9543 results
Cited 200 times since 2016 (21.9 per year)
source: EuropePMC
European urology,
Volume 71, Issue 4, 10 2 2016, Pages 680-687
The Detection of Androgen Receptor Splice Variant 7 in Plasma-derived Exosomal RNA Strongly Predicts Resistance to Hormonal Therapy in Metastatic Prostate Cancer Patients.
Del Re M, Biasco E, Crucitta S, Derosa L, Rofi E, Orlandini C, Miccoli M, Galli L, Falcone A, Jenster GW, van Schaik RH, Danesi R
Background: The androgen receptor splice variant 7 (AR-V7) is associated with resistance to hormonal therapy in castration-resistant prostate cancer (CRPC). Due to limitations of the methods available for AR-V7 analysis, the identification of a reliable detection method may facilitate the use of this biomarker in clinical practice. Objective: To confirm AR-V7 as a predictor of resistance to hormonal therapy and develop a new approach to assess AR-V7 by highly sensitive digital droplet polymerase...
Abstract
Cited 1 times since 2016 (0.1 per year)
source: EuropePMC
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG,
Volume 33, Issue 3, 7 1 2016, Pages 253-257
GSTT1 and GSTM1 gene polymorphisims in sarcoidosis.
Coskun F, Karkucak M, Yilmaz D, Yakut T, Uzaslan E
Introduction: Sarcoidosis is a granulomatous disease of unknown cause, which affects all systems, especially the lungs and the lymphatic system. Genetic and environmental factors are held accountable for the etiology. Based on the general opinion, sarcoidosis develops after exposure to a specific environmental agent by genetically susceptible individuals. The present study aimed to evaluate the disease susceptibility of the GSTT1 and GSTM1 gene polymorphisms in the patients with sarcoidosis. Me...
Abstract
Cited 31 times since 2016 (3.4 per year)
source: EuropePMC
Preventive veterinary medicine,
Volume 134, 6 1 2016, Pages 103-112
Surveillance of cattle health in the Netherlands: Monitoring trends and developments using routinely collected cattle census data.
Santman-Berends IMGA, Brouwer-Middelesch H, Van Wuijckhuise L, de Bont-Smolenaars AJG, Van Schaik G
Since 2002, a national cattle health surveillance system (CHSS) is in place that consists of several surveillance components. The CHSS combines enhanced passive reporting, diagnostic and post-mortem examinations, random surveys for prevalence estimation of endemic diseases and quarterly data analysis. The aim of the data-analysis component, which is called the Trend Analysis Surveillance Component (TASC), is to monitor trends and developments in cattle health using routine census data. The chall...
Abstract
Cited 83 times since 2016 (9.1 per year)
source: EuropePMC
Nature communications,
Volume 7, 6 1 2016, Pages 12989
A high-quality human reference panel reveals the complexity and distribution of genomic structural variants.
Hehir-Kwa JY, Marschall T, Kloosterman WP, Francioli LC, Baaijens JA, Dijkstra LJ, Abdellaoui A, Koval V, Thung DT, Wardenaar R, Renkens I, Coe BP, Deelen P, de Ligt J, Lameijer EW, van Dijk F, Hormozdiari F, Genome of the Netherlands Consortium, Uitterlinden AG, van Duijn CM, Eichler EE, de Bakker PI, Swertz MA, Wijmenga C, van Ommen GB, Slagboom PE, Boomsma DI, Schönhuth A, Ye K, Guryev V
Structural variation (SV) represents a major source of differences between individual human genomes and has been linked to disease phenotypes. However, the majority of studies provide neither a global view of the full spectrum of these variants nor integrate them into reference panels of genetic variation. Here, we analyse whole genome sequencing data of 769 individuals from 250 Dutch families, and provide a haplotype-resolved map of 1.9 million genome variants across 9 different variant classes...
Abstract
Cited 106 times since 2016 (11.6 per year)
source: EuropePMC
The New phytologist,
Volume 213, Issue 3, 4 1 2016, Pages 1346-1362
Genetic architecture of plant stress resistance: multi-trait genome-wide association mapping.
Thoen MP, Davila Olivas NH, Kloth KJ, Coolen S, Huang PP, Aarts MG, Bac-Molenaar JA, Bakker J, Bouwmeester HJ, Broekgaarden C, Bucher J, Busscher-Lange J, Cheng X, Fradin EF, Jongsma MA, Julkowska MM, Keurentjes JJ, Ligterink W, Pieterse CM, Ruyter-Spira C, Smant G, Testerink C, Usadel B, van Loon JJ, van Pelt JA, van Schaik CC, van Wees SC, Visser RG, Voorrips R, Vosman B, Vreugdenhil D, Warmerdam S, Wiegers GL, van Heerwaarden J, Kruijer W, van Eeuwijk FA, Dicke M
Plants are exposed to combinations of various biotic and abiotic stresses, but stress responses are usually investigated for single stresses only. Here, we investigated the genetic architecture underlying plant responses to 11 single stresses and several of their combinations by phenotyping 350 Arabidopsis thaliana accessions. A set of 214 000 single nucleotide polymorphisms (SNPs) was screened for marker-trait associations in genome-wide association (GWA) analyses using tailored multi-trait mix...
Abstract
Cited 186 times since 2016 (20.4 per year)
source: EuropePMC
Nature neuroscience,
Volume 19, Issue 12, 3 1 2016, Pages 1569-1582
Novel genetic loci underlying human intracranial volume identified through genome-wide association.
Adams HH, Hibar DP, Chouraki V, Stein JL, Nyquist PA, Rentería ME, Trompet S, Arias-Vasquez A, Seshadri S, Desrivières S, Beecham AH, Jahanshad N, Wittfeld K, Van der Lee SJ, Abramovic L, Alhusaini S, Amin N, Andersson M, Arfanakis K, Aribisala BS, Armstrong NJ, Athanasiu L, Axelsson T, Beiser A, Bernard M, Bis JC, Blanken LM, Blanton SH, Bohlken MM, Boks MP, Bralten J, Brickman AM, Carmichael O, Chakravarty MM, Chauhan G, Chen Q, Ching CR, Cuellar-Partida G, Braber AD, Doan NT, Ehrlich S, Filippi I, Ge T, Giddaluru S, Goldman AL, Gottesman RF, Greven CU, Grimm O, Griswold ME, Guadalupe T, Hass J, Haukvik UK, Hilal S, Hofer E, Hoehn D, Holmes AJ, Hoogman M, Janowitz D, Jia T, Kasperaviciute D, Kim S, Klein M, Kraemer B, Lee PH, Liao J, Liewald DC, Lopez LM, Luciano M, Macare C, Marquand A, Matarin M, Mather KA, Mattheisen M, Mazoyer B, McKay DR, McWhirter R, Milaneschi Y, Mirza-Schreiber N, Muetzel RL, Maniega SM, Nho K, Nugent AC, Loohuis LM, Oosterlaan J, Papmeyer M, Pappa I, Pirpamer L, Pudas S, Pütz B, Ra
Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five previously unknown loci for intracranial volume and confirmed two known signals. Four of the loci were also associated with adult human stature, but these remained associated with intracranial volume after adjustin...
Abstract
Cited 51 times since 2016 (5.6 per year)
source: EuropePMC
Giornale italiano di cardiologia (2006),
Volume 17, Issue 10, 1 1 2016, Pages 831-872
[2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC)].
Roffi M, Patrono C, Collet JP, Mueller C, Valgimigli M, Andreotti F, Bax JJ, Borger MA, Brotons C, Chew DP, Gencer B, Hasenfuss G, Kjeldsen K, Lancellotti P, Landmesser U, Mehilli J, Mukherjee D, Storey RF, Windecker S
Abstract
Cited 87 times since 2016 (9.5 per year)
source: EuropePMC
Current opinion in lipidology,
Volume 27, Issue 5, 1 1 2016, Pages 499-506
Plaque angiogenesis and its relation to inflammation and atherosclerotic plaque destabilization.
de Vries MR, Quax PH
Purpose of review: The review discusses the recent literature on plaque angiogenesis and its relation to inflammation and plaque destabilization. Furthermore, it discusses how plaque angiogenesis can be used to monitor atherosclerosis and serve as a therapeutic target. Recent findings: Histopathologic studies have shown a clear relationship between plaque angiogenesis, intraplaque hemorrhage (IPH), plaque vulnerability, and cardiovascular events. Hypoxia is a main driver of plaque angiogenesis a...
Abstract
Cited 45 times since 2016 (4.9 per year)
source: EuropePMC
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,
Volume 21, Issue 42, 1 1 2016
Prolonged colonisation with Escherichia coli O25:ST131 versus other extended-spectrum beta-lactamase-producing E. coli in a long-term care facility with high endemic level of rectal colonisation, the Netherlands, 2013 to 2014.
Overdevest I, Haverkate M, Veenemans J, Hendriks Y, Verhulst C, Mulders A, Couprie W, Bootsma M, Johnson J, Kluytmans J
The extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli clone ST131 (ESBL-ST131) has spread in healthcare settings worldwide. The reasons for its successful spread are unknown, but might include more effective transmission and/or longer persistence. We evaluated the colonisation dynamics of ESBL-producing E. coli (ESBL-EC), including ESBL-ST131, in a long-term care facility (LTCF) with an unusually high prevalence of rectal ESBL-EC colonisation. During a 14-month period, rectal or...
Abstract
Cited 12 times since 2016 (1.3 per year)
source: EuropePMC
The American journal of cardiology,
Volume 119, Issue 1, 30 5 2016, Pages 1-6
Influence of Myocardial Ischemia Extent on Left Ventricular Global Longitudinal Strain in Patients After ST-Segment Elevation Myocardial Infarction.
Dimitriu-Leen AC, Scholte AJ, Katsanos S, Hoogslag GE, van Rosendael AR, van Zwet EW, Bax JJ, Delgado V
Two-dimensional echocardiographic left ventricular (LV) global longitudinal strain (GLS) after ST-segment elevation myocardial infarction (STEMI) is moderately correlated with infarct size and reflects the residual LV systolic function. This correlation may be influenced by the presence of myocardial ischemia. The present study investigated how myocardial ischemia modulates the correlation between LV GLS and infarct size determined with single-photon emission computed tomography (SPECT) myocardi...
Abstract
Cited 10 times since 2016 (1.1 per year)
source: EuropePMC
BMC psychiatry,
Volume 16, Issue 1, 30 5 2016, Pages 338
The therapist's role in the implementation of internet-based cognitive behavioural therapy for patients with depression: study protocol.
Mol M, Dozeman E, van Schaik DJ, Vis CP, Riper H, Smit JH
Background: Internet-based Cognitive Behavioural Therapy (iCBT) for the treatment of depressive disorders is innovative and promising. Various studies have demonstrated large effect sizes up to 2.27, but implementation in routine practice lags behind. Mental health therapists play a significant role in the uptake of internet-based interventions. Therefore, it is interesting to study factors that influence the therapists in whether they apply internet-based therapy or not. This study, as part of...
Abstract
Cited 6 times since 2016 (0.7 per year)
source: EuropePMC
Global cardiology science & practice,
Volume 2016, Issue 3, 30 5 2016, Pages e201629
4D flow streamline characteristics of the great arteries twenty years after Lecompte and direct spiral arterial switch operation (DSASO) in simple TGA.
Sievers HH, Putman LM, Kheradvar A, Gabbert D, Wegner P, Scheewe J, Salehi-Ravesh M, Kramer HH, Rickers C
Transposition of the great arteries (TGA) is caused by discordance between the great arteries and the ventricles. If left untreated, this anomaly has a disastrous perspective. More recent surgical approach for correction includes the Lecompte technique in which the pulmonary bifurcation is transposed anterior to the aorta, which may be less physiologic. Although the early results are excellent, there is potential for future problems involving the great arteries and semilunar valves1. These poten...
Abstract
Cited 37 times since 2016 (4 per year)
source: EuropePMC
Frontiers in zoology,
Volume 13, 29 5 2016, Pages 43
Development of foraging skills in two orangutan populations: needing to learn or needing to grow?
Schuppli C, Forss SI, Meulman EJ, Zweifel N, Lee KC, Rukmana E, Vogel ER, van Noordwijk MA, van Schaik CP
Background: Orangutans have one of the slowest-paced life histories of all mammals. Whereas life-history theory suggests that the time to reach adulthood is constrained by the time needed to reach adult body size, the needing-to-learn hypothesis instead suggests that it is limited by the time needed to acquire adult-level skills. To test between these two hypotheses, we compared the development of foraging skills and growth trajectories of immature wild orangutans in two populations: at Tuanan (...
Abstract
Cited 24 times since 2016 (2.6 per year)
source: EuropePMC
Public health genomics,
Volume 19, Issue 6, 28 4 2016, Pages 352-363
Test Pricing and Reimbursement in Genomic Medicine: Towards a General Strategy.
Vozikis A, Cooper DN, Mitropoulou C, Kambouris ME, Brand A, Dolzan V, Fortina P, Innocenti F, Lee MT, Leyens L, Macek M, Al-Mulla F, Prainsack B, Squassina A, Taruscio D, van Schaik RH, Vayena E, Williams MS, Patrinos GP
This paper aims to provide an overview of the rationale and basic principles guiding the governance of genomic testing services, to clarify their objectives, and allocate and define responsibilities among stakeholders in a health-care system, with a special focus on the EU countries. Particular attention is paid to issues pertaining to pricing and reimbursement policies, the availability of essential genomic tests which differs between various countries owing to differences in disease prevalence...
Abstract
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 24, Issue 1, 26 4 2016, Pages 174-179
Multimodality Imaging: Bird's-Eye View from the 65th Annual Scientific Sessions of the American College of Cardiology, Chicago, Ill, April 2-4, 2016.
VanDecker WA, Bax JJ, Lloyd SG, Garcia MJ, Chaudhry FA, Blankstein R
Abstract
Cited 6 times since 2016 (0.7 per year)
source: EuropePMC
Transboundary and emerging diseases,
Volume 64, Issue 6, 26 4 2016, Pages 1771-1781
Effectiveness and Cost Efficiency of Different Surveillance Components for Proving Freedom and Early Detection of Disease: Bluetongue Serotype 8 in Cattle as Case Study for Belgium, France and the Netherlands.
Welby S, van Schaik G, Veldhuis A, Brouwer-Middelesch H, Peroz C, Santman-Berends IM, Fourichon C, Wever P, Van der Stede Y
Quick detection and recovery of country's freedom status remain a constant challenge in animal health surveillance. The efficacy and cost efficiency of different surveillance components in proving the absence of infection or (early) detection of bluetongue serotype 8 in cattle populations within different countries (the Netherlands, France, Belgium) using surveillance data from years 2006 and 2007 were investigated using an adapted scenario tree model approach. First, surveillance component...
Abstract
Cited 16 times since 2016 (1.7 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 153, Issue 4, 23 4 2016, Pages 845-852
Right ventricular dysfunction affects survival after surgical left ventricular restoration.
Couperus LE, Delgado V, Palmen M, van Vessem ME, Braun J, Fiocco M, Tops LF, Verwey HF, Klautz RJ, Schalij MJ, Beeres SL
Objective: Several clinical and left ventricular parameters have been associated with prognosis after surgical left ventricular restoration in patients with ischemic heart failure. The aim of this study was to determine the prognostic value of right ventricular function. Methods: A total of 139 patients with ischemic heart failure (62 ± 10 years; 79% were male; left ventricular ejection fraction 27% ± 7%) underwent surgical left ventricular restoration. Biventricular function was assessed with e...
Abstract
Cited 518 times since 2016 (56.5 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 50, Issue 5, 23 4 2016, Pages e1-e88
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS.
Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B, Castella M, Diener HC, Heidbuchel H, Hendriks J, Hindricks G, Manolis AS, Oldgren J, Popescu BA, Schotten U, Van Putte B, Vardas P, Agewall S, Camm J, Baron Esquivias G, Budts W, Carerj S, Casselman F, Coca A, De Caterina R, Deftereos S, Dobrev D, Ferro JM, Filippatos G, Fitzsimons D, Gorenek B, Guenoun M, Hohnloser SH, Kolh P, Lip GY, Manolis A, McMurray J, Ponikowski P, Rosenhek R, Ruschitzka F, Savelieva I, Sharma S, Suwalski P, Tamargo JL, Taylor CJ, Van Gelder IC, Voors AA, Windecker S, Zamorano JL, Zeppenfeld K
Abstract
Cited 8 times since 2016 (0.9 per year)
source: EuropePMC
Pharmacogenomics,
Volume 17, Issue 15, 20 3 2016, Pages 1621-1628
Rooted in risk: genetic predisposition for low-density lipoprotein cholesterol level associates with diminished low-density lipoprotein cholesterol response to statin treatment.
Smit RA, Postmus I, Trompet S, Barnes MR, Warren H, Arsenault BJ, Chasman DI, Cupples LA, Hitman GA, Krauss RM, Li X, Psaty BM, Stein CM, Rotter JI, Jukema JW
Aims: To utilize previously reported lead SNPs for low-density lipoprotein cholesterol (LDL-c) levels to find additional loci of importance to statin response, and examine whether genetic predisposition to LDL-c levels associates with differential statin response. Methods: We investigated effects on statin response of 59 LDL-c SNPs, by combining summary level statistics from the Global Lipids Genetics and Genomic Investigation of Statin Therapy consortia. Results: Lead SNPs for APOE, SORT1 and N...
Abstract
Cited 8 times since 2016 (0.9 per year)
source: EuropePMC
BMJ open,
Volume 6, Issue 9, 19 3 2016, Pages e012793
Self-reported hypoglycaemia in patients with type 2 diabetes treated with insulin in the Hoorn Diabetes Care System Cohort, the Netherlands: a prospective cohort study.
Rauh SP, Rutters F, Thorsted BL, Wolden ML, Nijpels G, van der Heijden AA, Walraven I, Elders PJ, Heymans MW, Dekker JM
Background: Our aim was to study the prevalence of self-reported hypoglycaemic sensations and its association with mortality in patients with type 2 diabetes (T2D) treated with insulin in usual care. Methods: Demographics, clinical characteristics and mortality data were obtained from 1667 patients with T2D treated with insulin in the Hoorn Diabetes Care System Cohort (DCS), a prospective cohort study using clinical care data. Self-reported hypoglycaemic sensations were defined as either mild: e...
Abstract
