Research

Publications

Below you can find a list of our published research.

9543 results

Cited 11 times since 2016 (1.2 per year) source: EuropePMC

International journal of legal medicine, Volume 131, Issue 1, 28 4 2016, Pages 45-51 Microbial population analysis improves the evidential value of faecal traces in forensic investigations. Quaak FC, de Graaf MM, Weterings R, Kuiper I

The forensic science community has a growing interest in microbial population analysis, especially the microbial populations found inside and on the human body. Both their high abundance, microbes outnumber human cells by a factor 10, and their diversity, different sites of the human body harbour different microbial communities, make them an interesting tool for forensics. Faecal material is a type of trace evidence which can be found in a variety of criminal cases, but is often being ignored in... Abstract

Cited 223 times since 2016 (23.5 per year) source: EuropePMC

Frontiers in microbiology, Volume 7, 26 4 2016, Pages 788 Global Emergence and Dissemination of Enterococci as Nosocomial Pathogens: Attack of the Clones? Guzman Prieto AM, van Schaik W, Rogers MR, Coque TM, Baquero F, Corander J, Willems RJ

Enterococci are Gram-positive bacteria that are found in plants, soil and as commensals of the gastrointestinal tract of humans, mammals, and insects. Despite their commensal nature, they have also become globally important nosocomial pathogens. Within the genus Enterococcus, Enterococcus faecium, and Enterococcus faecalis are clinically most relevant. In this review, we will discuss how E. faecium and E. faecalis have evolved to become a globally disseminated nosocomial pathogen. E. faecium has... Abstract

Cited 303 times since 2016 (31.9 per year) source: EuropePMC

Nature reviews. Microbiology, Volume 14, Issue 7, 23 4 2016, Pages 421-433 Human norovirus transmission and evolution in a changing world. de Graaf M, van Beek J, Koopmans MP

Norovirus infections are a major cause of gastroenteritis, and outbreaks occur frequently. Several factors are currently increasing the challenge posed by norovirus infections to global health, notably the increasing number of infections in immunocompromised individuals, who are more susceptible to disease, and the globalization of the food industry, which enables large norovirus outbreaks to occur on an international scale. Furthermore, the rapid rate of the genetic and antigenic evolution of c... Abstract

Cited 3946 times since 2016 (415.3 per year) source: EuropePMC

European heart journal, Volume 37, Issue 29, 23 4 2016, Pages 2315-2381 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts)Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Piepoli MF, Hoes AW, Agewall S, Albus C, Brotons C, Catapano AL, Cooney MT, Corrà U, Cosyns B, Deaton C, Graham I, Hall MS, Hobbs FDR, Løchen ML, Löllgen H, Marques-Vidal P, Perk J, Prescott E, Redon J, Richter DJ, Sattar N, Smulders Y, Tiberi M, van der Worp HB, van Dis I, Verschuren WMM, Binno S, ESC Scientific Document Group

Abstract

Cited 5 times since 2016 (0.5 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 32, Issue 8, 21 3 2016, Pages 1311-1322 Automatic detection of aorto-femoral vessel trajectory from whole-body computed tomography angiography data sets. Gao X, Kitslaar PH, Budde RP, Tu S, de Graaf MA, Xu L, Xu B, Scholte AJ, Dijkstra J, Reiber JH

Extraction of the aorto-femoral vessel trajectory is important to utilize computed tomography angiography (CTA) in an integrated workflow of the image-guided work-up prior to trans-catheter aortic valve replacement (TAVR). The aim of this study was to develop a new, fully-automated technique for the extraction of the entire arterial access route from the femoral artery to the aortic root. An automatic vessel tracking algorithm was first used to find the centerline that connected the femoral acce... Abstract

Cited 8048 times since 2016 (846.2 per year) source: EuropePMC

European heart journal, Volume 37, Issue 27, 20 3 2016, Pages 2129-2200 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JGF, Coats AJS, Falk V, González-Juanatey JR, Harjola VP, Jankowska EA, Jessup M, Linde C, Nihoyannopoulos P, Parissis JT, Pieske B, Riley JP, Rosano GMC, Ruilope LM, Ruschitzka F, Rutten FH, van der Meer P, ESC Scientific Document Group

Abstract

Cited 195 times since 2016 (20.5 per year) source: EuropePMC

Nature reviews. Cardiology, Volume 13, Issue 8, 19 3 2016, Pages 451-470 Vein graft failure: from pathophysiology to clinical outcomes. de Vries MR, Simons KH, Jukema JW, Braun J, Quax PH

Occlusive arterial disease is a leading cause of morbidity and mortality worldwide. Aside from balloon angioplasty, bypass graft surgery is the most commonly performed revascularization technique for occlusive arterial disease. Coronary artery bypass graft surgery is performed in patients with left main coronary artery disease and three-vessel coronary disease, whereas peripheral artery bypass graft surgery is used to treat patients with late-stage peripheral artery occlusive disease. The great... Abstract

Cited 7 times since 2016 (0.7 per year) source: EuropePMC

Herzschrittmachertherapie & Elektrophysiologie, Volume 27, Issue 2, 19 3 2016, Pages 131-136 Ventricular tachycardia in repaired congenital heart disease. Zeppenfeld K

Ventricular arrhythmias are an important cause of late morbidity and sudden cardiac death in the growing population of adults with repaired congenital heart disease. Risk stratification remains challenging because of the heterogeneity of the malformations and the surgical approaches. Therapeutic interventions depend on the type of ventricular arrhythmia, which can be polymorphic ventricular tachycardia (VT) or ventricular fibrillation in patients without ventricular scars, but also potentially f... Abstract

Cited 30 times since 2016 (3.2 per year) source: EuropePMC

British journal of pharmacology, Volume 173, Issue 12, 19 3 2016, Pages 2046-2061 A novel transgenic rabbit model with reduced repolarization reserve: long QT syndrome caused by a dominant-negative mutation of the KCNE1 gene. Major P, Baczkó I, Hiripi L, Odening KE, Juhász V, Kohajda Z, Horváth A, Seprényi G, Kovács M, Virág L, Jost N, Prorok J, Ördög B, Doleschall Z, Nattel S, Varró A, Bősze Z

Background and purpose: The reliable assessment of proarrhythmic risk of compounds under development remains an elusive goal. Current safety guidelines focus on the effects of blocking the KCNH2/HERG ion channel-in tissues and animals with intact repolarization. Novel models with better predictive value are needed that more closely reflect the conditions in patients with cardiac remodelling and reduced repolarization reserve. Experimental approach: We have developed a model for the long QT syndr... Abstract

Cited 33 times since 2016 (3.5 per year) source: EuropePMC

Water research, Volume 100, 19 3 2016, Pages 556-567 Quantification of human-associated fecal indicators reveal sewage from urban watersheds as a source of pollution to Lake Michigan. Templar HA, Dila DK, Bootsma MJ, Corsi SR, McLellan SL

Sewage contamination of urban waterways from sewer overflows and failing infrastructure is a major environmental and public health concern. Fecal coliforms (FC) are commonly employed as fecal indicator bacteria, but do not distinguish between human and non-human sources of fecal contamination. Human Bacteroides and human Lachnospiraceae, two genetic markers for human-associated indicator bacteria, were used to identify sewage signals in two urban rivers and the estuary that drains to Lake Michig... Abstract

Cited 33 times since 2016 (3.5 per year) source: EuropePMC

PloS one, Volume 11, Issue 5, 16 3 2016, Pages e0155468 Calcium Imaging of AM Dyes Following Prolonged Incubation in Acute Neuronal Tissue. Cameron M, Kékesi O, Morley JW, Tapson J, Breen PP, van Schaik A, Buskila Y

Calcium-imaging is a sensitive method for monitoring calcium dynamics during neuronal activity. As intracellular calcium concentration is correlated to physiological and pathophysiological activity of neurons, calcium imaging with fluorescent indicators is one of the most commonly used techniques in neuroscience today. Current methodologies for loading calcium dyes into the tissue require prolonged incubation time (45-150 min), in addition to dissection and recovery time after the slicing proced... Abstract

Cited 3 times since 2016 (0.3 per year) source: EuropePMC

BMC neurology, Volume 16, 16 3 2016, Pages 67 Erratum to: Pain management strategies for neuropathic pain in Fabry disease - a systematic review. Schuller Y, Linthorst GE, Hollak CE, Van Schaik IN, Biegstraaten M

Abstract

Cited 9 times since 2016 (0.9 per year) source: EuropePMC

The American journal of cardiology, Volume 118, Issue 3, 14 2 2016, Pages 326-331 Prognostic Implications of Elevated Pulmonary Artery Pressure After ST-Segment Elevation Myocardial Infarction. Haeck ML, Hoogslag GE, Boden H, Velders MA, Katsanos S, Al Amri I, Debonnaire P, Schalij MJ, Vliegen HW, Bax JJ, Marsan NA, Delgado V

Elevated systolic pulmonary artery pressure (SPAP) after ST-segment elevation myocardial infarction (STEMI) has been associated with adverse outcome. However, little is known about the development of increased SPAP after STEMI treated with primary percutaneous coronary intervention. The aims of this study were to investigate the incidence and determinants of elevated SPAP (SPAP ≥36 mm Hg at 12 months) after first STEMI and to analyze its prognostic implications. A total of 705 patients (60 ± 12 ... Abstract

Cited 8 times since 2016 (0.8 per year) source: Scopus

The Thoracic and cardiovascular surgeon, Volume 65, Issue 4, 13 2 2016, Pages 338-342 Titanium Plate Fixation versus Conventional Closure for Sternal Dehiscence after Cardiac Surgery. Vos RJ, Jongbloed L, Sonker U, Kloppenburg GTL

Background Postoperative sternal dehiscence with or without mediastinitis is a complication of cardiac surgery leading to considerable disability. Titanium plate fixation can provide sternal stability in patients with a dehiscent sternum. The aim of this study is to compare clinical outcomes of titanium plate fixation with conventional treatment methods such as steel wire cerclage and pectoralis muscle reconstruction. Patients and Methods A retrospective analysis was performed on 42 patients who... Abstract

Cited 22 times since 2016 (2.3 per year) source: EuropePMC

Neurology. Genetics, Volume 2, Issue 3, 12 2 2016, Pages e78 Homozygous GNAL mutation associated with familial childhood-onset generalized dystonia. Masuho I, Fang M, Geng C, Zhang J, Jiang H, Özgul RK, Yılmaz DY, Yalnızoğlu D, Yüksel D, Yarrow A, Myers A, Burn SC, Crotwell PL, Padilla-Lopez S, Dursun A, Martemyanov KA, Kruer MC

Abstract

Cited 10 times since 2016 (1 per year) source: EuropePMC

BMC psychiatry, Volume 16, 12 2 2016, Pages 139 Non-fatal disease burden for subtypes of depressive disorder: population-based epidemiological study. Biesheuvel-Leliefeld KE, Kok GD, Bockting CL, de Graaf R, Ten Have M, van der Horst HE, van Schaik A, van Marwijk HW, Smit F

Background: Major depression is the leading cause of non-fatal disease burden. Because major depression is not a homogeneous condition, this study estimated the non-fatal disease burden for mild, moderate and severe depression in both single episode and recurrent depression. All estimates were assessed from an individual and a population perspective and presented as unadjusted, raw estimates and as estimates adjusted for comorbidity. Methods: We used data from the first wave of the second Nether... Abstract

Cited 6 times since 2016 (0.6 per year) source: EuropePMC

Frontiers in psychology, Volume 7, 10 2 2016, Pages 685 Varied Practice in Laparoscopy Training: Beneficial Learning Stimulation or Cognitive Overload? Spruit EN, Kleijweg L, Band GP, Hamming JF

Determining the optimal design for surgical skills training is an ongoing research endeavor. In education literature, varied practice is listed as a positive intervention to improve acquisition of knowledge and motor skills. In the current study we tested the effectiveness of a varied practice intervention during laparoscopy training. Twenty-four trainees (control group) without prior experience received a 3 weeks laparoscopic skills training utilizing four basic and one advanced training task.... Abstract

Cited 30 times since 2016 (3.1 per year) source: EuropePMC

PLoS genetics, Volume 12, Issue 5, 5 1 2016, Pages e1006034 Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure. Smith JG, Felix JF, Morrison AC, Kalogeropoulos A, Trompet S, Wilk JB, Gidlöf O, Wang X, Morley M, Mendelson M, Joehanes R, Ligthart S, Shan X, Bis JC, Wang YA, Sjögren M, Ngwa J, Brandimarto J, Stott DJ, Aguilar D, Rice KM, Sesso HD, Demissie S, Buckley BM, Taylor KD, Ford I, Yao C, Liu C, CHARGE-SCD consortium, EchoGen consortium, QT-IGC consortium, CHARGE-QRS consortium, Sotoodehnia N, van der Harst P, Stricker BH, Kritchevsky SB, Liu Y, Gaziano JM, Hofman A, Moravec CS, Uitterlinden AG, Kellis M, van Meurs JB, Margulies KB, Dehghan A, Levy D, Olde B, Psaty BM, Cupples LA, Jukema JW, Djousse L, Franco OH, Boerwinkle E, Boyer LA, Newton-Cheh C, Butler J, Vasan RS, Cappola TP, Smith NL

Failure of the human heart to maintain sufficient output of blood for the demands of the body, heart failure, is a common condition with high mortality even with modern therapeutic alternatives. To identify molecular determinants of mortality in patients with new-onset heart failure, we performed a meta-analysis of genome-wide association studies and follow-up genotyping in independent populations. We identified and replicated an association for a genetic variant on chromosome 5q22 with 36% incr... Abstract

Cited 58 times since 2016 (6.1 per year) source: EuropePMC

Journal of dairy science, Volume 99, Issue 5, 1 1 2016, Pages 3753-3764 Effect of different scenarios for selective dry-cow therapy on udder health, antimicrobial usage, and economics. Scherpenzeel CGM, den Uijl IEM, van Schaik G, Riekerink RGMO, Hogeveen H, Lam TJGM

The goal of dry-cow therapy (DCT) is to reduce the prevalence of intramammary infections (IMI) by eliminating existing IMI at drying off and preventing new IMI from occurring during the dry period. Due to public health concerns, however, preventive use of antimicrobials has become questionable. In this study, we evaluated the effects of 8 scenarios for selecting animals for DCT, taking into account variation in parity and cow-level somatic cell count (SCC) at drying off. The aim of this study wa... Abstract

Cited 9 times since 2016 (0.9 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 49, Issue 5, 1 1 2016, Pages e91-6 Reoperation for right ventricular outflow tract obstruction after arterial switch operation for transposition of the great arteries and aortic arch obstruction. Bokenkamp R, Aguilar E, van der Palen RL, Sojak V, Bruggemans EF, Hruda J, Kuipers IM, Hazekamp MG

Objectives: Right ventricular outflow tract obstruction (RVOTO) is one of the reasons for late reinterventions after repair of transposition of the great arteries (TGA) with aortic arch obstruction (AAO). The aim of the present study was to identify predictors of reoperation for RVOTO in patients who underwent arterial switch operation (ASO) and arch repair for TGA or Taussig-Bing anomaly with AAO. Methods: Between 1977 and 2015, 45 patients [TGA/intact ventricular septum (IVS) 5, TGA/ventricula... Abstract