, Issue 1, 17 3 2018, Pages 240-252 The Anatomical Location Shapes the Immune Infiltrate in Tumors of Same Etiology and Affects Survival. Santegoets SJ, van Ham VJ, Ehsan I, Charoentong P, Duurland CL, van Unen V, Höllt T, van der Velden LA, van Egmond SL, Kortekaas KE, de Vos van Steenwijk PJ, van Poelgeest MIE, Welters MJP, van der Burg SH

Purpose: The tumor immune microenvironment determines clinical outcome. Whether the original tissue in which a primary tumor develops influences this microenvironment is not well understood. Experimental design: We applied high-dimensional single-cell mass cytometry [Cytometry by Time-Of-Flight (CyTOF)] analysis and functional studies to analyze immune cell populations in human papillomavirus (HPV)-induced primary tumors of the cervix (cervical carcinoma) and oropharynx (oropharyngeal squamous c... Abstract