Research

Publications

Below you can find a list of our published research.

9543 results

Cited 13 times since 2018 (1.7 per year) source: EuropePMC

Journal of cardiology, Volume 72, Issue 6, 31 5 2018, Pages 473-479 Long-term results of mitral valve repair for severe mitral regurgitation in asymptomatic patients. Tomšič A, Hiemstra YL, van Hout FMA, van Brakel TJ, Versteegh MIM, Marsan NA, Klautz RJM, Palmen M

Background: In asymptomatic patients with severe degenerative mitral valve regurgitation (MR), early surgery is often performed in experienced centers. The patient- and valve-related results and the quality of life after surgery in these patients remain insufficiently explored. Methods: Between 1/2000 and 12/2015, 83 asymptomatic patients (mean age 56.6±12.6 years, 21 female) without any complications related to long-lasting MR underwent early surgery. Follow-up clinical and echocardiographic da... Abstract

Cited 43 times since 2018 (5.7 per year) source: EuropePMC

Clinical epigenetics, Volume 10, 30 5 2018, Pages 71 Urine cell-based DNA methylation classifier for monitoring bladder cancer. van der Heijden AG, Mengual L, Ingelmo-Torres M, Lozano JJ, van Rijt-van de Westerlo CCM, Baixauli M, Geavlete B, Moldoveanud C, Ene C, Dinney CP, Czerniak B, Schalken JA, Kiemeney LALM, Ribal MJ, Witjes JA, Alcaraz A

Background: Current standard methods used to detect and monitor bladder cancer (BC) are invasive or have low sensitivity. This study aimed to develop a urine methylation biomarker classifier for BC monitoring and validate this classifier in patients in follow-up for bladder cancer (PFBC). Methods: Voided urine samples (N = 725) from BC patients, controls, and PFBC were prospectively collected in four centers. Finally, 626 urine samples were available for analysis. DNA was extracted from the urin... Abstract

Cited 475 times since 2018 (63.4 per year) source: EuropePMC

Nature communications, Volume 9, Issue 1, 29 5 2018, Pages 2098 Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Davies G, Lam M, Harris SE, Trampush JW, Luciano M, Hill WD, Hagenaars SP, Ritchie SJ, Marioni RE, Fawns-Ritchie C, Liewald DCM, Okely JA, Ahola-Olli AV, Barnes CLK, Bertram L, Bis JC, Burdick KE, Christoforou A, DeRosse P, Djurovic S, Espeseth T, Giakoumaki S, Giddaluru S, Gustavson DE, Hayward C, Hofer E, Ikram MA, Karlsson R, Knowles E, Lahti J, Leber M, Li S, Mather KA, Melle I, Morris D, Oldmeadow C, Palviainen T, Payton A, Pazoki R, Petrovic K, Reynolds CA, Sargurupremraj M, Scholz M, Smith JA, Smith AV, Terzikhan N, Thalamuthu A, Trompet S, van der Lee SJ, Ware EB, Windham BG, Wright MJ, Yang J, Yu J, Ames D, Amin N, Amouyel P, Andreassen OA, Armstrong NJ, Assareh AA, Attia JR, Attix D, Avramopoulos D, Bennett DA, Böhmer AC, Boyle PA, Brodaty H, Campbell H, Cannon TD, Cirulli ET, Congdon E, Conley ED, Corley J, Cox SR, Dale AM, Dehghan A, Dick D, Dickinson D, Eriksson JG, Evangelou E, Faul JD, Ford I, Freimer NA, Gao H, Giegling I, Gillespie NA, Gordon SD, Gottesman RF, Griswold ME, Gudnason V, Harris

General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P Abstract

Cited 25 times since 2018 (3.3 per year) source: EuropePMC

Journal of the American Heart Association, Volume 7, Issue 11, 27 4 2018, Pages e009592 Interaction of Left Ventricular Size and Sex on Outcome of Cardiac Resynchronization Therapy Among Patients With a Narrow QRS Duration in the EchoCRT Trial. Varma N, Sogaard P, Bax JJ, Abraham WT, Borer JS, Dickstein K, Singh JP, Gras D, Holzmeister J, Brugada J, Ruschitzka F

Background: Longer QRS duration (QRSd) improves, but increased left ventricular (LV) end-diastolic volume (LVEDV) reduces, efficacy of cardiac resynchronization therapy (CRT). QRSd/LVEDV ratios differ between sexes. We hypothesized that in the EchoCRT (Echocardiography Guided Cardiac Resynchronization Therapy) trial enrolling patients with heart failure with QRSd Abstract

Cited 18 times since 2018 (2.4 per year) source: EuropePMC

Preventive veterinary medicine, Volume 157, 25 4 2018, Pages 86-93 Using routinely collected data to evaluate risk factors for mortality of veal calves. Santman-Berends IMGA, de Bont-Smolenaars AJG, Roos L, Velthuis AGJ, van Schaik G

From 2009 to 2012 a gradual increase in on-farm mortality of Dutch veal calves was observed. In 2012, the cattle industry decided that more information was needed on risk factors for mortality in both veal herds and herds of origin to enable implementation of risk mitigating measures. Routinely collected data were available from seven different data sources and contained information from 2.4 million white veal calves that were fattened in the period between 1 January 2011 and 30 June 2014. Survi... Abstract

PloS one, Volume 13, Issue 5, 24 4 2018, Pages e0198376 Correction: Latent tuberculosis infection in foreign-born communities: Import vs. transmission in The Netherlands derived through mathematical modelling. Korthals Altes H, Kloet S, Cobelens F, Bootsma M

[This corrects the article DOI: 10.1371/journal.pone.0192282.]. Abstract

Cited 21 times since 2018 (2.8 per year) source: EuropePMC

Veterinary microbiology, Volume 221, 24 4 2018, Pages 13-18 Porcine epidemic diarrhea virus (PEDV) introduction into a naive Dutch pig population in 2014. Dortmans JCFM, Li W, van der Wolf PJ, Buter GJ, Franssen PJM, van Schaik G, Houben M, Bosch BJ

Porcine epidemic diarrhea virus (PEDV) is the highly contagious, causative agent of an economically important acute enteric disease in pigs of all ages. The disease is characterized by diarrhea and dehydration causing mortality and growth retardation. In the last few decades, only classical PEDV was reported sporadically in Europe, but in 2014 outbreaks of PEDV were described in Germany. Phylogenetic analysis showed a very high nucleotide similarity with a variant of PEDV that was isolated in th... Abstract

Cited 21 times since 2018 (2.8 per year) source: EuropePMC

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, Volume 105, 24 4 2018, Pages 1-10 Chronic sequelae and severe complications of norovirus infection: A systematic review of literature. Petrignani M, Verhoef L, de Graaf M, Richardus JH, Koopmans M

Norovirus causes an estimated 18% of all cases of acute gastroenteritis worldwide and is found to be associated with mortality. To create a first overview of severe complications and chronic sequelae of norovirus infections, a systematic review of literature was performed. Of 3928 individual hits, 176 publications remained for data extraction. Study periods varied between 1974 and 2017, though strongly skewed towards the last decade (n = 122, 70%). Countries of studies were worldwide, though Afr... Abstract

Cited 11 times since 2018 (1.5 per year) source: EuropePMC

International journal of cardiology, Volume 268, 23 4 2018, Pages 106-112 Biological versus mechanical heart valve prosthesis during pregnancy in women with congenital heart disease. Lameijer H, van Slooten YJ, Jongbloed MRM, Oudijk MA, Kampman MAM, van Dijk AP, Post MC, Mulder BJ, Sollie KM, van Veldhuisen DJ, Ebels T, van Melle JP, Pieper PG

Background: We evaluate pregnancy outcome and anticoagulation regimes in women with mechanical and biological prosthetic heart valves (PHV) for congenital heart disease. Methods: Retrospective multicenter cohort studying pregnancy outcomes in an existing cohort of patients with PHV. Results: 52 women had 102 pregnancies of which 78 pregnancies (46 women) ≥20 weeks duration (59 biological, 19 mechanical PHV). Miscarriages (n = 19, ≤20 weeks) occurred more frequently in women using anticoagulation... Abstract

Cited 11 times since 2018 (1.5 per year) source: EuropePMC

Pharmacogenomics, Volume 19, Issue 8, 23 4 2018, Pages 715-726 A gene variant near ATM affects the response to metformin and metformin plasma levels: a post hoc analysis of an RCT. Out M, Becker ML, van Schaik RH, Lehert P, Stehouwer CD, Kooy A

Aim: To determine the influence of polymorphisms on the effects of metformin on HbA1c, daily dose of insulin and metformin plasma concentration. Methods: In a post hoc analysis of a 4.3 year placebo-controlled randomized trial with 390 patients with Type 2 diabetes already on insulin, we analyzed the influence of polymorphisms in genes coding for ATM and the transporters OCT1 and MATE1. Outcome measures were a combined HbA1c + daily dose of insulin Z score and metformin plasma concentrations. Re... Abstract

Cited 13 times since 2018 (1.7 per year) source: EuropePMC

Journal of cardiovascular computed tomography, Volume 12, Issue 3, 19 3 2018, Pages 231-237 Impact of Non-obstructive left main disease on the progression of coronary artery disease: A PARADIGM substudy. Weir-McCall JR, Blanke P, Sellers SL, Ahmadi AA, Andreini D, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Chun EJ, Conte E, Gottlieb I, Hadamitzky M, Kim YJ, Lee BK, Lee SE, Maffei E, Marques H, Pontone G, Raff GL, Shin S, Sung JM, Stone P, Samady H, Virmani R, Narula J, Berman DS, Shaw LJ, Bax JJ, Lin FY, Min JK, Chang HJ, Leipsic JA

Background: The aim of the study is examine the impact of non-obstructive ( Abstract

Cited 28 times since 2018 (3.7 per year) source: EuropePMC

BMC surgery, Volume 18, Issue 1, 18 3 2018, Pages 27 MEDIASTinal staging of non-small cell lung cancer by endobronchial and endoscopic ultrasonography with or without additional surgical mediastinoscopy (MEDIASTrial): study protocol of a multicenter randomised controlled trial. Bousema JE, Dijkgraaf MGW, Papen-Botterhuis NE, Schreurs HW, Maessen JG, van der Heijden EH, Steup WH, Braun J, Noyez VJJM, Hoeijmakers F, Beck N, van Dorp M, Claessens NJM, Hiddinga BI, Daniels JMA, Heineman DJ, Zandbergen HR, Verhagen AFTM, van Schil PE, Annema JT, van den Broek FJC, MEDIASTrial study group

Background: In case of suspicious lymph nodes on computed tomography (CT) or fluorodeoxyglucose positron emission tomography (FDG-PET), advanced tumour size or central tumour location in patients with suspected non-small cell lung cancer (NSCLC), Dutch and European guidelines recommend mediastinal staging by endosonography (endobronchial ultrasound (EBUS) and endoscopic ultrasound (EUS)) with sampling of mediastinal lymph nodes. If biopsy results from endosonography turn out negative, additional... Abstract

Cited 12 times since 2018 (1.6 per year) source: EuropePMC

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, Volume 72, 17 3 2018, Pages 63-68 A novel view on the pathogenesis of complications after intravesical BCG for bladder cancer. Bilsen MP, van Meijgaarden KE, de Jong HK, Joosten SA, Prins C, Kroft LJM, Jonker JT, Crobach S, Pelger RC, Ottenhoff THM, Arend SM

Intravesical bacillus Calmette-Guérin (BCG) is widely used for high-risk, non-muscle-invasive bladder cancer. This report describes four cases that illustrate the spectrum of BCG-induced complications, varying from granulomatous prostatitis to sepsis. There is considerable debate regarding whether inflammation or infection is the predominant mechanism in the pathogenesis of BCG disease. In two patients with a systemic illness, the symptoms first resolved after adding prednisone, indicating a pri... Abstract

Cited 66 times since 2018 (8.8 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 11, Issue 10, 16 3 2018, Pages 1461-1471 Natural History of Diabetic Coronary Atherosclerosis by Quantitative Measurement of Serial Coronary Computed Tomographic Angiography: Results of the PARADIGM Study. Kim U, Leipsic JA, Sellers SL, Shao M, Blanke P, Hadamitzky M, Kim YJ, Conte E, Andreini D, Pontone G, Budoff MJ, Gottlieb I, Lee BK, Chun EJ, Cademartiri F, Maffei E, Marques H, Shin S, Choi JH, Virmani R, Samady H, Stone PH, Berman DS, Narula J, Shaw LJ, Bax JJ, Min JK, Chang HJ

Objectives: This study aimed to determine the rate and extent of plaque progression (PP), changes in plaque features, and clinical predictors of PP in patients with diabetes mellitus (DM). Background: The natural history of coronary PP in patients with DM is not well established. Methods: A total of 1,602 patients (age 61.3 ± 9.0 years; 60.3% men; median scan interval 3.8 years) who underwent serial coronary computed tomography angiography over a period of at least 24 months were enrolled and an... Abstract

Cited 6 times since 2018 (0.8 per year) source: EuropePMC

Clinical pharmacology and therapeutics, Volume 104, Issue 2, 15 3 2018, Pages 311-316 A Rapid (Differential) Effect of Rosuvastatin and Atorvastatin on High-Sensitivity Cardiac Troponin-I in Subjects With Stable Cardiovascular Disease. Bodde MC, Welsh P, Bergheanu SC, Lijfering WM, Mertens B, Liem AH, van der Laarse A, Sattar N, Jukema JW

Serum troponin within the normal range is an emerging predictor of cardiovascular mortality. We aimed to determine how rapidly high-sensitivity troponin-I (hs-cTnI) levels are lowered by statin therapy in patients with stable cardiovascular disease. In the RADAR substudy, patients were randomized to atorvastatin 20 mg/day (n = 39) or rosuvastatin 10 mg/day (n = 39) and up-titrated at 6-week intervals to 80 mg of atorvastatin or 40 mg of rosuvastatin. Hs-cTnI concentrations were measured at basel... Abstract

Cited 15 times since 2018 (2 per year) source: EuropePMC

Heart rhythm, Volume 15, Issue 11, 9 2 2018, Pages 1683-1689 Reduced left ventricular mechanical dispersion at 6 months follow-up after cardiac resynchronization therapy is associated with superior long-term outcome. van der Bijl P, Khidir MJH, Leung M, Yilmaz D, Mertens B, Ajmone Marsan N, Delgado V, Bax JJ

Background: In heart failure (HF) patients, left ventricular mechanical dispersion (LVMD) reflects heterogeneous mechanical activation of the left ventricle. In HF patients, LVMD can be reduced after CRT. Whether lesser LVMD is associated with improved outcome is unknown. Objective: The purpose of this study was to relate LVMD to long-term prognosis in a large cohort of HF patients after 6 months of cardiac resynchronization therapy (CRT). Methods: Clinical, echocardiographic, and ventricular ar... Abstract

Cited 5 times since 2018 (0.7 per year) source: EuropePMC

Heart, lung & circulation, Volume 28, Issue 6, 8 2 2018, Pages 893-900 Prognostic Importance of Increased Right Ventricular Afterload in Orthotopic Liver Transplantation Recipients With Endstage Cirrhosis. Couperus LE, Vliegen HW, Sorgdrager BJ, den Dulk AC, Beeres SLMA, Sarton EY, Dubbeld J, Schalij MJ, Jukema JW, van Hoek B, Scherptong RWC

Background: Severely increased right ventricular (RV) afterload is considered a contra-indication for orthotopic liver transplantation (OLT). This study assesses the effects of mildly increased RV afterload on long-term outcome after OLT in relation to RV function. Methods: 139 OLT recipients (53±12years, 76% male) were included. Preoperative RV afterload was assessed invasively or, if not available, echocardiographically and categorised as normal, high-normal (mean pulmonary artery pressure [PA... Abstract

Cited 6 times since 2018 (0.8 per year) source: EuropePMC

American journal of physiology. Heart and circulatory physiology, Volume 315, Issue 3, 4 1 2018, Pages H669-H680 Acute stimulation of the soluble guanylate cyclase does not impact on left ventricular capacitance in normal and hypertrophied porcine hearts in vivo. Alogna A, Schwarzl M, Manninger M, Hamdani N, Zirngast B, Kloth B, Steendijk P, Verderber J, Zweiker D, Westermann D, Blankenberg S, Maechler H, Tschöpe C, Linke WA, Marsche G, Pieske BM, Post H

Experimental data indicate that stimulation of the nitric oxide-soluble guanylate cyclase(sGC)-cGMP-PKG pathway can increase left ventricular (LV) capacitance via phosphorylation of the myofilamental protein titin. We aimed to test whether acute pharmacological sGC stimulation with BAY 41-8543 would increase LV capacitance via titin phosphorylation in healthy and deoxycorticosteroneacetate (DOCA)-induced hypertensive pigs. Nine healthy Landrace pigs and 7 pigs with DOCA-induced hypertension and... Abstract

Cited 5 times since 2018 (0.7 per year) source: EuropePMC

Journal of the European Academy of Dermatology and Venereology : JEADV, Volume 32, Issue 12, 3 1 2018, Pages e436-e437 A breathtaking DRESS due to amoxicillin-clavulanate presenting as polymorphic eruption of the pregnancy. van Kester MS, Langeveld TJC, Bouwsma H, van Rees JB, Holman ER, Teng YKO, van Zuuren EJ

Abstract

Cited 17 times since 2018 (2.2 per year) source: EuropePMC

Journal of medical Internet research, Volume 20, Issue 5, 3 1 2018, Pages e174 Behind the Scenes of Online Therapeutic Feedback in Blended Therapy for Depression: Mixed-Methods Observational Study. Mol M, Dozeman E, Provoost S, van Schaik A, Riper H, Smit JH

Background: In Internet-delivered cognitive behavioral therapies (iCBT), written feedback by therapists is a substantial part of therapy. However, it is not yet known how this feedback should be given best and which specific therapist behaviors and content are most beneficial for patients. General instructions for written feedback are available, but the uptake and effectiveness of these instructions in iCBT have not been studied yet. Objective: This study aimed to identify therapist behaviors in... Abstract