9543 results
Cited 63 times since 2018 (8.3 per year)
source: EuropePMC
Nanomaterials (Basel, Switzerland),
Volume 8, Issue 5, 3 1 2018, Pages E296
Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics.
van der Valk DC, van der Ven CFT, Blaser MC, Grolman JM, Wu PJ, Fenton OS, Lee LH, Tibbitt MW, Andresen JL, Wen JR, Ha AH, Buffolo F, van Mil A, Bouten CVC, Body SC, Mooney DJ, Sluijter JPG, Aikawa M, Hjortnaes J, Langer R, Aikawa E
In calcific aortic valve disease (CAVD), microcalcifications originating from nanoscale calcifying vesicles disrupt the aortic valve (AV) leaflets, which consist of three (biomechanically) distinct layers: the fibrosa, spongiosa, and ventricularis. CAVD has no pharmacotherapy and lacks in vitro models as a result of complex valvular biomechanical features surrounding resident mechanosensitive valvular interstitial cells (VICs). We measured layer-specific mechanical properties of the human AV and...
Abstract
Cited 14 times since 2018 (1.9 per year)
source: EuropePMC
Journal of the American Heart Association,
Volume 7, Issue 10, 2 1 2018, Pages e008609
Evaluation of the Impact of a Chronic Total Coronary Occlusion on Ventricular Arrhythmias and Long-Term Mortality in Patients With Ischemic Cardiomyopathy and an Implantable Cardioverter-Defibrillator (the eCTOpy-in-ICD Study).
van Dongen IM, Yilmaz D, Elias J, Claessen BEPM, Delewi R, Knops RE, Wilde AAM, van Erven L, Schalij MJ, Henriques JPS
Background: Previous studies report conflicting results about a higher incidence of ventricular arrhythmias in patients with a chronic total coronary occlusion (CTO). We aimed to investigate this association in a large cohort of implantable cardioverter defibrillator patients with long-term follow-up. Methods and results: All consecutive patients from 1992 onwards who underwent implantable cardioverter defibrillator implantation for ischemic cardiomyopathy at the Leiden University Medical Center...
Abstract
Cited 19 times since 2018 (2.5 per year)
source: EuropePMC
Circulation. Genomic and precision medicine,
Volume 11, Issue 5, 1 1 2018, Pages e002037
Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval.
Lin H, van Setten J, Smith AV, Bihlmeyer NA, Warren HR, Brody JA, Radmanesh F, Hall L, Grarup N, Müller-Nurasyid M, Boutin T, Verweij N, Lin HJ, Li-Gao R, van den Berg ME, Marten J, Weiss S, Prins BP, Haessler J, Lyytikäinen LP, Mei H, Harris TB, Launer LJ, Li M, Alonso A, Soliman EZ, Connell JM, Huang PL, Weng LC, Jameson HS, Hucker W, Hanley A, Tucker NR, Chen YI, Bis JC, Rice KM, Sitlani CM, Kors JA, Xie Z, Wen C, Magnani JW, Nelson CP, Kanters JK, Sinner MF, Strauch K, Peters A, Waldenberger M, Meitinger T, Bork-Jensen J, Pedersen O, Linneberg A, Rudan I, de Boer RA, van der Meer P, Yao J, Guo X, Taylor KD, Sotoodehnia N, Rotter JI, Mook-Kanamori DO, Trompet S, Rivadeneira F, Uitterlinden A, Eijgelsheim M, Padmanabhan S, Smith BH, Völzke H, Felix SB, Homuth G, Völker U, Mangino M, Spector TD, Bots ML, Perez M, Kähönen M, Raitakari OT, Gudnason V, Arking DE, Munroe PB, Psaty BM, van Duijn CM, Benjamin EJ, Rosand J, Samani NJ, Hansen T, Kääb S, Polasek O, van der Harst P, Heckbert SR, Jukema JW, Stricker BH
Background: Electrical conduction from the cardiac sinoatrial node to the ventricles is critical for normal heart function. Genome-wide association studies have identified more than a dozen common genetic loci that are associated with PR interval. However, it is unclear whether rare and low-frequency variants also contribute to PR interval heritability. Methods: We performed large-scale meta-analyses of the PR interval that included 83 367 participants of European ancestry and 9436 of African an...
Abstract
Cited 4 times since 2018 (0.5 per year)
source: EuropePMC
Nature genetics,
Volume 50, Issue 5, 1 1 2018, Pages 766-767
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, Karaderi T, Lempradl A, Locke AE, Mahajan A, Marouli E, Sivapalaratnam S, Young KL, Alfred T, Feitosa MF, Masca NGD, Manning AK, Medina-Gomez C, Mudgal P, Ng MCY, Reiner AP, Vedantam S, Willems SM, Winkler TW, Abecasis G, Aben KK, Alam DS, Alharthi SE, Allison M, Amouyel P, Asselbergs FW, Auer PL, Balkau B, Bang LE, Barroso I, Bastarache L, Benn M, Bergmann S, Bielak LF, Blüher M, Boehnke M, Boeing H, Boerwinkle E, Böger CA, Bork-Jensen J, Bots ML, Bottinger EP, Bowden DW, Brandslund I, Breen G, Brilliant MH, Broer L, Brumat M, Burt AA, Butterworth AS, Campbell PT, Cappellani S, Carey DJ, Catamo E, Caulfield MJ, Chambers JC, Chasman DI, Chen YI, Chowdhury R, Christensen C, Chu AY, Cocca M, Collins FS, Cook JP, Corley J, Corominas Galbany J, Cox AJ, Crosslin DS, Cuellar-Partida G, D'Eustacchio A, Danesh J, Davies G, Bakker PIW, Groot MCH, Mutsert R, Deary IJ, Dedoussis G, Demerath EW, Heij
In the version of this article originally published, one of the two authors with the name Wei Zhao was omitted from the author list and the affiliations for both authors were assigned to the single Wei Zhao in the author list. In addition, the ORCID for Wei Zhao (Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA) was incorrectly assigned to author Wei Zhou. The errors have been corrected in the HTML and PDF versions of th...
Abstract
Cited 29 times since 2018 (3.8 per year)
source: EuropePMC
Journal of orthopaedic trauma,
Volume 32, Issue 5, 1 1 2018, Pages 223-230
Factors Associated With Revision Surgery After Internal Fixation of Hip Fractures.
Sprague S, Schemitsch EH, Swiontkowski M, Della Rocca GJ, Jeray KJ, Liew S, Slobogean GP, Bzovsky S, Heels-Ansdell D, Zhou Q, Bhandari M, FAITH Investigators
Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months p...
Abstract
Cited 63 times since 2018 (8.3 per year)
source: EuropePMC
Circulation,
Volume 137, Issue 22, 1 1 2018, Pages 2393-2407
Energetics of Blood Flow in Cardiovascular Disease: Concept and Clinical Implications of Adverse Energetics in Patients With a Fontan Circulation.
Rijnberg FM, Hazekamp MG, Wentzel JJ, de Koning PJH, Westenberg JJM, Jongbloed MRM, Blom NA, Roest AAW
Visualization and quantification of the adverse effects of distorted blood flow are important emerging fields in cardiology. Abnormal blood flow patterns can be seen in various cardiovascular diseases and are associated with increased energy loss. These adverse energetics can be measured and quantified using 3-dimensional blood flow data, derived from computational fluid dynamics and 4-dimensional flow magnetic resonance imaging, and provide new, promising hemodynamic markers. In patients with p...
Abstract
Cited 38 times since 2018 (5 per year)
source: EuropePMC
Circulation. Genomic and precision medicine,
Volume 11, Issue 5, 1 1 2018, Pages e002034
CETP (Cholesteryl Ester Transfer Protein) Concentration: A Genome-Wide Association Study Followed by Mendelian Randomization on Coronary Artery Disease.
Blauw LL, Li-Gao R, Noordam R, de Mutsert R, Trompet S, Berbée JFP, Wang Y, van Klinken JB, Christen T, van Heemst D, Mook-Kanamori DO, Rosendaal FR, Jukema JW, Rensen PCN, Willems van Dijk K
Background: We aimed to identify independent genetic determinants of circulating CETP (cholesteryl ester transfer protein) to assess causal effects of variation in CETP concentration on circulating lipid concentrations and cardiovascular disease risk. Methods: A genome-wide association discovery and replication study on serum CETP concentration were embedded in the NEO study (Netherlands Epidemiology of Obesity). Based on the independent identified variants, Mendelian randomization was conducted...
Abstract
Cited 7 times since 2018 (0.9 per year)
source: EuropePMC
Journal of pediatric orthopedics,
Volume 38, Issue 5, 1 1 2018, Pages 260-265
Prognostication in Developmental Dysplasia of the Hip Using the Ossific Nucleus Center Edge Angle.
Firth GB, Robertson AJF, Ramguthy Y, Ramachandran M, Schepers A
Background: The aim of this paper was to determine the prognostic potential of the ossific nucleus center edge angle (ONCEA) in patients below 5 years of age treated for developmental dysplasia of the hip (DDH) to predict final outcome and the need for a secondary procedure. Methods: The interobserver and intraobserver reliability was calculated using the intraclass correlation coefficient for measurement of the ONCEA. The ONCEA was divided a priori into 3 groups: group A≥10 degrees, group B -9...
Abstract
Cited 7 times since 2018 (0.9 per year)
source: EuropePMC
Interactive cardiovascular and thoracic surgery,
Volume 26, Issue 5, 1 1 2018, Pages 783-789
Early and long-term outcomes of mitral valve repair for Barlow's disease: a single-centre 16-year experience.
Tomšic A, Hiemstra YL, van der Pas SL, Putter H, Versteegh MIM, van Brakel TJ, Ajmone Marsan N, Klautz RJM, Palmen M
Objectives: Following mitral valve repair for Barlow's disease, recurrent mitral regurgitation (MR) is believed to occur frequently and is mainly attributed to disease progression. Methods: Between January 2000 and December 2015, 180 patients (40% women, mean age 58.7 ± 13.5 years) with Barlow's disease underwent mitral valve repair. To provide a longitudinal assessment of mitral valve repair durability, a multistate model for interval-censored observations (4 states: 1, Grade 0/1+ MR;...
Abstract
Cited 89 times since 2018 (11.8 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 19, Issue 5, 1 1 2018, Pages 475-481
Focus cardiac ultrasound core curriculum and core syllabus of the European Association of Cardiovascular Imaging.
Neskovic AN, Skinner H, Price S, Via G, De Hert S, Stankovic I, Galderisi M, Donal E, Muraru D, Sloth E, Gargani L, Cardim N, Stefanidis A, Cameli M, Habib G, Cosyns B, Lancellotti P, Edvardsen T, Popescu BA, Reviewers: This document was reviewed by members of the 2016–2018 EACVI Scientific Documents Committee
There is a growing trend of using ultrasound examination of the heart as a first-line diagnostic tool for initial patient evaluation in acute settings. Focus cardiac ultrasound (FoCUS) is a standardized but restricted cardiac ultrasound examination that may be undertaken by a range of medical professionals with diverse backgrounds. The intention of this core curriculum and syllabus is to define a unifying framework for educational and training processes/programmes that should result in competenc...
Abstract
The Lancet. Neurology,
Volume 17, Issue 5, 1 1 2018, Pages 393-394
Intravenous versus subcutaneous immunoglobulin - Authors' reply.
van Schaik IN, Mielke O, PATH study group
Abstract
Nature genetics,
Volume 50, Issue 5, 1 1 2018, Pages 765-766
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, Karaderi T, Lempradl A, Locke AE, Mahajan A, Marouli E, Sivapalaratnam S, Young KL, Alfred T, Feitosa MF, Masca NGD, Manning AK, Medina-Gomez C, Mudgal P, Ng MCY, Reiner AP, Vedantam S, Willems SM, Winkler TW, Abecasis G, Aben KK, Alam DS, Alharthi SE, Allison M, Amouyel P, Asselbergs FW, Auer PL, Balkau B, Bang LE, Barroso I, Bastarache L, Benn M, Bergmann S, Bielak LF, Blüher M, Boehnke M, Boeing H, Boerwinkle E, Böger CA, Bork-Jensen J, Bots ML, Bottinger EP, Bowden DW, Brandslund I, Breen G, Brilliant MH, Broer L, Brumat M, Burt AA, Butterworth AS, Campbell PT, Cappellani S, Carey DJ, Catamo E, Caulfield MJ, Chambers JC, Chasman DI, Chen YI, Chowdhury R, Christensen C, Chu AY, Cocca M, Collins FS, Cook JP, Corley J, Corominas Galbany J, Cox AJ, Crosslin DS, Cuellar-Partida G, D'Eustacchio A, Danesh J, Davies G, Bakker PIW, Groot MCH, Mutsert R, Deary IJ, Dedoussis G, Demerath EW, Heij
In the published version of this paper, the name of author Emanuele Di Angelantonio was misspelled. This error has now been corrected in the HTML and PDF versions of the article.
Abstract
Cited 19 times since 2018 (2.5 per year)
source: EuropePMC
Journal of intensive care medicine,
Volume 35, Issue 6, 1 1 2018, Pages 595-605
Early Prediction of Intensive Care Unit-Acquired Weakness: A Multicenter External Validation Study.
Witteveen E, Wieske L, Sommers J, Spijkstra JJ, de Waard MC, Endeman H, Rijkenberg S, de Ruijter W, Sleeswijk M, Verhamme C, Schultz MJ, van Schaik IN, Horn J
Objectives: An early diagnosis of intensive care unit-acquired weakness (ICU-AW) is often not possible due to impaired consciousness. To avoid a diagnostic delay, we previously developed a prediction model, based on single-center data from 212 patients (development cohort), to predict ICU-AW at 2 days after ICU admission. The objective of this study was to investigate the external validity of the original prediction model in a new, multicenter cohort and, if necessary, to update the model. Metho...
Abstract
Cited 38 times since 2018 (5 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 11, Issue 5, 1 1 2018, Pages 736-754
Imaging Needs in Novel Transcatheter Tricuspid Valve Interventions.
Prihadi EA, Delgado V, Hahn RT, Leipsic J, Min JK, Bax JJ
The advent of novel transcatheter therapies for severe tricuspid regurgitation (TR) has attracted much attention. Novel 3-dimensional imaging techniques have permitted analysis of the tricuspid valve (TV) anatomy from unparalleled views and better understanding of the underlying pathophysiology of TR. Grading TR and assessment of right ventricular function remain challenging, and although 2-dimensional echocardiography is the mainstay imaging technique to evaluate patients with severe TR the use...
Abstract
Cited 8 times since 2018 (1.1 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 19, Issue 5, 1 1 2018, Pages 516-523
Right ventricular outflow tract dimensions in arrhythmogenic right ventricular cardiomyopathy/dysplasia-a multicentre study comparing echocardiography and cardiovascular magnetic resonance.
Gotschy A, Saguner AM, Niemann M, Hamada S, Akdis D, Yoon JN, Parmon EV, Delgado V, Bax JJ, Kozerke S, Brunckhorst C, Duru F, Tanner FC, Manka R
Aims: Right ventricular outflow tract (RVOT) dilation is one of the echocardiographic criteria in the 2010 revised Task Force Criteria (TFC) of arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D). However, studies comparing cardiac magnetic resonance (CMR) and transthoracic echocardiography (TTE) suggest a lower diagnostic accuracy of TTE due to its operator dependence and limited reproducibility. The goal of this study was to compare the 2010 TFC measures of RVOT dilation with th...
Abstract
Cited 36 times since 2018 (4.8 per year)
source: EuropePMC
Scientific reports,
Volume 8, Issue 1, 30 5 2018, Pages 6753
Annexin A5 reduces infarct size and improves cardiac function after myocardial ischemia-reperfusion injury by suppression of the cardiac inflammatory response.
de Jong RCM, Pluijmert NJ, de Vries MR, Pettersson K, Atsma DE, Jukema JW, Quax PHA
Annexin A5 (AnxA5) is known to have anti-inflammatory and anti-apoptotic properties. Inflammation and apoptosis are key processes in post-ischemic cardiac remodeling. In this study, we investigated the effect of AnxA5 on left ventricular (LV) function and remodeling three weeks after myocardial ischemia-reperfusion (MI-R) injury in hypercholesterolemic ApoE*3-Leiden mice. Using a mouse model for MI-R injury, we demonstrate AnxA5 treatment resulted in a 27% reduction of contrast-enhanced MRI asse...
Abstract
Cited 100 times since 2018 (13.2 per year)
source: EuropePMC
Journal of cardiovascular computed tomography,
Volume 12, Issue 3, 30 5 2018, Pages 204-209
Maximization of the usage of coronary CTA derived plaque information using a machine learning based algorithm to improve risk stratification; insights from the CONFIRM registry.
van Rosendael AR, Maliakal G, Kolli KK, Beecy A, Al'Aref SJ, Dwivedi A, Singh G, Panday M, Kumar A, Ma X, Achenbach S, Al-Mallah MH, Andreini D, Bax JJ, Berman DS, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan K, Chow BJW, Cury RC, DeLago A, Feuchtner G, Hadamitzky M, Hausleiter J, Kaufmann PA, Kim YJ, Leipsic JA, Maffei E, Marques H, Pontone G, Raff GL, Rubinshtein R, Shaw LJ, Villines TC, Gransar H, Lu Y, Jones EC, Peña JM, Lin FY, Min JK
Introduction: Machine learning (ML) is a field in computer science that demonstrated to effectively integrate clinical and imaging data for the creation of prognostic scores. The current study investigated whether a ML score, incorporating only the 16 segment coronary tree information derived from coronary computed tomography angiography (CCTA), provides enhanced risk stratification compared with current CCTA based risk scores. Methods: From the multi-center CONFIRM registry, patients were inclu...
Abstract
Cited 14 times since 2018 (1.8 per year)
source: EuropePMC
Clinical oral investigations,
Volume 22, Issue 5, 30 5 2018, Pages 2135-2140
Gingival crevicular fluid levels of human beta-defensin-1 in type 2 diabetes mellitus and periodontitis.
Yilmaz D, Caglayan F, Buber E, Könönen E, Aksoy Y, Gursoy UK, Guncu GN
Objectives: Human β-defensin (hBD)-1 is an important gatekeeper of the gingiva against constant bacterial challenge, and glucose levels are involved in its optimal expression. The aims of the study were to investigate hBD-1 levels in gingival crevicular fluid (GCF) and to compare these levels between type 2 diabetics with or without periodontitis and healthy individuals. Materials and methods: Altogether, 81 subjects were included in the study: 21 subjects with type 2 diabetes mellitus (T2DM) su...
Abstract
Cited 43 times since 2018 (5.7 per year)
source: EuropePMC
Diabetes/metabolism research and reviews,
Volume 34, Issue 5, 26 4 2018, Pages e3004
Risk of dipeptidyl peptidase-4 (DPP-4) inhibitors on site-specific cancer: A systematic review and meta-analysis.
Overbeek JA, Bakker M, van der Heijden AAWA, van Herk-Sukel MPP, Herings RMC, Nijpels G
The long-term impact of dipeptidyl peptidase-4 (DPP-4) inhibition is unknown, and there are concerns about the influence of DPP-4 inhibition on carcinogenesis of the pancreas and thyroid. As DPP-4 is a rather unselective enzyme present in many tissues, we focused on all specific cancer types. PubMed and EMBASE were searched between January 2005 and April 2017 to identify studies comparing DPP-4 inhibitors with either placebo or active drugs on cancer risk. Studies were included if they reported...
Abstract
Cited 49 times since 2018 (6.5 per year)
source: EuropePMC
British journal of cancer,
Volume 118, Issue 10, 26 4 2018, Pages 1296-1301
Association between single-nucleotide polymorphisms and adverse events in nivolumab-treated non-small cell lung cancer patients.
Bins S, Basak EA, El Bouazzaoui S, Koolen SLW, Oomen-de Hoop E, van der Leest CH, van der Veldt AAM, Sleijfer S, Debets R, van Schaik RHN, Aerts JGJV, Mathijssen RHJ
Background: Treatment with PD-1 inhibitors can be hampered by severe auto-immune-related toxicities. Our objective was to identify single-nucleotide polymorphisms (SNPs) in genes previously associated with auto-immunity, which are associated with toxicities in nivolumab-treated NSCLC patients. This was in order to identify patients prone to develop severe toxicities and to gain more insight into the underlying pathobiology. Methods: We analysed 322 nivolumab-treated patients and assessed the ass...
Abstract
