9543 results
Cited 15 times since 2017 (1.8 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 25, Issue 12, 1 1 2017, Pages 675-681
A Dutch MYH7 founder mutation, p.(Asn1918Lys), is associated with early onset cardiomyopathy and congenital heart defects.
van der Linde IHM, Hiemstra YL, Bökenkamp R, van Mil AM, Breuning MH, Ruivenkamp C, Ten Broeke SW, Veldkamp RF, van Waning JI, van Slegtenhorst MA, van Spaendonck-Zwarts KY, Lekanne Deprez RH, Herkert JC, Boven L, van der Zwaag PA, Jongbloed JDH, Bootsma M, Barge-Schaapveld DQCM
Background: Mutations in the myosin heavy chain 7 (MYH7) gene commonly cause cardiomyopathy but are less frequently associated with congenital heart defects. Methods: In this study, we describe a mutation in the MYH7 gene, c. 5754C > G; p. (Asn1918Lys), present in 15 probands and 65 family members. Results: Of the 80 carriers (age range 0-88 years), 46 (57.5%) had cardiomyopathy (mainly dilated cardiomyopathy (DCM)) and seven (8.8%) had a congenital heart defect. Childhood onset of cardiomyop...
Abstract
Cited 25 times since 2017 (3 per year)
source: EuropePMC
Circulation. Cardiovascular imaging,
Volume 10, Issue 9, 1 1 2017, Pages e005987
Bicuspid Aortic Valve: What to Image in Patients Considered for Transcatheter Aortic Valve Replacement?
Kong WKF, Delgado V, Bax JJ
Abstract
JAMA cardiology,
Volume 2, Issue 9, 1 1 2017, Pages 1047-1048
Bicuspid Aortopathy-Reply.
Delgado V, Kong WKF, Bax JJ
Abstract
Cited 3 times since 2017 (0.4 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 25, Issue 9, 1 1 2017, Pages 490-497
Classical determinants of coronary artery disease as predictors of complexity of coronary lesions, assessed with the SYNTAX score.
Montero-Cabezas JM, Karalis I, Wolterbeek R, Kraaijeveld AO, Hoefer IE, Pasterkamp G, Pijls NH, Doevendans PA, Walterberger J, Kuiper J, van Zonneveld AJ, Jukema JW
Background: We need new biomarkers that can predict cardiovascular disease to improve both diagnosis and therapeutic strategies. The CIRCULATING CELLS study was designed to study the role of several cellular mediators of atherosclerosis as biomarkers of coronary artery disease (CAD). An objective and reproducible method for the quantification of CAD extension is required to establish relationships with these potential biomarkers. We sought to analyse the correlation of the SYNTAX score with know...
Abstract
Heart (British Cardiac Society),
Volume 104, Issue 4, 1 1 2017, Pages 332-339
Impact of presynaptic sympathetic imbalance in long-QT syndrome by positron emission tomography.
Zumhagen S, Vrachimis A, Stegger L, Kies P, Wenning C, Ernsting M, Müller J, Seebohm G, Paul M, Schäfers K, Stallmeyer B, Schäfers M, Schulze-Bahr E
Objective: We investigated the impact of cardiac presynaptic norepinephrine recycling in patients with long-QT syndrome (LQTS) using positron emission tomography (PET) with 11C-meta-hydroxyephedrine ([11C]mHED-PET). Methods: [11C]mHED-PET was performed in 25 patients with LQTS (LQT1: n=14; LQT2: n=11) and 20 healthy controls and correlated with clinical parameters. [11C]mHED-PET images were analysed for global and regional retention indices (RI) and washout rates (WO) reflecting dynamic paramete...
Abstract
Cited 21 times since 2017 (2.6 per year)
source: EuropePMC
Scientific reports,
Volume 7, Issue 1, 31 5 2017, Pages 10269
Deficiency of TLR4 homologue RP105 aggravates outward remodeling in a murine model of arteriovenous fistula failure.
Bezhaeva T, Wong C, de Vries MR, van der Veer EP, van Alem CMA, Que I, Lalai RA, van Zonneveld AJ, Rotmans JI, Quax PHA
Arteriovenous access dysfunction is a major cause of morbidity for hemodialysis patients. The pathophysiology of arteriovenous fistula (AVF) maturation failure is associated with inflammation, impaired outward remodeling (OR) and intimal hyperplasia. RP105 is a critical physiologic regulator of TLR4 signaling in numerous cell types. In the present study, we investigated the impact of RP105 on AVF maturation, and defined cell-specific effects of RP105 on macrophages and vascular smooth muscle cel...
Abstract
Cited 6 times since 2017 (0.7 per year)
source: EuropePMC
European radiology,
Volume 28, Issue 2, 30 5 2017, Pages 844-850
Accurate late gadolinium enhancement prediction by early T1- based quantitative synthetic mapping.
van Dijk R, Kuijpers D, Kaandorp TAM, van Dijkman PRM, Vliegenthart R, van der Harst P, Oudkerk M
Objectives: Early synthetic gadolinium enhancement (ESGE) imaging from post-contrast T1 mapping after adenosine stress-perfusion cardiac magnetic resonance (CMR) was compared to conventional late gadolinium enhancement (LGE) imaging for assessing myocardial scar. Methods: Two hundred fourteen consecutive patients suspected of myocardial ischaemia were referred for stress-perfusion CMR. Myocardial infarct volume was quantified on a per-subsegment basis in both synthetic (2-3 min post-gadolinium)...
Abstract
Cited 15 times since 2017 (1.8 per year)
source: EuropePMC
The American journal of cardiology,
Volume 120, Issue 11, 30 5 2017, Pages 2008-2016
Usefulness of the CRT-SCORE for Shared Decision Making in Cardiac Resynchronization Therapy in Patients With a Left Ventricular Ejection Fraction of ≤35.
Höke U, Mertens B, Khidir MJH, Schalij MJ, Bax JJ, Delgado V, Ajmone Marsan N
Individualized estimation of prognosis after cardiac resynchronization therapy (CRT) remains challenging. Our aim was to develop a multiparametric prognostic risk score (CRT-SCORE) that could be used for patient-specific clinical shared decision making about CRT implantation. The CRT-SCORE was derived from an ongoing CRT registry, including 1,053 consecutive patients (age 67 ± 10 years, 76% male). Using preimplantation variables, 100 multiple imputed datasets were generated for model calibration...
Abstract
Cited 22 times since 2017 (2.7 per year)
source: EuropePMC
The American journal of cardiology,
Volume 120, Issue 11, 30 5 2017, Pages 2065-2072
Influence of Aging on Level and Layer-Specific Left Ventricular Longitudinal Strain in Subjects Without Structural Heart Disease.
Abou R, Leung M, Khidir MJH, Wolterbeek R, Schalij MJ, Ajmone Marsan N, Bax JJ, Delgado V
Values for level- (apical, mid, and basal) and layer-based (endocardial, mid-myocardial, and epicardial) left ventricular (LV) longitudinal strain across age are scarce. The present study evaluates the effect of aging on level- and layer-specific LV longitudinal strain in subjects without structural heart disease. A total of 408 subjects (mean age 58 years [range 16 to 91]; 49% men) were evaluated retrospectively. Subjects were divided into equal groups based on age and gender. Subjects with evi...
Abstract
Cited 22 times since 2017 (2.7 per year)
source: EuropePMC
Trials,
Volume 18, Issue 1, 29 5 2017, Pages 402
Mobile phones in cryptogenic strOke patients Bringing sIngle Lead ECGs for Atrial Fibrillation detection (MOBILE-AF): study protocol for a randomised controlled trial.
Treskes RW, Gielen W, Wermer MJ, Grauss RW, van Alem AP, Dehnavi RA, Kirchhof CJ, van der Velde ET, Maan AC, Wolterbeek R, Overbeek OM, Schalij MJ, Trines SA
Background: Recently published randomised clinical trials indicate that prolonged electrocardiom (ECG) monitoring might enhance the detection of paroxysmal atrial fibrillation (AF) in cryptogenic stroke or transient ischaemic attack (TIA) patients. A device that might be suitable for prolonged ECG monitoring is a smartphone-compatible ECG device (Kardia Mobile, Alivecor, San Francisco, CA, USA) that allows the patient to record a single-lead ECG without the presence of trained health care staff....
Abstract
Cited 10 times since 2017 (1.2 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 25, Issue 3, 28 4 2017, Pages 860-871
Invasive assessment of coronary artery disease.
Pyxaras SA, Wijns W, Reiber JHC, Bax JJ
Coronary artery disease is associated to high mortality and morbidity rates and an accurate diagnostic assessment during heart catheterization has a fundamental role in prognostic stratification and treatment choices. Coronary angiography has been integrated by intravascular imaging modalities, namely intravascular ultrasound and optical coherence tomography, which allow the precise quantification of the atherosclerotic burden of coronary arteries. The hemodynamic relevance of a given coronary s...
Abstract
Cited 13 times since 2017 (1.6 per year)
source: EuropePMC
Frontiers in microbiology,
Volume 8, 28 4 2017, Pages 1596
Characterization of <i>Enterococcus</i> Isolates Colonizing the Intestinal Tract of Intensive Care Unit Patients Receiving Selective Digestive Decontamination.
Bello Gonzalez TDJ, Pham P, Top J, Willems RJL, van Schaik W, van Passel MWJ, Smidt H
Enterococci have emerged as important opportunistic pathogens in intensive care units (ICUs). In this study, enterococcal population size and Enterococcus isolates colonizing the intestinal tract of ICU patients receiving Selective Digestive Decontamination (SDD) were investigated. All nine patients included in the study showed substantial shifts in the enterococcal 16S rRNA gene copy number in the gut microbiota during the hospitalization period. Furthermore, 41 Enterococcus spp. strains were i...
Abstract
Cited 47 times since 2017 (5.7 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 104, Issue 7, 28 4 2017, Pages 574-580
Factors associated with coronary artery disease and stroke in adults with congenital heart disease.
Bokma JP, Zegstroo I, Kuijpers JM, Konings TC, van Kimmenade RRJ, van Melle JP, Kiès P, Mulder BJM, Bouma BJ
Objective: To determine factors associated with coronary artery disease (CAD) and ischaemic stroke in ageing adult congenital heart disease (ACHD) patients. Methods: We performed a multicentre case-control study, using data from the national CONgenital CORvitia (CONCOR) registry to identify ACHD patients within five participating centres. Patients with CAD were matched (1:2 ratio) with ACHD patients without CAD on age, CHD defect group and gender. Patients with ischaemic stroke (or transient isc...
Abstract
Cited 11 times since 2017 (1.3 per year)
source: EuropePMC
Travel medicine and infectious disease,
Volume 19, 24 4 2017, Pages 33-36
Travel-related acquisition of diarrhoeagenic bacteria, enteral viruses and parasites in a prospective cohort of 98 Dutch travellers.
van Hattem JM, Arcilla MS, Grobusch MP, Bart A, Bootsma MC, van Genderen PJ, van Gool T, Goorhuis A, van Hellemond JJ, Molenkamp R, Molhoek N, Oude Lashof AM, Stobberingh EE, de Wever B, Verbrugh HA, Melles DC, Penders J, Schultsz C, de Jong MD
Background: Limited prospective data are available on the acquisition of viral, bacterial and parasitic diarrhoeagenic agents by healthy individuals during travel. Methods: To determine the frequency of travel associated acquisition of 19 pathogens in 98 intercontinental travellers, qPCR was used to detect 8 viral pathogens, 6 bacterial enteric pathogens and 5 parasite species in faecal samples collected immediately before and after travel. Results: We found high pre-travel carriage rates of Bla...
Abstract
Cited 22 times since 2017 (2.7 per year)
source: EuropePMC
Scientific reports,
Volume 7, Issue 1, 23 4 2017, Pages 9193
Leukocytic Toll-Like Receptor 2 Deficiency Preserves Cardiac Function And Reduces Fibrosis In Sustained Pressure Overload.
Wang JW, Fontes MSC, Wang X, Chong SY, Kessler EL, Zhang YN, de Haan JJ, Arslan F, de Jager SCA, Timmers L, van Veen TAB, Lam CSP, Kleijn DPV
An involement of Toll-like receptor 2 (TLR2) has been established in cardiac dysfunction after acute myocardial infarction; however, its role in chronic pressure overload is unclear. We sought to evaluate the role of TLR2 in cardiac hypertrophy, fibrosis and dysfunction in sustained pressure overload. We induced pressure overload via transverse aortic constriction (TAC) in TLR2-/- and wild type (WT) mice, and followed temporal changes over 8 weeks. Despite similar increases in heart weight, left...
Abstract
Cited 173 times since 2017 (20.9 per year)
source: EuropePMC
Microbial genomics,
Volume 3, Issue 10, 18 3 2017, Pages e000128
On the (im)possibility of reconstructing plasmids from whole-genome short-read sequencing data.
Arredondo-Alonso S, Willems RJ, van Schaik W, Schürch AC
To benchmark algorithms for automated plasmid sequence reconstruction from short-read sequencing data, we selected 42 publicly available complete bacterial genome sequences spanning 12 genera, containing 148 plasmids. We predicted plasmids from short-read data with four programs (PlasmidSPAdes, Recycler, cBar and PlasmidFinder) and compared the outcome to the reference sequences. PlasmidSPAdes reconstructs plasmids based on coverage differences in the assembly graph. It reconstructed most of the...
Abstract
Cited 3 times since 2017 (0.4 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 104, Issue 6, 16 3 2017, Pages 454-455
Surgical treatment of Marfan syndrome and related disorders is all about dealing with uncertainties.
Groenink M, Koolbergen DR
Abstract
Cited 23 times since 2017 (2.8 per year)
source: EuropePMC
Nano letters,
Volume 17, Issue 9, 16 3 2017, Pages 5238-5243
Transport Properties of a Two-Dimensional PbSe Square Superstructure in an Electrolyte-Gated Transistor.
Alimoradi Jazi M, Janssen VAEC, Evers WH, Tadjine A, Delerue C, Siebbeles LDA, van der Zant HSJ, Houtepen AJ, Vanmaekelbergh D
Self-assembled nanocrystal solids show promise as a versatile platform for novel optoelectronic materials. Superlattices composed of a single layer of lead-chalcogenide and cadmium-chalcogenide nanocrystals with epitaxial connections between the nanocrystals, present outstanding questions to the community regarding their predicted band structure and electronic transport properties. However, the as-prepared materials are intrinsic semiconductors; to occupy the bands in a controlled way, chemical...
Abstract
Cited 77 times since 2017 (9.3 per year)
source: EuropePMC
Microbiome,
Volume 5, Issue 1, 14 2 2017, Pages 88
Comparative gut microbiota and resistome profiling of intensive care patients receiving selective digestive tract decontamination and healthy subjects.
Buelow E, Bello González TDJ, Fuentes S, de Steenhuijsen Piters WAA, Lahti L, Bayjanov JR, Majoor EAM, Braat JC, van Mourik MSM, Oostdijk EAN, Willems RJL, Bonten MJM, van Passel MWJ, Smidt H, van Schaik W
Background: The gut microbiota is a reservoir of opportunistic pathogens that can cause life-threatening infections in critically ill patients during their stay in an intensive care unit (ICU). To suppress gut colonization with opportunistic pathogens, a prophylactic antibiotic regimen, termed "selective decontamination of the digestive tract" (SDD), is used in some countries where it improves clinical outcome in ICU patients. Yet, the impact of ICU hospitalization and SDD on the gut m...
Abstract
Cited 8 times since 2017 (1 per year)
source: EuropePMC
The American journal of hospice & palliative care,
Volume 35, Issue 3, 10 2 2017, Pages 390-397
Pilot Study of an Interprofessional Palliative Care Curriculum: Course Content and Participant-Reported Learning Gains.
Starks H, Coats H, Paganelli T, Mauksch L, van Schaik E, Lindhorst T, Hurd C, Doorenbos A
Context: The National Consensus Project for Quality Palliative Care Clinical Practice Guidelines recommend that palliative care clinicians work together as interprofessional teams. We created and piloted a 9-month curriculum that focused on 3 related domains: (1) patient-centered, narrative communication skills; (2) interprofessional team practice; and (3) metrics and systems integration. The multifaceted curriculum was delivered through 16 webinars, 8 online modules, 4 in-person workshops, refl...
Abstract
