9543 results
Cited 87 times since 2016 (9.2 per year)
source: EuropePMC
Immunobiology,
Volume 221, Issue 10, 16 3 2016, Pages 1102-1109
Complement resistance mechanisms of Klebsiella pneumoniae.
Doorduijn DJ, Rooijakkers SH, van Schaik W, Bardoel BW
The current emergence of antibiotic-resistant bacteria causes major problems in hospitals worldwide. To survive within the host, bacterial pathogens exploit several escape mechanisms to prevent detection and killing by the immune system. As a major player in immune defense, the complement system recognizes and destroys bacteria via different effector mechanisms. The complement system can label bacteria for phagocytosis or directly kill Gram-negative bacteria via insertion of a pore-forming compl...
Abstract
Cited 4 times since 2016 (0.4 per year)
source: EuropePMC
Clinica chimica acta; international journal of clinical chemistry,
Volume 467, 16 3 2016, Pages 59-69
Pre-examination factors affecting molecular diagnostic test results and interpretation: A case-based approach.
Payne DA, Baluchova K, Peoc'h KH, van Schaik RHN, Chan KCA, Maekawa M, Mamotte C, Russomando G, Rousseau F, Ahmad-Nejad P, IFCC Committee for Molecular Diagnostics (C-MD)
Background: Multiple organizations produce guidance documents that provide opportunities to harmonize quality practices for diagnostic testing. The International Organization for Standardization ISO 15189 standard addresses requirements for quality in management and technical aspects of the clinical laboratory. One technical aspect addresses the complexities of the pre-examination phase prior to diagnostic testing. Methods: The Committee for Molecular Diagnostics of the International Federation...
Abstract
Dermatology online journal,
Volume 22, Issue 6, 15 3 2016, Pages 13030/qt4f48g7jc
Unusual location of median raphe cyst presenting as perianal polyp: a case report.
Arer IM, Yilmaz D, Ozek OC, Yabanoglu H, Caliskan K
Median raphe cysts (MRC) are uncommon, benign congenital lesions that may present anywhere in the midline between the urinary meatus and the anus, with the shaft of the penis and the glans penis being the most common sites. We report a 52-year-old man with median raphe cyst unusually located in perianal region and treated by surgical excision.
Abstract
Cited 29 times since 2016 (3.1 per year)
source: EuropePMC
Atherosclerosis,
Volume 251, 11 2 2016, Pages 139-146
IL-6: A Janus-like factor in abdominal aortic aneurysm disease.
Kokje VBC, Gäbel G, Koole D, Northoff BH, Holdt LM, Hamming JF, Lindeman JHN
Background and aims: An abdominal aortic aneurysm (AAA) is part of the atherosclerotic spectrum of diseases. The disease is hallmarked by a comprehensive localized inflammatory response with striking IL-6 hyperexpression. IL-6 is a multifaceted cytokine that, depending on the context, acts as a pro- or anti-inflammatory factor. In this study, we explore a putative role for IL-6 in AAA disease. Methods: ELISA's, Western blot analysis, real time PCR and array analysis were used to investigate...
Abstract
Cited 51 times since 2016 (5.4 per year)
source: EuropePMC
Journal of virology,
Volume 90, Issue 13, 10 2 2016, Pages 5928-5938
Multiple Natural Substitutions in Avian Influenza A Virus PB2 Facilitate Efficient Replication in Human Cells.
Mänz B, de Graaf M, Mögling R, Richard M, Bestebroer TM, Rimmelzwaan GF, Fouchier RAM
Unlabelled: A strong restriction of the avian influenza A virus polymerase in mammalian cells generally limits viral host-range switching. Although substitutions like E627K in the PB2 polymerase subunit can facilitate polymerase activity to allow replication in mammals, many human H5N1 and H7N9 viruses lack this adaptive substitution. Here, several previously unknown, naturally occurring, adaptive substitutions in PB2 were identified by bioinformatics, and their enhancing activity was verified u...
Abstract
Cited 12 times since 2016 (1.3 per year)
source: EuropePMC
Journal of magnetic resonance imaging : JMRI,
Volume 45, Issue 1, 2 1 2016, Pages 215-228
Quantification of common carotid artery and descending aorta vessel wall thickness from MR vessel wall imaging using a fully automated processing pipeline.
Gao S, van 't Klooster R, Brandts A, Roes SD, Alizadeh Dehnavi R, de Roos A, Westenberg JJ, van der Geest RJ
Purpose: To develop and evaluate a method that can fully automatically identify the vessel wall boundaries and quantify the wall thickness for both common carotid artery (CCA) and descending aorta (DAO) from axial magnetic resonance (MR) images. Materials and methods: 3T MRI data acquired with T1 -weighted gradient-echo black-blood imaging sequence from carotid (39 subjects) and aorta (39 subjects) were used to develop and test the algorithm. The vessel wall segmentation was achieved by respecti...
Abstract
Cited 2 times since 2016 (0.2 per year)
source: EuropePMC
AJR. American journal of roentgenology,
Volume 207, Issue 2, 1 1 2016, Pages 339-343
Tests, Quizzes, and Self-Assessments: How to Construct a High-Quality Examination.
van der Gijp A, Ravesloot CJ, Ten Cate OT, van Schaik JP, Webb EM, Naeger DM
Objective: The purposes of this article are to highlight aspects of tests that increase or decrease their effectiveness and to provide guidelines for constructing high-quality tests in radiology. Conclusion: Many radiologists help construct tests for a variety of purposes. Only well-constructed tests can provide reliable and valuable information about the test taker.
Abstract
Cited 5 times since 2016 (0.5 per year)
source: EuropePMC
Human nature (Hawthorne, N.Y.),
Volume 27, Issue 2, 1 1 2016, Pages 141-159
The Conditions Favoring Between-Community Raiding in Chimpanzees, Bonobos, and Human Foragers.
Pandit SA, Pradhan GR, Balashov H, Van Schaik CP
Chimpanzees, bonobos, and human foragers share a fission-fusion social system and a mating system of joint male resource defense polygyny. Within-community skew in male strength varies among and within species. In this study, we extend a mathematical model of within-group male coalition formation among primates to derive the conditions for between-community conflicts in the form of raids. We show that the main factor affecting the presence of successful raiding is the likelihood of major discrep...
Abstract
Cited 1 times since 2016 (0.1 per year)
source: EuropePMC
European journal of heart failure,
Volume 18, Issue 6, 1 1 2016, Pages 727
Erratum to "Traditional and new composite endpoints in heart failure clinical trials: facilitating comprehensive efficacy assessments and improving trial efficiency" [Eur J Heart Fail 2016;18:482-489].
Anker SD, Schroeder S, Atar D, Bax JJ, Ceconi C, Cowie MR, Crisp A, Dominjon F, Ford I, Ghofrani HA, Gropper S, Hindricks G, Hlatky MA, Holcomb R, Honarpour N, Jukema JW, Kim AM, Kunz M, Lefkowitz M, Floch CL, Landmesser U, McDonagh TA, McMurray JJ, Merkely B, Packer M, Prasad K, Revkin J, Rosano GM, Somaratne R, Stough WG, Voors AA, Ruschitzka F
Abstract
Cited 93 times since 2016 (9.8 per year)
source: EuropePMC
Science translational medicine,
Volume 8, Issue 341, 1 1 2016, Pages 341ra76
A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease.
Scott RA, Freitag DF, Li L, Chu AY, Surendran P, Young R, Grarup N, Stancáková A, Chen Y, Varga TV, Yaghootkar H, Luan J, Zhao JH, Willems SM, Wessel J, Wang S, Maruthur N, Michailidou K, Pirie A, van der Lee SJ, Gillson C, Al Olama AA, Amouyel P, Arriola L, Arveiler D, Aviles-Olmos I, Balkau B, Barricarte A, Barroso I, Garcia SB, Bis JC, Blankenberg S, Boehnke M, Boeing H, Boerwinkle E, Borecki IB, Bork-Jensen J, Bowden S, Caldas C, Caslake M, CVD50 consortium, Cupples LA, Cruchaga C, Czajkowski J, den Hoed M, Dunn JA, Earl HM, Ehret GB, Ferrannini E, Ferrieres J, Foltynie T, Ford I, Forouhi NG, Gianfagna F, Gonzalez C, Grioni S, Hiller L, Jansson JH, Jørgensen ME, Jukema JW, Kaaks R, Kee F, Kerrison ND, Key TJ, Kontto J, Kote-Jarai Z, Kraja AT, Kuulasmaa K, Kuusisto J, Linneberg A, Liu C, Marenne G, Mohlke KL, Morris AP, Muir K, Müller-Nurasyid M, Munroe PB, Navarro C, Nielsen SF, Nilsson PM, Nordestgaard BG, Packard CJ, Palli D, Panico S, Peloso GM, Perola M, Peters A, Poole CJ, Quirós JR, Rolandsson O, Sa
Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be associated with an unacceptable increase in cardiovascular risk. Human genetics may be able to guide development of antidiabetic therapies by predicting cardiovascular and other health endpoints. We therefore investigated the association of variants in six genes that encode drug targets for obesity or T2D with a range of metabolic traits in up to 11,806 individuals by targeted exome sequencing and f...
Abstract
Cited 9 times since 2016 (0.9 per year)
source: EuropePMC
Current opinion in lipidology,
Volume 27, Issue 3, 1 1 2016, Pages 288-294
The multifaceted interplay between lipids and epigenetics.
Dekkers KF, Slagboom PE, Jukema JW, Heijmans BT
Purpose of review: The interplay between lipids and epigenetic mechanisms has recently gained increased interest because of its relevance for common diseases and most notably atherosclerosis. This review discusses recent advances in unravelling this interplay with a particular focus on promising approaches and methods that will be able to establish causal relationships. Recent findings: Complementary approaches uncovered close links between circulating lipids and epigenetic mechanisms at multipl...
Abstract
Cited 43 times since 2016 (4.5 per year)
source: EuropePMC
Journal of vascular surgery,
Volume 63, Issue 6, 1 1 2016, Pages 1451-1457
Experience with the GORE EXCLUDER iliac branch endoprosthesis for common iliac artery aneurysms.
van Sterkenburg SM, Heyligers JM, van Bladel M, Verhagen HJ, Eefting D, van Sambeek MR, Zeebregts CJ, Reijnen MM, Dutch IBE Collaboration
Objective: In this study, we analyzed the procedural success and early outcome of endovascular treatment of a multicenter cohort of patients with common iliac artery (CIA) aneurysms treated with the new GORE EXCLUDER (W. L. Gore & Associates, Flagstaff, Ariz) iliac branch endoprosthesis (IBE). Methods: A retrospective cohort analysis was performed in 13 sites in The Netherlands. Anatomic, demographic, procedural, and follow-up data were assessed from hospital records. Results: From November...
Abstract
Cited 17 times since 2016 (1.8 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 9, Issue 6, 1 1 2016, Pages e003924
Effect of Gender on Outcomes After Cardiac Resynchronization Therapy in Patients With a Narrow QRS Complex: A Subgroup Analysis of the EchoCRT Trial.
Steffel J, Varma N, Robertson M, Singh JP, Bax JJ, Borer JS, Dickstein K, Ford I, Gorcsan J, Gras D, Krum H, Sogaard P, Holzmeister J, Brugada J, Abraham WT, Ruschitzka F
Background: In EchoCRT, a randomized controlled trial evaluating the effect of cardiac resynchronization therapy (CRT) in patients with a QRS duration of
Abstract
Cited 180 times since 2016 (19 per year)
source: EuropePMC
JAMA cardiology,
Volume 1, Issue 3, 1 1 2016, Pages 335-340
Differences in the Clinical Profile and Outcomes of Typical and Atypical Takotsubo Syndrome: Data From the International Takotsubo Registry.
Ghadri JR, Cammann VL, Napp LC, Jurisic S, Diekmann J, Bataiosu DR, Seifert B, Jaguszewski M, Sarcon A, Neumann CA, Geyer V, Prasad A, Bax JJ, Ruschitzka F, Lüscher TF, Templin C, International Takotsubo (InterTAK) Registry
Importance: Apical ballooning is broadly recognized as the classic form of takotsubo syndrome (TTS). Atypical subtypes of TTS also exist, which constitute about 20% of all cases. To date, clinical profile and course of atypical TTS types have rarely been studied. Objective: To characterize the clinical profile and outcomes of typical vs atypical types of TTS in a large patient cohort. Design, setting, and participants: Records of 1750 patients from the International Takotsubo Registry, comprisin...
Abstract
Cited 13 times since 2016 (1.4 per year)
source: EuropePMC
Journal of the peripheral nervous system : JPNS,
Volume 21, Issue 2, 1 1 2016, Pages 74-81
Does ability to walk reflect general functionality in inflammatory neuropathies?
Draak TH, Gorson KC, Vanhoutte EK, van Nes SI, van Doorn PA, Cornblath DR, van den Berg LH, Faber CG, Merkies IS, PeriNomS Study Group
The "ability to walk" is considered a benchmark for good clinical recovery and prognosis, particularly in patients with Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). However, it has never been determined whether being "able to walk" represents general functionality. The purpose of this study was to examine whether the ability to walk outside independently reflects general functional improvement in patients with GBS, CIDP,...
Abstract
Cited 20 times since 2016 (2.1 per year)
source: EuropePMC
Academic medicine : journal of the Association of American Medical Colleges,
Volume 91, Issue 6, 1 1 2016, Pages 807-812
Perceptions of Peer-to-Peer Interprofessional Feedback Among Students in the Health Professions.
van Schaik SM, Regehr G, Eva KW, Irby DM, O'Sullivan PS
Purpose: Interprofessional teamwork should include interprofessional feedback to optimize performance and collaboration. Social identity theory predicts that hierarchy and stereotypes may limit receptiveness to interprofessional feedback, but literature on this is sparse. This study explores perceptions among health professions students regarding interprofessional peer feedback received after a team exercise. Method: In 2012-2013, students from seven health professions schools (medicine, pharmac...
Abstract
Cited 70 times since 2016 (7.4 per year)
source: EuropePMC
Inflammatory bowel diseases,
Volume 22, Issue 6, 1 1 2016, Pages 1403-1411
Dairy Products, Dietary Calcium, and Risk of Inflammatory Bowel Disease: Results From a European Prospective Cohort Investigation.
Opstelten JL, Leenders M, Dik VK, Chan SS, Chan SS, van Schaik FD, Khaw KT, Luben R, Hallmans G, Karling P, Lindgren S, Grip O, Key TJ, Crowe FL, Boeing H, Bergmann MM, Overvad K, Palli D, Masala G, Racine A, Carbonnel F, Boutron-Ruault MC, Tjønneland A, Olsen A, Andersen V, Kaaks R, Katzke VA, Tumino R, Trichopoulou A, Siersema PD, Bueno-de-Mesquita HB, Hart AR, Oldenburg B
Background: Dairy products may be involved in the etiology of inflammatory bowel disease by modulating gut microbiota and immune responses, but data from epidemiological studies examining this relationship are limited. We investigated the association between prediagnostic intake of these foods and dietary calcium, and the subsequent development of Crohn's disease (CD) and ulcerative colitis (UC). Methods: In total, 401,326 participants were enrolled in the European Prospective Investigation...
Abstract
Cited 16 times since 2016 (1.7 per year)
source: EuropePMC
Laboratory investigation; a journal of technical methods and pathology,
Volume 96, Issue 7, 30 5 2016, Pages 784-790
Activation of the vitamin D receptor selectively interferes with calcineurin-mediated inflammation: a clinical evaluation in the abdominal aortic aneurysm.
Nieuwland AJ, Kokje VB, Koning OH, Hamming JF, Szuhai K, Claas FH, Lindeman JH
In vitro and in vivo studies attribute potent immune regulatory properties to the vitamin D receptor (VDR). Yet, it is unclear to what extend these observations translate to the clinical context of (vascular) inflammation. This clinical study evaluates the potential of a VDR agonist to quench vascular inflammation. Patients scheduled for open abdominal aneurysm repair received paricalcitol 1 μg daily during 2-4 weeks before repair. Results were compared with matched controls. Evaluation in a par...
Abstract
Cited 11 times since 2016 (1.2 per year)
source: Scopus
The American journal of cardiology,
Volume 118, Issue 4, 29 5 2016, Pages 567-571
Impact of Different Iterations of Devices and Degree of Aortic Valve Calcium on Paravalvular Regurgitation After Transcatheter Aortic Valve Implantation.
Kong WK, van Rosendael PJ, van der Kley F, de Weger A, Kamperidis V, Regeer MV, Marsan NA, Bax JJ, Delgado V
The iterations of the SAPIEN prosthesis might impact the incidence and grade of paravalvular regurgitation (PVR). The aim of this study was to assess the impact of iterations of balloon-expandable valves (SAPIEN, SAPIEN XT, and SAPIEN 3) and degree of aortic valve calcification (AVC) on the severity of PVR after transcatheter aortic valve implantation (TAVI). Comprehensive echocardiographic examinations and multidetector computed tomography (MDCT) were performed in 272 patients (127 men, 81 ± 7 ...
Abstract
Cited 46 times since 2016 (4.8 per year)
source: EuropePMC
American heart journal,
Volume 178, 28 4 2016, Pages 135-144
Evaluating bococizumab, a monoclonal antibody to PCSK9, on lipid levels and clinical events in broad patient groups with and without prior cardiovascular events: Rationale and design of the Studies of PCSK9 Inhibition and the Reduction of vascular Events (SPIRE) Lipid Lowering and SPIRE Cardiovascular Outcomes Trials.
Ridker PM, Amarenco P, Brunell R, Glynn RJ, Jukema JW, Kastelein JJ, Koenig W, Nissen S, Revkin J, Santos RD, Schwartz PF, Yunis C, Tardif JC, Studies of PCSK9 Inhibition and the Reduction of vascular Events (SPIRE) Investigators
Background: Although statins significantly reduce vascular event rates, residual cholesterol risk remains high in many patient groups, including those with known vascular disease as well as in the setting of high-risk primary prevention. Bococizumab is a humanized monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9), prolongs the half-life of hepatic low-density lipoprotein (LDL) receptors, and reduces circulating atherogenic cholesterol levels. Design: The SPI...
Abstract
