Research

Publications

Below you can find a list of our published research.

9543 results

Cited 16 times since 2015 (1.5 per year) source: EuropePMC

Drug metabolism and personalized therapy, Volume 30, Issue 1, 1 1 2015, Pages 43-48 No effect of CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) on lipid-lowering response to statins in Greek patients with primary hypercholesterolemia. Ragia G, Kolovou V, Tavridou A, Elens L, Tselepis AD, Elisaf M, Van Schaik RH, Kolovou G, Manolopoulos VG

Background: Interindividual variability exists in statin lipid-lowering response, partially attributed to genetic factors. CYP3A4 intron 6 C>T polymorphism (CYP3A4*22 allele, rs35599367) has been recently identified and was associated with reduced CYP3A4 expression. We analyzed the association of CYP3A4*22 allele with response to atorvastatin and simvastatin. Methods: A total of 416 statin-treated (207 atorvastatin- and 209 simvastatin-treated) adults with primary hypercholesterolemia were in... Abstract

Cited 7 times since 2015 (0.7 per year) source: EuropePMC

Pediatric emergency care, Volume 31, Issue 3, 1 1 2015, Pages 186-189 Useful but not used: pediatric critical care physician views on bedside ultrasound. Kornblith AE, van Schaik S, Reynolds T

Objective: The purpose of this study was to assess the learning needs of pediatric critical care (PCC) physicians in bedside ultrasound (BUS) use. Methods: This was a survey-based study conducted at an academic center with a PCC fellowship program. We surveyed PCC fellows and faculty to elicit their views on BUS and asked them about the frequency of use, their perception of the clinical utility, and their level of confidence in performing different BUS applications. Results: There was no statist... Abstract

Cited 3 times since 2015 (0.3 per year) source: EuropePMC

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, Volume 26, Issue 2, 1 1 2015, Pages 168-172 A successful desensitization protocol for horse-derived antithymocyte globulin in severe aplastic anemia. Demir E, Cigerci Günaydın N, Karadaş N, Gülen F, Tanac R, Yılmaz D

Background: Horse antithymocyte globulin (h-ATG) (ATGAM(®) ) is the first choice of treatment in very severe patients with aplastic anemia who do not have any HLA matched sibling donor. h-ATG is a heterologous serum that may cause anaphylaxis. Alternative treatment strategies must be planned in case of hypersensitivity. Desensitization must be considered in patients without an alternative treatment of choice. We aimed to present the h-ATG desensitization protocol and consider its effectiveness i... Abstract

Cited 242 times since 2015 (22.6 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 8, Issue 3, 1 1 2015, Pages e002179 Detection of significant coronary artery disease by noninvasive anatomical and functional imaging. Neglia D, Rovai D, Caselli C, Pietila M, Teresinska A, Aguadé-Bruix S, Pizzi MN, Todiere G, Gimelli A, Schroeder S, Drosch T, Poddighe R, Casolo G, Anagnostopoulos C, Pugliese F, Rouzet F, Le Guludec D, Cappelli F, Valente S, Gensini GF, Zawaideh C, Capitanio S, Sambuceti G, Marsico F, Perrone Filardi P, Fernández-Golfín C, Rincón LM, Graner FP, de Graaf MA, Fiechter M, Stehli J, Gaemperli O, Reyes E, Nkomo S, Mäki M, Lorenzoni V, Turchetti G, Carpeggiani C, Marinelli M, Puzzuoli S, Mangione M, Marcheschi P, Mariani F, Giannessi D, Nekolla S, Lombardi M, Sicari R, Scholte AJ, Zamorano JL, Kaufmann PA, Underwood SR, Knuuti J, EVINCI Study Investigators

Background: The choice of imaging techniques in patients with suspected coronary artery disease (CAD) varies between countries, regions, and hospitals. This prospective, multicenter, comparative effectiveness study was designed to assess the relative accuracy of commonly used imaging techniques for identifying patients with significant CAD. Methods and results: A total of 475 patients with stable chest pain and intermediate likelihood of CAD underwent coronary computed tomographic angiography an... Abstract

Cited 18 times since 2015 (1.7 per year) source: EuropePMC

International journal of cardiology, Volume 184, 25 4 2015, Pages 405-411 High-sensitive troponin-T in adult congenital heart disease. Eindhoven JA, Roos-Hesselink JW, van den Bosch AE, Kardys I, Cheng JM, Veenis JF, Cuypers JAAE, Witsenburg M, van Schaik RHN, Boersma E

Background: Adult congenital heart disease (ACHD) patients are at risk of late complications including arrhythmias, heart failure and sudden death. High-sensitive troponin-T (hs-TnT) is the standard for diagnosing acute coronary syndrome, but is also associated with cardiac function and prognosis in other cardiac diseases. We aimed to describe hs-TnT level in ACHD patients, and determine its relationship with cardiac function and other biomarkers. Methods: Consecutive ACHD patients, visiting the... Abstract

Cited 37 times since 2015 (3.4 per year) source: EuropePMC

Journal of virological methods, Volume 217, 21 3 2015, Pages 55-63 Optimization of an enzyme-linked lectin assay suitable for rapid antigenic characterization of the neuraminidase of human influenza A(H3N2) viruses. Westgeest KB, Bestebroer TM, Spronken MI, Gao J, Couzens L, Osterhaus AD, Eichelberger M, Fouchier RA, de Graaf M

Antibodies to neuraminidase (NA), the second most abundant surface protein of the influenza virus, contribute to protection against influenza virus infection. Although traditional and miniaturized thiobarbituric acid (TBA) neuraminidase inhibition (NI) assays have been successfully used to characterize the antigenic properties of NA, these methods are cumbersome and not easily amendable to rapid screening. An additional difficulty of the NI assay is the interference by hemagglutinin (HA)-specifi... Abstract

Cited 18 times since 2015 (1.7 per year) source: EuropePMC

Academic radiology, Volume 22, Issue 5, 20 3 2015, Pages 632-639 Volumetric and two-dimensional image interpretation show different cognitive processes in learners. van der Gijp A, Ravesloot CJ, van der Schaaf MF, van der Schaaf IC, Huige JC, Vincken KL, Ten Cate OT, van Schaik JP

Rationale and objectives: In current practice, radiologists interpret digital images, including a substantial amount of volumetric images. We hypothesized that interpretation of a stack of a volumetric data set demands different skills than interpretation of two-dimensional (2D) cross-sectional images. This study aimed to investigate and compare knowledge and skills used for interpretation of volumetric versus 2D images. Materials and methods: Twenty radiology clerks were asked to think out loud... Abstract

Cited 44 times since 2015 (4.1 per year) source: EuropePMC

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, Volume 17, 19 3 2015, Pages 18 Characterization and quantification of dynamic eccentric regurgitation of the left atrioventricular valve after atrioventricular septal defect correction with 4D Flow cardiovascular magnetic resonance and retrospective valve tracking. Calkoen EE, Westenberg JJ, Kroft LJ, Blom NA, Hazekamp MG, Rijlaarsdam ME, Jongbloed MR, de Roos A, Roest AA

Background: To characterize and directly quantify regurgitant jets of left atrioventricular valve (LAVV) in patients with corrected atrioventricular septal defect (AVSD) by four-dimensional (4D)Flow Cardiovascular Magnetic Resonance (CMR), streamline visualization and retrospective valve tracking. Methods: Medical ethical committee approval and informed consent from all patients or their parents were obtained. In 32 corrected AVSD patients (age 26 ± 12 years), echocardiography and whole-heart 4D... Abstract

Cited 224 times since 2015 (20.8 per year) source: EuropePMC

Circulation research, Volume 116, Issue 8, 19 3 2015, Pages 1346-1360 Meta-Analysis of Cell-based CaRdiac stUdiEs (ACCRUE) in patients with acute myocardial infarction based on individual patient data. Gyöngyösi M, Wojakowski W, Lemarchand P, Lunde K, Tendera M, Bartunek J, Marban E, Assmus B, Henry TD, Traverse JH, Moyé LA, Sürder D, Corti R, Huikuri H, Miettinen J, Wöhrle J, Obradovic S, Roncalli J, Malliaras K, Pokushalov E, Romanov A, Kastrup J, Bergmann MW, Atsma DE, Diederichsen A, Edes I, Benedek I, Benedek T, Pejkov H, Nyolczas N, Pavo N, Bergler-Klein J, Pavo IJ, Sylven C, Berti S, Navarese EP, Maurer G, ACCRUE Investigators

Rationale: The meta-Analysis of Cell-based CaRdiac study is the first prospectively declared collaborative multinational database, including individual data of patients with ischemic heart disease treated with cell therapy. Objective: We analyzed the safety and efficacy of intracoronary cell therapy after acute myocardial infarction (AMI), including individual patient data from 12 randomized trials (ASTAMI, Aalst, BOOST, BONAMI, CADUCEUS, FINCELL, REGENT, REPAIR-AMI, SCAMI, SWISS-AMI, TIME, LATE... Abstract

Cited 27 times since 2015 (2.5 per year) source: EuropePMC

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 49, Issue 4, 18 3 2015, Pages 480-486 Elastin is a key regulator of outward remodeling in arteriovenous fistulas. Wong CY, Rothuizen TC, de Vries MR, Rabelink TJ, Hamming JF, van Zonneveld AJ, Quax PH, Rotmans JI

Objectives: Maturation failure is the major limitation of arteriovenous fistulas (AVFs) as hemodialysis access conduits. Indeed, 30-50% of AVFs fail to mature due to intimal hyperplasia and insufficient outward remodeling. Elastin has emerged as an important determinant of vascular remodeling. Here the role of elastin in AVF remodeling in elastin haplodeficient (eln(+/-)) mice undergoing AVF surgery has been studied. Methods: Unilateral AVFs between the branch of the jugular vein and carotid art... Abstract

Cited 34 times since 2015 (3.2 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 17, Issue 5, 16 3 2015, Pages 689-700 How adequate are the current methods of lead extraction? A review of the efficiency and safety of transvenous lead extraction methods. Buiten MS, van der Heijden AC, Schalij MJ, van Erven L

Currently several extraction tools are available in order to allow safe and successful transvenous lead extraction (TLE) of pacemaker and ICD leads; however, no directives exist to guide physicians in their choice of extraction tools and approaches. To aim of the current review is to provide an overview of the success and complication rates of different extraction methods and tools available. A comprehensive search of all published literature was conducted in the databases of PubMed, Embase, Web... Abstract

Cited 13 times since 2015 (1.2 per year) source: EuropePMC

Autonomic neuroscience : basic & clinical, Volume 189, 14 2 2015, Pages 60-67 New insights in the neuroanatomy of the human adult superior hypogastric plexus and hypogastric nerves. Kraima AC, van Schaik J, Susan S, van de Velde CJ, Hamming JF, Lakke EA, DeRuiter MC

Background: The superior hypogastric plexus (SHP) is an autonomic plexus, located ventrally to the abdominal aorta and its bifurcation, innervating pelvic viscera. It is classically described as being composed of merely sympathetic fibres. However, post-operative complications after surgery damaging the peri-aortic retroperitoneal compartment suggest the existence of parasympathetic fibres. This immunohistochemical study describes the neuroanatomical composition of the human mature SHP. Material... Abstract

Cited 15 times since 2015 (1.4 per year) source: EuropePMC

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, Volume 24, Issue 8, 13 2 2015, Pages 2015-2023 Short Musculoskeletal Function Assessment: normative data of the Dutch population. de Graaf MW, El Moumni M, Heineman E, Wendt KW, Reininga IH

Background: The Short Musculoskeletal Function Assessment (SMFA) is widely used in both research and clinical practice. Despite its frequent use, normative data of the SMFA have remained limited. Aim of this study was to gather normative data for the Dutch SMFA (SMFA-NL). Methods: The SMFA-NL consists of two indices (function index and bother index) and four subscales (upper extremity dysfunction, lower extremity dysfunction, mental and emotional problems, and problems with daily activities). A... Abstract

Cited 5 times since 2015 (0.5 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 16, Issue 8, 13 2 2015, Pages 863-870 Changes in ischaemia as assessed with single-photon emission computed tomography myocardial perfusion imaging in high-risk patients with diabetes without cardiac symptoms: relation with coronary atherosclerosis on computed tomography coronary angiography. de Graaf MA, Roos CJ, Mansveld JM, Kharagjitsingh AV, Dibbets-Schneider P, Kroft LJ, Jukema JW, Ficaro EP, Bax JJ, Scholte AJ

Aims: The study aims (i) to evaluate changes in myocardial ischaemia on single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) after 2 years in a cohort of high-risk patients with diabetes without cardiac symptoms or known coronary artery disease (CAD) and (ii) to assess the value of baseline computed tomography coronary angiography (CTA)-derived coronary atherosclerosis parameters to predict changes in myocardial ischaemia. Methods and results: The population cons... Abstract

Cited 8 times since 2015 (0.7 per year) source: EuropePMC

Academic radiology, Volume 22, Issue 5, 13 2 2015, Pages 640-645 Support for external validity of radiological anatomy tests using volumetric images. Ravesloot CJ, van der Gijp A, van der Schaaf MF, Huige JC, Vincken KL, Mol CP, Bleys RL, ten Cate OT, van Schaik JP

Rationale and objectives: Radiology practice has become increasingly based on volumetric images (VIs), but tests in medical education still mainly involve two-dimensional (2D) images. We created a novel, digital, VI test and hypothesized that scores on this test would better reflect radiological anatomy skills than scores on a traditional 2D image test. To evaluate external validity we correlated VI and 2D image test scores with anatomy cadaver-based test scores. Materials and methods: In 2012,... Abstract

Cited 11 times since 2015 (1 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 17, Issue 7, 10 2 2015, Pages 1122-1128 An easy-to-use, operator-independent, clinical model to predict the left vs. right ventricular outflow tract origin of ventricular arrhythmias. Penela D, De Riva M, Herczku C, Catto V, Pala S, Fernández-Armenta J, Acosta J, Cipolletta L, Andreu D, Borras R, Rios J, Mont L, Brugada J, Carbucicchio C, Zeppenfeld K, Berruezo A

Aims: To identify clinical characteristics able to predict a left ventricular outflow tract (LVOT) origin in outflow tract ventricular arrhythmias (OTVAs). Methods and results: We included 117 consecutive patients (training sample) with successful radiofrequency ablation of OTVA in one centre. A predictive model for LVOT origin was obtained using clinical data. The model was prospectively validated in a second population (testing sample) of 143 patients from two additional centres. In training s... Abstract

Cited 9 times since 2015 (0.8 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 28, Issue 4, 9 2 2015, Pages 455-462 Mitral valve geometry changes in patients with aortic regurgitation. Regeer MV, Al Amri I, Versteegh MI, Bax JJ, Marsan NA, Delgado V

Background: Changes in mitral valve geometry in patients with significant aortic regurgitation (AR) have not been evaluated. The aim of the present study was to assess the prevalence of significant secondary mitral regurgitation (MR; grade ≥ 2) and the geometric characteristics of the mitral valve in patients with moderate and severe AR (grade ≥ 2) undergoing aortic valve and root surgery. Methods: One-hundred twenty patients (mean age, 54 ± 15 years; 65% men) with AR grade ≥ 2 undergoing aortic... Abstract

Cited 138 times since 2015 (12.8 per year) source: EuropePMC

Circulation. Cardiovascular genetics, Volume 8, Issue 2, 7 1 2015, Pages 398-409 Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI. Verhaaren BF, Debette S, Bis JC, Smith JA, Ikram MK, Adams HH, Beecham AH, Rajan KB, Lopez LM, Barral S, van Buchem MA, van der Grond J, Smith AV, Hegenscheid K, Aggarwal NT, de Andrade M, Atkinson EJ, Beekman M, Beiser AS, Blanton SH, Boerwinkle E, Brickman AM, Bryan RN, Chauhan G, Chen CP, Chouraki V, de Craen AJ, Crivello F, Deary IJ, Deelen J, De Jager PL, Dufouil C, Elkind MS, Evans DA, Freudenberger P, Gottesman RF, Guðnason V, Habes M, Heckbert SR, Heiss G, Hilal S, Hofer E, Hofman A, Ibrahim-Verbaas CA, Knopman DS, Lewis CE, Liao J, Liewald DC, Luciano M, van der Lugt A, Martinez OO, Mayeux R, Mazoyer B, Nalls M, Nauck M, Niessen WJ, Oostra BA, Psaty BM, Rice KM, Rotter JI, von Sarnowski B, Schmidt H, Schreiner PJ, Schuur M, Sidney SS, Sigurdsson S, Slagboom PE, Stott DJ, van Swieten JC, Teumer A, Töglhofer AM, Traylor M, Trompet S, Turner ST, Tzourio C, Uh HW, Uitterlinden AG, Vernooij MW, Wang JJ, Wong TY, Wardlaw JM, Windham BG, Wittfeld K, Wolf C, Wright CB, Yang Q, Zhao W, Zijdenbos A, Jukema JW,

Background: The burden of cerebral white matter hyperintensities (WMH) is associated with an increased risk of stroke, dementia, and death. WMH are highly heritable, but their genetic underpinnings are incompletely characterized. To identify novel genetic variants influencing WMH burden, we conducted a meta-analysis of multiethnic genome-wide association studies. Methods and results: We included 21 079 middle-aged to elderly individuals from 29 population-based cohorts, who were free of dementia... Abstract

Cited 7 times since 2015 (0.6 per year) source: EuropePMC

BMC surgery, Volume 15, 6 1 2015, Pages 12 Wound Infections Following Implant removal below the knee: the effect of antibiotic prophylaxis; the WIFI-trial, a multi-centre randomized controlled trial. Backes M, Dingemans SA, Schep NW, Bloemers FW, Van Dijkman B, Garssen FP, Haverlag R, Hoogendoorn JM, Joosse P, Mirck B, Postma V, Ritchie E, Roerdink WH, Sintenie JB, Soesman NM, Sosef NL, Twigt BA, Van Veen RN, Van der Veen AH, Van Velde R, Vos DI, De Vries MR, Winkelhagen J, Goslings JC, Schepers T

Background: In the Netherlands about 18,000 procedures with implant removal are performed annually following open or closed reduction and fixation of fractures, of which 30-80% concern the foot, ankle and lower leg region. For clean surgical procedures, the rate of postoperative wound infections (POWI) should be less than ~2%. However, rates of 10-12% following implant removal have been reported, specifically after foot, ankle and lower leg fractures. Currently, surgeons individually decide if a... Abstract

Cited 15 times since 2015 (1.4 per year) source: EuropePMC

Frontiers in psychology, Volume 6, 6 1 2015, Pages 91 Apes have culture but may not know that they do. Gruber T, Zuberbühler K, Clément F, van Schaik C

There is good evidence that some ape behaviors can be transmitted socially and that this can lead to group-specific traditions. However, many consider animal traditions, including those in great apes, to be fundamentally different from human cultures, largely because of lack of evidence for cumulative processes and normative conformity, but perhaps also because current research on ape culture is usually restricted to behavioral comparisons. Here, we propose to analyze ape culture not only at the... Abstract