Research

Publications

Below you can find a list of our published research.

9543 results

Cited 8 times since 2016 (0.9 per year) source: EuropePMC

The American journal of cardiology, Volume 118, Issue 8, 29 5 2016, Pages 1217-1224 Long-Term Echocardiographic Outcome in Super-Responders to Cardiac Resynchronization Therapy and the Association With Mortality and Defibrillator Therapy. van der Heijden AC, Höke U, Thijssen J, Willem Borleffs CJ, Wolterbeek R, Schalij MJ, van Erven L

Super-response to cardiac resynchronization therapy (CRT) is associated with significant left ventricular (LV) reverse remodeling and improved clinical outcome. The study aimed to: (1) evaluate whether LV reverse remodeling remains sustained during long-term follow-up in super-responders and (2) analyze the association between the course of LV reverse remodeling and ventricular arrhythmias. Of all, primary prevention super-responders to CRT were selected. Super-response was defined as LV end-sys... Abstract

Cited 4 times since 2016 (0.4 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 23, Issue 6, 29 5 2016, Pages 1399-1410 Diagnostic and prognostic roles of echocardiography and cardiac magnetic resonance. Delgado V, Bucciarelli-Ducci C, Bax JJ

Accurate prediction of sudden cardiac death due to ventricular arrhythmia remains challenging. Left ventricular ejection fraction has shown an association with increased risk of ventricular arrhythmias and is included in the recommendations for implantable cardioverter defibrillator as primary prevention. However, left ventricular ejection fraction may be normal in a large number of patients who are at risk of ventricular arrhythmias. Echocardiography remains the imaging technique of first choic... Abstract

Cited 11 times since 2016 (1.2 per year) source: EuropePMC

Pharmacogenomics, Volume 17, Issue 13, 29 5 2016, Pages 1391-1403 Opioid treatment failure in cancer patients: the role of clinical and genetic factors. Oosten AW, Matic M, van Schaik RH, Look MP, Jongen JL, Mathijssen RH, van der Rijt CC

Aim: To identify clinical and genetic factors associated with outcome of opioid treatment. Patients & methods: We performed an exploratory analysis in a cohort of 353 patients treated with fentanyl, morphine, oxycodone and/or hydromorphone for cancer-related pain, exploring selected clinical and pharmacogenetic factors for a correlation with treatment failure for all and per type of opioid. Results: Use of adjuvant pain medication, intensity of pain at rest and age were associated with treat... Abstract

Cited 93 times since 2016 (10 per year) source: EuropePMC

The Behavioral and brain sciences, Volume 40, 28 4 2016, Pages e195 The evolution of general intelligence. Burkart JM, Schubiger MN, van Schaik CP

The presence of general intelligence poses a major evolutionary puzzle, which has led to increased interest in its presence in nonhuman animals. The aim of this review is to critically evaluate this question and to explore the implications for current theories about the evolution of cognition. We first review domain-general and domain-specific accounts of human cognition in order to situate attempts to identify general intelligence in nonhuman animals. Recent studies are consistent with the pres... Abstract

Cited 27 times since 2016 (2.9 per year) source: EuropePMC

Scientific reports, Volume 6, 28 4 2016, Pages 30516 Cognitive differences between orang-utan species: a test of the cultural intelligence hypothesis. Forss SI, Willems E, Call J, van Schaik CP

Cultural species can - or even prefer to - learn their skills from conspecifics. According to the cultural intelligence hypothesis, selection on underlying mechanisms not only improves this social learning ability but also the asocial (individual) learning ability. Thus, species with systematically richer opportunities to socially acquire knowledge and skills should over time evolve to become more intelligent. We experimentally compared the problem-solving ability of Sumatran orang-utans (Pongo... Abstract

Cited 30 times since 2016 (3.2 per year) source: EuropePMC

Scientific reports, Volume 6, 27 4 2016, Pages 30439 Liposomal prednisolone inhibits vascular inflammation and enhances venous outward remodeling in a murine arteriovenous fistula model. Wong C, Bezhaeva T, Rothuizen TC, Metselaar JM, de Vries MR, Verbeek FP, Vahrmeijer AL, Wezel A, van Zonneveld AJ, Rabelink TJ, Quax PH, Rotmans JI

Arteriovenous fistulas (AVF) for hemodialysis access have a 1-year primary patency rate of only 60%, mainly as a result of maturation failure that is caused by insufficient outward remodeling and intimal hyperplasia. The exact pathophysiology remains unknown, but the inflammatory vascular response is thought to play an important role. In the present study we demonstrate that targeted liposomal delivery of prednisolone increases outward remodeling of the AVF in a murine model. Liposomes accumulat... Abstract

Cited 37 times since 2016 (4 per year) source: EuropePMC

Digestive diseases and sciences, Volume 61, Issue 10, 26 4 2016, Pages 2963-2971 Exposure to Ambient Air Pollution and the Risk of Inflammatory Bowel Disease: A European Nested Case-Control Study. Opstelten JL, Beelen RMJ, Leenders M, Hoek G, Brunekreef B, van Schaik FDM, Siersema PD, Eriksen KT, Raaschou-Nielsen O, Tjønneland A, Overvad K, Boutron-Ruault MC, Carbonnel F, de Hoogh K, Key TJ, Luben R, Chan SSM, Chan SSM, Hart AR, Bueno-de-Mesquita HB, Oldenburg B

Background: Industrialization has been linked to the etiology of inflammatory bowel disease (IBD). Aim: We investigated the association between air pollution exposure and IBD. Methods: The European Prospective Investigation into Cancer and Nutrition cohort was used to identify cases with Crohn's disease (CD) (n = 38) and ulcerative colitis (UC) (n = 104) and controls (n = 568) from Denmark, France, the Netherlands, and the UK, matched for center, gender, age, and date of recruitment. Air po... Abstract

Cited 22 times since 2016 (2.4 per year) source: EuropePMC

Trials, Volume 17, Issue 1, 25 4 2016, Pages 345 Subcutaneous immunoglobulin for maintenance treatment in chronic inflammatory demyelinating polyneuropathy (The PATH Study): study protocol for a randomized controlled trial. van Schaik IN, van Geloven N, Bril V, Hartung HP, Lewis RA, Sobue G, Lawo JP, Mielke O, Cornblath DR, Merkies IS, PATH study group

Background: Subcutaneous administration of Ig (SCIg) has gained popularity as an alternative route of administration but has never been rigorously examined in chronic inflammatory demyelinating polyneuropathy (CIDP). Methods/design: The primary objective of the PATH study (Polyneuropathy and Treatment with Hizentra) is to determine the efficacy of two different doses of SCIg IgPro20 (0.2 g/kg bw or 0.4 g/kg bw) in a 24-week maintenance treatment of CIDP in comparison to placebo. The primary effi... Abstract

Cited 25 times since 2016 (2.7 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 102, Issue 6, 22 4 2016, Pages 1981-1987 Effect of Aortic Valve Replacement on Aortic Root Dilatation Rate in Patients With Bicuspid and Tricuspid Aortic Valves. Regeer MV, Versteegh MI, Klautz RJ, Schalij MJ, Bax JJ, Marsan NA, Delgado V

Background: It remains unclear whether aortic valve replacement (AVR) has an effect on the aortic root dilatation rate in patients with bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV). The present study evaluated the pre- and postoperative annual aortic root dilatation rates in BAV and TAV. Methods: A total of 93 patients (67 ± 11 years; 71% men) who underwent AVR between 2003 and 2013 and had at least 2 pre- and postoperative echocardiographic studies 1 year or more apart were incl... Abstract

Cited 3 times since 2016 (0.3 per year) source: EuropePMC

Cancer epidemiology, Volume 44, 21 3 2016, Pages 5-15 Quantitative and qualitative assessment of real world data comparative effectiveness research of systemic therapies in lung oncology: A systematic review. Peters BJM, Janssen VEMT, Schramel FM, van de Garde EMW

Introduction: The growing interest in comparative effectiveness research (CER) based on data from routine clinical practice also extends towards lung oncology. Although CER studies using real world data (RWD) have the potential to assist clinical decision-making, concerns about the quality and validity of studies with observational data subsist. The primary objective of the present study is to assess the current status of observational CER in the field of lung oncology, both quantitatively as qu... Abstract

Cited 3 times since 2016 (0.3 per year) source: EuropePMC

Nuklearmedizin. Nuclear medicine, Volume 55, Issue 5, 20 3 2016, Pages 196-202 Sex differences in absolute myocardial perfusion. Non-invasive H2(15)O-PET in young healthy adults. Range FT, Kies P, Schäfers KP, Breithardt G, Schober O, Wichter T, Schäfers MA

Aim: To investigate sex differences in myocardial perfusion especially in healthy individuals since former studies are rare and findings are controversial. Participants, methods: 26 subjects were enrolled: 16 healthy women (age: 34 ±7 years) were compared with 10 healthy men (age: 34 ± 3 years; p = ns). Myocardial blood flow (MBF) and coronary vascular resistance (CVR) were quantified at rest, during adenosine infusion and cold-pressor-testing, using positron emission tomography and radioactive-... Abstract

Cited 21 times since 2016 (2.2 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 29, Issue 9, 19 3 2016, Pages 871-878 Prevalence and Correlates of Early Right Ventricular Dysfunction in Sarcoidosis and Its Association with Outcome. Joyce E, Kamperidis V, Ninaber MK, Katsanos S, Debonnaire P, Schalij MJ, Taube C, Bax JJ, Delgado V, Ajmone Marsan N

Background: Right ventricular (RV) function has not been systematically assessed in sarcoidosis. The aim of this study was to assess the prevalence and associates of RV dysfunction in sarcoidosis using global longitudinal peak systolic strain (GLS). Furthermore, whether RV dysfunction was associated with clinical outcomes was investigated. Methods: A total of 88 patients with sarcoidosis (mean age, 54 ± 13 years; 51% men) without known sarcoid-related or other structural heart disease or alterna... Abstract

Cited 6 times since 2016 (0.6 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 50, Issue 3, 19 3 2016, Pages 476-481 Valve-sparing root replacement in children. Kluin J, Koolbergen DR, Sojak V, Hazekamp MG

Objectives: In children, words of caution have been raised about valve-sparing procedures especially regarding the valve-remodelling technique. This study reviewed our experience with the valve-sparing reimplantation technique in children. Methods: All consecutive paediatric ( Abstract

Cited 88 times since 2016 (9.4 per year) source: EuropePMC

Advances in health sciences education : theory and practice, Volume 22, Issue 3, 19 3 2016, Pages 765-787 How visual search relates to visual diagnostic performance: a narrative systematic review of eye-tracking research in radiology. van der Gijp A, Ravesloot CJ, Jarodzka H, van der Schaaf MF, van der Schaaf IC, van Schaik JPJ, Ten Cate TJ

Eye tracking research has been conducted for decades to gain understanding of visual diagnosis such as in radiology. For educational purposes, it is important to identify visual search patterns that are related to high perceptual performance and to identify effective teaching strategies. This review of eye-tracking literature in the radiology domain aims to identify visual search patterns associated with high perceptual performance. Databases PubMed, EMBASE, ERIC, PsycINFO, Scopus and Web of Sci... Abstract

Cited 5 times since 2016 (0.5 per year) source: EuropePMC

Journal of interpersonal violence, Volume 34, Issue 10, 19 3 2016, Pages 2110-2137 "It's a Dog's Life": Culture, Empathy, Gender, and Domestic Violence Predict Animal Abuse in Adolescents-Implications for Societal Health. Plant M, van Schaik P, Gullone E, Flynn C

Whereas the majority of previous research conducted on animal abuse has been in environments where animal abuse is rarely evidenced, the current study investigated the ramifications of animal abuse in an environment wherein the national culture creates an ethos of the "social acceptability" of animal abuse in society. Two survey studies were conducted with adolescent participants, to investigate the role played by several factors in the prediction of animal abuse in this age group. In... Abstract

Cited 15 times since 2016 (1.6 per year) source: EuropePMC

Congenital heart disease, Volume 12, Issue 1, 18 3 2016, Pages 40-48 Comparative Evaluation of Flow Quantification across the Atrioventricular Valve in Patients with Functional Univentricular Heart after Fontan's Surgery and Healthy Controls: Measurement by 4D Flow Magnetic Resonance Imaging and Streamline Visualization. She HL, Roest AA, Calkoen EE, van den Boogaard PJ, van der Geest RJ, Hazekamp MG, de Roos A, Westenberg JJ

Purpose: To evaluate the inflow pattern and flow quantification in patients with functional univentricular heart after Fontan's operation using 4D flow magnetic resonance imaging (MRI) with streamline visualization when compared with the conventional 2D flow approach. Method: Seven patients with functional univentricular heart after Fontan's operation and twenty-three healthy controls underwent 4D flow MRI. In two orthogonal two-chamber planes, streamline visualization was applied, and... Abstract

Cited 12 times since 2016 (1.3 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 32, Issue 10, 12 2 2016, Pages 1567-1575 Incidence of persistent renal dysfunction after contrast enhanced coronary CT angiography in patients with suspected coronary artery disease. Maaniitty T, Stenström I, Uusitalo V, Ukkonen H, Kajander S, Bax JJ, Saraste A, Knuuti J

Contrast-induced nephropathy (CIN) is a potentially serious complication of contrast agents used in computed tomography angiography (CTA). The aim of this study was to evaluate whether persistent renal dysfunction occurs in patients undergoing coronary CTA for suspected stable coronary artery disease (CAD). From a cohort of 957 patients undergone coronary CTA, we identified 402 patients with plasma creatinine levels collected before and within 6 months after CTA. According to the definition of C... Abstract

Cited 35 times since 2016 (3.7 per year) source: EuropePMC

Frontiers in neuroscience, Volume 10, 12 2 2016, Pages 312 A Review of Control Strategies in Closed-Loop Neuroprosthetic Systems. Wright J, Macefield VG, van Schaik A, Tapson JC

It has been widely recognized that closed-loop neuroprosthetic systems achieve more favorable outcomes for users then equivalent open-loop devices. Improved performance of tasks, better usability, and greater embodiment have all been reported in systems utilizing some form of feedback. However, the interdisciplinary work on neuroprosthetic systems can lead to miscommunication due to similarities in well-established nomenclature in different fields. Here we present a review of control strategies... Abstract

Cited 62 times since 2016 (6.6 per year) source: EuropePMC

European journal of cancer (Oxford, England : 1990), Volume 64, 11 2 2016, Pages 127-136 A five-gene expression signature to predict progression in T1G3 bladder cancer. van der Heijden AG, Mengual L, Lozano JJ, Ingelmo-Torres M, Ribal MJ, Fernández PL, Oosterwijk E, Schalken JA, Alcaraz A, Witjes JA

Objective: The aim of this study was to analyze tumour gene expression profiles of progressive and non-progressive T1G3 bladder cancer (BC) patients to develop a gene expression signature to predict tumour progression. Methods: Retrospective, multicenter study of 96 T1G3 BC patients without carcinoma in situ (CIS) who underwent a transurethral resection. Formalin-fixed paraffin-embedded tissue samples were collected. Global gene expression patterns were analyzed in 21 selected samples from progr... Abstract

International journal of cardiology, Volume 221, 9 2 2016, Pages 682-687 Haptoglobin polymorphism in relation to coronary plaque characteristics on radiofrequency intravascular ultrasound and near-infrared spectroscopy in patients with coronary artery disease. Buljubasic N, Oemrawsingh RM, Smeets MB, Cheng JM, Regar E, van Geuns RJ, Serruys PW, Boersma E, Akkerhuis KM, Kardys I, Arslan F

Background: Conflicting results exist regarding the association between a common Haptoglobin (Hp) polymorphism and risk of coronary artery disease. We investigated the association of three functionally different anti-oxidant and anti-inflammatory Hp phenotypes (Hp1-1, Hp2-1, Hp2-2) with invasively measured degree and composition of coronary atherosclerosis as determined by intravascular ultrasound (-virtual histology) (IVUS(-VH)) as well as near-infrared spectroscopy (NIRS). Methods: Non-culprit... Abstract