7401 results
Molecular therapy : the journal of the American Society of Gene Therapy,
20 3 2025, Pages S1525-0016(25)00656-2
In vivo base editing reduces liver cysts in autosomal dominant polycystic kidney disease.
Ibel A, Bhardwaj R, Yilmaz DE, Kong S, Wendlinger S, Cordero C, Papaioannou D, Papazian M, Schönauer R, Meng Q, Eckardt KU, Hassan F, Volpe I, Klämbt V, Halbritter J, Fedeles S, Krappitz M, Kaminski MM
Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent genetic kidney disorder, affecting over 10 million individuals worldwide. Cystic expansion typically progresses to kidney failure and also involves the liver with limited treatment options. Pathogenic variants in PKD1 or PKD2 account for 85%-90% of cases. Genetic re-expression of Pkd1 or Pkd2 has been shown to partially reverse key characteristics of the disease phenotype in mice. Despite advancements in understanding the...
Abstract
JMIR cardio,
Volume 9, 18 3 2025, Pages e56236
Adherence Patterns of Patients Using Remote Patient Management After Myocardial Infarction: Mixed Methods Persona Approach.
Hondmann SM, Schrauwen L, Reijnders T, Stoop E, Evers AW, Visch VT, Atsma DE, Janssen VR
Background: Remote patient management (RPM) using smartphone-enabled health monitoring devices (SHMDs) can be an effective, value-added part of cardiovascular care. However, cardiac patients' adherence to RPM is variable. Personas are fictional representations of users with common behaviors, needs, and motivation and can thereby help guide tailoring of interventions to be meaningful and possibly more effective. Personas can be used to understand the needs of the patient group and guide tail...
Abstract
American journal of physiology. Renal physiology,
Volume 329, Issue 4, 18 3 2025, Pages F453-F464
The impact of chronic kidney disease on arteriovenous fistula remodeling: studies in a murine model of autosomal dominant polycystic kidney disease.
Laboyrie SL, Peters DJM, Bijkerk R, de Winter EP, Duijs JMGJ, de Klerk JA, de Vries MR, Rotmans JI
The arteriovenous fistula (AVF) is the gold standard for hemodialysis vascular access, although inadequate vascular remodeling and intimal hyperplasia pose a major limitation. It is essential to study this in a clinically relevant model. We used an autosomal dominant polycystic kidney disease (ADPKD) model, the most common hereditary cause of chronic kidney disease (CKD), to study the effect of CKD on AVFs. Jugular-carotid AVFs were created in adult B6OlaPkd1nl/nl (ADPKD) mice and B6OlaPkd1+/+ l...
Abstract
BMJ open,
Volume 15, Issue 8, 16 3 2025, Pages e100002
Multiparametric MRI for local staging in patients with suspected muscle-invasive bladder cancer: study protocol for a multicentre, non-inferiority randomised controlled trial (the BladParadigm study).
van Koeverden SW, van Hoogstraten LM, de Rooij M, van der Leest M, Grutters JP, BladParadigm study group, Kiemeney LA, van der Heijden AG
Introduction: Muscle-invasive bladder cancer (MIBC) is an aggressive type of cancer. About 50% of patients will die from the disease within 5 years despite radical treatment. This implies that in many patients, the disease has already spread at the time of radical treatment, even though imaging shows no signs of metastasis. We hypothesise that the standard local staging method, transurethral resection of the bladder tumour (TURBT), is partly responsible for tumour cell spread. Furthermore, TURBT...
Abstract
The American journal of cardiology,
Volume 255, 16 3 2025, Pages 116-125
Diagnosis and Treatment of Unrecognized Spontaneous Coronary Artery Dissection in Young Women Presenting With an Acute Coronary Syndrome.
Al-Gully J, Montero-Cabezas JM, Eikenboom J, den Exter PL, van der Kley F, Jukema W, Bingen BO, Al Amri I
Spontaneous coronary artery dissection (SCAD) is often overlooked as a cause of acute coronary syndrome (ACS), particularly in young women. SCAD requires distinct management, underscoring the importance of its timely and accurate diagnosis for effective treatment. This study aims to evaluate the frequency of SCAD underdiagnosis in young women with ACS and pinpoints potential SCAD indicators. All consecutive women ≤55 years with ACS who underwent coronary angiography (CAG) at our tertiary center...
Abstract
Cited 1 times since 2025 (9.5 per year)
source: EuropePMC
Nature communications,
Volume 16, Issue 1, 14 2 2025, Pages 7569
Impact of early life antibiotic and probiotic treatment on gut microbiome and resistome of very-low-birth-weight preterm infants.
Kiu R, Darby EM, Alcon-Giner C, Acuna-Gonzalez A, Camargo A, Lamberte LE, Phillips S, Sim K, Shaw AG, Clarke P, van Schaik W, Kroll JS, Hall LJ
Preterm infants (
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JACC. Advances,
Volume 4, Issue 9, 13 2 2025, Pages 102063
Ventricular Tachycardia Predicts All-Cause Mortality and Nonsudden Cardiac Death in Nonischemic Cardiomyopathy.
Omara S, Jensen TN, Koeber L, Thune JJ, Pehrson S, Mertens B, Tedrow UB, Hindricks G, Ebert M, Carbucicchio C, Berruezo A, Vaseghi M, Shivkumar K, Deneke T, Wijnmaalen AP, Stevenson WG, Nielsen JC, Zeppenfeld K
Background: Patients with nonischemic cardiomyopathies (NICMs) are at a risk for end-stage heart failure and death from ventricular arrhythmias. Implanted defibrillators (ICDs) protect against sudden arrhythmic death, but several studies suggest that ventricular arrhythmias are associated with worse outcomes despite ICDs. Objectives: This study evaluated the relationship of ventricular tachycardia (VT) with total mortality and nonsudden cardiovascular death (NSCVD) in NICM patients with ICDs enr...
Abstract
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine,
Volume 225, 13 2 2025, Pages 112097
Investigation of structural and radiation shielding properties of natural granite, clay, natural cement, and quartz supplied from Hakkâri region.
Kabamakli E, Yalcin S, Aktas B, Yilmaz D
This study aims to investigate the physical, structural, and radiation shielding properties of four rock types commonly used in natural cement, including clay, granite, and quartz originating from the Hakkâri region of Turkey. Structural characterization was performed using ICP-MS, XRD, and FT-IR analyses. At the same time, radiation shielding effectiveness was determined through measurements of mass attenuation coefficient (MAC), linear attenuation coefficient (LAC), half-value layer (HVL), mea...
Abstract
Nature communications,
Volume 16, Issue 1, 13 2 2025, Pages 7493
CYP1B1-AS1 regulates CYP1B1 to promote Coxiella burnetii pathogenesis by inhibiting ROS and host cell death.
Arunima A, Niyakan S, Butler SM, Clark SD, Pinson A, Kwak D, Case EDR, Qian X, de Figueiredo P, van Schaik EJ, Samuel JE
Coxiella burnetii (Cb), the causative agent of Q fever, replicates within host macrophages by modulating immune responses through poorly understood mechanisms. Long non-coding RNAs (lncRNAs) are crucial yet underexplored regulators of inflammation, particularly in Cb pathogenesis. Employing a comparative transcriptomic analysis of THP-1 macrophages infected with 16 different microbes, we dissect a core set of immune-responsive lncRNAs such as MAILR, LINC01215, PACER, and MROCKI-common to human a...
Abstract
Acta dermato-venereologica,
Volume 105, 12 2 2025, Pages adv44209
Topical Steroid Withdrawal: Perspectives of Dutch Healthcare Professionals.
Vroman F, Schimmel CS, Van der Rijst LP, De Graaf M, De Bruin-Weller M, Kemperman PMJH, Hijnen DJ, Haeck IM
Topical steroid withdrawal (TSW) is a highly controversial condition, typically reported following prolonged and/or frequent use of topical corticosteroids. Despite growing public awareness, knowledge of topical steroid withdrawal remains limited. Therefore, this study aimed to explore the perspectives of Dutch healthcare professionals (HCPs) on topical steroid withdrawal. A web-based survey was conducted among 168 Dutch HCPs. The results show that erythema (64.1%) and a burning sensation (60.3%...
Abstract
BMC medical informatics and decision making,
Volume 25, Issue 1, 12 2 2025, Pages 302
Applying text-mining to clinical notes: the identification of patient characteristics from electronic health records (EHRs).
Ten Hoope S, Welvaars K, van Geijtenbeek K, Klok-Everaars M, van Schaik S, Karapinar-Çarkit F
Background: Clinical notes contain information on critical patient characteristics, which, if overlooked, could escalate the risk of adverse events as well as miscommunication between the healthcare professional and the patient. This study investigates the feasibility of employing text-mining to extract patient characteristics from Electronic Health Records (EHRs) and compares the effectiveness of text-mining against human intelligence for identifying four patient characteristics: language barri...
Abstract
Food chemistry,
Volume 493, Issue Pt 4, 9 2 2025, Pages 145890
Engineering gold nanoparticles aggregation in acrylate hydrogel-photopolymers for SERS-based on-site highly sensitive dimethoate detection on olives.
Yilmaz D, Miranda B, Nocerino V, Esposito A, Rea I, Lonardo E, De Stefano L, De Luca AC
Hydrogel-based flexible plasmonic devices represent a cutting-edge technology for real-time monitoring of food safety, particularly for pesticide detection. This study presents a cost-effective, portable, and sensitive method to detect dimethoate (DMT), a hazardous organophosphorus pesticide, at concentrations below the maximum residue limit (MRL) of 0.01 ppm on olives. By integrating surface-enhanced Raman scattering (SERS) with gold nanoparticles (AuNPs) embedded in polyethylene glycol diacryl...
Abstract
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
9 2 2025, Pages 102470
Stenosis degree and plaque burden differ between the major epicardial coronary arteries supplying ischemic territories.
Kero T, Knuuti J, Bär S, Bax JJ, Saraste A, Maaniitty T
Background: It is unclear whether coronary artery stenosis, plaque burden, and composition differ between major epicardial arteries supplying ischemic myocardial territories. Methods: We studied 837 symptomatic patients undergoing coronary computed tomography angiography (CTA) and 15O-water positron emission tomography (PET) myocardial perfusion imaging for suspected obstructive coronary artery disease. Coronary CTA was analyzed using artificial intelligence-guided quantitative computed tomograp...
Abstract
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine,
Volume 225, 8 2 2025, Pages 112089
Albedo parameter-based characterization of surface roughness in chemically etched zirconium samples.
Yılmaz D, Pathman AF, Kalecik S, Kurucu Y, Demir L
In this study, we investigate the potential of gamma-ray albedo parameters as a non-contact and radiation-based technique to characterize surface roughness variations in zirconium foils subjected to chemical etching. Zirconium samples were etched in 20 % hydrofluoric acid (HF) for different durations (30, 60, 90, and 120 s), and their surface morphology was evaluated using profilometry and gamma spectrometry. Albedo parameters were derived from the intensities of Compton and coherent scattering...
Abstract
BMC psychology,
Volume 13, Issue 1, 6 1 2025, Pages 872
Effects of demographic characteristics on burnout, psychological resilience, and family functioning in parents of children with disabilities.
Yildirim MS, Firat MÖ, Atay ME, Yilmaz DA, Dege G
Background: Parents of children with disabilities face unique challenges beyond typical parenting responsibilities. The ongoing demands of caregiving can increase burnout, negatively affecting psychological well-being and family functionality. Psychological resilience is crucial in managing stress and maintaining family dynamics, yet the relationship between burnout, resilience, and family functionality remains underexplored. Objective: This study aims to examine the effects of demographic chara...
Abstract
Applied neuropsychology. Child,
6 1 2025, Pages 1-7
Cognitive function and inflammatory markers of survivors of MIS-C.
Üstündağ G, Özyurt G, Elvan Tüz A, Argüz Çıldır D, Akman S, Kara Aksay A, Yılmaz D, Karadağ Öncel E
Background: Multisystem inflammatory syndrome in children (MIS-C) presents severe clinical challenges due to its severe outcomes and diagnostic complexities. Recent studies suggest cognitive functions may also be affected. This study evaluates cognitive functions in MIS-C survivors over 12 months and explores the relationship with inflammatory markers. Methods: This prospective observational cohort study included children diagnosed with MIS-C hospitalized in a tertiary pediatric care unit. Follo...
Abstract
The Journal of thoracic and cardiovascular surgery,
5 1 2025, Pages S0022-5223(25)00648-8
Personalized external aortic root support: The Dutch experience.
Kougioumtzoglou AM, Lam BCY, Bouma BJ, Groenink M, Scholte AJHA, Dolmaci OB, Corsmit OT, Pandey AK, de Blok ACJ, Noter SL, Austin C, Klautz RJM, Hazekamp MG, Koolbergen D
Introduction: Patients with connective tissue disease and aortic root aneurysm are at risk of dissection and progression of the dilatation. Standard treatment of aortic root aneurysm is either a total root replacement or valve-sparing root replacement. Both procedures have drawbacks, such as the need for anticoagulation and long-term exposure to the chance of reoperation or endocarditis. The ExoVasc personalized external aortic root support (PEARS) is a perivascular stent that has been introduce...
Abstract
Virchows Archiv : an international journal of pathology,
5 1 2025
Diagnosing the silent: the molecular landscape of non-functional parathyroid carcinoma.
Jentus MM, Corver WE, Snel M, van Haalen FM, van Wezel T, Ruano D, Kapiteijn E, Crobach S, Appelman-Dijkstra NM, Schepers A, Morreau H
Non-functional parathyroid carcinoma (NFPC) is an exceptionally rare malignancy, with approximately 50 cases reported since the parathyroid glands were first described in the late nineteenth century. Unlike functional parathyroid carcinomas (PC), which typically present with severe hyperparathyroidism (HPT) and are monitored via serum calcium and parathyroid hormone (PTH) levels, NFPC lacks biochemical markers and is monitored solely through imaging. In this study, we present two new cases of pr...
Abstract
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 67, Issue 8, 1 1 2025, Pages ezaf276
2025 ESC/EACTS Guidelines for the management of valvular heart disease.
Praz F, Borger MA, Lanz J, Marin-Cuartas M, Abreu A, Adamo M, Marsan NA, Barili F, Bonaros N, Cosyns B, De Paulis R, Gamra H, Jahangiri M, Jeppsson A, Klautz RJM, Mores B, Pérez-David E, Pöss J, Prendergast BD, Rocca B, Rossello X, Suzuki M, Thiele H, Tribouilloy CM, Wojakowski W, ESC/EACTS Scientific Document Group
Abstract
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 27, Issue 8, 1 1 2025, Pages euaf136
Different underlying aetiologies in patients presenting with ventricular tachycardia fulfilling task force criteria for arrhythmogenic right ventricular cardiomyopathy: initial suspicion based on the 12-lead electrocardiogram.
Hoogendoorn JC, Bosman LP, van der Heijden JF, Wilde AA, van den Berg MP, Yap SC, van Tintelen JP, Dooijes D, Te Riele ASJM, Zeppenfeld K
Aims: The task force criteria (TFC) for arrhythmogenic right ventricular cardiomyopathy (ARVC) are highly sensitive but lack specificity. Atypical RV involvement (aRVi) may indicate different underlying aetiologies and prognosis, requiring specific therapeutic interventions. We aimed to evaluate the role of the baseline 12-lead ECG for initial suspicion of aRVi. Methods: From the Netherlands Heart Institute Arrhythmogenic Cardiomyopathy (NHI-ACM) registry, patients were selected who (i) fulfille...
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