7971 results
Cited 10 times since 2024 (10.9 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 37, Issue 11, 29 5 2024, Pages 1038-1046
Left Atrioventricular Coupling Index: A Novel Diastolic Parameter to Refine Prognosis in Heart Failure.
Fortuni F, Biagioli P, Myagmardorj R, Mengoni A, Chua AP, Zuchi C, Sforna S, Bax J, Ajmone Marsan N, Ambrosio G, Carluccio E
Background: Left atrioventricular coupling index (LACI), an index coupling left atrial to left ventricular (LV) volume at end-diastole, has been shown to be associated with prognosis in different clinical settings. However, the relation between LACI and LV diastolic dysfunction (DD) remains to be established. The aims of the present study were to investigate the association between LACI and LV DD and to assess its prognostic value in patients with heart failure (HF). Methods: A total of 1,158 pa...
Abstract
Appetite,
Volume 205, 29 5 2024, Pages 107585
Interaction as the foundation for eating practices in shared mealtimes.
van der Heijden A, Wiggins S
Mealtimes shared with other people define how, what, how much, and with whom we eat. On such occasions, whether in private or public spaces, and as formal or informal events, our eating practices are inseparable from our interactions with other people. In this Editorial for the Special Issue on Interactional approaches to eating together and shared mealtimes, we provide an overview of the interdisciplinary field of research on eating together and shared mealtimes to illustrate the breadth and de...
Abstract
Cited 1 times since 2024 (1.1 per year)
source: EuropePMC
Journal of gastrointestinal and liver diseases : JGLD,
Volume 33, Issue 2, 29 5 2024, Pages 203-211
Does Genetic Variation in PNPLA3, TM6SF2 and HSD17B13 have a Role in the Development or Prognosis of Hepatocellular Carcinoma in Turkish Patients with Hepatitis B?
Demirtas CO, Eren F, Yilmaz D, Ozdogan OC, Gunduz F
Background and aims: Progression to hepatocellular carcinoma (HCC) is restricted by viral suppression in chronic hepatitis B (CHB); however, some patients still progress despite antiviral therapy. Presence of single nucleotide polymorphisms (SNPs) such as PNPLA3 rs738409 and TM6SF2 rs58542926 are associated with the development and progression of steatotic liver disease to HCC, whereas a splice variant in HSD17B13 rs72613567:TA has been shown to be protective. We investigated the role of these S...
Abstract
The American journal of emergency medicine,
Volume 83, 27 4 2024, Pages 95-100
MIS-C Treatment: Is glucocorticoid monotherapy enough for mild cases?
Sütçü M, Kara EM, Yıldız F, Gül D, Yıldız R, Yılmaz D, Atik F, Özkaya O
Background: The effectiveness of using only glucocorticoids (GCs) in mild multisystem inflammatory syndrome (MIS-C) cases was compared with combined treatment [GCs + Intravenous immune globulin (IVIG)]. Methods: This retrospective cohort study was conducted between June 1, 2020, and June 1, 2022, in a tertiary care center in Istanbul, Turkey. Clinical and investigational data of the MIS-C patients were analyzed. The patients were divided into two groups: those who received only GCs and those who...
Abstract
Cited 1 times since 2024 (1.1 per year)
source: EuropePMC
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
Volume 104, Issue 2, 26 4 2024, Pages 203-212
Current applications, procedural and 1-year outcomes of Rotatripsy for the treatment of calcified coronary lesions.
van Oort MJH, Al Amri I, Bingen BO, Oliveri F, Vilalta V, Jurado-Roman A, Pereira AR, Cordoba-Soriano JG, Rumiz González E, Fernández-Peregrina E, van der Kley F, Jukema JW, Montero-Cabezas JM
Background: Intravascular lithotripsy (IVL) combined with rotational atherectomy (RA), known as Rotatripsy, is used to treat severe coronary artery calcification (CAC), though data on efficacy, midterm safety and use sequence is limited. We aimed to identify indicators for Rotatripsy use and to assess its safety and success rates, both acutely and at 1-year follow-up. Methods: Patients undergoing Rotatripsy for severe CAC across six centers from May 2019 to December 2023 were included. Demograph...
Abstract
Cited 1 times since 2024 (1.1 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 17, Issue 10, 26 4 2024, Pages 1149-1163
Reappraisal of the Concept and Implications of Pulmonary Hypertension in Degenerative Mitral Regurgitation.
Essayagh B, Benfari G, Antoine C, Grigioni F, Le Tourneau T, Roussel JC, Bax JJ, Ajmone Marsan N, Butcher SC, Tribouilloy C, Rusinaru D, Hochstadt A, Topilsky Y, El-Am E, Thapa P, Michelena HI, Enriquez-Sarano M
Background: European and U.S. clinical guidelines diverge regarding pulmonary hypertension (PHTN) in degenerative mitral regurgitation (DMR). Gaps in knowledge underpinning these divergences affect risk assessment and management recommendations attached to systolic pulmonary pressure (SPAP) in DMR. Objectives: This study sought to define PHTN links to DMR severity, prognostic thresholds, and independent outcome impact in a large quantitative DMR registry. Methods: This study gathered a large mul...
Abstract
Cited 1 times since 2024 (1.1 per year)
source: EuropePMC
Structural heart : the journal of the Heart Team,
Volume 8, Issue 5, 26 4 2024, Pages 100333
Pulmonary Vein Systolic Flow Reversal and Outcomes in Patients From the Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation (COAPT) Trial.
Bohra C, Asch FM, Lerakis S, Little SH, Redfors B, Zhou Z, Li Y, Weissman NJ, Grayburn PA, Kar S, Lim DS, Abraham WT, Lindenfeld J, Mack MJ, Bax JJ, Stone GW
Background: The implications of pulmonary vein (PV) flow patterns in patients with heart failure (HF) and mitral regurgitation (MR) are uncertain. We examined PV flow patterns in the Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation (COAPT) trial (NCT01626079), in which patients with HF and moderate-to-severe or severe functional MR were randomized to transcatheter edge-to-edge repair (TEER) with the MitraClip...
Abstract
Cited 5 times since 2024 (5.4 per year)
source: EuropePMC
Molecular cell,
Volume 84, Issue 14, 26 4 2024, Pages 2785-2796.e4
A cell-free transcription-translation pipeline for recreating methylation patterns boosts DNA transformation in bacteria.
Vento JM, Durmusoglu D, Li T, Patinios C, Sullivan S, Ttofali F, van Schaik J, Yu Y, Wang Y, Barquist L, Crook N, Beisel CL
The bacterial world offers diverse strains for understanding medical and environmental processes and for engineering synthetic biological chassis. However, genetically manipulating these strains has faced a long-standing bottleneck: how to efficiently transform DNA. Here, we report imitating methylation patterns rapidly in TXTL (IMPRINT), a generalized, rapid, and scalable approach based on cell-free transcription-translation (TXTL) to overcome DNA restriction, a prominent barrier to transformat...
Abstract
Frontiers in plant science,
Volume 15, 26 4 2024, Pages 1349209
Counting nematodes made easy: leveraging AI-powered automation for enhanced efficiency and precision.
Saikai KK, Bresilla T, Kool J, de Ruijter NCA, van Schaik C, Teklu MG
Counting nematodes is a labor-intensive and time-consuming task, yet it is a pivotal step in various quantitative nematological studies; preparation of initial population densities and final population densities in pot, micro-plot and field trials for different objectives related to management including sampling and location of nematode infestation foci. Nematologists have long battled with the complexities of nematode counting, leading to several research initiatives aimed at automating this pr...
Abstract
Cited 3 times since 2024 (3.2 per year)
source: EuropePMC
Heart rhythm,
Volume 22, Issue 1, 25 4 2024, Pages 90-99
Cardiac stereotactic body radiotherapy to treat malignant ventricular arrhythmias directly affects the cardiomyocyte electrophysiology.
Mages C, Gampp H, Rahm AK, Hackbarth J, Pfeiffer J, Petersenn F, Kramp X, Kermani F, Zhang J, Pijnappels DA, de Vries AAF, Seidensaal K, Rhein B, Debus J, Ullrich ND, Frey N, Thomas D, Lugenbiel P
Background: Promising as a treatment option for life-threatening ventricular arrhythmias, cardiac stereotactic body radiotherapy (cSBRT) has demonstrated early antiarrhythmic effects within days of treatment. The mechanisms underlying the immediate and short-term antiarrhythmic effects are poorly understood. Objective: We hypothesize that cSBRT has a direct antiarrhythmic effect on cellular electrophysiology through reprogramming of ion channel and gap junction protein expression. Methods: After...
Abstract
Cited 2 times since 2024 (2.1 per year)
source: EuropePMC
European urology oncology,
Volume 8, Issue 1, 21 3 2024, Pages 105-110
Consistencies in Follow-up After Radical Cystectomy for Bladder Cancer: A Framework Based on Expert Practices Collaboratively Developed by the European Association of Urology Bladder Cancer Guideline Panels.
Mertens LS, Bruins HM, Contieri R, Babjuk M, Rai BP, Puig AC, Escrig JLD, Gontero P, van der Heijden AG, Liedberg F, Martini A, Masson-Lecomte A, Meijer RP, Mostafid H, Neuzillet Y, Pradere B, Redlef J, van Rhijn BWG, Rouanne M, Rouprêt M, Sæbjørnsen S, Seisen T, Shariat SF, Soria F, Soukup V, Thalmann G, Xylinas E, Mariappan P, Alfred Witjes J
Background and objective: There is no standardized regimen for follow-up after radical cystectomy (RC) for bladder cancer (BC). To address this gap, we conducted a multicenter study involving urologist members from the European Association of Urology (EAU) bladder cancer guideline panels. Our objective was to identify consistent post-RC follow-up strategies and develop a practice-based framework based on expert opinion. Methods: We surveyed 27 urologist members of the EAU guideline panels for no...
Abstract
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine,
Volume 211, 21 3 2024, Pages 111417
Removal of <sup>177</sup>Lu from radioactive wastewater using Montmorillonite clay.
Yılmaz D, Gürses A, Kalecik S, Maman A, Şahin E, Güneş K
Because radioactive 177Lu has a wide range of possible applications in radiopharmaceuticals, its removal from medical wastewater is particularly important. Montmorillonite clay was employed as an adsorbent in this study. Radioactive solutions were prepared with dilutions of the solution containing 177Lu at various concentrations, in which it was present as Lu3+. ULEGe detector in gamma spectrometer was used to measure 177Lu gamma rays emitted from the radioactive aqueous solutions. The results o...
Abstract
Cited 3 times since 2024 (3.2 per year)
source: EuropePMC
Med (New York, N.Y.),
Volume 5, Issue 9, 20 3 2024, Pages 1083-1095.e6
SMIM1 absence is associated with reduced energy expenditure and excess weight.
Stefanucci L, Moslemi C, Tomé AR, Virtue S, Bidault G, Gleadall NS, Watson LPE, Kwa JE, Burden F, Farrow S, DBDS Genetic Consortium, Chen J, MAGIC, Võsa U, Burling K, Walker L, Ord J, Barker P, Warner J, Frary A, Renhstrom K, Ashford SE, Piper J, Biggs G, Erber WN, Hoffman GJ, Schoenmakers N, Erikstrup C, Rieneck K, Dziegiel MH, Ullum H, Azzu V, Vacca M, Aparicio HJ, Hui Q, Cho K, Sun YV, Wilson PW, Bayraktar OA, Vidal-Puig A, Ostrowski SR, Astle WJ, Olsson ML, Storry JR, Pedersen OB, Ouwehand WH, Chatterjee K, Vuckovic D, Frontini M
Background: Obesity rates have nearly tripled in the past 50 years, and by 2030 more than 1 billion individuals worldwide are projected to be obese. This creates a significant economic strain due to the associated non-communicable diseases. The root cause is an energy expenditure imbalance, owing to an interplay of lifestyle, environmental, and genetic factors. Obesity has a polygenic genetic architecture; however, single genetic variants with large effect size are etiological in a minority of c...
Abstract
Cited 5 times since 2024 (5.3 per year)
source: EuropePMC
Acta physiologica (Oxford, England),
Volume 240, Issue 8, 17 3 2024, Pages e14190
Immunosuppression with cyclosporine versus tacrolimus shows distinctive nephrotoxicity profiles within renal compartments.
Demirci H, Popovic S, Dittmayer C, Yilmaz DE, El-Shimy IA, Mülleder M, Hinze C, Su M, Mertins P, Kirchner M, Osmanodja B, Paliege A, Budde K, Amann K, Persson PB, Mutig K, Bachmann S
Aim: Calcineurin inhibitors (CNIs) are the backbone for immunosuppression after solid organ transplantation. Although successful in preventing kidney transplant rejection, their nephrotoxic side effects contribute to allograft injury. Renal parenchymal lesions occur for cyclosporine A (CsA) as well as for the currently favored tacrolimus (Tac). We aimed to study whether chronic CsA and Tac exposures, before reaching irreversible nephrotoxic damage, affect renal compartments differentially and wh...
Abstract
Cited 2 times since 2024 (2.1 per year)
source: EuropePMC
Journal of neurology, neurosurgery, and psychiatry,
Volume 95, Issue 7, 17 3 2024, Pages 595-604
Proximity extension assay-based discovery of biomarkers for disease activity in chronic inflammatory demyelinating polyneuropathy.
Wieske L, Michael MR, In 't Veld SGJG, Visser A, van Schaik IN, Eftimov F, Teunissen CE
Background: Objective disease activity biomarkers are lacking in chronic inflammatory demyelinating polyneuropathy (CIDP), impacting treatment decisions in clinical care and outcomes in clinical trials. Using a proximity extension assay, we aimed to identify candidate serum protein biomarkers for disease activity in CIDP. Method: We collected clinical data and serum of 106 patients with CIDP. Patients starting induction treatment (n=53) and patients on maintenance treatment starting treatment wi...
Abstract
Cited 1 times since 2024 (1 per year)
source: EuropePMC
Journal of surgical education,
Volume 81, Issue 8, 14 2 2024, Pages 1034-1043
How to Support Communication Between Nurses and Residents During Shift Work: A Mixed-Methods Study Into Local Practices and Perceptions.
Verhagen MJ, Frouws MA, Timmer RA, Schepers A, Brunsveld-Reinders AH, de Vos MS, Hamming JF
Objective: The aim of this study was to explore local practices and perceptions of effective nurse-resident communication during shifts. Subsequently, effective communication was sought to be reinforced by implementing an initiative for improvement. Design: A mixed-methods study was performed, combining a questionnaire with focus groups. Following qualitative analysis, 3 initiatives for improvement of nurse-resident communication were scrutinized, after which 1 initiative was implemented. Overal...
Abstract
Cited 6 times since 2024 (6.3 per year)
source: EuropePMC
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation,
Volume 43, Issue 8, 14 2 2024, Pages 1199-1234
An ISHLT consensus statement on strategies to prevent and manage hemocompatibility related adverse events in patients with a durable, continuous-flow ventricular assist device.
Hollis IB, Jennings DL, Krim S, Ton VK, Ducharme A, Cowger J, Looby M, Eulert-Green JJ, Bansal N, Horn E, Byku M, Katz J, Michaud CJ, Rajapreyar I, Campbell P, Vale C, Cosgrove R, Hernandez-Montfort J, Otero J, Ingemi A, Raj S, Weeks P, Agarwal R, Martinez ES, Tops LF, Ahmed MM, Kiskaddon A, Kremer J, Keebler M, Ratnagiri RK
Life expectancy of patients with a durable, continuous-flow left ventricular assist device (CF-LVAD) continues to increase. Despite significant improvements in the delivery of care for patients with these devices, hemocompatability-related adverse events (HRAEs) are still a concern and contribute to significant morbility and mortality when they occur. As such, dissemination of current best evidence and practices is of critical importance. This ISHLT Consensus Statement is a summative assessment...
Abstract
Cited 2 times since 2024 (2.1 per year)
source: EuropePMC
Heliyon,
Volume 10, Issue 12, 13 2 2024, Pages e32949
Elucidating the mechano-molecular dynamics of TRAP activity using CRISPR/Cas9 mediated fluorescent reporter mice.
Yılmaz D, Marques FC, Fischer Y, Zimmermann S, Hwang G, Atkins PR, Mathavan N, Singh A, de Souza PPC, Kuhn GA, Wehrle E, Müller R
Osteoclasts are essential for bone remodeling by adapting their resorptive activity in response to their mechanical in vivo environment. However, the molecular mechanisms underlying this process remain unclear. Here, we demonstrated the role of tartrate-resistant acid phosphatase (TRAP, Acp5), a key enzyme secreted by osteoclasts, in bone remodeling and mechanosensitivity. Using CRISPR/Cas9 reporter mice, we demonstrated bone cell reporter (BCRIbsp/Acp5) mice feature fluorescent TRAP-deficient o...
Abstract
International journal of tryptophan research : IJTR,
Volume 17, 12 2 2024, Pages 11786469241257816
Periconceptional Non-medical Maternal Determinants Influence the Tryptophan Metabolism: The Rotterdam Periconceptional Cohort (Predict Study).
van Zundert SK, van Rossem L, Mirzaian M, Griffioen PH, Willemsen SP, van Schaik RH, Steegers-Theunissen RP
Background: The vital role of the maternal tryptophan (TRP) metabolism in maternal health and pregnancy is well established. However, non-medical maternal determinants influencing the TRP metabolism have been poorly investigated. We hypothesise that periconceptional maternal non-medical determinants alter the TRP metabolism, affecting both kynurenine (KP) and serotonin pathway (SP) metabolite concentrations. Therefore, we investigated the influence of non-medical maternal determinants on the TRP...
Abstract
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery,
Volume 40, Issue 9, 10 2 2024, Pages 2775-2780
Evaluation of traumatic spinal injuries: a pediatric perspective.
Şık N, Bulut SK, Şalbaş ÖY, Yılmaz D, Duman M
Purpose: The aim of the present study is to provide information about pediatric patients with spinal trauma. Methods: A single-center retrospective chart review was carried out. Children who arrived at the pediatric emergency department due to trauma and those with spinal pathology confirmed by radiological assessment were included. Demographics, mechanisms of trauma, clinical findings, radiological investigations, applied treatments, hospital stay and prognosis were recorded. Results: A total o...
Abstract
