9543 results
Cited 48 times since 2018 (6.5 per year)
source: EuropePMC
Genome biology,
Volume 19, Issue 1, 17 3 2018, Pages 87
Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.
Prins BP, Mead TJ, Brody JA, Sveinbjornsson G, Ntalla I, Bihlmeyer NA, van den Berg M, Bork-Jensen J, Cappellani S, Van Duijvenboden S, Klena NT, Gabriel GC, Liu X, Gulec C, Grarup N, Haessler J, Hall LM, Iorio A, Isaacs A, Li-Gao R, Lin H, Liu CT, Lyytikäinen LP, Marten J, Mei H, Müller-Nurasyid M, Orini M, Padmanabhan S, Radmanesh F, Ramirez J, Robino A, Schwartz M, van Setten J, Smith AV, Verweij N, Warren HR, Weiss S, Alonso A, Arnar DO, Bots ML, de Boer RA, Dominiczak AF, Eijgelsheim M, Ellinor PT, Guo X, Felix SB, Harris TB, Hayward C, Heckbert SR, Huang PL, Jukema JW, Kähönen M, Kors JA, Lambiase PD, Launer LJ, Li M, Linneberg A, Nelson CP, Pedersen O, Perez M, Peters A, Polasek O, Psaty BM, Raitakari OT, Rice KM, Rotter JI, Sinner MF, Soliman EZ, Spector TD, Strauch K, Thorsteinsdottir U, Tinker A, Trompet S, Uitterlinden A, Vaartjes I, van der Meer P, Völker U, Völzke H, Waldenberger M, Wilson JG, Xie Z, Asselbergs FW, Dörr M, van Duijn CM, Gasparini P, Gudbjartsson DF, Gudnason V, Hansen T, Kääb S,
Background: Genome-wide association studies conducted on QRS duration, an electrocardiographic measurement associated with heart failure and sudden cardiac death, have led to novel biological insights into cardiac function. However, the variants identified fall predominantly in non-coding regions and their underlying mechanisms remain unclear. Results: Here, we identify putative functional coding variation associated with changes in the QRS interval duration by combining Illumina HumanExome Bead...
Abstract
Cited 9 times since 2018 (1.2 per year)
source: EuropePMC
Heart rhythm,
Volume 15, Issue 12, 12 2 2018, Pages 1816-1822
Impact of atrial fibrillation on improvement of functional mitral regurgitation in cardiac resynchronization therapy.
van der Bijl P, Vo NM, Leung M, Ajmone Marsan N, Delgado V, Stone GW, Bax JJ
Background: Functional mitral regurgitation (FMR) and atrial fibrillation (AF) are frequent heart failure (HF) complications. Cardiac resynchronization therapy (CRT) can improve FMR; however, little is known about the influence of AF on FMR improvement. Objective: The purpose of this study was to investigate the mechanisms and impact of baseline AF on FMR improvement after CRT. Methods: CRT recipients with HF, AF, or sinus rhythm (SR) at baseline with moderate or severe FMR, were included from a...
Abstract
Cited 7 times since 2018 (0.9 per year)
source: EuropePMC
Pharmacogenomics,
Volume 19, Issue 11, 11 2 2018, Pages 895-903
CYP3A5 and ABCB1 polymorphisms in living donors do not impact clinical outcome after kidney transplantation.
Yang L, de Winter BC, van Schaik RH, Xie RX, Li Y, Andrews LM, Shuker N, Bahmany S, Koch B, van Gelder T, Hesselink DA
Aim: To investigate the association between donor CYP3A5 and ABCB1 polymorphisms and tacrolimus (Tac)-induced nephrotoxicity and renal function in kidney transplant recipients. Methods: The CYP3A5 6986A>G and ABCB1 3435C>T polymorphisms were determined in 237 recipients and donors. Results: There was no significant association between Tac-related nephrotoxicity and donor CYP3A5 and ABCB1 genotype. The donor ABCB1 3435C>T polymorphism was associated with estimated glomerular filtration r...
Abstract
Cited 44 times since 2018 (6 per year)
source: EuropePMC
The Lancet. Neurology,
Volume 17, Issue 8, 9 2 2018, Pages 689-698
Oral fingolimod for chronic inflammatory demyelinating polyradiculoneuropathy (FORCIDP Trial): a double-blind, multicentre, randomised controlled trial.
Hughes R, Dalakas MC, Merkies I, Latov N, Léger JM, Nobile-Orazio E, Sobue G, Genge A, Cornblath D, Merschhemke M, Ervin CM, Agoropoulou C, Hartung HP, FORCIDP Trial Investigators
Background: Fingolimod is approved for the treatment of relapsing-remitting multiple sclerosis and was effective in experimental autoimmune neuritis in rats, a possible model for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). We aimed to evaluate the efficacy of fingolimod in delaying disability progression in patients with CIDP who withdrew from currently effective treatments (intravenous immunoglobulin [IVIg] or corticosteroids). Methods: This double-blind, multicentre, rand...
Abstract
Cited 13 times since 2018 (1.8 per year)
source: EuropePMC
Pharmacology research & perspectives,
Volume 6, Issue 4, 5 1 2018, Pages e00419
Enantioselective pharmacokinetics of tramadol and its three main metabolites; impact of <i>CYP2D6</i>, <i>CYP2B6</i>, and <i>CYP3A4</i> genotype.
Haage P, Kronstrand R, Josefsson M, Calistri S, van Schaik RHN, Green H, Kugelberg FC
Tramadol is a complex drug, being metabolized by polymorphic enzymes and administered as a racemate with the (+)- and (-)-enantiomers of the parent compound and metabolites showing different pharmacological effects. The study aimed to simultaneously determine the enantiomer concentrations of tramadol, O-desmethyltramadol, N-desmethyltramadol, and N,O-didesmethyltramadol following a single dose, and elucidate if enantioselective pharmacokinetics is associated with the time following drug intake a...
Abstract
Cited 12 times since 2018 (1.6 per year)
source: EuropePMC
Journal of periodontal research,
Volume 53, Issue 5, 4 1 2018, Pages 916-923
Matrix metalloproteinase-7 in periodontitis with type 2 diabetes mellitus.
Zeidán-Chuliá F, Yilmaz D, Häkkinen L, Könönen E, Neves de Oliveira BH, Güncü G, Uitto VJ, Caglayan F, Gürsoy UK
Background and objective: Elevated levels of matrix metalloproteinase-7 (MMP7) have been observed in serum samples of subjects with type 2 diabetes mellitus (T2DM) and in gingival tissues of subjects with periodontitis. The aim of the present study was to collect in vivo and in silico evidence on the role of MMP7 in the interplay between T2DM and generalized periodontitis (GP). Material and methods: The extent of MMP7 expression and localization were immunohistochemically analyzed in gingival ti...
Abstract
Cited 53 times since 2018 (7.2 per year)
source: EuropePMC
Applied and environmental microbiology,
Volume 84, Issue 14, 2 1 2018, Pages e00309-18
Human-Associated Lachnospiraceae Genetic Markers Improve Detection of Fecal Pollution Sources in Urban Waters.
Feng S, Bootsma M, McLellan SL
The human microbiome contains many organisms that could potentially be used as indicators of human fecal pollution. Here we report the development of two novel human-associated genetic marker assays that target organisms within the family Lachnospiraceae Next-generation sequencing of the V6 region of the 16S rRNA gene from sewage and animal stool samples identified 40 human-associated marker candidates with a robust signal in sewage and low or no occurrence in samples from nonhuman hosts. Two we...
Abstract
Cited 30 times since 2018 (4.1 per year)
source: EuropePMC
Journal of neurology,
Volume 265, Issue 9, 2 1 2018, Pages 2052-2059
Corticosteroids in chronic inflammatory demyelinating polyneuropathy : A retrospective, multicentre study, comparing efficacy and safety of daily prednisolone, pulsed dexamethasone, and pulsed intravenous methylprednisolone.
van Lieverloo GGA, Peric S, Doneddu PE, Gallia F, Nikolic A, Wieske L, Verhamme C, van Schaik IN, Nobile-Orazio E, Basta I, Eftimov F
Background: Chronic inflammatory demyelinating polyneuropathy (CIDP) can be treated with corticosteroids or intravenous immunoglobulins. Various corticosteroid regimens are currently used in CIDP, but it is unknown whether they are equally efficacious. In this retrospective study, we compared efficacy and safety of three corticosteroid regimens in CIDP patients. Methods: We included treatment naïve patients that fulfilled the EFNS/PNS criteria for CIDP. Patients were treated with corticosteroids...
Abstract
Cited 423 times since 2018 (57.2 per year)
source: EuropePMC
JAMA cardiology,
Volume 3, Issue 7, 1 1 2018, Pages 619-627
Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies: A Mendelian Randomization Analysis.
Burgess S, Ference BA, Staley JR, Freitag DF, Mason AM, Nielsen SF, Willeit P, Young R, Surendran P, Karthikeyan S, Bolton TR, Peters JE, Kamstrup PR, Tybjærg-Hansen A, Benn M, Langsted A, Schnohr P, Vedel-Krogh S, Kobylecki CJ, Ford I, Packard C, Trompet S, Jukema JW, Sattar N, Di Angelantonio E, Saleheen D, Howson JMM, Nordestgaard BG, Butterworth AS, Danesh J, European Prospective Investigation Into Cancer and Nutrition–Cardiovascular Disease (EPIC-CVD) Consortium
Importance: Human genetic studies have indicated that plasma lipoprotein(a) (Lp[a]) is causally associated with the risk of coronary heart disease (CHD), but randomized trials of several therapies that reduce Lp(a) levels by 25% to 35% have not provided any evidence that lowering Lp(a) level reduces CHD risk. Objective: To estimate the magnitude of the change in plasma Lp(a) levels needed to have the same evidence of an association with CHD risk as a 38.67-mg/dL (ie, 1-mmol/L) change in low-dens...
Abstract
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 54, Issue 1, 1 1 2018, Pages 199
Mitral valve infective endocarditis: putting the puzzle pieces together.
Tomšic A, Klautz RJM, Palmen M
Abstract
Heart, lung & circulation,
Volume 27, Issue 7, 1 1 2018, Pages 782-784
Lessons from an International Bicuspid Aortic Valve Disease Registry: the Raphe and Beyond.
Ng ACT, Delgado V, Kong WKF, Bax JJ
Abstract
Cited 83 times since 2018 (11.2 per year)
source: EuropePMC
Circulation. Cardiovascular imaging,
Volume 11, Issue 7, 1 1 2018, Pages e007562
Quantification of Coronary Atherosclerosis in the Assessment of Coronary Artery Disease.
Lee SE, Sung JM, Rizvi A, Lin FY, Kumar A, Hadamitzky M, Kim YJ, Conte E, Andreini D, Pontone G, Budoff MJ, Gottlieb I, Lee BK, Chun EJ, Cademartiri F, Maffei E, Marques H, Leipsic JA, Shin S, Hyun Choi J, Chinnaiyan K, Raff G, Virmani R, Samady H, Stone PH, Berman DS, Narula J, Shaw LJ, Bax JJ, Min JK, Chang HJ
Background: Diagnosis of coronary artery disease and management strategies have relied solely on the presence of diameter stenosis ≥50%. We assessed whether direct quantification of plaque burden (PB) and plaque characteristics assessed by coronary computed tomography angiography could provide additional value in terms of predicting rapid plaque progression. Methods and results: From a 13-center, 7-country prospective observational registry, 1345 patients (60.4±9.4 years old; 57.1% male) who und...
Abstract
Cited 2 times since 2018 (0.3 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 11, Issue 7, 1 1 2018, Pages 984-986
Will Cardiac Magnetic Resonance Change the Management of Severe Aortic Stenosis Patients?
Delgado V, Bax JJ
Abstract
Cited 8 times since 2018 (1.1 per year)
source: EuropePMC
European heart journal,
Volume 39, Issue 27, 1 1 2018, Pages 2600-2601
New prospects for PCSK9 inhibition?
Landmesser U, Chapman MJ, Stock JK, Amarenco P, Belch JJF, Borén J, Farnier M, Ference BA, Gielen S, Graham I, Grobbee DE, Hovingh GK, Lüscher TF, Piepoli MF, Ray KK, Ray KK, Stroes ES, Wiklund O, Windecker S, Zamorano JL, Pinto F, Tokgözoglu L, Bax JJ, Catapano AL, European Society of Cardiology/European Atherosclerosis Society Task Force
Abstract
Cited 3 times since 2018 (0.4 per year)
source: EuropePMC
Interactive cardiovascular and thoracic surgery,
Volume 27, Issue 1, 1 1 2018, Pages 124-130
Papillary muscle head repositioning for commissural prolapse in degenerative mitral valve disease.
Tomšic A, Klautz RJM, van Brakel TJ, Ajmone Marsan N, Versteegh MIM, Palmen M
Objectives: Surgical correction of commissural mitral valve prolapse can be challenging. Several surgical techniques, including commissural closure, leaflet resection with sliding plasty and chordal replacement, remain commonly in use. Conversely, papillary muscle head repositioning remains uncommonly utilized for the treatment of commissural prolapse. Methods: Between January 2003 and December 2015, 518 patients underwent primary mitral valve repair for severe degenerative mitral valve regurgit...
Abstract
Cited 2 times since 2018 (0.3 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 54, Issue 1, 1 1 2018, Pages 98-105
Programmed electrical stimulation-guided encircling cryoablation concomitant to surgical ventricular reconstruction for primary prevention of ventricular arrhythmias.
van Huls van Taxis CF, Wijnmaalen AP, Klein P, Dekkers OM, Braun J, Verwey HF, Schalij MJ, Klautz RJ, Zeppenfeld K
Objectives: Surgical ventricular reconstruction (SVR) is an effective treatment to improve left ventricular (LV) function in patients with ischaemic heart failure and an LV anterior-apical aneurysm. Ventricular arrhythmia (VA) is an important cause for morbidity and mortality in these patients. Therefore, encircling cryoablation targeting the VA substrate may be required. Programmed electrical stimulation (PES) can identify patients at risk for VA. The objective of this study was to evaluate the...
Abstract
Cited 65 times since 2018 (8.8 per year)
source: EuropePMC
FEMS microbiology ecology,
Volume 94, Issue 7, 1 1 2018
Limited influence of hospital wastewater on the microbiome and resistome of wastewater in a community sewerage system.
Buelow E, Bayjanov JR, Majoor E, Willems RJ, Bonten MJ, Schmitt H, van Schaik W
Effluents from wastewater treatment plants (WWTPs) have been proposed to act as point sources of antibiotic-resistant bacteria (ARB) and antimicrobial resistance genes (ARGs) in the environment. Hospital sewage may contribute to the spread of ARB and ARGs as it contains the feces and urine of hospitalized patients, who are more frequently colonized with multi-drug resistant bacteria than the general population. However, whether hospital sewage noticeably contributes to the quantity and diversity...
Abstract
Cited 12 times since 2018 (1.6 per year)
source: EuropePMC
Revista espanola de cardiologia (English ed.),
Volume 71, Issue 11, 30 5 2018, Pages 961-970
Sudden Cardiac Death Risk Prediction: The Role of Cardiac Magnetic Resonance Imaging.
van der Bijl P, Podlesnikar T, Bax JJ, Delgado V
Sudden cardiac death (SCD) accounts for more than 4 million global deaths per year. While it is most commonly caused by coronary artery disease, a final common pathway of ventricular arrhythmias is shared by different etiologies. The most effective primary and secondary prevention strategy is an implantable cardioverter-defibrillator (ICD). The decision to implant an ICD for primary prevention is largely based on a left ventricular ejection fraction ≤ 35%, but this criterion in isolation is neit...
Abstract
Cited 12 times since 2018 (1.6 per year)
source: EuropePMC
Journal of clinical and translational hepatology,
Volume 6, Issue 3, 28 4 2018, Pages 339-344
Incidental Collision Tumor of Hepatocellular Carcinoma and Neuroendocrine Carcinoma.
Yılmaz DB, Bayramoğlu Z, Ünay G, Ayık E, Başsorgun Cİ, Elpek GÖ
The composite tumors of the liver are very rare, including the coexistence of HCC (hepatocellular carcinoma) with NEC (neuroendocrine carcinoma). The rare occurrence of these tumors necessitates more reported cases in order to fully understand their clinical characteristics, behaviors and treatments. Herein is described an incidental collision tumor of HCC-NEC, along with a review of the literature focusing on their clinicopathological findings and prognosis. The tumor presented here was found i...
Abstract
Cited 3 times since 2018 (0.4 per year)
source: EuropePMC
BMJ open,
Volume 8, Issue 6, 27 4 2018, Pages e020844
A Reduction in Time with Electronic Monitoring In Stroke (ARTEMIS): study protocol for a randomised multicentre trial.
Koster GT, Nguyen TTM, Groot AED, Coutinho JM, Bosch J, den Hertog HM, van Walderveen MAA, Algra A, Wermer MJH, Roos YB, Kruyt ND, ARTEMIS investigators
Introduction: Time is the most crucial factor limiting efficacy of intravenous thrombolysis (IVT) and intra-arterial thrombectomy (IAT). The delay between alarming the Emergency Medical Services (EMS) dispatch office and IVT/IAT initiation, that is, the 'total system delay' (TSD), depends on logistics and team effort. A promising method to reduce TSD is real-time audio-visual feedback to caregivers involved. With 'A Reduction in Time with Electronic Monitoring in Stroke' (ART...
Abstract
