Research

Publications

Below you can find a list of our published research.

9543 results

Cited 8 times since 2015 (0.8 per year) source: EuropePMC

EBioMedicine, Volume 2, Issue 9, 31 5 2015, Pages 1217-1223 Continuous Postoperative Pericardial Flushing: A Pilot Study on Safety, Feasibility, and Effect on Blood Loss. Manshanden JS, Gielen CL, de Borgie CA, Klautz RJ, de Mol BA, Koolbergen DR

Background: Prolonged or excessive blood loss is a common complication after cardiac surgery. Blood remnants and clots, remaining in the pericardial space in spite of chest tube drainage, induce high fibrinolytic activity that may contribute to bleeding complications. Continuous postoperative pericardial flushing (CPPF) with an irrigation solution may reduce blood loss by preventing the accumulation of clots. In this pilot study, the safety and feasibility of CPPF were evaluated and the effect o... Abstract

Cited 83 times since 2015 (8 per year) source: EuropePMC

Nature protocols, Volume 10, Issue 9, 30 5 2015, Pages 1285-1296 Population-specific genotype imputations using minimac or IMPUTE2. van Leeuwen EM, Kanterakis A, Deelen P, Kattenberg MV, Genome of the Netherlands Consortium, Slagboom PE, de Bakker PI, Wijmenga C, Swertz MA, Boomsma DI, van Duijn CM, Karssen LC, Hottenga JJ

In order to meaningfully analyze common and rare genetic variants, results from genome-wide association studies (GWASs) of multiple cohorts need to be combined in a meta-analysis in order to obtain enough power. This requires all cohorts to have the same single-nucleotide polymorphisms (SNPs) in their GWASs. To this end, genotypes that have not been measured in a given cohort can be imputed on the basis of a set of reference haplotypes. This protocol provides guidelines for performing imputation... Abstract

Cited 38 times since 2015 (3.7 per year) source: EuropePMC

Physiology & behavior, Volume 151, 29 5 2015, Pages 246-251 Strongly bonded family members in common marmosets show synchronized fluctuations in oxytocin. Finkenwirth C, van Schaik C, Ziegler TE, Burkart JM

Oxytocin is a key regulator of social bonding and is positively linked to affiliation and prosocial behavior in several mammal species. In chimpanzees, this link is dyad-specific as affiliative interactions only elicit high oxytocin release if they involve strongly bonded individuals. These studies involved isolated dyads and sampling events. Little is known about the role of oxytocin in affiliation and social bonding, and about potential long-term patterns of bonding-related and dyad-specific o... Abstract

Cited 88 times since 2015 (8.5 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 100, Issue 3, 28 4 2015, Pages 1126-1131 Reported Outcome After Valve-Sparing Aortic Root Replacement for Aortic Root Aneurysm: A Systematic Review and Meta-Analysis. Arabkhani B, Mookhoek A, Di Centa I, Lansac E, Bekkers JA, De Lind Van Wijngaarden R, Bogers AJ, Takkenberg JJ

Valve-sparing aortic root techniques have progressively gained ground in the treatment of aortic root aneurysm and aortic insufficiency. By avoiding anticoagulation therapy they offer a good alternative to composite graft replacement. This systematic review describes the reported outcome of valve-sparing aortic root replacement, focusing on the remodeling and reimplantation technique. A systematic literature search on the characteristics of and outcomes after valve-sparing aortic root replacemen... Abstract

Cited 4 times since 2015 (0.4 per year) source: EuropePMC

European heart journal, Volume 36, Issue 40, 28 4 2015, Pages 2681-2685 Research ethics needs fine tuning, not rigidity: how to promote evidence in neglected patient populations by rethinking informed consent. Jukema JW, Brouwer JR, Lüscher TF, Engberts DP, Quax PH

Abstract

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 50, Issue 3, 28 4 2015, Pages 288 Kinking of a Superior Mesenteric Artery Stent due to Contraction of the Abdominal Wall. van Schaik P, Toorop R

Abstract

Cited 29 times since 2015 (2.8 per year) source: EuropePMC

Infection control and hospital epidemiology, Volume 36, Issue 10, 24 4 2015, Pages 1148-1154 Modeling spread of KPC-producing bacteria in long-term acute care hospitals in the Chicago region, USA. Haverkate MR, Bootsma MC, Weiner S, Blom D, Lin MY, Lolans K, Moore NM, Lyles RD, Weinstein RA, Bonten MJ, Hayden MK

Objective: Prevalence of bla KPC-encoding Enterobacteriaceae (KPC) in Chicago long-term acute care hospitals (LTACHs) rose rapidly after the first recognition in 2007. We studied the epidemiology and transmission capacity of KPC in LTACHs and the effect of patient cohorting. Methods: Data were available from 4 Chicago LTACHs from June 2012 to June 2013 during a period of bundled interventions. These consisted of screening for KPC rectal carriage, daily chlorhexidine bathing, medical staff educat... Abstract

Cited 160 times since 2015 (15.5 per year) source: EuropePMC

Lancet (London, England), Volume 386, Issue 10000, 22 4 2015, Pages 1269-1277 Laparoscopic peritoneal lavage or sigmoidectomy for perforated diverticulitis with purulent peritonitis: a multicentre, parallel-group, randomised, open-label trial. Vennix S, Musters GD, Mulder IM, Swank HA, Consten EC, Belgers EH, van Geloven AA, Gerhards MF, Govaert MJ, van Grevenstein WM, Hoofwijk AG, Kruyt PM, Nienhuijs SW, Boermeester MA, Vermeulen J, van Dieren S, Lange JF, Bemelman WA, Ladies trial colloborators

Background: Case series suggest that laparoscopic peritoneal lavage might be a promising alternative to sigmoidectomy in patients with perforated diverticulitis. We aimed to assess the superiority of laparoscopic lavage compared with sigmoidectomy in patients with purulent perforated diverticulitis, with respect to overall long-term morbidity and mortality. Methods: We did a multicentre, parallel-group, randomised, open-label trial in 34 teaching hospitals and eight academic hospitals in Belgium... Abstract

Cited 3 times since 2015 (0.3 per year) source: EuropePMC

Case reports in gastrointestinal medicine, Volume 2015, 22 4 2015, Pages 648417 A Rare Cause of Acute Abdomen: Perforation of Double Meckel's Diverticulum. Tas İ, Culcu S, Duzkoylu Y, Eryilmaz S, Deniz MM, Yilmaz D

Meckel's diverticulum is the most common congenital anomaly of the gastrointestinal tract. In this report, we aimed to represent a case of intestinal perforation, caused by double Meckel's diverticulum, which is a very rare entity in surgical practice. The patient was a 20-year-old Caucasian man, admitted to hospital with complaints of abdominal pain, nausea, and vomitting during the last 3 days. Physical examination indicated tenderness, rebound, and guarding in the right lower quadra... Abstract

European heart journal. Cardiovascular Imaging, Volume 17, Issue 6, 22 4 2015, Pages 652-659 Differential response of LV sublayer twist during dobutamine stress echocardiography as a novel marker of contractile reserve after acute myocardial infarction: relationship with follow-up LVEF improvement. Joyce E, Debonnaire P, Leong DP, Abate E, Katsanos S, Bax JJ, Delgado V, Ajmone Marsan N

Aims: Dobutamine stress echocardiography (DSE) is frequently performed to assess left ventricular (LV) contractile reserve in patients following myocardial infarction (STEMI). Given that resting LV sublayer twist assessment has been proposed as a marker of infarct transmurality, this study aimed to investigate whether response of LV subepicardial twist on DSE represents a novel quantitative marker of contractile reserve. Methods and results: First STEMI patients treated with primary percutaneous... Abstract

Cited 5 times since 2015 (0.5 per year) source: EuropePMC

Chirurgie de la main, Volume 34, Issue 4, 21 3 2015, Pages 205-209 Surgical treatment after a failed trapeziectomy: A case report. Goorens CK, Van Schaik DE, Goubau JF

Several treatment options exist to surgically treat end-stage trapeziometacarpal osteoarthritis. Trapeziectomy is recognized as leading to a mostly acceptable functional outcome. Although rarely encountered, persisting failure of the trapeziectomy is difficult to address. We present a case where several procedures were subsequently performed to treat a failed trapeziectomy condition. First, a trapeziometacarpal prosthesis (Arpe(®), Biomet(®)) was inserted with the two components reversed: the cu... Abstract

Cited 18 times since 2015 (1.7 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 150, Issue 5, 18 3 2015, Pages 1233-40.e1 Altered left ventricular vortex ring formation by 4-dimensional flow magnetic resonance imaging after repair of atrioventricular septal defects. Calkoen EE, Elbaz MS, Westenberg JJ, Kroft LJ, Hazekamp MG, Roest AA, van der Geest RJ

Objectives: During normal left ventricular (LV) filling, a vortex ring structure is formed distal to the left atrioventricular valve (LAVV). Vortex structures contribute to efficient flow organization. We aimed to investigate whether LAVV abnormality in patients with a corrected atrioventricular septal defect (AVSD) has an impact on vortex ring formation. Methods: Whole-heart 4D flow MRI was performed in 32 patients (age: 26 ± 12 years), and 30 healthy subjects (age: 25 ± 14 years). Vortex ring... Abstract

Cited 133 times since 2015 (12.8 per year) source: EuropePMC

Atherosclerosis, Volume 242, Issue 1, 17 3 2015, Pages 251-260 Valvular interstitial cells suppress calcification of valvular endothelial cells. Hjortnaes J, Shapero K, Goettsch C, Hutcheson JD, Keegan J, Kluin J, Mayer JE, Bischoff J, Aikawa E

Background: Calcific aortic valve disease (CAVD) is the most common heart valve disease in the Western world. We previously proposed that valvular endothelial cells (VECs) replenish injured adult valve leaflets via endothelial-to-mesenchymal transformation (EndMT); however, whether EndMT contributes to valvular calcification is unknown. We hypothesized that aortic VECs undergo osteogenic differentiation via an EndMT process that can be inhibited by valvular interstitial cells (VICs). Approach an... Abstract

Cited 15 times since 2015 (1.4 per year) source: EuropePMC

BMC cardiovascular disorders, Volume 15, 14 2 2015, Pages 68 Cathether-based interventional strategies for cor triatriatum in the adult - feasibility study through a hybrid approach. Li WW, Koolbergen DR, Bouma BJ, Hazekamp MG, de Mol BA, de Winter RJ

Background: Cor triatriatum is a rare congenital cardiac abnormality, consisting of an obstructing membrane between the pulmonary veins and the mitral valve in varying patterns. The entitiy can mimick the pathophysiology of mitral stenosis, necessitating surgical resection. Occasionally, percutaneous balloon dilatation of the membrane has been successfully performed. Case presentation: We report two cases with cor triatriatum where intraoperative balloon dilatation of the membrane was attempted... Abstract

Cited 48 times since 2015 (4.6 per year) source: EuropePMC

British journal of sports medicine, Volume 51, Issue 6, 14 2 2015, Pages 531-538 Early mobilisation versus plaster immobilisation of simple elbow dislocations: results of the FuncSiE multicentre randomised clinical trial. Iordens GI, Van Lieshout EM, Schep NW, De Haan J, Tuinebreijer WE, Eygendaal D, Van Beeck E, Patka P, Verhofstad MH, Den Hartog D, FuncSiE Trial Investigators

Background/aim: To compare outcome of early mobilisation and plaster immobilisation in patients with a simple elbow dislocation. We hypothesised that early mobilisation would result in earlier functional recovery. Methods: From August 2009 to September 2012, 100 adult patients with a simple elbow dislocation were enrolled in this multicentre randomised controlled trial. Patients were randomised to early mobilisation (n=48) or 3 weeks plaster immobilisation (n=52). Primary outcome measure was the... Abstract

Cited 13 times since 2015 (1.3 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 101, Issue 21, 14 2 2015, Pages 1717-1723 Individualised prediction of pulmonary homograft durability in tetralogy of Fallot. Bokma JP, Winter MM, Oosterhof T, Vliegen HW, van Dijk AP, Hazekamp MG, Koolbergen DR, Groenink M, Mulder BJ, Bouma BJ

Background: In patients with repaired tetralogy of Fallot (rTOF), multiple reoperations or percutaneous interventions after pulmonary valve replacement (PVR) may be necessary due to limited homograft durability. However, data to guide individualised prediction of homograft durability remain scarce. The aim of this study was to provide risk models for RV to pulmonary artery homograft durability. Methods: This retrospective multicentre study included consecutive patients with rTOF who had undergon... Abstract

Cited 40 times since 2015 (3.9 per year) source: EuropePMC

Neuroendocrinology, Volume 103, Issue 3-4, 14 2 2015, Pages 291-299 Subclinical Thyroid Dysfunction and Depressive Symptoms among the Elderly: A Prospective Cohort Study. Blum MR, Wijsman LW, Virgini VS, Bauer DC, den Elzen WP, Jukema JW, Buckley BM, de Craen AJ, Kearney PM, Stott DJ, Gussekloo J, Westendorp RG, Mooijaart SP, Rodondi N, PROSPER study group

Background: Subclinical hypothyroidism has been associated with depressive symptoms in cross-sectional studies, but prospective data and data on subclinical hyperthyroidism are scarce. Methods: In the Leiden substudy of the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER), thyroid-stimulating hormone and free T4 levels were measured at baseline and repeated after 6 months in adults aged 70-82 years with preexisting cardiovascular disease or known cardiovascular risk factors to d... Abstract

Cited 26 times since 2015 (2.5 per year) source: EuropePMC

European heart journal, Volume 36, Issue 29, 13 2 2015, Pages 1851-1877 Clinical trial design principles and endpoint definitions for transcatheter mitral valve repair and replacement: part 1: clinical trial design principles: A consensus document from the mitral valve academic research consortium. Stone GW, Vahanian AS, Adams DH, Abraham WT, Borer JS, Bax JJ, Schofer J, Cutlip DE, Krucoff MW, Blackstone EH, Généreux P, Mack MJ, Siegel RJ, Grayburn PA, Enriquez-Sarano M, Lancellotti P, Filippatos G, Kappetein AP, Mitral Valve Academic Research Consortium (MVARC)

Mitral regurgitation (MR) is one of the most prevalent valve disorders and has numerous aetiologies, including primary (organic) MR, due to underlying degenerative/structural mitral valve (MV) pathology, and secondary (functional) MR, which is principally caused by global or regional left ventricular remodelling and/or severe left atrial dilation. Diagnosis and optimal management of MR requires integration of valve disease and heart failure specialists, MV cardiac surgeons, interventional cardio... Abstract

Cited 138 times since 2015 (13.3 per year) source: EuropePMC

European heart journal, Volume 36, Issue 29, 13 2 2015, Pages 1878-1891 Clinical trial design principles and endpoint definitions for transcatheter mitral valve repair and replacement: part 2: endpoint definitions: A consensus document from the Mitral Valve Academic Research Consortium. Stone GW, Adams DH, Abraham WT, Kappetein AP, Généreux P, Vranckx P, Mehran R, Kuck KH, Leon MB, Piazza N, Head SJ, Filippatos G, Vahanian AS, Mitral Valve Academic Research Consortium (MVARC)

Cited 11 times since 2015 (1.1 per year) source: EuropePMC

SpringerPlus, Volume 4, 10 2 2015, Pages 336 Myocardial infarction models in NOD/Scid mice for cell therapy research: permanent ischemia vs ischemia-reperfusion. van Zuylen VL, den Haan MC, Roelofs H, Fibbe WE, Schalij MJ, Atsma DE

Myocardial infarction animal studies are used to study disease mechanisms and new treatment options. Typically, myocardial infarction (MI) is induced by permanent occlusion of the left anterior descending artery. Since in MI patients coronary blood flow is often restored new experimental models better reflecting clinical practice are needed. Here, permanent ischemia MI (PI group) was compared with transient ischemia (45 min) (IR group) in immunodeficient NOD/Scid mice. Cardiac function, infarct... Abstract