9543 results
Cited 12 times since 2015 (1.2 per year)
source: EuropePMC
Pharmacogenomics,
Volume 16, Issue 11, 12 2 2015, Pages 1231-1241
Predicting paclitaxel-induced neutropenia using the DMET platform.
Nieuweboer AJ, Smid M, de Graan AJ, Elbouazzaoui S, de Bruijn P, Martens JW, Mathijssen RH, van Schaik RH
Aim: The use of paclitaxel in cancer treatment is limited by paclitaxel-induced neutropenia. We investigated the ability of genetic variation in drug-metabolizing enzymes and transporters to predict hematological toxicity. Patients & methods: Using a discovery and validation approach, we identified a pharmacogenetic predictive model for neutropenia. For this, a drug-metabolizing enzymes and transporters plus DNA chip was used, which contains 1936 SNPs in 225 metabolic enzyme and drug-transpo...
Abstract
Cited 16 times since 2015 (1.6 per year)
source: EuropePMC
British journal of clinical pharmacology,
Volume 80, Issue 3, 12 2 2015, Pages 560-568
4β-hydroxycholesterol as an endogenous CYP3A marker in cancer patients treated with taxanes.
de Graan AJ, Sparreboom A, de Bruijn P, de Jonge E, van der Holt B, Wiemer EA, Verweij J, Mathijssen RH, van Schaik RH
Aim: Taxanes are anti-cancer agents used to treat several types of solid tumours. They are metabolized by cytochrome P450 (CYP) 3A, displaying a large pharmacokinetic (PK) variability. In this study, we evaluated the endogenous CYP3A4 marker 4β-hydroxycholesterol (4β-OHC) as a potential individual taxane PK predictor. Methods: Serum 4β-OHC and cholesterol concentrations were determined in 291 paclitaxel and 151 docetaxel-treated patients, and were subsequently correlated with taxane clearance. R...
Abstract
Cited 45 times since 2015 (4.4 per year)
source: EuropePMC
BMJ open,
Volume 5, Issue 8, 11 2 2015, Pages e008808
Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium.
Morris RW, Taylor AE, Fluharty ME, Bjørngaard JH, Åsvold BO, Elvestad Gabrielsen M, Campbell A, Marioni R, Kumari M, Korhonen T, Männistö S, Marques-Vidal P, Kaakinen M, Cavadino A, Postmus I, Husemoen LL, Skaaby T, Ahluwalia TV, Treur JL, Willemsen G, Dale C, Wannamethee SG, Lahti J, Palotie A, Räikkönen K, McConnachie A, Padmanabhan S, Wong A, Dalgård C, Paternoster L, Ben-Shlomo Y, Tyrrell J, Horwood J, Fergusson DM, Kennedy MA, Nohr EA, Christiansen L, Kyvik KO, Kuh D, Watt G, Eriksson JG, Whincup PH, Vink JM, Boomsma DI, Davey Smith G, Lawlor D, Linneberg A, Ford I, Jukema JW, Power C, Hyppönen E, Jarvelin MR, Preisig M, Borodulin K, Kaprio J, Kivimaki M, Smith BH, Hayward C, Romundstad PR, Sørensen TI, Munafò MR, Sattar N
Objectives: To investigate, using a Mendelian randomisation approach, whether heavier smoking is associated with a range of regional adiposity phenotypes, in particular those related to abdominal adiposity. Design: Mendelian randomisation meta-analyses using a genetic variant (rs16969968/rs1051730 in the CHRNA5-CHRNA3-CHRNB4 gene region) as a proxy for smoking heaviness, of the associations of smoking heaviness with a range of adiposity phenotypes. Participants: 148,731 current, former and never...
Abstract
Cited 12 times since 2015 (1.2 per year)
source: EuropePMC
PloS one,
Volume 10, Issue 8, 11 2 2015, Pages e0134254
Fast, Simple and Accurate Handwritten Digit Classification by Training Shallow Neural Network Classifiers with the 'Extreme Learning Machine' Algorithm.
McDonnell MD, Tissera MD, Vladusich T, van Schaik A, Tapson J
Recent advances in training deep (multi-layer) architectures have inspired a renaissance in neural network use. For example, deep convolutional networks are becoming the default option for difficult tasks on large datasets, such as image and speech recognition. However, here we show that error rates below 1% on the MNIST handwritten digit benchmark can be replicated with shallow non-convolutional neural networks. This is achieved by training such networks using the 'Extreme Learning Machine...
Abstract
Cited 14 times since 2015 (1.4 per year)
source: EuropePMC
Journal of bacteriology,
Volume 197, Issue 20, 10 2 2015, Pages 3283-3293
Loss of Antibiotic Tolerance in Sod-Deficient Mutants Is Dependent on the Energy Source and Arginine Catabolism in Enterococci.
Ladjouzi R, Bizzini A, van Schaik W, Zhang X, Rincé A, Benachour A, Hartke A
Unlabelled: Enterococci are naturally tolerant to typically bactericidal cell wall-active antibiotics, meaning that their growth is inhibited but they are not killed even when exposed to a high concentration of the drug. The molecular reasons for this extraordinary tolerance are still incompletely understood. Previous work showed that resistance to killing collapsed specifically in mutants affected in superoxide dismutase (Sod) activity, arguing that bactericidal antibiotic treatment led to indu...
Abstract
Cited 5 times since 2015 (0.5 per year)
source: EuropePMC
BMC neurology,
Volume 15, 7 1 2015, Pages 133
Association between changes in brain microstructure and cognition in older subjects at increased risk for vascular disease.
Sala M, de Roos A, Blauw GJ, Middelkoop HA, Jukema JW, Mooijaart SP, van Buchem MA, de Craen AJ, van der Grond J
Background: The purpose of this study is to investigate whether changes in brain microstructure, detected by magnetization transfer imaging, are associated with cognition in older subjects at increased risk for vascular disease. Methods: One hundred ninety three nondemented subjects (105 men, mean age 77 ± 3 years) from the Prospective Study of Pravastatin in the Elderly at Risk were included. To assess cross-sectional associations between magnetization transfer ratio (MTR) peak height and cogni...
Abstract
Cited 7 times since 2015 (0.7 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 48, Issue 4, 6 1 2015, Pages e64-70
Stopping antiplatelet medication before coronary artery bypass graft surgery: is there an optimal timing to minimize bleeding?
Gielen CL, Bruggemans EF, Stijnen T, Eikenboom J, Tavilla G, Brand A, Klautz RJ
Objectives: As the indication for antiplatelet medication expands, patients may be exposed to an increased risk of excessive blood loss when cardiac surgery is required. The optimal timing to stop acetylsalicylic acid (ASA) or ASA combined with clopidogrel (ASA+Clo) before surgery is the subject of controversy. Methods: A total of 1065 patients were selected from a prospective randomized study on the effect of a fibrin sealant application in coronary artery bypass graft surgery [Fibrin sealant I...
Abstract
Cited 26 times since 2015 (2.5 per year)
source: EuropePMC
Neurology,
Volume 85, Issue 9, 5 1 2015, Pages 783-789
Executive function, but not memory, associates with incident coronary heart disease and stroke.
Rostamian S, van Buchem MA, Westendorp RG, Jukema JW, Mooijaart SP, Sabayan B, de Craen AJ
Objective: To evaluate the association of performance in cognitive domains executive function and memory with incident coronary heart disease and stroke in older participants without dementia. Methods: We included 3,926 participants (mean age 75 years, 44% male) at risk for cardiovascular diseases from the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) with Mini-Mental State Examination score ≥24 points. Scores on the Stroop Color-Word Test (selective attention) and the Letter...
Abstract
Cited 7 times since 2015 (0.7 per year)
source: EuropePMC
Intensive care medicine,
Volume 41, Issue 11, 4 1 2015, Pages 2013-2014
Gain-of-function single nucleotide variants of the CYP2C19 gene (CYP2C19*17) can identify subtherapeutic voriconazole concentrations in critically ill patients: a case series.
Weigel JD, Hunfeld NG, Koch BC, Egal M, Bakker J, van Schaik RH, van Gelder T
Abstract
Cited 25 times since 2015 (2.4 per year)
source: EuropePMC
PloS one,
Volume 10, Issue 8, 4 1 2015, Pages e0133888
Optimisations and Challenges Involved in the Creation of Various Bioluminescent and Fluorescent Influenza A Virus Strains for In Vitro and In Vivo Applications.
Spronken MI, Short KR, Herfst S, Bestebroer TM, Vaes VP, van der Hoeven B, Koster AJ, Kremers GJ, Scott DP, Gultyaev AP, Sorell EM, de Graaf M, Bárcena M, Rimmelzwaan GF, Fouchier RA
Bioluminescent and fluorescent influenza A viruses offer new opportunities to study influenza virus replication, tropism and pathogenesis. To date, several influenza A reporter viruses have been described. These strategies typically focused on a single reporter gene (either bioluminescent or fluorescent) in a single virus backbone. However, whilst bioluminescence is suited to in vivo imaging, fluorescent viruses are more appropriate for microscopy. Therefore, the idea l reporter virus varies dep...
Abstract
Cited 31 times since 2015 (3 per year)
source: EuropePMC
American heart journal,
Volume 170, Issue 5, 4 1 2015, Pages 981-985.e1
Ticagrelor or prasugrel versus clopidogrel in elderly patients with an acute coronary syndrome: Optimization of antiplatelet treatment in patients 70 years and older--rationale and design of the POPular AGE study.
Qaderdan K, Ishak M, Heestermans AA, de Vrey E, Jukema JW, Voskuil M, de Boer MJ, van't Hof AW, Groenemeijer BE, Vos GJ, Janssen PW, Bergmeijer TO, Kelder JC, Deneer VH, ten Berg JM
Rationale: Dual antiplatelet therapy with acetylsalicylic acid in combination with a more potent P2Y12- inhibitor (ticagrelor or prasugrel) is recommended in patients with acute coronary syndrome without ST-segment elevation (NSTE-ACS) to prevent atherothrombotic complications. The evidence on which this recommendation is based shows that ticagrelor and prasugrel reduce atherothrombotic events at the expense of an increase in bleeding events when compared with clopidogrel. However, it remains un...
Abstract
Cited 28 times since 2015 (2.7 per year)
source: EuropePMC
PloS one,
Volume 10, Issue 8, 3 1 2015, Pages e0134245
Serum Cardiac Troponin-I is Superior to Troponin-T as a Marker for Left Ventricular Dysfunction in Clinically Stable Patients with End-Stage Renal Disease.
Buiten MS, de Bie MK, Rotmans JI, Dekker FW, van Buren M, Rabelink TJ, Cobbaert CM, Schalij MJ, van der Laarse A, Jukema JW
Background: Serum troponin assays, widely used to detect acute cardiac ischemia, might be useful biomarkers to detect chronic cardiovascular disease (CVD). Cardiac-specific troponin-I (cTnI) and troponin-T (cTnT) generally detect myocardial necrosis equally well. In dialysis patients however, serum cTnT levels are often elevated, unlike cTnI levels. The present study aims to elucidate the associations of cTnI and cTnT with CVD in clinically stable dialysis patients. Methods: Troponin levels were...
Abstract
Cited 21 times since 2015 (2 per year)
source: EuropePMC
Circulation. Cardiovascular interventions,
Volume 8, Issue 8, 1 1 2015, Pages e002740
Repeated Intramyocardial Bone Marrow Cell Injection in Previously Responding Patients With Refractory Angina Again Improves Myocardial Perfusion, Anginal Complaints, and Quality of Life.
Mann I, Rodrigo SF, van Ramshorst J, Beeres SL, Dibbets-Schneider P, de Roos A, Wolterbeek R, Zwaginga JJ, Fibbe WE, Bax JJ, Schalij MJ, Atsma DE
Background: Intramyocardial bone marrow cell injection is associated with improvements in myocardial perfusion and anginal symptoms in patients with refractory angina pectoris. This study evaluates the effect of repeated intramyocardial bone marrow cell injection in patients with residual or recurrent myocardial ischemia. Methods and results: Twenty-three patients (17 men; 69±9 years) who had improved myocardial perfusion after the first injection but had residual or recurrent angina and ischemi...
Abstract
Cited 5 times since 2015 (0.5 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 23, Issue 9, 1 1 2015, Pages 447-449
Heart failure in 2015: let's get organised!
Lucas CM, van Pol PE, Eysink Smeets JB, Niesing M, Verwey HF, Beeres SL
Abstract
Cited 19 times since 2015 (1.8 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 8, Issue 4, 1 1 2015, Pages 951-962
Twelve-lead ECG of ventricular tachycardia in structural heart disease.
de Riva M, Watanabe M, Zeppenfeld K
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 23, Issue 9, 1 1 2015, Pages 453-454
Carotid sinus massage for diagnosis in narrow QRS tachycardia.
Henkens IR, Zeppenfeld K, Hauer AD
Abstract
Cited 10 times since 2015 (1 per year)
source: EuropePMC
Therapeutic drug monitoring,
Volume 37, Issue 4, 1 1 2015, Pages 501-507
The Effect of Tamoxifen Dose Increment in Patients With Impaired CYP2D6 Activity.
Welzen ME, Dezentjé VO, van Schaik RH, Colbers AP, Guchelaar HJ, van Erp NP, den Hartigh J, Burger DM, van Laarhoven HW
Background: The effect of tamoxifen dose elevation on endoxifen serum concentration was investigated in patients with reduced CYP2D6 activity resulting from genetic variation and/or CYP2D6 inhibitor use. Additionally, baseline differences in endoxifen concentrations between the different CYP2D6 phenotypes were studied. Methods: Patients, treated with tamoxifen 20 mg once daily (QD) for at least 4 weeks, were classified as phenotypic extensive (EM), intermediate (IM), or poor (PM) metabolizer bas...
Abstract
Cited 43 times since 2015 (4.2 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 17 Suppl 4, 1 1 2015, Pages iv1-72
Current trends in the use of cardiac implantable electronic devices and interventional electrophysiological procedures in the European Society of Cardiology member countries: 2015 report from the European Heart Rhythm Association.
Raatikainen MJ, Arnar DO, Zeppenfeld K, Merino JL, Kuck KH, Hindricks G
Aims: The aim was to provide comprehensive information on the use of cardiac implantable electronic device (CIED) and catheter ablation therapy in the European Society of Cardiology (ESC) area. Methods and results: The European Heart Rhythm Association (EHRA) has collected data on use of invasive arrhythmia managements since 2008. Fifty-one of the 56 ESC member countries provided data for the EHRA White Book 2015. This analysis is based on the current and previous editions of the EHRA White Book...
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 23, Issue 9, 1 1 2015, Pages 450
Carotid sinus massage for diagnosis in narrow QRS tachycardia.
Henkens IR, Zeppenfeld K, Hauer AD
Abstract
Cited 19 times since 2015 (1.8 per year)
source: EuropePMC
Echocardiography (Mount Kisco, N.Y.),
Volume 33, Issue 2, 1 1 2015, Pages 193-206
Reference Values for Echocardiography in Middle-Aged Population: The Cardiovascular Risk in Young Finns Study.
Ruohonen S, Koskenvuo JW, Wendelin-Saarenhovi M, Savontaus M, Kähönen M, Laitinen T, Lehtimäki T, Jokinen E, Viikari J, Juonala M, Taittonen L, Tossavainen P, Kallio M, Bax JJ, Raitakari O
Background: Population and sex-specific reference limits produced with modern ultrasound equipment are needed for accurate clinical echocardiography diagnostics. We report a comprehensive set of reference limits of cardiac function and dimensions in a group of young and middle-aged Finnish men and women produced by the recommendations of European Society of Echocardiography and American Society of Cardiology. Methods and results: Cardiac structure and function was studied in a standardized compr...
Abstract
